更新于：2024-11-01

HLA class II抗原 x IgM

更新于：2024-11-01

基本信息

关联

项与 HLA class II抗原 x IgM 相关的药物

BTA-106

靶点

HLA class II抗原 x IgM

作用机制

HLA class II抗原调节剂 [+1]

在研机构

Zenyaku Kogyo Co., Ltd.

原研机构

Zenyaku Kogyo Co., Ltd.

在研适应症

B细胞淋巴瘤

非在研适应症-

最高研发阶段药物发现

首次获批国家/地区-

首次获批日期1800-01-20

100 项与 HLA class II抗原 x IgM 相关的临床结果

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100 项与 HLA class II抗原 x IgM 相关的转化医学

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0 项与 HLA class II抗原 x IgM 相关的专利（医药）

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123

项与 HLA class II抗原 x IgM 相关的文献（医药）

2024-03-01·Brain

Cell-binding IgM in CSF is distinctive of multiple sclerosis and targets the iron transporter SCARA5

Article

作者: Callegari, Ilaria ; Cagol, Alessandro ; Kuhle, Jens ; Diebold, Martin ; Derfuss, Tobias ; Voortman, Margarete M ; Du Pasquier, Renaud ; Lanner, Ulrike ; Becher, Burkhard ; Oechtering, Johanna ; Khalil, Michael ; Sanderson, Nicholas S R ; Junker, Andreas ; Holdermann, Sebastian ; Schneider, Mika ; Mathias, Amandine ; Kreiner, Victor ; Kappos, Ludwig ; Granziera, Cristina ; Perriot, Sylvain

AbstractIntrathecal IgM production in multiple sclerosis is associated with a worse disease course. To investigate pathogenic relevance of autoreactive IgM in multiple sclerosis, CSF from two independent cohorts, including multiple sclerosis patients and controls, were screened for antibody binding to induced pluripotent stem cell-derived neurons and astrocytes, and a panel of CNS-related cell lines. IgM binding to a primitive neuro-ectodermal tumour cell line discriminated 10% of multiple sclerosis donors from controls. Transcriptomes of single IgM producing CSF B cells from patients with cell-binding IgM were sequenced and used to produce recombinant monoclonal antibodies for characterization and antigen identification. We produced five cell-binding recombinant IgM antibodies, of which one, cloned from an HLA-DR + plasma-like B cell, mediated antigen-dependent complement activation. Immunoprecipitation and mass spectrometry, and biochemical and transcriptome analysis of the target cells identified the iron transport scavenger protein SCARA5 as the antigen target of this antibody. Intrathecal injection of a SCARA5 antibody led to an increased T cell infiltration in an experimental autoimmune encephalomyelitis (EAE) model. CSF IgM might contribute to CNS inflammation in multiple sclerosis by binding to cell surface antigens like SCARA5 and activating complement, or by facilitating immune cell migration into the brain.

2022-12-01·BMC Pulmonary Medicine

B cell subsets were associated with prognosis in elderly patients with community acquired pneumonia

Article

作者: Liu, Si-Ting ; Li, Zhi-Fang ; Zhang, Xiao-Ming ; Li, Yin-Zhen ; Xu, Hui-Hui ; Zhang, Ying ; Huo, Fang-Jie ; Li, Hong-Qiang ; Wang, Chun-Mei ; Bai, Jian-Wen

AbstractBackgroundThe role of B cell subsets remained to be elucidated in a variety of immune diseases, though which was used as an effective biomarker for anti-inflammatory or antiviral response. This study aimed to evaluate the early changes of B cell subtypes distribution in elderly patients with community acquired pneumonia (CAP), as well as the association between B cell subtypes and prognosis.MethodsThis prospective study included elderly patients with CAP, severe CAP (sCAP) and healthy elderly subjects between April 2016 and March 2018. Flow cytometry was used to detect CD3, CD20, HLA-DR, CD24, CD27, CD38, IgM, and IgD. CD20+ B cells were further divided into naïve B cells (Bn), IgM/D+ memory B cells (IgM+ Bm), switched B cells (SwB), and transitional B cells (Btr).ResultsA total of 22 healthy controls, 87 patients with CAP and 58 patients with sCAP were included in the study. Compared to CAP, sCAP was characterized by significantly lower absolute number of B cells, Bn and Btr, significantly lower Btr and Bn subset percentage, while percentage of IgM+ Bm was significantly higher. Heat map showed Bn and Btr on day 3 and day 7 was negatively correlated with activated partial prothrombin time (APTT), international normalized ratio (INR), sequential organ failure assessment score (SOFA) and Acute Physiology and Chronic Health Evaluation II (APACHE II). After 28-day follow-up, Btr percentage in survival group was significantly higher. Receiver operator characteristic (ROC) curve analysis found that Btr count showed sensitivity of 48.6% and specificity of 87.0% for predicting the 28-day survival, with an area under the ROC curves of 0.689 (p = 0.019).ConclusionsSeverity and prognosis of CAP in elderly people is accompanied by changes in the B cell subsets. Btr subsets could play prognostic role for a short-term mortality of elderly CAP patients.

2022-09-01·Microbial Pathogenesis

Characterization of the pathogenesis and immune response to a highly virulent Edwardsiella tarda strain responsible for mass mortality in the hybrid snakehead (Channa maculate ♀ × Channa argus ♂)

Article

作者: Guo, Mengya ; Cao, Pan ; Zhang, Liwen ; Ye, Jiaxin ; Liu, Xiaodan ; Zhou, Zicheng ; He, Xiao

Edwardsiella tarda is reported as the causative agent of the systemic disease Edwardsiellosis in fish, which lead to huge economic losses in aquaculture. The pathogenicity and immune response to a highly virulent E. tarda isolate responsible for mass mortality in hybrid snakehead were performed. After species identification, morphology and virulence gene detection of Edwardsiella isolated from hybrid snakehead, the pathogenicity of the strain and histopathological changes in infected fish were analyzed. The infected fish exhibited typical acute hemorrhagic symptoms and enlarged internal organs. Histopathology revealed that the liver, spleen, kidney and intestinal tissues of diseased fish exhibited marked inflammatory with vacuolar degeneration and cell necrosis. Subsequently, humoral immune factors such as superoxide dismutase, lysozyme and acid phosphatase activities were detected as serum indicators, and real-time quantitative PCR was used to investigate immune-related genes (STAT1, HSP70, IgM, IL-6, IL-8, TRAF2, CD40, HLA-DMA and LCK) expression patterns in liver, spleen and head kidney. The results showed that these enzyme activity indicators and immune-related gene expression were significantly activated compared with healthy fish. These data provide insight into the pathogenic mechanisms and host immune responses of E. tarda, which could be useful for the future prevention and treatment of Edwardsiellosis in fish.