更新于：2024-11-01

SQOR

更新于：2024-11-01

基本信息

别名

CGI-44、SQOR、SQR

+ [4]

简介

Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone-10, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro) (PubMed:22852582). It is believed the in vivo electron acceptor is glutathione (PubMed:25225291, PubMed:29715001).

关联

项与 SQOR 相关的药物

STI1

靶点

SQOR

作用机制

SQOR inhibitors

在研机构

Drexel University

原研机构

Drexel University

在研适应症

射血分数降低的心力衰竭

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期1800-01-20

100 项与 SQOR 相关的临床结果

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100 项与 SQOR 相关的转化医学

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0 项与 SQOR 相关的专利（医药）

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300

项与 SQOR 相关的文献（医药）

2024-12-01·Water Research

Mechanistic insights into Fe3O4-mediated inhibition of H2S gas production in sludge anaerobic digestion

Article

作者: Fu, Qizi ; Xu, Yunhao ; Liu, Xuran ; Li, Xuemei ; Ma, Xingyu ; Yang, Fan ; Wang, Yan ; Wang, Dongbo

The addition of iron-based conductive materials has been extensively validated as a highly effective approach to augment methane generation from anaerobic digestion (AD) process. In this work, it was additionally discovered that Fe₃O₄ notably suppressed the production of hazardous H₂S gas during sludge AD. As the addition of Fe₃O₄ increased from 0 to 20 g/L, the accumulative H₂S yields decreased by 89.2 % while the content of element sulfur and acid volatile sulfide (AVS) respectively increased by 55.0 % and 30.4 %. Mechanism analyses showed that the added Fe₃O₄ facilitated sludge conductive capacity, and boosted the efficiency of extracellular electron transfer, which accelerated the bioprocess of sulfide oxidation. Although Fe₃O₄ can chemically oxidize sulfide to elemental sulfur, microbial oxidation plays a major role in reducing H₂S accumulation. Moreover, the released iron ions reacted with soluble sulfide, which promoted the chemical equilibrium of sulfide species from H₂S to metal sulfide. Microbial analysis showed that some SRBs (i.e., Desulfomicrobium and Defluviicoccus) and SOB (i.e., Sulfuritalea) changed into keystone taxa (i.e., connectors and module hubs) in the reactor with Fe₃O₄ addition, showing that the functions of sulfate reduction and sulfur oxidation may play important roles in Fe₃O₄-present system. Fe₃O₄ presence also increased the content of functional genes encoding sulfide quinone reductase and flavocytochrome c sulfidedehydrogenase (e.g., Sqr and Fcc) that could oxidize sulfide to sulfur. The impact of other iron-based conductive material (i.e., zero-valent iron) was also verified, and the results showed that it could also significantly reduce H₂S production. These findings provide new insights into the effect of iron-based conductive materials on anaerobic process, especially sulfur conversion.

2024-12-01·Journal of Hazardous Materials

Bioelectricity drives transformation of nitrogen and perfluorooctanoic acid in constructed wetlands: Performances and mechanisms

Article

作者: Wang, Luming ; Yao, Jiawei ; Qian, Xiuwen ; Wu, Yufeng ; Huang, Juan ; Wang, Xinyue ; Cao, Chong

In this study, constructed wetland-microbial fuel cell (CW-MFC) filled with modified basalt fiber (MBF) via iron modification was utilized for treating perfluorooctanoic acid (PFOA) containing sewage. Results showed the significant promotion by bioelectricity on ammonium and total nitrogen by 7.80-8.14 %. Although such enhancement was suppressed by PFOA, higher removal was still observed with closed circuit, and PFOA removal also increased by 9.05 %. Bioelectricity contributed to enrichment of bacteria involved in nitrifying (Nitrospira and Ellin6067), denitrifying (like Thauera and Dechloromonas), iron redox (Geobacter), and sulfate-reducing (Desulfobacter), aligned with up-regulated of functional genes, including amoA, narG , napA, narK, narS, nrfA, sulp and sqr. Enrichment of autohydrogenotrophic and sulfide-oxidizing autotrophic denitrifiers, and nitrate dependent iron oxidation bacteria by bioelectricity all promoted denitrification. Moreover, bioelectricity boosted relative abundance of organic compounds degradation enzymes, such as dehydrogenase, decarboxylase, and dehalogenase, supporting the enhancement on PFOA removal. Generally, PFOA was converted to short-chain perfluorocarboxylic acids (PFCAs) via decarboxylation, hydroxylation, HF elimination, hydrolysis, F^- elimination, C-C bond scission, and dehydration in CW-MFC. The final PFCAs-products determined was perfluorobutyric acid. This work estimated feasibility of treating PFOA containing sewage by CM-MFC, and offered new insights on enhancing mechanisms of nitrogen and PFOA conversion.

2024-10-01·Bioresource Technology

Effects of O2 on accumulation of nitrous and elemental sulfur and microbial community structure in double short-cut sulfur autotrophic denitrification system

Article

作者: Li, Xiang ; Shi, Miao ; Dang, Pengze ; Huang, Tianyu ; Yuan, Yan ; Zhou, Cheng ; Xu, Qian ; Huang, Yong

Understanding the effect of O₂ on the accumulation characteristics of NO₂^--N and S⁰ in the sulfur autotrophic denitrification (DSSADN) system is crucial for enhancing the denitrification efficiency of partial nitrification-anammox using DSSADN. The results revealed that in an environment without O₂ entry, the NO₂^--N accumulation efficiency (NiAE) and S⁰ accumulation efficiency (S⁰AE) of the DSSADN system reached 89.40 % and 93.41 %, respectively. Once system entered O₂, ORP value kept increasing. When ORP increased to -59.9 mV (DO = 0.1 mg/L), soxB and nirK gene expression rose and as well NiAE and S⁰AE continuously decreased to 48.13 % and 29.35 %. When ORP was above 30.9 mV (DO >0.2 mg/L) but below 81.0 mV (DO<0.4 mg/L), narG gene expression reduced and the relatively high sqr gene expression allowed NiAE and S⁰AE remained at 45.08 % and 33.31 %. O₂ promoted the synergistic effect of Thiobacillus and Azoarcus without the proliferation of nitrite oxidizing bacteria.

项与 SQOR 相关的新闻（医药）

2022-09-28

·中国生物技术网

mLife | 深海硫酸盐还原菌可通过代谢硫代硫酸钠形成单质硫

中国科学院海洋研究所孙超岷研究员团队的文章“A deep‐sea sulfate‐reducing bacterium generates zero‐valent sulfur via metabolizing thiosulfate”于2022年9月23日在mLife 正式上线。该研究团队基于从南海冷泉中获得的硫酸盐还原菌及深海原位条件下该菌代谢不同硫源等开展了实验，发现了南海冷泉中硫酸盐还原菌能够通过代谢硫代硫酸钠形成单质硫，为研究我国南海冷泉广泛分布单质硫的成因提供了新思路。背景介绍单质硫是硫地球生物化学循环中的重要中间体。我国科研人员基于拉曼光谱检测到南海冷泉环境中单质硫含量丰富，但其形成原因尚不清晰。前期的研究成果表明，硫氧化菌是深海环境中单质硫形成的重要贡献者。然而，在深海冷泉环境中广泛分布的硫酸盐还原菌是否会介导单质硫的形成却鲜有报道。科学发现借助“科学号”科考船2018年南海冷泉航次获得的样品，孙超岷研究团队分离培养了一株典型硫酸盐还原菌Oceanidesulfovibrio marinus CS1。结合拉曼光谱及扫描电镜结果证实该硫酸盐还原菌能通过代谢硫代硫酸钠形成单质硫；结合蛋白组学及蛋白体外表达和功能分析等手段证实硫代硫酸盐还原酶(PhsA)及硫化:醌氧化还原酶(SQR)在驱动单质硫形成过程中起到关键作用。在这个过程中，硫代硫酸盐先被PhsA还原生成硫化物，然后硫化物被SQR氧化生成单质硫（图1）。图1 深海硫酸盐还原菌Oceanidesulfovibrio marinus CS1代谢硫代硫酸钠形成单质硫为了验证该硫酸盐还原菌在深海原位是否也能发挥类似的功能，科研人员借助“科学号”科考船2020年的南海冷泉航次，将该硫酸盐还原菌布放在深海冷泉喷口附近并培养了10 天。通过蛋白组学等实验证实：与实验室条件类似，PhsA和SQR的表达显著上调，提示该菌株极有可能在深海冷泉环境中也形成单质硫（图2）。图2 PhsA和SQR的表达在深海原位条件下显著上调值得注意的是，通过宏基因组分析，研究人员发现在南海冷泉不同深度沉积物中的硫酸盐还原菌基因组中phsA和sqr的同源基因广泛存在。考虑到硫酸盐还原菌是深海冷泉环境的一类高丰度微生物，因此，研究人员认为硫酸盐还原菌是介导深海冷泉环境单质硫形成的重要类群。总结展望前期大部分研究主要关注于硫氧化菌对深海环境单质硫形成的贡献，而忽略了硫酸盐还原菌在单质硫形成过程中的作用。本研究从新的视角折射了硫酸盐还原菌在深海环境硫元素循环中的重要地位，提示后期研究需要综合评估其在深海环境单质硫形成中的贡献，并揭示相应分子机制及其对深海硫元素循环的驱动作用。扫码或点击文章左下角查看英文原文https://onlinelibrary.wiley.com/doi/full/10.1002/mlf2.12038引用本论文：Liu R, Shan Y, Xi S, Zhang X, Sun C. A deep‐sea sulfate‐reducing bacterium generates zero‐valent sulfur via metabolizing thiosulfate. mLife. 2022. https://doi.org/10.1002/mlf2.12038

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