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更新于：2025-05-07

KCNT2

更新于：2025-05-07

基本信息

别名

KCa4.2、KCNT2、Potassium channel subfamily T member 2

+ [8]

简介

Sodium-activated and chloride-activated potassium channel (PubMed:14684870, PubMed:16687497, PubMed:25214519, PubMed:27682982, PubMed:29069600, PubMed:29740868). Produces rapidly activating outward rectifier K(+) currents (PubMed:14684870). Contributes to regulate neuronal excitability (PubMed:29069600).

关联

项与 KCNT2 相关的药物

CPK-20

靶点

KCNT2

作用机制

KCNT2 blockers

在研机构

Università degli Studi di Napoli Federico II

原研机构

Università degli Studi di Napoli Federico II

在研适应症

癫痫

非在研适应症-

最高研发阶段药物发现

首次获批国家/地区-

首次获批日期1800-01-20

100 项与 KCNT2 相关的临床结果

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100 项与 KCNT2 相关的转化医学

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0 项与 KCNT2 相关的专利（医药）

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133

项与 KCNT2 相关的文献（医药）

2025-05-01·Gene

Divergent adaptation to highland and tropical environments in Bolivian Creole cattle

Article

作者: Giovambattista, Guillermo ; Calcaterra, Francisco ; Vega, Ariel Loza ; Peral-García, Pilar ; Fernández, María E ; Olivera, Leónidas H ; Cecco, Paulo Álvarez ; Pereira Rico, Juan A ; Muñoz, Andrés Rogberg ; Marcuzzi, Olivia

Bolivian Creole cattle populations evolved under low levels of breeding management and, during more than 500 years of natural selection, became adapted to various environments such as the contrasting highland and subtropical environments. Recently, highland Creole cattle were crossbred with Holstein to improve dairy production. The aim of this research was to evaluate the divergent adaptation through selection footprints of Bolivian Creole cattle from Andean highland and tropical lowlands, and to evaluate the effect of Holstein introgression in highland Creole. For this purpose, 130 Creole cattle (75 highland, 55 lowland) and 88 Holstein were genotyped using a microarray. The database was used to determine population structure and admixture and detect selection sweeps using F_ST, Rsb, XP-EHH, and ROH. Ancestry inference suggested that selection peaks were not due to Holstein introgression. The NCBI database was used to retrieve genes from the common regions and then perform gene ontology analysis. The most prominent selection peaks were on BTA20 and BTA23 and included the PRLR (slick phenotype) and Class I and IIa BoLA genes. Other windows contained candidate genes for hypoxia (ANXA2, NDUFA4L2), angiogenesis and haematological parameters (ANXA2, CPLANE1, NRP1, NRP2), immune response (IL7R, IL6ST, IL31RA, C6, C7, STAT6, NKG2A, IRAK4, KLR, CLEC), oxidative stress (GSTA, HSD17B6) and morphological traits (PLAG1, CHCHD7, CAP2, ARL15). GO analysis revealed enrichment terms and pathways related to immune response, glutathione and retinol metabolism and reported QTLs for coat characteristics, immune response and tick resistance. The results suggest the complex mechanism in the adaptation of Bolivian Creole cattle to the contrasting highland and subtropical environments.

2025-04-01·Journal of Cellular Physiology

SLO2.1/NALCN Functional Complex Activity in Mouse Myometrial Smooth Muscle Cells During Pregnancy

Article

作者: Zhang, Alexander ; Santi, Celia M. ; Kent, Lindsey N. ; Li, Ethan ; Whitter, Grace C. ; Ma, Xiaofeng ; Butler, Alice ; Ferreira, Juan J. ; Amazu, Chinwendu ; McCarthy, Ronald ; England, Sarah K. ; Peramsetty, Nikita

ABSTRACTAt the end of pregnancy, the uterus transitions from a quiescent to a highly contractile state. This is partly due to the depolarization of the resting membrane potential in uterine (myometrial) smooth muscle cells (MSMCs). In human MSMCs, the membrane potential is regulated by a functional complex between the sodium (Na+)‐activated potassium (K+) channel SLO2.1 and the Na+ leak channel nonselective (NALCN). Na+ entering through NALCN activates SLO2.1, leading to K+ efflux, membrane hyperpolarization (cells become more negative inside), and reduced contractility. Decreased SLO2.1/NALCN activity results in reduced K+ efflux, leading to membrane depolarization, Ca2+ influx via voltage‐dependent calcium channels, and increased MSMC contractility. However, all of these data are from MSMCs isolated from women at term, so the role of the SLO2.1/NALCN complex early in pregnancy was speculative. To address this question here, we examined the role of the SLO2.1/NALCN complex in regulating mouse MSMC membrane potential across pregnancy. We report that Slo2.1 and Nalcn are more highly expressed in MSMCs from nonpregnant and early pregnant mice than in those from late‐pregnant mice. Functional studies revealed that SLO2.1 channels mediate a significant portion of the K+ current in mouse MSMCs, particularly in cells from nonpregnant and early pregnant mice. Activation of SLO2.1 by Na+ influx through NALCN led to membrane hyperpolarization in MSMCs from early pregnancy but not in MSMCs from later pregnancy. Moreover, the NALCN/SLO2.1 complex regulates intracellular Ca2+ responses more in MSMCs from nonpregnant and early pregnancy mice than in MSMCs from late pregnancy. Together, these findings reveal that the SLO2.1/NALCN functional complex is conserved between mice and humans and functions throughout pregnancy. This study could open avenues for targeted pharmacological interventions for pregnancy‐related complications.

2025-02-01·Animal Genetics

Analysis of SLICK allele in African taurine and Zebu cattle breeds

Article

作者: Soudré, Albert ; Heins, Bradley ; Sölkner, Johann ; Mészáros, Gábor ; Sonstegard, Tad ; Gebeyehu, Samrawit ; Traoré, Amadou

A review.The SLICK trait enhances heat tolerance by modifying physiol. traits, such as improving sweating ability, and is phenotypically expressed as short and sleek coats (Davis etal., 2016; Olson etal., 2003).The SLICK coat trait in cattle is attributed to six naturally occurring truncation mutations in the prolactin receptor (PRLR) gene on bovine chromosome 20 (Florez etal., 2020; Sosa etal., 2021).This results in frameshift mutations in the PRLR gene, particularly in exons 10 and 11, which disrupt the open reading frame, and leads to truncated receptor proteins that confer the SLICK phenotype (Davis etal., 2017; Porto- Neto etal., 2018).These mutations have been identified in many South American breeds, such as Senepol, Carora and Limonero, and the trait is inherited in an autosomal- dominant manner (Florez etal., 2020; Florez Murillo etal., 2024; Nicholas etal., 2024; Olson etal., 2003).This could significantly improve the resilience and adaptability of African cattle, providing a clear motivation for further research and application.

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