更新于：2024-11-01

IGFBP5 x IGFBP2

更新于：2024-11-01

基本信息

关联

项与 IGFBP5 x IGFBP2 相关的药物

OGX-225

靶点

IGFBP2 x IGFBP5

作用机制

IGFBP2抑制剂 [+1]

在研机构-

原研机构

Ionis Pharmaceuticals, Inc.

在研适应症-

非在研适应症

乳腺癌

最高研发阶段终止

首次获批国家/地区-

首次获批日期1800-01-20

100 项与 IGFBP5 x IGFBP2 相关的临床结果

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100 项与 IGFBP5 x IGFBP2 相关的转化医学

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0 项与 IGFBP5 x IGFBP2 相关的专利（医药）

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331

项与 IGFBP5 x IGFBP2 相关的文献（医药）

2024-05-01·PROTEOMICS

Identification of gravity‐responsive serum proteins in spaceflight mice using a quantitative proteomic approach with data‐independent acquisition mass spectrometry

Article

作者: Nakai, Yusuke ; Moriyama, Kayano ; Kimura, Yayoi ; Kumagai, Ken ; Ryo, Akihide ; Hirano, Hisashi ; Saito, Tomoyuki ; Ohira, Takashi ; Ino, Yoko ; Inaba, Yutaka ; Akiyama, Tomoko

AbstractPhysical inactivity associated with gravity unloading, such as microgravity during spaceflight and hindlimb unloading (HU), can cause various physiological changes. In this study, we attempted to identify serum proteins whose levels fluctuated in response to gravity unloading. First, we quantitatively assessed changes in the serum proteome profiles of spaceflight mice using mass spectrometry with data‐independent acquisition. The serum levels of several proteins involved in the responses to estrogen and glucocorticoid, blood vessel maturation, osteoblast differentiation, and ossification were changed by microgravity exposure. Furthermore, a collective evaluation of serum proteomic data from spaceflight and HU mice identified 30 serum proteins, including Mmp2, Igfbp2, Tnc, Cdh5, and Pmel, whose levels varied to a similar extent in both gravity unloading models. These changes in serum levels could be involved in the physiological changes induced by gravity unloading. A collective evaluation of serum, femur, and soleus muscle proteome data of spaceflight mice also showed 24 serum proteins, including Igfbp5, Igfbp3, and Postn, whose levels could be associated with biological changes induced by microgravity. This study examined serum proteome profiles in response to gravity unloading, and may help deepen our understanding of microgravity adaptation mechanisms during prolonged spaceflight missions.

2023-12-01·Tropical Animal Health and Production

Genome-wide association study for reproduction traits in Colombian Creole Blanco Orejinegro cattle

Article

作者: Londoño-Gil, Marisol ; Flórez, Juan Carlos Rincón ; Nasner, Sindy Liliana Caivio ; Rios, Ana Cristina Herrera ; Gonzalez-Herrera, Luis Gabriel ; Lopez-Herrera, Albeiro

The profitability of the beef cattle production system relies heavily on reproductive traits. Unfortunately, certain traits, such as age at first calving (AFC), calving interval (CI), and gestation length (GL), can pose challenges in traditional breeding programs because of their low heritability (0.01-0.12) and sex-limited characteristics. Another important aspect is the conservation of the genetic resources of animals adapted to the Colombian regions, which implies the preservation and rational use of the creole breeds in the country market. Therefore, this study aimed to identify genomic regions in the creole cattle breed Blanco Orejinegro (BON) that influence the reproductive traits in females. The dataset comprised 439 animals and 118,116 single-nucleotide polymorphisms' (SNPs) markers. The GS3 program was used to identify the SNP effects employing the BAYES Cπ methodology. The number of SNPs with effect for AFC was 25, 1527 for CI, and 23 for GL. Some of the genes found associated with reproductive and growth traits as well as immune response and environmental adaptation ECE1, EPH, EPHB2, SMARCAL1, IGFBP5, IGFBP2, FCGRT, EGFR, MUL1, PINK1, STPG1, CNGB1, TGFB1, OXTR, IL22RA1, MYOM3, OXTR, CNR2, HIVEP3, CTPS1, CXCL8, FCGRT, MREG, TMEM169, PECR, and MC1R. Our results evidenced a high contribution of the genetic architecture of the Colombian creole cattle breed Blanco Orejinegro that may impact should be included in implementing genetic improvement and conservation programs.

2023-09-28·Brain sciences

Molecular Study of the Protective Effect of a Low-Carbohydrate, High-Fat Diet against Brain Insulin Resistance in an Animal Model of Metabolic Syndrome.

Article

作者: Elsamanoudy, Ayman ; Sakr, Hussein ; Bima, Abdulhadi ; Ghoneim, Fatma Mohamed ; Eldakhakhny, Basmah ; Alamoudi, Aliaa A ; Awan, Zuhier ; Alnami, Abrar ; Abo-Elkhair, Salwa Mohamed

Brain insulin resistance is linked to metabolic syndrome (MetS). A low-carbohydrate, high-fat (LCHF) diet has been proposed to have a protective effect. Therefore, this study aimed to investigate the brain insulin resistance markers in a rat animal model of MetS and the protective effects of the LCHF diet. Four groups of male rats (10/group) were created. Group I (Control) was fed a regular diet. Groups II-IV were injected with dexamethasone (DEX) to induce MetS. Group II received DEX with a regular diet. Group III (DEX + LCHF) rates were fed a low-carbohydrate, high-fat diet, while Group IV (DEX + HCLF) rats were fed a high-carbohydrate, low-fat (HCLF) diet. At the end of the four-week experiment, HOMA-IR was calculated. Moreover, cerebral gene expression analysis of S-100B, BDNF, TNF-α, IGF-1, IGF-1 R, IGFBP-2, IGFBP-5, Bax, Bcl-2, and caspase-3 was carried out. In the DEX group, rats showed a significant increase in the HOMA-IR and a decrease in the gene expression of IGF-1, IGF-1 R, IGFBP-2, IGFBP-5, BDNF, and Bcl2, with a concomitant rise in S100B, TNF-α, Bax, and caspase-3. The LCHF diet group showed a significantly opposite effect on all parameters. In conclusion, MetS is associated with dysregulated cerebral gene expression of BDNF, S100B, and TNF-α and disturbed IGF-1 signaling, with increased apoptosis and neuroinflammation. Moreover, the LCHF diet showed a protective effect, as evidenced by preservation of the investigated biochemical and molecular parameters.