更新于：2024-11-01

IGF-1R x PPT1

更新于：2024-11-01

基本信息

关联

项与 IGF-1R x PPT1 相关的药物

AGT-194

靶点

IGF-1R x PPT1

作用机制

IGF-1R拮抗剂 [+1]

在研机构-

原研机构

ArmaGen, Inc.

在研适应症-

非在研适应症

神经元蜡样质脂褐质沉积症

最高研发阶段无进展

首次获批国家/地区-

首次获批日期1800-01-20

100 项与 IGF-1R x PPT1 相关的临床结果

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100 项与 IGF-1R x PPT1 相关的转化医学

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0 项与 IGF-1R x PPT1 相关的专利（医药）

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项与 IGF-1R x PPT1 相关的文献（医药）

2024-01-02·Autophagy

The presence of blastocyst within the uteri facilitates lumenal epithelium transformation for implantation via upregulating lysosome proteostasis activity

Article

作者: Wang, Haibin ; Bao, Haili ; Huang, Ziying ; Deng, Wenbo ; Wang, Peike ; Guo, Chuanhui ; Ni, Zhangli ; Deng, Na ; Kong, Shuangbo ; Du, Shuailin ; Lu, Jinhua ; Zhang, Hua

ABBREVIATIONSACTB: actin beta; AREG: amphiregulin; ATP6V0A4: ATPase, H⁺ transporting, lysosomal V0 subunit A4; Baf A1: bafilomycin A₁; BSA: bovine serum albumin; CLDN1: claudin 1; CTSB: cathepsin B; DEGs: differentially expressed genes; E₂: 17β-estradiol; ESR: estrogen receptor; GATA2: GATA binding protein 2; GLA: galactosidase, alpha; GO: gene ontology; HBEGF: heparin-binding EGF-like growth factor; IGF1R: insulin-like growth factor 1 receptor; Ihh: Indian hedgehog; ISH: in situ hybridization; LAMP1: lysosomal-associated membrane protein 1; LCM: laser capture microdissection; Le: lumenal epithelium; LGMN: legumain; LIF: leukemia inhibitory factor; LIFR: LIF receptor alpha; MSX1: msh homeobox 1; MUC1: mucin 1, transmembrane; P₄: progesterone; PBS: phosphate-buffered saline; PCA: principal component analysis; PPT1: palmitoyl-protein thioesterase 1; PGR: progesterone receptor; PSP: pseudopregnancy; PTGS2/COX2: prostaglandin-endoperoxide synthase 2; qPCR: quantitative real-time polymerase chain reaction; SP: pregnancy; TFEB: transcription factor EB.

2012-06-15·Journal of Drug Delivery

Native and Complexed IGF-1: Biodistribution and Pharmacokinetics in Infantile Neuronal Ceroid Lipofuscinosis

Article

作者: Huhtala, Tuulia ; Riikonen, Raili ; Salonen, Jarno ; Jalanko, Anu ; Rytkönen, Jussi ; Kaasalainen, Martti ; Närvänen, Ale

Infantile neuronal ceroid lipofuscinosis (INCL) is a severe neurodegenerative disorder of childhood characterized by selective death of cortical neurons. Insulin-like growth factor 1 (IGF-1) is important in embryonic development and is considered as a potential therapeutic agent for several disorders of peripheral and central nervous systems. In circulation IGF-1 is mainly bound to its carrier protein IGFBP-3. As a therapeutic agent IGF-1 has shown to be more active as free than complexed form. However, this may cause side effects during the prolonged treatment. In addition to IGFBP-3 the bioavailability of IGF-1 can be modulated by using mesoporous silicon nanoparticles (NPs) which are optimal carriers for sustained release of unstable peptide hormones like IGF-1. In this study we compared biodistribution, pharmacokinetics, and bioavailability of radiolabeled free IGF-1, IGF-1/IGFBP-3, and IGF-1/NP complexes in a Cln1-/- knockout mouse model. IGF-1/NP was mainly accumulated in liver and spleen in all studied time points, whereas minor and more constant amounts were measured in other organs compared to free IGF-1 or IGF-1/IGFBP-3. Also concentration of IGF-1/NP in blood was relatively high and stable during studied time points suggesting continuous release of IGF-1 from the particles.

2000-05-09·Neurology1区 · 医学

CSF insulin-like growth factor-1 in infantile neuronal ceroid lipofuscinosis

1区 · 医学

Article

作者: Riikonen, R. ; Vanhanen, S.-L. ; Turpeinen, U. ; Tyynelä, J. ; Santavuori, P.

BACKGROUNDInfantile neuronal ceroid lipofuscinosis (INCL) is a progressive encephalopathy in which the patients are severely disabled by the age of 3 years. It is characterized by cerebral atrophy, selective loss of cortical neurons, and secondary loss of axons and myelin sheaths of the white matter. INCL has been shown to result from a palmitoyl protein thioesterase deficiency. The authors suggested that insulin-like growth hormones and apoptosis might play a role in the pathogenesis of INCL.METHODSThe authors measured insulin-like growth factor-1 (IGF-1) and IGF binding protein 3 (IGFBP-3) in the CSF of patients with INCL by radioimmunoassay at an early stage when myelin was starting to diminish.RESULTSThe authors found low CSF IGF-1 but normal IGFBP-3 in patients with INCL compared with control subjects. Also, they observed apoptotic cell death in biopsies of INCL patients.CONCLUSIONSBecause the IGF system seems to be important for early brain development, myelination, and neuroprotection, the authors suggest that the pathology in INCL may be associated with low CSF IGF-1.