更新于：2024-11-01

Trace amine receptor x ADRA1

更新于：2024-11-01

基本信息

关联

项与 Trace amine receptor x ADRA1 相关的药物

DA-OTC-002

靶点

ADRA1

作用机制

ADRA1激动剂 [+1]

在研机构

Applied Biology, Inc.

原研机构

Applied Biology, Inc.

在研适应症

脱发

非在研适应症-

最高研发阶段临床阶段不明

首次获批国家/地区-

首次获批日期1800-01-20

项与 Trace amine receptor x ADRA1 相关的临床试验

NCT06095739 / CompletedN/A

Study to Investigate the Effectiveness of a Topical Cosmetic Formulation DA-OTC-002

The primary objective of the study was to assess the efficacy of DA-OTC-002 as a topical cosmetic hair treatment. The investigators conducted a prospective, institution-level, interventional, single-blinded, placebo-controlled investigation to assess the efficacy of a combination an alpha-1 agonist and a TAAR receptor agonist (DA-OTC-002) as a topical cosmetic hair treatment.

开始日期2022-11-18

申办/合作机构

Applied Biology, Inc.

100 项与 Trace amine receptor x ADRA1 相关的临床结果

登录后查看更多信息

100 项与 Trace amine receptor x ADRA1 相关的转化医学

登录后查看更多信息

0 项与 Trace amine receptor x ADRA1 相关的专利（医药）

登录后查看更多信息

项与 Trace amine receptor x ADRA1 相关的文献（医药）

2020-10-01·Biomedicine & Pharmacotherapy2区 · 医学

Modulatory effects of Xihuang Pill on lung cancer treatment by an integrative approach

2区 · 医学

Article

作者: Fei, Xiaofei ; Dong, Bin ; Qi, Shuya ; Cao, Bo ; Wang, Jiabo ; Li, Chunyu ; Li, RuiSheng ; Zhang, Mingyu ; Zhang, Congen ; Li, Xingjie ; Zhang, Yujun ; Chen, Wei ; Li, Guohui

Lung cancer has a rapidly increasing incidence and remains the highest ranked cancer in terms of mortality worldwide. Xihuang Pill(XHW), a famous four-herb traditional Chinese formulation, has been used to treat lung cancer in China for more than 100 years. It is usually prescribed as a complementary and alternative medicine for cancer therapy. However, the main active ingredients of XHW that treat lung cancer and their regulatory effects remain unclear. Here, we revealed modulatory effects effects of XHW on lung cancer in a mouse model of Lewis lung cancer (LLC) by a comprehensive strategy combining network pharmacology with metabolomics. The results demonstrated that XHW inhibited tumour growth in this model. Additionally, 11 differentially expressed metabolites were identified in the XHW group compared to those in the model group or normal group by untargeted metabolomics. They were enriched in amino acid-related metabolic pathways, and the top three pathways were phenylalanine metabolism; phenylalanine, tyrosine and tryptophan biosynthesis; and aminoacyl-tRNA biosynthesis. A total of 107 active components derived from Niuhuang, Shexiang, Ruxiang and Moyao, directly acted on 13 important targets (NR3C2, AKR1D1, MPO, PNP, NT5E, TAAR1, ADRB2, ADRB1, ADRA1A, ADRA2B, ADRA2A, MAOA and MAOB) to regulate 4 metabolites (L-phenylalanine, l-adrenaline, corticosterone and guanosine). Our results suggested that the key metabolites of XHW involved in the treatment of lung cancer were regulated by a multi-component and multi-target interaction network. This research elucidated the modulatory effect and therapeutic advantages of XHW treatment for lung tumours through an integrated approach.

Anais da Academia Brasileira de Ciências4区 · 综合性期刊

Fibromyalgia: A Review of Related Polymorphisms and Clinical Relevance

4区 · 综合性期刊

ReviewOA

作者: Souza, Andressa DE ; Silva, Juliana DA ; Janssen, Luísa P ; Medeiros, Liciane F

Fibromyalgia (FM) is a chronic pain syndrome that affects the central nervous system and generates disability, which is characterized by generalized pain, fatigue, and functional decline. In this review, we aimed to identify the polymorphisms related to the pathophysiology of FM and the clinical characteristics generated by genetic influence. Only original studies with genes related to FM were considered, totaling 27 articles. The genes found were: MTHFR, RGS4, MYT1L, TACR1, SCN9A, DRD3, ADRB2, IL-4, HLA-DRB1, EDN1, CNR1, TAAR1, OPRM1, ADRA1A, ADRB3, BDNF, GRIA4, HTR3A, HTR3B, HTR2A, SERPINA 1 or A1AT, NRXN3, GCH1, MEFV, TRPV3, SLC6A4, ACE I/D, TSPO, COMT, and MAOA. Several genes related to different pain syndromes and altered pain thresholds have been identified and some polymorphisms were related to susceptibility to FM. It was observed that 73.33% of the genes related to FM were also associated with some psychological disorders, such as anxiety, depression, schizophrenia, and obsessive and compulsive disorder, and 40.00% with pain sensitivity and/or migraine, besides other disorders associated (drug addiction, autoimmune disorders, circulatory problems, and metabolic alterations). This review demonstrated an association of FM and genetic polymorphisms that can expand our knowledge about the pathophysiology of this disease.

Nutrients

In Vitro Activation of Human Adrenergic Receptors and Trace Amine-Associated Receptor 1 by Phenethylamine Analogues Present in Food Supplements

Article

作者: Schooten, Frederik-Jan van ; Blankesteijn, W Matthijs ; Shi, Xiao ; Vrolijk, Misha F ; Opperhuizen, Antoon ; Mircheva, Anastasiya ; Pinckaers, Nicole E T

Pre-workout supplements are popular among sport athletes and overweight individuals. Phenethylamines (PEAs) and alkylamines (AA) are widely present in these supplements. Although the health effects of these analogues are not well understood yet, they are hypothesised to be agonists of adrenergic (ADR) and trace amine-associated receptors (TAARs). Therefore, we aimed to pharmacologically characterise these compounds by investigating their activating properties of ADRs and TAAR1 in vitro. The potency and efficacy of the selected PEAs and AAs was studied by using cell lines overexpressing human ADRα1A/α1B/α1D/α2a/α2B/β1/β2 or TAAR1. Concentration–response relationships are expressed as percentages of the maximal signal obtained by the full ADR agonist adrenaline or the full TAAR1 agonist phenethylamine. Multiple PEAs activated ADRs (EC50 = 34 nM–690 µM; Emax = 8–105%). Almost all PEAs activated TAAR1 (EC50 = 1.8–92 µM; Emax = 40–104%). Our results reveal the pharmacological profile of PEAs and AAs that are often used in food supplements. Several PEAs have strong agonistic properties on multiple receptors and resemble potencies of the endogenous ligands, indicating that they might further stimulate the already activated sympathetic nervous system in exercising athletes via multiple mechanisms. The use of supplements containing one, or a combination of, PEA(s) may pose a health risk for their consumers.