更新于：2024-11-01

PDGFB x VEGFR

更新于：2024-11-01

基本信息

关联

项与 PDGFB x VEGFR 相关的药物

Dual VEGF/PDGF-B-targeting SOMAmers (SomaLogic)

靶点

PDGFB x VEGFR

作用机制

PDGFB抑制剂 [+1]

在研机构-

原研机构

SomaLogic Operating Co., Inc.

在研适应症-

非在研适应症

黄斑变性

最高研发阶段无进展

首次获批国家/地区-

首次获批日期1800-01-20

100 项与 PDGFB x VEGFR 相关的临床结果

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100 项与 PDGFB x VEGFR 相关的转化医学

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0 项与 PDGFB x VEGFR 相关的专利（医药）

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项与 PDGFB x VEGFR 相关的文献（医药）

2024-09-01·Current Medicinal Chemistry

Comprehensive Analysis of Ligand-receptor Interactions in Colon Adenocarcinoma to Identify of Tumor Microenvironment Oxidative Stress and Prognosis Model

Article

作者: Zhao, Peng ; Hu, Jun ; Zhu, Wenbo ; Wang, Wenpeng ; Yue, Xin ; Kong, Dalu

Background:Single-cell technology enables a deep study on the mechanism of cancers. This work delineated the function of ligand-receptor interaction in colon adenocarcinoma (COAD), and developed a LR pairs-based prognostic model.Methods:For identifying important LR pairs, Single-cell RNA sequencing data of COAD was included. Unsupervised consensus clustering constructed molecular subtypes. LASSO established a prognostic model. Infiltration of 22 immune cells was evaluated by Cibersort. Enrichment score of oxidative stress related pathways was determined by SsGSEA in each patient.Results:Forty-seven LR pairs were closely associated with the prognosis of COAD. Three molecular subtypes were differentiated according to 47 LR pairs, which displayed differential clinical features and molecular features. There were significant differences in immune T cell lytic activity among different subtypes. In clust1 with poor prognosis, significantly enriched oncogenic pathways were found, especially epithelial-mesenchymal transition (EMT). Additionally, it has been found that clust3 had significantly higher immune infiltration. A prognostic model containing eight LR pairs (PDGFB-PDGFRA, FLT4-VEGFC, CSF1R-CSF1, DLL1-NOTCH4, PDGFB-LRP1, DLL1- NOTCH3, FLT4-PDGFC, and NRP2-PGF) was established, which could effectively divide samples into low-risk and high-risk groups. Significantly higher oxidative stress was found among high-risk patients.Conclusion:This study integrated expression data and single-cell data for demonstrating the effectiveness of LR pairs in establishing the prognostic model and constructing molecular subtypes. Prognostic LR pairs may contribute to tumorigenesis and progression in COAD. The prognostic model was the potential for predicting prognosis and guiding immunotherapy for COAD patients.

2024-07-01·Heliyon

The common pathogenesis of nodular goiter in both sexes: An exploration into gene expression and signaling pathways

Article

作者: Sun, Ya ; Zhao, Jing ; Geng, Li ; Wang, Changlin ; Wang, Jieqiong ; Gao, Xiangju ; Qiao, Mingqi ; Gao, Jie

The past few years have witnessed an increasing incidence of nodular goiter (NG), with a well-documented higher prevalence in females than males. This gender disparity has led research to focus primarily on female subjects, potentially overlooking common pathogenic mechanisms in both sexes. In this study, we investigated the shared pathogenesis of NG in males and females. Utilizing a rat model and RNA sequencing, we identified differentially expressed genes associated with the disease. We further validated these findings in normal human thyroid cells and human papillary thyroid cancer cells. A randomized experiment was conducted with equal numbers of male and female rats divided into control and NG model groups. The NG model was established using propylthiouracil and various assessments such as thyroid ultrasonography, thyroid index, thyroid function, and thyroid histology were performed. Transcriptome analysis revealed numerous upregulated and downregulated genes in both male and female model groups. Key genes like KDR, FLT1, PDGFB, and CAV1, and pathways including PI3K-Akt, MAPK, Ras, fluid shear stress and atherosclerosis, calcium signaling, and Rap1 signaling pathways were linked with the disease. Western blot and immunofluorescence analysis confirmed these findings, which were further supported by cell-based experiments. In conclusion, our findings suggest that abnormal expression of specific genes and pathways leading to irregular cell growth, blood vessel formation, and inflammation may be common factors in the pathogenesis of NG in both males and females.

2024-02-15·Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery

[Experimental study of tetramethylpyrazine-loaded electroconductive hydrogel on angiogenesis and neuroprotection after spinal cord injury].

Article

作者: Bai, Huizhong ; Xu, Lin ; Jiang, Shengyuan ; Deng, Bowen ; Huo, Luyao ; Li, Xiaoye ; Xu, Jie ; Liu, Gang ; Mu, Xiaohong

目的探索携川芎嗪导电水凝胶（简称“TGTP”）修复脊髓损伤（spinal cord injury，SCI）的潜在机制。.方法将72只雌性SD大鼠随机分为4组，假手术组（A组）、SCI组（B组）、SCI+导电水凝胶组（C组）和SCI+TGTP组（D组）。A组仅切除椎板，其余组构建切除2 mm长脊髓的全横断模型。通过BBB评分法和改良Rivlin-Tator斜板实验分别于术前及术后1、3、7、14、28 d评估大鼠后肢运动功能恢复情况。术后7、28 d动物取材，通过免疫荧光染色观察新生血管，采用Western blot评估血管生成素1（angiopoietin 1，Ang-1）、Tie-2蛋白表达；术后28 d采用Western blot进一步评估促血管新生相关蛋白PDGF-B、PDGF受体β（PDGF receptor β，PDGFR-β）、VEGF-A、VEGF受体2（VEGF receptor 2，VEGFR-2）的表达情况。术后28 d，采用Masson染色评估损伤区域瘢痕增生，Nissl染色观察神经元存活，LFB染色检测髓鞘分布和再生情况，免疫荧光染色和Western blot评估神经丝蛋白200（neurofilament 200，NF200）的表达。.结果各组大鼠术后3 d起后肢运动功能逐渐恢复，D组术后3～28 d BBB评分和斜坡角度显著高于B组，术后14、28 d显著高于C组（ P<0.05）。Masson染色示B～D组胶原容积分数显著高于A组，D组显著低于B、C组（ P<0.05）；D组断端可见少量散在黑色导电颗粒，周围胶原纤维成分少于C组。Nissl和LFB染色示D组损伤区域脊髓组织神经元及髓鞘结构相对完整、连续，尼氏体数量和髓鞘阳性表达面积明显优于B、C组（ P<0.05）。NF200免疫荧光染色和Western blot检测示，D组损伤区域NF200蛋白相对表达量显著优于B、C组（ P<0.05）。CD31免疫荧光染色示D组术后28 d荧光强度优于B、C组，可见管状或线性新生血管影。Western blot检测示术后7 d和28 d D组Ang-1、Tie-2蛋白相对表达量高于B、C组，差异均有统计学意义（ P<0.05）。术后28 d D组PDGF-B、PDGFR-β蛋白相对表达量显著高于B、C组，B组显著高于C组，差异均有统计学意义（ P<0.05）。术后28 d D组VEGF-A和VEGFR-2蛋白相对表达量优于B、C组，与B组比较差异有统计学意义（ P<0.05），但与C组比较仅VEGF-A蛋白差异有统计学意义（ P<0.05）；B、C组间比较仅VEGFR-2蛋白差异有统计学意义（ P<0.05）。.结论TGTP可能增强损伤区域再血管化，同时发挥神经元保护作用，从而减轻脊髓组织结构损伤，促进大鼠SCI后神经功能恢复。.