别名 Calcitonin-receptor-like receptor activity-modifying protein 3、CRLR activity-modifying protein 3、RAMP3 + [2] |
简介 Accessory protein that interacts with and modulates the function of G-protein coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL), calcitonin receptor (CALCR) and G-protein coupled estrogen receptor 1 (GPER1) (PubMed:23674134, PubMed:9620797). Required for the transport of CALCRL and GPER1 receptors to the plasma membrane (PubMed:23674134, PubMed:9620797). Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner (PubMed:23674134). Together with CALCRL, form a receptor complex for adrenomedullin/ADM and intermedin/ADM2 (PubMed:32296767). Together with CALCR, act as a receptor complex for amylin/IAPP (PubMed:35324283). |
靶点 |
作用机制 RAMP3 inhibitors |
在研机构- |
在研适应症- |
最高研发阶段无进展 |
首次获批国家/地区- |
首次获批日期1800-01-20 |