更新于：2024-11-01

OXTR x α-adrenergic receptor

更新于：2024-11-01

基本信息

关联

项与 OXTR x α-adrenergic receptor 相关的药物

Oxytocin/Ergometrine Maleate

靶点

OXTR x α-adrenergic receptor

作用机制

OXTR激动剂 [+1]

在研机构

Phebra Pty Ltd.

原研机构-

在研适应症

产后出血

非在研适应症-

最高研发阶段批准上市

首次获批国家/地区

澳大利亚

首次获批日期1991-08-21

项与 OXTR x α-adrenergic receptor 相关的临床试验

NCT02046499 / CompletedN/AIIT

A Randomized Trial Comparing Oxytocin and Oxytocin + Ergometrine for Prevention of Postpartum Haemorrhage at Caesarean Section

This is a randomized trial comparing oxytocin versus oxytocin + syntometrine in the prevention of post partum haemorrhage in patients undergoing caesarean section

开始日期2014-01-01

申办/合作机构

University of Pretoria

NCT01236482 / Unknown status临床4期IIT

Comparing Oxytocin and Oxytocin-ergometrine Combinations for Increasing Uterine Tone in Cesarean Delivery: a Pharmacokinetic-pharmacodynamic Study.

In this study the investigators hypothesize that infused combinations of oxytocin and ergometrine will exhibit fewer cardiac and neurological side effects than equipotent infusion of oxytocin alone. In order to perform this study the investigators perform the following steps:
The investigators validate a quantitative measure of uterine tone as our primary endpoint.
The investigators use this endpoint measure in order to determine equipotential doses of different tocotonic drug regimens, based on the ED50 for each.
Using equipontial ratios based on the ED50, the investigators compare hemodynamic and other side effects of these tocotonic drug regimes. Plasma levels of oxytocin will be measured.

开始日期2010-11-01

申办/合作机构

Hadassah University Hospital

NCT00499005 / Completed临床4期IIT

Carbetocin Versus Syntometrine for the Third Stage of Labour Following Vaginal Delivery - A Double-blind Randomised Trial

Intramuscular carbetocin is as effective as intramuscular syntometrine for the prevention of postpartum haemorrhage

开始日期2006-11-01

申办/合作机构

National University Hospital

[+1]

100 项与 OXTR x α-adrenergic receptor 相关的临床结果

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100 项与 OXTR x α-adrenergic receptor 相关的转化医学

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0 项与 OXTR x α-adrenergic receptor 相关的专利（医药）

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项与 OXTR x α-adrenergic receptor 相关的文献（医药）

2017-04-01·Experimental and Therapeutic Medicine4区 · 医学

Identification of genes associated with the effect of inflammation on the neurotransmission of vascular smooth muscle cell

4区 · 医学

Article

作者: Wan, Zhong ; Qiu, Shenlong ; Zhang, Yanping ; Gan, Shujie ; Feng, Yiwen ; Tang, Jingdong ; Qian, Qin

Vascular smooth muscle cell (VSMC) accumulation and hypertrophy are common in vascular disorders, and inflammation has a crucial role in the development of these diseases. To investigate the effect of inflammation on the neurotransmission of VSMC, bioinformatic analysis was performed, following next generation sequencing. Genes of lipopolysaccharide (LPS)-treated A7r5 cells and phosphate-buffered saline (PBS)-treated A7r5 cells were sequenced via next generation sequencing, and each assay was repeated three times. Differentially expressed genes (DEGs) were obtained using the NOISeq package in R. Subsequently, their potential functions were predicted by functional and pathway enrichment analyses using the Database for Annotation, Visualization and Integrated Discovery online tool. Interaction relationships of the proteins enriched in pathways associated with neurological diseases, the proteins which had interaction relationships with adrenoceptor α 1D (ADRA1D) or calcium voltage-gated channel subunit α1 S (CACNA1S), separately, were obtained from STRING, and protein-protein interaction (PPI) networks were constructed using Cytoscape software. A total of 2,038 DEGs, including 1,094 upregulated and 944 downregulated genes in the LPS treatment group were identified when compared with the control group. Enrichment analyses showed that NADH:Ubiquinone Oxidoreductase Core Subunit V2 (NDUFV2) was involved in several neurological diseases, including oxidative phosphorylation, Alzheimer's disease, Parkinson's disease and Huntington's disease. Furthermore, NDUFV2 (degree, 20) had a higher degree in the PPI network for DEGs enriched in pathways associated with neurological diseases. In the PPI network for ADRA1D, CACNA1S and the DEGs interacting with them, prohibitin (PHB), oxytocin receptor (OXTR), collapsin response mediator protein 1 (CRMP1) and dihydropyrimidinase like 2 (DPYSL2) had interaction relationships with both ADRA1D and CACNA1S. To conclude, the present study revealed that NDUFV2, PHB, OXTR, CRMP1 and DPYSL2 may have key roles in the effect of inflammation on neurotransmission of VSMC.

2004-11-01·The Journals of Gerontology: Series A1区 · 医学

Chronic Exercise Improves Myocardial Inotropic Reserve Capacity Through α1-Adrenergic and Protein Kinase C-Dependent Effects in Senescent Rats

1区 · 医学

Article

作者: La Toya D. Carson ; James C. Hunter ; Marlena M. Tickerhoof ; Donna H. Korzick ; Mark K. McDowell ; Michael D. Delp

AbstractWe have previously demonstrated that α1-adrenergic (AR)-mediated contraction is diminished in the senescent rat heart, in part due to alterations in protein kinase C (PKC) signaling. Since chronic exercise training (EX) can exert independent effects on increasing α1-AR contraction in the adult rat heart, we sought to determine whether age-related defects in α1-AR contraction could be reversed by chronic EX. We further hypothesized that improved α1-AR contraction by EX may be PKC dependent. Adult (4 months; Y) and aged (24 months; O) male F344 rats were treadmill-trained (n = 12–13/group; TR) at ∼70% of VO2max for 12 weeks or remained sedentary (YSED, YTR, OSED, OTR). Training status was verified by plantaris citrate synthase activity and left ventricular (LV) contractile responses (dP/dt) to α1-AR stimulation were assessed in Langendorff-perfused hearts using the α1-AR agonist phenylephrine (PE; 10−5 M) with and without the PKC inhibitor chelerythrine (CE; 10−6 M). α1-AR stimulation elicited greater increases in LV dP/dt in hearts isolated from OTR (4525.4 ± 224.1 mmHg/s) versus OSED (3658.9 ± 291.0 mmHg/s), while CE abolished PE-induced effects (OTR, 4069.2 ± 341.2) versus (OSED, 3608.9 ± 321.2) (p <.01). Upon western blotting, phosphospecific antibodies directed at PKCε (pSer729) revealed greater levels in LV isolated from YTR versus YSED, and EX ameliorated aged-related reductions in OSED (p <.001). Basal PKCε mRNA levels were also greater in YTR and OTR versus YSED (p <.01). PE-induced increases in phosphor-PKCδ (pThr507) levels observed in OSED were attenuated in OTR (p <.03). Chronic EX was also associated with significant reductions in PKCα (pSer657) levels following PE in OTR (p <.002). The results indicate that age-related reductions in α1-AR contraction can be partially reversed by EX in the rat heart. These results further suggest that alterations in PKC levels underlie, at least in part, EX-induced improvements in α1-AR contraction.

2003-08-01·Journal of Dairy Research4区 · 农林科学

Effects of α- and β-adrenergic receptor stimulation and oxytocin receptor blockade on milking characteristics in dairy cows before and after removal of the teat sphincter

4区 · 农林科学

Article

作者: Evangelos Kiossis ; Johannes Riedl ; Rupert M. Bruckmaier ; Tyra Inderwies

Alpha (α)- and beta (β)-adrenergic receptors in the bovine mammary gland are mainly present in the teat muscles and in the region where large milk ducts reach the cisternal cavities. The aim of the study was to test the hypothesis that the region of the large mammary ducts is the most important location of α- and β-adrenergic receptor stimulation affecting milk ejection and milk removal. Effects of α- and β-adrenergic receptor stimulation and of oxytocin (OT) receptor blockade on milking characteristics were tested in six cows. Milk flow was measured before and after the distal part of one teat, including the teat canal and teat sphincter, had been partly amputated. Before the operation, milk yield and peak flow rate decreased during α-adrenergic receptor stimulation and during the OT receptor blockade, and increased during β-adrenergic stimulation. After removal of the teat tip, relations of milk yield and peak flow rates after administration of α- and β-agonists and after application of an OT receptor blocking agent were similar to those before operation. Only total milk yield had decreased in the teat-amputated quarter owing to unhindered flow of cisternal milk before cluster attachment. Since responses to α- and β-adrenergic receptor stimulation as well as to OT receptor blockade do not differ with or without the teat sphincter, it is concluded that milk flow is mainly influenced by the muscle tone of the large mammary ducts.