更新于：2024-11-01

Mucous secretions

粘液分泌物

更新于：2024-11-01

基本信息

别名

Mucous secretions

简介-

关联

项与粘液分泌物相关的药物

PRT-068

靶点-

作用机制-

在研机构

四川普锐特药业有限公司

原研机构

四川普锐特药业有限公司

在研适应症

粘液分泌物

非在研适应症-

最高研发阶段临床申请批准

首次获批国家/地区-

首次获批日期1800-01-20

项与粘液分泌物相关的临床试验

RBR-2dwhkm / Not yet recruitingN/A

Effects of a new vibrotherapy instrument Pulsar and vibro in children in the hospital

开始日期2016-05-01

申办/合作机构

Faculdade de Medicina de Marília

[+1]

100 项与粘液分泌物相关的临床结果

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100 项与粘液分泌物相关的转化医学

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0 项与粘液分泌物相关的专利（医药）

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413

项与粘液分泌物相关的文献（医药）

2024-10-15·Children (Basel, Switzerland)

High-Frequency Percussive Ventilation: A Promising Rescue Strategy in Severe Lung Disease of Extremely Low Gestational Age Neonates.

Article

作者: Parton, Lance A ; Ericksen, Kristina ; Louie, Kevin

Objective: The aim of this study was to evaluate high-frequency percussive ventilation (HFPV) as a rescue strategy for extremely low gestational age neonates (ELGANs) with severe lung disease. Methods: This is a retrospective review of 16 ELGANs with severe lung disease who were placed on HFPV following a lack of improvement on other modes of conventional and high-frequency ventilation. Results: The gestational age of these 16 infants was 25 (24, 26) weeks and their birth weight was 640 (535, 773) grams [median (IQR)], with the survivors being more immature compared to those who died [24 (23, 26) and 26 (25, 28) weeks, respectively; (p = 0.04)]; and with an overall mortality of 31% (N = 5). Of those who died, 60% were SGA (p = 0.02). Following placement on HFPV, the survivors had a statistically significant decrease in their respiratory severity scores (RSSs) [11 (9, 14) to 6 (5, 13), p = 0.03] compared to those who did not survive [15 (11, 16) to 11 (6.8, 14.5), p = 0.32] due to an improvement in their oxygenation [FiO₂: 0.95 (0.85, 1) to 0.6 (0.4, 0.9), p = 0.01; compared to 1 (1, 1) to 1 (0.7, 1); survivors and non-survivors, respectively; p = 0.32]. Chest X-rays also showed significantly improved aeration due to decreased areas of atelectasis in those who survived. Conclusions: HFPV may be an appropriate rescue mode of high-frequency ventilation in the ELGAN population with severe lung disease, particularly for patients with impaired oxygenation and ventilation difficulties due to shifting atelectasis and mucous plugging.

2024-09-03·Zhonghua yi xue za zhi

[Olfactory neuroblastoma in children: clinical analysis of five cases].

Article

作者: Huang, D S ; Hu, H M ; Gu, H L ; Zhang, Y ; Wang, Y Z ; Liu, A P ; Zhang, W L ; Meng, X ; Wen, Y

回顾性分析首都医科大学附属北京同仁医院儿科2012年1月至2024年1月收治的确诊儿童嗅神经母细胞瘤（ONB）的5例患儿临床资料。男2例，女3例，年龄6.2（5.7~15.8）岁，首发临床症状主要为鼻塞、鼻分泌物增多、头痛、视力下降等；病理分级Ⅱ级2例，Ⅲ级1例，Ⅳ例2例；改良Kadish分期B期1例，C期2例，D期2例。所有患儿均接受了手术、化疗和放疗。5例患儿中4例存活，1例死亡，随访时间22.3（10.4~56.4）个月，无一例复发。儿童ONB经手术、化疗、放疗为主的综合治疗可获得较好疗效和预后，但需长期随访。.

2024-09-01·Journal of Asthma

Rapidly progressive mucus plugs in allergic bronchopulmonary mycosis

Article

作者: Sato, Kento ; Igarashi, Akira ; Hasegawa, Ryo ; Kodama, Sahoko ; Yokoyama, Ryuto ; Watanabe, Masafumi ; Nakane, Masaki ; Ueki, Shigeharu ; Watanabe, Akira ; Inoue, Sumito ; Miyazaki, Osamu ; Yaguchi, Takashi

INTRODUCTIONAllergic bronchopulmonary mycosis (ABPM) is a chronic airway disease characterized by the presence of fungi that trigger allergic reactions and airway obstruction. Here, we present a unique case of ABPM in which a patient experienced sudden respiratory failure due to mucus plug-induced airway obstruction. The patient's life was saved by venovenous extracorporeal membrane oxygenation (VV-ECMO) and bronchoscopic removal of the plug. This case emphasizes the clinical significance of mucus plug-induced airway obstruction in the differential diagnosis of respiratory failure in patients with ABPM.CASE STUDYA 52-year-old female clerical worker with no smoking history, presented with dyspnea. CT scan revealed mucus plugs in both lungs. Despite treatment, the dyspnea progressed rapidly to respiratory failure, leading to VV-ECMO placement.RESULTSCT revealed bronchial wall thickening, obstruction, and extensive atelectasis. Bronchoscopy revealed extensive mucus plugs that were successfully removed within two days. The patient's respiratory status significantly improved. Follow-up CT revealed no recurrence. Fungal cultures identified Schizophyllum commune, confirming ABPM. Histological examination of the mucus plugs revealed aggregated eosinophils, eosinophil granules, and Charcot-Leyden crystals. Galectin-10 and major basic protein (MBP) staining supported these findings. Eosinophil extracellular traps (EETs) and eosinophil cell death (ETosis), which contribute to mucus plug formation, were identified by citrullinated histone H3 staining.CONCLUSIONDifferentiating between asthma exacerbation and mucus plug-induced airway obstruction in patients with ABPM and those with acute respiratory failure is challenging. Prompt evaluation of mucous plugs and atelectasis using CT and timely decision to introduce ECMO and bronchoscopic mucous plug removal are required.