更新于：2024-11-01

Chronic lower urinary tract infection

慢性下尿路感染

更新于：2024-11-01

基本信息

别名

Chronic lower UTI (urinary tract infection)、Chronic lower urinary tract infection、Chronic lower urinary tract infection (diagnosis)

+ [2]

简介-

关联

项与慢性下尿路感染相关的药物

Tonglin Capsule

通淋胶囊

靶点-

作用机制-

在研机构-

原研机构

河南省医学科学研究所

在研适应症-

非在研适应症

慢性下尿路感染

最高研发阶段暂停

首次获批国家/地区-

首次获批日期1800-01-20

项与慢性下尿路感染相关的临床试验

NCT04100980 / Unknown statusN/A

A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Chronic Urinary Tract Infections (UTI)

Correlation of Microbiome to Chronic Urinary Tract Infections (UTI) via Relative Abundance Found in Microbiome Sequencing

开始日期2020-03-02

申办/合作机构

ProgenaBiome LLC初创企业

NL-OMON39651 / CompletedN/AIIT

POETIC: Point Of carE Testing for urinary tract Infection in primary Care: Study Stages 3 & 4: Randomised controlled trial and post-RCT observational study - POETIC

开始日期2014-02-18

申办/合作机构-

NCT01123603 / CompletedN/AIIT

Lower UTI Evaluation in Women With Uterine Leiomyomata

To the investigators knowledge there is no research data published to date regarding the lower urinary tract symptoms in women with leiomyomas. The primary aims of this study are:
To determine prevalence of lower urinary tract symptoms in patients who present for care for symptomatic leiomyomata.
To compare change in lower urinary tract symptoms within treatment groups measured by the UDI-6 total before and at six months after three common treatments for symptomatic uterine fibroids including: hysterectomy, myomectomy, or uterine artery embolization.
The study proposed here will hopefully answer the question if one particular therapy is appropriate to treat fibroids and relieve lower urinary tract symptoms.

开始日期2010-05-01

申办/合作机构

The Cleveland Clinic Foundation

100 项与慢性下尿路感染相关的临床结果

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100 项与慢性下尿路感染相关的转化医学

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0 项与慢性下尿路感染相关的专利（医药）

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项与慢性下尿路感染相关的文献（医药）

2024-03-01·Research in Veterinary Science

No viable bacterial communities reside in the urinary bladder of cats with feline idiopathic cystitis

Article

作者: Rizzardi, Alessia ; Cornaggia, Matteo ; Dondi, Francesco ; Vasylyeva, Kateryna ; Terrusi, Alessia ; Urbani, Lorenza ; Balboni, Andrea ; Battilani, Mara ; Bano, Luca ; Segatore, Sofia ; Franzo, Giovanni ; Cordioli, Benedetta

Urinary microbial diversities have been reported in humans according to sex, age and clinical status, including painful bladder syndrome/interstitial cystitis (PBS/IC). To date, the role of the urinary microbiome in the pathogenesis of PBS/IC is debated. Feline idiopathic cystitis (FIC) is a chronic lower urinary tract disorder affecting cats with similarities to PBS/IC in women and represents an important problem in veterinary medicine as its aetiology is currently unknown. In this study, the presence of a bacterial community residing in the urinary bladder of cats with a diagnosis of FIC was investigated. Nineteen cats with clinical signs and history of FIC and without growing bacteria in standard urine culture were included and urine collected with ultrasound-guided cystocentesis. Bacterial community was investigated using a culture-dependent approach consisted of expanded quantitative urine culture techniques and a culture-independent approach consisted of 16S rRNA NGS. Several methodological practices were adopted to both avoid and detect any contamination or bias introduced by means of urine collection and processing which could be relevant due to the low microbial biomass environment of the bladder and urinary tract, including negative controls analysis. All the cats included showed no growing bacteria in the urine analysed. Although few reads were originated using 16S rRNA NGS, a comparable pattern was observed between urine samples and negative controls, and no taxa were confidently classified as non-contaminant. The results obtained suggest the absence of viable bacteria and of bacterial DNA of urinary origin in the urinary bladder of cats with FIC.

2023-05-01·Urologiia (Moscow, Russia : 1999)

[Cytological examination of urine in the differential diagnosis of recurrent lower urinary tract infection].

Article

作者: Mamedov, V K ; Naboka, Yu L ; Ibishev, Kh S ; Kogan, M I ; Ilyasov, Kh Kh

INTRODUCTIONA diagnosis and treatment of recurrent lower urinary tract infection (UTI) in women is still one of the unresolved problems of urology. The proper identification of the etiological factor determines the treatment tactics. Therefore, the most urgent issue of recurrent lower UTI is the differential diagnosis of the causative pathogens.MATERIALS AND METHODSA cytological study of urine was performed in 151 patients with recurrent lower UTI, who, according to the results of bacteriological and PCR studies of urine, were divided into three groups, depending on the etiological factor. The group 1 (n=70) included women with recurrent lower UTI of bacterial etiology, while in group 2 (n= 70) papillomavirus etiology was found, and in group 3 (n=11) candida species were the causative pathogens. The age of the patients ranged from 20 to 45 years (32.3+/-7.8).RESULTSIn the majority of patients with recurrent lower UTI of bacterial etiology, the cytological features were represented by leukocytes, plasma, epithelial cells and bacteria in combination with actively phagocytic macrophages. In group 3, in addition to a large number of leukocytes (neutrophils) and epithelial cells, Candida mycelium was found. In group 2, signs of bacterial inflammation were minimal, while a predominance of lymphocytes, epithelial cells, and the presence of single neutrophils was seen. With papillomavirus lesions of the bladder, urothelial cell dystrophy with the presence of koilocytes developed.CONCLUSIONSA cytological examination of urine can confirm the etiology of the recurrent lower UTI and be an evidence-based criterion in the differential diagnosis of bacterial, candidiasis, and papillomavirus infection. Total transformation of the urothelium and vacuolization of urothelial cells, as well as an excess of lymphocytes in the urine in the absence of neutrophils, are the characteristic features of viral recurrent lower UTI.

2021-09-03·Urologiia

Эффективность применения пробиотиков в профилактике рецидивирующих инфекций нижних мочевыводящих путей и бактериального вагиноза

Article

作者: T A Gyaurgiev ; Kuzmenko ; I N Korotkikh ; A V Kuzmenko ; Yu E Dobrohotova

INTRODUCTIONThe literature data indicate that bacterial vaginosis (BV) increases the risk of development of lower urinary tract infections (LUTI). Thus, it is reasonable to assume that the use of probiotics, in particular Lactoginal, can be effective in preventing relapses of LUTI.AIMTo study the efficiency of probiotics, particularly Lactoginal, for the prevention of recurrent LUTI and BV.MATERIALS AND METHODSA total of 120 women with chronic recurrent bacterial cystitis in the acute stage and concomitant bacterial vaginosis were randomized into two groups of 60 patients. In group 1, standard antibacterial therapy was used according to guidelines of professional societies. In group 2, vaginal probiotic Lactoginal was prescribed after standard treatment.RESULTSThe results obtained in this study correspond to the literature data. The additional use of probiotics in the complex therapy of chronic lower urinary tract inflammation contributed to the normalization of the lactobacilli concentration in 93% of cases, in contrast to standard antibacterial therapy, after which the normal flora was preserved only in 40% of cases. In addition, a reduction in the number of relapses of BV was seen. Moreover, it was found that in the group of patients treated with Lactoginal, there was 18.3% less recurrence of cystitis within 6 months than in the control group (p<0.05).CONCLUSIONThe use of probiotics, in particular, Lactoginal vaginal capsules, in women with BV after antibacterial therapy contributes to a faster recovery and longer preservation of the normal vaginal flora, which allows to the prolongate the relapse-free period of both chronic bacterial cystitis and BV.