更新于：2024-11-01

Pilonidal Sinus

藏毛性窦道

更新于：2024-11-01

基本信息

别名

CYST, PILONIDAL、Coccygeal fistula、Coccygeal sinus

+ [49]

简介

A hair-containing cyst or sinus, occurring chiefly in the coccygeal region.

关联

项与藏毛性窦道相关的药物

Metronidazole

甲硝唑

靶点-

作用机制

DNA合成抑制剂

在研机构

Baxter Healthcare Corp. [+14]

原研机构

Pfizer Inc.

在研适应症

贾第虫病 [+24]

非在研适应症

复杂腹腔感染 [+5]

最高研发阶段批准上市

首次获批国家/地区

法国

首次获批日期1960-01-01

N-butyl-2-cyanoacrylate

靶点-

作用机制-

在研机构-

原研机构-

在研适应症-

非在研适应症

脓肿 [+4]

最高研发阶段无进展

首次获批国家/地区-

首次获批日期1800-01-20

Ortem

靶点-

作用机制-

在研机构-

原研机构

S.L.A. Pharma AG

在研适应症-

非在研适应症

克罗恩病 [+1]

最高研发阶段无进展

首次获批国家/地区-

首次获批日期1800-01-20

173

项与藏毛性窦道相关的临床试验

NCT06406621 / Not yet recruitingN/AIIT

Pilot Trial Assessing the Effectiveness of Laser Hair Depilation on Pilonidal Disease Recurrence in Patients With Darker Skin Color

Pilot randomized trial assessing the effectiveness of laser hair depilation on pilonidal disease recurrence in patients with darker skin color

开始日期2025-01-01

申办/合作机构

Nemours Children's Clinic

NCT06286397 / Not yet recruiting临床2期IIT

Topical Anti-Androgens in Pilonidal Sinus Disease

The goal of this randomized clinical trial is to test the topical drug clascoterone in patients with pilonidal disease, which is a common, benign skin condition of the gluteal cleft. The main questions it aims to answer are:
* Does clascoterone improve the severity of pilonidal disease as scored by a physician?
* Does clascoterone improve patient symptoms due to pilonidal disease?
* Does clascoterone improve the inflammation seen under the microscope in pilonidal disease removed at surgery Participants will apply clascoterone or a placebo cream to the diseased area for 3 months. They will be assessed every 4 weeks for disease severity assessed by a physician viewing patient photos and a symptom-based survey.
Researchers will compare participants who received clascoterone treatment to those who received placebo.

开始日期2024-11-01

申办/合作机构

University of Pennsylvania

CTRI/2024/09/074403 / Not yet recruitingN/AIIT

A comparative study on the effectiveness of vibhitaki kshara sutra against apamarga kshara sutra in pilonidal sinus - Nil

开始日期2024-10-28

申办/合作机构-

100 项与藏毛性窦道相关的临床结果

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100 项与藏毛性窦道相关的转化医学

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0 项与藏毛性窦道相关的专利（医药）

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1,806

项与藏毛性窦道相关的文献（医药）

2024-12-01·Techniques in Coloproctology

Efficacy and safety of RD2 Ver.02, a whole blood clot therapy, coupled with a minimally invasive procedure in pilonidal sinus: a phase II study

Article

作者: Haik, J ; Ram, E ; Zager, Y ; Horesh, N ; Nachmany, I ; Carter, D ; Anteby, R

BACKGROUNDPNS is caused by an infection in the sacrococcygeal area triggered by hair particle accumulation in skin tunnels, resulting in infection. Surgical options range from simple excision to complex flap constructions. Primary wound healing failure and recurrence rates contribute to the burden of PNS. RD2 Ver.02, a novel autologous whole-blood clot product, demonstrated safety and efficacy in treating complex cutaneous wounds and was investigated for the management of PNS.METHODSA Phase II open-label, pilot, single-arm prospective study was conducted from May 2021 to May 2023 (Ethics Committee approval #7952-20). Patients with PNS underwent a minimally invasive trephine procedure under local anesthesia followed by RD2 Ver.02 instillation into the cavity. Primary healing was assessed at 3, 6, and 12 months. Secondary outcomes included the collection of adverse events.RESULTSOverall, 51 patients participated in the study. At 3 months, 42/51 healed (82.4%), 7/51 (13.7%) were granulating but not completely healed, and 2/51 (3.9%) failed to heal. At 6 and 12 months, 46/51 (90.2%) and 42/51 (82.4%) achieved complete healing, respectively. At 6 months, two PNSs recurred after initial healing and an additional four instances of PNS recurrence observed in 12 months, so a total of recurrence in six patients (11.8%). There were five adverse events (AEs) with no severe adverse events.CONCLUSIONRD2 Ver.02 is a safe and effective treatment of PNS when coupled with a minimally invasive trephine PNS procedure. Further comparative studies are needed to fully assess the role of this novel therapy for PNS.

2024-12-01·Techniques in Coloproctology

Adolescent pilonidal disease laser treatment (a-PiLaT): a pilot study

Article

作者: Alrefai, M ; Deska, T ; Nissen, M ; Hubertus, J ; Romanova, A ; Senkal, M

AbstractBackgroundPilonidal disease (PD) is an acquired condition related to hair-induced mechanical forces on the skin surface of the intergluteal cleft, with subsequent abscess formation with or without a concomitant draining sinus (pit). While surgical management currently is the mainstay of treatment, pilonidal disease laser treatment (PiLaT) has recently been recognized as a promising treatment option for non-inflammatory diseases. Nonetheless, there is a paucity of available data on adolescent pilonidal disease laser treatment (a-PiLaT).MethodsWe describe our preliminary experience with PiLaT performed in adolescents aged 10–17 years at our tertiary paediatric surgical hospital from 2019 to 2023. Data on perioperative characteristics and clinical outcomes at follow-up were retrospectively analysed.ResultsA total of 17 consecutive patients (n = 12 female, 71%) underwent a-PiLaT. At the time of treatment, the patients’ mean age and body mass index were 13.6 ± 1.6 years and 25.3 ± 5.6 kg m−2, respectively. The mean operative time was 21.5 ± 10.4 min, whereas the mean follow-up period was 24.5 ± 16.8 months, with a complication rate of 24% (n = 4) and recurrence rate of 18% (n = 3). With respect to postsurgical scar assessment, the mean Patient and Observer Scar Assessment Scale scores (score range 6–60, with higher scores indicating worse outcome) were 14.2 ± 6.5 (patients’ evaluation) and 11.4 ± 4.7 (observers’ evaluation).ConclusionThe a-PiLaT represents a novel approach for managing PD in adolescents. Our preliminary data on the outcomes of a small series of patients with pilonidal sinuses after a-PiLaT indicated complication and recurrence rates comparable to those reported in the literature for adults. This new minimally invasive technique has great potential and is therefore worthy of further research on a larger population.

2024-12-01·Techniques in Coloproctology

Surgical outcomes of minimally invasive trephine surgery for pilonidal sinus disease with and without laser therapy: a comparative study

Article

作者: Nachmany, I ; Horesh, N ; Zager, Y ; Carter, D ; Ram, E ; Anteby, R ; Maman, R ; Weksler, Y

BACKGROUNDOver the last decades, novel therapeutic options have emerged for the surgical treatment of pilonidal sinus disease (PSD). The aim of this study was to evaluate the outcomes of trephine/pit excision surgery with or without laser therapy in patients with PSD.METHODSA retrospective cohort study was conducted at a large tertiary medical center, including all adult patients with PNS who underwent trephine surgery with/without laser therapy between 2016 and 2021[AUTHORS TO INSERT MONTH]. Propensity score matching was used to address confounding factors, and the primary outcome was the 1-year recurrence rate.RESULTSThe study included 221 patients with PSD, with a mean age of 23.73 years (87.7% male). In the unmatched cohort (130 trephine surgery alone, 91 trephine surgery + laser therapy), significant differences were observed in mean age (23 vs. 25 years; p < 0.01)[AUTHROS TO USE MEDIAN PLUS RANGE OR ADD SD] and surgeons' experience (p = 0.014). Propensity score matching was applied to overcome confounding factors, resulting in a matched cohort including 73 patients in each group. The addition of laser therapy demonstrated a significantly lower recurrence rate (8.2% vs. 32.9%; p < 0.001) compared to pit excision without laser therapy. Logistic regression analysis showed that the addition of laser was significantly associated with a lower risk for recurrence (OR 0.23; 95% CI 0.089-0.633; p < 0.01).CONCLUSIONThe incorporation of laser therapy along with trephine/pit excision surgery significantly reduces the recurrence rate in patients with PNS. Further prospective studies are needed to confirm our findings.