更新于：2024-11-01

Exserohilum Infection

出血热感染

更新于：2024-11-01

基本信息

别名

Exserohilum infection、Exserohilum infections、Exserohilum rostratum infection

+ [6]

简介-

关联

靶点

Capsid x Envelope glycoprotein gp160

作用机制

Capsid抑制剂 [+1]

在研机构

Consejo Superior de Investigaciones Científicas

原研机构

Consejo Superior de Investigaciones Científicas

在研适应症

出血热感染

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期1800-01-20

100 项与出血热感染相关的临床结果

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100 项与出血热感染相关的转化医学

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0 项与出血热感染相关的专利（医药）

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项与出血热感染相关的文献（医药）

2024-01-01·Journal of Veterinary Diagnostic Investigation

Granulomatous dermatitis caused by Exserohilum mcginnisii infection in a cow

Article

作者: Weaver, Dustin ; Ilha, Marcia R. S. ; Graham, Erin A.

A 5-y-old, Piedmontese cow had a 4-mo history of ongoing development of skin masses. This was the only cow affected in a herd of 20 cows. Up to 12, hairless, red-to-black, raised nodules-to-plaques were distributed along the dorsum and tail head. Biopsies were taken for histopathology and ancillary testing. An ulcerated skin section contained dermal infiltrates of eosinophils, plasma cells, neutrophils, macrophages, lymphocytes, and multinucleate giant cells, and pyogranulomas. Fungal hyphae were seen within the dermis, multinucleate giant cells, and pyogranulomas. In pyogranulomas, fungi were surrounded by a Splendore–Hoeppli reaction. Dematiaceous (pigmented) hyphae were rarely observed with H&E-stained and unstained (cleared and mounted) sections, but stained well with a Fontana–Masson stain. Exserohilum mcginnisii was identified by fungal culture, followed by PCR assay and sequencing. Exserohilum is a dematiaceous fungus that causes disease in humans and rarely in animals. The use of unstained sections and Fontana–Masson stain are important to demonstrate pigment because dematiaceous fungi have little melanin and appear as hyaline hyphae histologically. PCR assay and sequencing aid in the differentiation and classification of fungal species. To our knowledge, E. mcginnisii dermal granulomas have not been reported previously in cattle.

2020-06-01·Open Forum Infectious Diseases3区 · 医学

Long-term Outcomes of Patients With Fungal Infections Associated With Contaminated Methylprednisolone Injections

3区 · 医学

ArticleOA

作者: McCotter, Orion ; Kaufman, David H ; Jackson, Brendan R ; Chiller, Tom M ; Latham, Robert ; Bloch, Karen C ; Peglow, Sheree ; Pappas, Peter G ; Ledtke, Christopher S ; Malani, Anurag N ; Triplett, Patricia F ; Toda, Mitsuru ; Kerkering, Thomas M ; Wright, Patty W ; Kauffman, Carol A

AbstractBackgroundThe largest health care–associated infection outbreak in the United States occurred during 2012–2013. Following injection of contaminated methylprednisolone, 753 patients developed infection with a dematiaceous mold, Exserohilum rostratum. The long-term outcomes of these infections have not been described.MethodsThis retrospective cohort study of 440 of a total of 753 patients with proven or probable Exserohilum infection evaluated clinical and radiographic findings, antifungal therapy and associated adverse effects, and outcomes at 6 weeks, 3, 6, 9, and 12 months after diagnosis. Patients were grouped into 4 disease categories: meningitis with/without stroke, spinal or paraspinal infections, meningitis/stroke plus spinal/paraspinal infections, and osteoarticular infections.ResultsAmong the 440 patients, 223 (51%) had spinal/paraspinal infection, 82 (19%) meningitis/stroke, 123 (28%) both, and 12 (3%) osteoarticular infection. Of 82 patients with meningitis/stroke, 18 (22%) died; among those surviving, 87% were cured at 12 months. Only 7 (3%) of 223 patients with spinal/paraspinal infection died, but at 12 months, 68% had persistent or worsening pain and only 47% were cured. For the 123 patients with both meningitis/stroke and spinal/paraspinal infection, 10 (8%) died, pain persisted in 72%, and 52% were cured at 12 months. Only 37% of those with osteoarticular infection were cured at 12 months. Adverse events from antifungal therapy were noted at 6 weeks in 71% of patients on voriconazole and 81% on amphotericin B.ConclusionsFungal infections related to contaminated methylprednisolone injections culminated in death in 8% of patients. Persistent pain and disability were seen at 12 months in most patients with spinal/paraspinal infections.

2019-03-01·Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis4区 · 医学

Exserohilum Peritonitis in Peritoneal Dialysis in Northern China: A Case Report

4区 · 医学

Article

作者: Liu, Yan ; Jiang, Lihua ; Yu, Yanming ; Gong, Wenjing

Fungal peritonitis is a catastrophic complication of peritoneal dialysis (PD) and often requires termination of PD. It is usually caused by Candida species. Here we report a rare case of Exserohilum peritonitis. The patient was successfully treated with catheter removal and anti-fungal therapy.