更新于：2024-11-01

Autonomic seizure

植物神经性发作

更新于：2024-11-01

基本信息

别名

Autonomic seizure、autonomic; seizures、seizure; autonomic

+ [2]

简介-

关联

项与植物神经性发作相关的药物

Acetylpheneturide

靶点-

作用机制-

在研机构

Sumitomo Pharma Co., Ltd.

原研机构

Sumitomo Pharma Co., Ltd.

在研适应症

植物神经性发作 [+2]

非在研适应症-

最高研发阶段批准上市

首次获批国家/地区

日本

首次获批日期1962-04-06

项与植物神经性发作相关的临床试验

CTR20242404 / Active, not recruitingN/A

苯巴比妥片人体生物等效性研究

本试验旨在研究单次空腹和餐后口服山东新华制药股份有限公司研制、生产的苯巴比妥片（30 mg）的药代动力学特征；以Fujinaga pharm Co.,Ltd.持证、藤永製薬株式会社生产的苯巴比妥片（Phenobal®，30 mg）为参比制剂，比较两制剂中药动学参数Cmax、AUC0-72，评价两制剂的人体生物等效性。

开始日期2024-07-28

申办/合作机构

山东新华制药股份有限公司

100 项与植物神经性发作相关的临床结果

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100 项与植物神经性发作相关的转化医学

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0 项与植物神经性发作相关的专利（医药）

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158

项与植物神经性发作相关的文献（医药）

2024-08-07·Cureus

Self-Limited Epilepsy With Autonomic Seizures: A Case Report

Article

作者: Ferreira, Diogo M ; Felgueiras, Armando ; Raimundo, Dina ; Bolas, Sérgio

This case report describes a six-year-old girl without relevant personal or family history, who had a seizure at awakening with loss of muscle tone, sialorrhea and ocular retroversion. The episode lasted >5 minutes, with vomiting and post-ictal confusion. Upon the hospital visit, she was misdiagnosed with acute gastroenteritis and discharged with symptomatic treatment. After another seizure, she was diagnosed with Panayiotopoulos syndrome and started receiving treatment. Since then, the child has been followed up through neuropediatric appointments and by her family doctor. The psychological assessment revealed normal general intellectual functioning with vulnerability in the language area.

2024-07-01·Epilepsy & Behavior

KCNQ2 mutations cause unique neonatal behavior arrests without motor seizures: Functional characterization

Article

作者: Liou, Ying-Ming ; Lee, Inn-Chi ; Wong, Swee-Hee ; Yang, Jiann-Jou

OBJECTIVEKCNQ2 gene mutation usually manifests as neonatal seizures in the first week of life. Nonsense mutations cause a unique self-limited familial neonatal epilepsy (SLFNE), which is radically different from developmental epileptic encephalopathy (DEE). However, the exact underlying mechanisms remain unclear.METHODSThe proband, along with their mother and grandmother, carried the c.1342C > T (p.Arg448Ter) mutation in the KCNQ2 gene. The clinical phenotypes, electroencephalography (EEG) findings, and neurodevelopmental outcomes were comprehensively surveyed. The mutant variants were transfected into HEK293 cells to investigate functional changes.RESULTSThe proband exhibited behavior arrests, autonomic and non-motor neonatal seizures with changes in heart rate and respiration. EEG exhibited focal sharp waves. Seizures were remitted after three months of age. The neurodevelopmental outcomes at three years of age were unremarkable. A functional study demonstrated that the currents of p.Arg448Ter were non-functional in homomeric p.Arg448Ter compared with that of the KCNQ2 wild type. However, the current density and V_1/2 exhibited significant improvement and close to that of the wild-type after transfection with heteromeric KCNQ2 + p.Arg448Ter and KCNQ2 + KCNQ3 + p.Arg448Ter respectively. Channel expression on the cell membrane was not visible after homomeric transfection, but not after heteromeric transfection. Retigabine did not affect homomeric p.Arg448Ter but improved heteromeric p. Arg448Ter + KCNQ2 and heteromeric KCNQ2 + Arg448Ter + KCNQ3.CONCLUSIONSThe newborn carrying the p. Arg448Ter mutation presented frequent behavioral arrests, autonomic, and non-motor neonatal seizures. This unique pattern differs from KCNQ2 seizures, which typically manifest as motor seizures. Although p.Arg448Ter is a non-sense decay, the functional study demonstrated an almost-full compensation mechanism after transfection of heteromeric KCNQ2 and KCNQ3.

2023-11-01·European Journal of Paediatric Neurology

A reappraisal of interictal EEG characteristics in self-limited epilepsy with autonomic seizures, formerly known as Panayiotopoulos syndrome or early-onset benign occipital epilepsy

Review

作者: Oguni, Hirokazu

PURPOSEIn the 2022 New International Classification of Epilepsy Syndromes, self-limited epilepsy with autonomic seizures (SeLEAS), formerly known as Panayiotopoulos syndrome is recognized as an electroclinical syndrome that is clinically characterized by autonomic seizures and electroencephalographically by multifocal EEG foci. EEG studies were reviewed herein and the suitability of the EEG definition to characterize SeLEAS was assessed.METHODS AND RESULTSThe EEG findings of SeLEAS studies published to date were reviewed and typical sites of EEG foci and their evolutionary changes with age were analyzed. Although previous studies investigated the details of interictal EEG characteristics in a sufficient number of SeLEAS cases, there were few systematically analyzing cross sectional and longitudinal EEG changes except one study. Despite these limited evidence, I propose the following practical and useful EEG definition. The interictal EEG characteristics of SeLEAS are multifocal EEG foci with age-dependent predominant locations; occipital (O) at 2-5 years old, and occipital and frontopolar (synchronous and independent O and Fp spikes) at 4-7 years old and centro-parieto-temporal (CPT) at 6-10 years old. O EEG foci evolve to multifocal EEG foci with a O-Fp or CPT predominance with age and disappear by 12∼16 years old. O-Fp EEG foci may further evolve to generalized spike-wave complexes and rarely to spike-wave activated in sleep. In rare cases, the EEGs do not have epileptic EEG foci.CONCLUSIONInterictal EEG foci in SeLAES may have different EEG patterns in terms of location and the mode of appearance depending on the age at which EEG is recorded. O-Fp EEG foci may be a specific EEG pattern indicating a diagnosis of SeLEAS.