更新于：2024-11-01

Trichostrongylosis

毛圆线虫病

更新于：2024-11-01

基本信息

别名

Infection by Trichostrongylus、Infection by Trichostrongylus species、TRICHOSTRONGYLIASIS

+ [13]

简介

Infestation with nematode worms of the genus TRICHOSTRONGYLUS. Man and animals become infected by swallowing larvae, usually with contaminated food or drink, although the larvae may penetrate human skin.

关联

项与毛圆线虫病相关的药物

Pyrantel Pamoate

双羟萘酸噻嘧啶

靶点

Cholinesterase

作用机制

胆碱酯酶抑制剂

在研机构

Sato Pharmaceutical Co., Ltd. [+1]

原研机构

Pfizer AS

在研适应症

钩虫症 [+3]

非在研适应症-

最高研发阶段批准上市

首次获批国家/地区

中国

首次获批日期1984-01-01

Bephenium Hydroxynaphthoate

羟萘苄芬宁

靶点-

作用机制-

在研机构-

原研机构-

在研适应症

蛔虫病 [+2]

非在研适应症-

最高研发阶段批准上市

首次获批国家/地区-

首次获批日期1800-01-20

SB-203105

靶点-

作用机制-

在研机构-

原研机构

Pfizer Inc.

在研适应症-

非在研适应症

毛圆线虫病

最高研发阶段终止

首次获批国家/地区-

首次获批日期1800-01-20

100 项与毛圆线虫病相关的临床结果

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100 项与毛圆线虫病相关的转化医学

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0 项与毛圆线虫病相关的专利（医药）

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137

项与毛圆线虫病相关的文献（医药）

2024-04-01·International Journal for Parasitology: Parasites and Wildlife

Influence of seasonality and biological activity on infection by helminths in Cantabrian bear

Article

作者: Bombieri, Giulia ; González-Bernardo, Enrique ; Penteriani, Vincenzo ; Sánchez-Andrade Fernández, Rita ; Zarzo-Arias, Alejandra ; Valderrábano Cano, Esther ; Delgado, María Del Mar ; Vega, Iris ; Paz-Silva, Adolfo

This study aimed to investigate the variations of parasites in the feces of brown bears Ursus arctos inhabiting the Cantabrian Mountains (NW Spain). A total of 248 bear fecal samples were collected throughout one year, spanning from August 2018 to September 2019, at an approximate frequency of 20 samples per month. The results were analyzed in relation to both the season and the biological activity of the brown bears, i.e., hibernation, mating and hyperphagia. Among the examined samples, eggs of Dicrocoelium dendriticum (32.2%; 95% Confidence Interval: 26.4-38.1), Baylisascaris sp. (44.8%; 38.5-50.9), ancylostomatids (probably belonging to Uncinaria spp.) (16.5%; 11.9-21.1) and Trichuris sp. (1.2%; 0-2.6) were observed. Significant seasonal differences were noted for Baylisascaris and ancylostomatids (χ² = 21.02, P = 0.001 and χ² = 34.41, P = 0.001, respectively). Furthermore, the presence of helminth eggs was correlated with the activity phase of the brown bears. Dicrocoelium attained the highest prevalence during the mating phase, while Baylisascaris and ancylostomatids were more frequent during hyperphagia. Notably, the highest egg-output counts for Dicrocoelium and Baylisascaris sp. were recorded during the mating phase and hibernation, respectively, whereas ancylostomatids eggs peaked during hyperphagia. Additionally, variations in egg-output counts were significant for all helminths concerning the season, with the exception of Trichuris sp., and for Dicrocoelium and Baylisascaris sp. According to bear activity. It is concluded that infection by gastrointestinal helminths depends on the season and the biological activity of the bears from the Cantabrian Mountains, and their health status could result influenced.

2023-12-01·International Journal for Parasitology: Parasites and Wildlife

Unveiling a novel parasitosis: Trichostrongylus colubriformis infection in captive ring-tailed lemurs (Lemur catta)

Article

作者: Galuppi, Roberta ; Dini, Filippo Maria ; Tedesco, Perla ; Capasso, Michele ; Caffara, Monica ; Cotignoli, Chiara ; Galliani, Matteo

Ring-tailed Lemur (Lemur catta) is the only surviving semi-terrestrial diurnal lemur in Madagascar. Despite being the most intensively studied of lemur taxa, only a few helminths have been described in this species. In this study we describe a persistent infection due to Trichostrongylus colubriformis in a captive population of L. catta hosted in a zoological park of northern Italy. In the context of a parasitological survey on zoo animals, we investigated parasites in a captive colony of ring-tailed lemurs within a zoological park. Parasitological analysis included necropsy of a deceased lemur in 2019, subsequent fecal sample collections in 2021-2022, followed by coprological examination and coprocolture. Morphological and molecular analyses were conducted on adult helminths, larvae and eggs, involving microscopy, scanning electron microscopy (SEM), and sequencing of the ITS rDNA region. Trichostrongylidae parasites were primarily found after necropsy in the intestine of the lemur. Morphological and molecular investigations on adults and eggs/larvae recovered from feces collected at different times from lemurs of the same captive population, allowed to properly identify the parasite as T. colubriformis. To the best of our knowledge this is the first description of T. colubriformis in L. catta. Although its presence in wild populations is not necessarily implied by our finding, this parasitosis represent a cause of concern in captive lemurs, considering the possibility of interspecies transmission and the zoonotic implications.

2023-01-01·Journal of Helminthology

Trichostrongylosis: a zoonotic disease of small ruminants

Review

作者: Tak, H ; Bhat, A H ; Zehbi, N ; Malik, I M ; Ganai, B A

In the present world a significant threat to human health is posed by zoonotic diseases. Helminth parasites of ruminants are one of the most common zoonotic organisms on the planet. Among them, trichostrongylid nematodes of ruminants, found worldwide, parasitize humans in different parts of the world with varying rates of incidence, particularly among rural and tribal communities with poor hygiene, pastoral livelihood and poor access to health services. In the Trichostrongyloidea superfamily, Haemonchus contortus, Teladorsagia circumcincta, Marshallagia marshalli, Nematodirus abnormalis and Trichostrongylus spp. are zoonotic in nature. Species of the genus Trichostrongylus are the most prevalent gastrointestinal nematode parasites of ruminants that transmit to humans. This parasite is prevalent in pastoral communities around the world and causes gastrointestinal complications with hypereosinophilia which is typically treated with anthelmintic therapy. The scientific literature from 1938 to 2022 revealed the occasional incidence of trichostrongylosis throughout the world with abdominal complications and hypereosinophilia as the predominant manifestation in humans. The primary means of transmission of Trichostrongylus to humans was found to be close contact with small ruminants and food contaminated by their faeces. Studies revealed that conventional stool examination methods such as formalin-ethyl acetate concentration or Willi's technique combined with polymerase chain reaction-based approaches are important for the accurate diagnosis of human trichostrongylosis. This review further found that interleukin 33, immunoglobulin E, immunoglobulin G1, immunoglobulin G2, immunoglobulin M, histamine, leukotriene C4, 6-keto prostaglandin F1α, and thromboxane B2 are vital in the fight against Trichostrongylus infection with mast cells playing a key role. This review focuses on the prevalence, pathogenicity and immunological aspects of Trichostrongylus spp. in humans.