预约演示

更新于：2025-05-07

Arcus Senilis

老年环

更新于：2025-05-07

基本信息

别名

ARCUS CORNEAE、ARCUS SENILIS、Anterior embryotoxon

+ [31]

简介

A corneal disease in which there is a deposition of phospholipid and cholesterol in the corneal stroma and anterior sclera.

关联

项与老年环相关的药物

LSCD101

靶点-

作用机制-

在研机构-

原研机构

CLIPS SA

在研适应症-

非在研适应症

老年环 [+1]

最高研发阶段无进展

首次获批国家/地区-

首次获批日期1800-01-20

项与老年环相关的临床试验

NCT04773431

/ Completed临床1期

Phase I Study to Evaluate Safety of LSCD101(Cultured Autologous Limbal Epithelial Cell Sheet) Transplantation for Limbal Stem Cell Deficiency

Clinical Study Objective:
To evaluate the tolerability and safety after transplantation of LSCD101 in patients with intractable limbal stem cell deficiency
Study Method:
Subjects who finally meet the inclusion/exclusion criteria results of the subject eligibility evaluation will receive transplantation of the investigational product. Adverse drug reaction will be confirmed during 24 weeks after transplantation.

开始日期2020-01-31

申办/合作机构

CLIPS SA

NCT03198897

/ WithdrawnN/A

BioHoFH - Biomarker for Homozygous Familial Hypercholesterolemia AN INTERNATIONAL, MULTICENTER, EPIDEMIOLOGICAL PROTOCOL

Development of a new MS-based biomarker for the early and sensitive diagnosis of Homozygous familial Hypercholesterolemia from blood

开始日期2018-08-20

申办/合作机构-

NCT03612284

/ CompletedN/AIIT

Scleral Contact Lens Insertion Solution Study

The purpose of this study is to determine the clinical ocular compatibility (feasibility of safety and efficacy) of a patented solution (US Patent 2,259,437, Stone) which contains multiple essential ions and has a pH and tonicity which more closely mimics human tears as compared to the subjects' current habitual scleral lens insertion solution.

开始日期2017-11-27

申办/合作机构

The Ohio State University

100 项与老年环相关的临床结果

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100 项与老年环相关的转化医学

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0 项与老年环相关的专利（医药）

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374

项与老年环相关的文献（医药）

2025-03-01·European Journal of Ophthalmology

H syndrome with bilateral choroidal osteoma: Coincidence or association?

Article

作者: Elmas, Muhsin ; Sariyeva Ismayilov, Ayna ; Doğanay, Derya ; Ulusoy, Mahmut Oğuz ; Akacı, Okan ; Topak, Ali

Purpose To report a case with bilateral corneal arcus and bilateral choroidal osteoma associated with H syndrome Methods Descriptive case report Results A 16-year-old girl with H syndrome was followed up in the pediatric nephrology clinic for chronic renal failure and was consulted to the ophthalmology clinic. She had low vision for more than 5 years. Slit lamp examination revealed bilateral corneal arcus . Lens and iris were normal. Axial length was 19.99 mm in the right eye and 21.85 mm in the left eye. A bilateral orange-yellow plaque was noted in the posterior pole in the funduscopic examination. Fundus autofluorescence (FAF) showed a bilateral diffuse macular hipoautofluorescence area in correspondence with the decalcified portion of the mass. Optical coherence tomography (OCT) showed a bilateral choroidal mass with a dome-shaped pushing effect on the overlying retina and damage to the outer layers of the retina. Fluorescein angiography (FA) with bilateral patchy diffuse late hyperfluorescence and B scan ultrasonography showed a bilateral solid highly reflective choroidal mass with acoustic shadowing. Orbital computerized tomography (CT) scans showed bilateral hyperdense plaques in the posterior pole. A diagnosis of choroidal osteomas was made for both eyes. Conclusions This report presents a case with bilateral corneal arcus and bilateral choroidal osteoma associated with H syndrome that has not been previously reported in the literature. Patients diagnosed with this syndrome should undergo routine eye examination, and due to the progressive nature of histiocytosis, they should also be followed closely ophthalmologically.

2025-01-01·Eye & Contact Lens: Science & Clinical Practice

Corneal Higher-Order Aberrations and Visual Acuity After Anterior Lamellar Keratoplasty in Treating Limbal Dermoid

Article

作者: Kasamatsu, Hirotsugu ; Yamaguchi, Takefumi ; Ogiwara, Yurina ; Daisuke Tomida ; Matsumae, Hiroshi ; Yagi-Yaguchi, Yukari ; Takanori Suzuki ; Shimazaki, Jun ; Hashi, Shiori

Purpose:To evaluate the corneal higher-order aberrations (HOAs) in eyes with limbal dermoids before and after excision and anterior lamellar keratoplasty (ALK) and its impact on visual acuity.Methods:This retrospective consecutive study included 39 eyes of 39 patients with limbal dermoid who underwent ALK. Higher-order aberrations were measured using anterior segment optical coherence tomography. The correlation between HOAs and visual acuity was investigated.Results:The mean logarithm of the minimum angle of resolution significantly improved from 0.21±0.41 to 0.12±0.34 after ALK (P=0.038). The HOAs of the total cornea within a 4-mm diameter significantly decreased from 2.66±5.51 μm to 1.09±1.48 after ALK (P=0.006). Logarithm of the minimum angle of resolution was significantly correlated with corneal HOAs (r=0.610, P<0.001 before ALK, r=0.518, P=0.008 after ALK), preoperative corneal astigmatism (r = −0.336, P=0.036), and dermoid diameter (r=0.467, P=0.004) but not with postoperative corneal astigmatism (r=0.017, P=0.934).Conclusions:Corneal HOAs and dermoid diameter were associated with decreased visual acuity in limbal dermoid. Excision of limbal dermoids and ALK significantly reduced corneal HOA and improved visual acuity.

2025-01-01·Journal of Family Medicine and Primary Care

Case report of familial hypercholesterolemia with internal carotid neck swelling

Article

作者: Ray, Prajna ; Sahana, Ranita ; Kumar, Sudesh

ABSTRACTFamilial hypercholesterolemia is a multi-gene disorder affecting 1 in 200-500 individual which is characterized by increased level of total cholesterol and low density lipoprotein (LDL) which deposit cholesterol reach protein leading to xanthomas, corneal arcus and prone to develop risk for atherosclerosis and coronary heart disease. 11 year female, born of consanguineous marriage attended with yellowish patches (Xanthelasma) bilaterally present over upper eyelid, buttock since 5-6 years. In family history younger girl along with both parents has Xanthelasma. In investigations, routine blood, urine and ECG& ECHO was normal except lipid profile of patient and sibling was abnormal. Child was treated with atorvastatin and dietary advice. In follow up after 3 month, child had complained of neck pain and swelling to left side. Then USG neck and Color Doppler showed reduced diastolic flow of left ICA and type two plaques and type 111 plaque in Rt common carotid artery. Anti-platelets was added and referred to cardiologist for coronary angiography which showed LAD – proximal mid distal diffuse plaque, LCX- proximal eccentric plaque. This case highlights the significance of conscious and proactive genetic screening for familial hypercholesterolemia especially in consanguineous marriage, to diagnose, treat and prevent mortality with premature coronary artery disease.

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