更新于：2024-11-01

Mammary Paget's Disease

乳腺佩吉特氏病

更新于：2024-11-01

基本信息

别名

Breast Paget Disease、Disease, Mammary Paget、Disease, Mammary Paget's

+ [64]

简介

An intraductal in situ carcinoma of the breast, characterized clinically by eczema-like inflammatory skin changes and histologically by infiltration of the dermis by malignant cells (Paget's cells).

关联

项与乳腺佩吉特氏病相关的药物

Pamidronate Disodium

帕米膦酸二钠

靶点

Bone resorption factor x FDPS

作用机制

骨吸收因子抑制剂 [+1]

在研机构

Hikma Pharmaceuticals USA, Inc. [+2]

原研机构

Novartis Pharma AG

在研适应症

畸形性骨炎 [+3]

非在研适应症

乳腺佩吉特氏病

最高研发阶段批准上市

首次获批国家/地区

美国

首次获批日期1991-10-31

项与乳腺佩吉特氏病相关的临床试验

ChiCTR2000032336 / CompletedN/AIIT

IS PREDICTION OF LOCAL RECURRENCE POSSIBLE IN PAGET’S DISEASE OF THE BREAST?

开始日期2020-04-25

申办/合作机构-

ChiCTR1800014979 / RecruitingIIT

A clinical trials of Rapamycin cream in the treatment of pagets disease

开始日期2018-02-26

申办/合作机构-

RBR-3wfshm / Active, not recruitingN/A

Mammillary traumas during breastfeeding and the action of low intensity laser:Randomized Clinical Trial

开始日期2018-01-03

申办/合作机构-

100 项与乳腺佩吉特氏病相关的临床结果

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100 项与乳腺佩吉特氏病相关的转化医学

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0 项与乳腺佩吉特氏病相关的专利（医药）

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491

项与乳腺佩吉特氏病相关的文献（医药）

2024-12-01·Radiology Case Reports

Primary nipple melanoma in a patient with breast cancer: A diagnosis to consider

Article

作者: Antonini, Pietro ; Naro, Federica Di ; Giudice, Lucia ; Incardona, Ludovica Anna ; De Giorgi, Vincenzo ; Vidali, Sofia ; Nori, Jacopo ; Vezzosi, Vania ; Nucci, Elena

Melanoma in situ of the nipple is an uncommon diagnosis, with only a few reports in the literature. Due to the variety of pathologies that can affect the nipple-areola complex, the diagnosis can be challenging. In this case report we describe a patient with cosmetic bilateral breast implants who presented with eczema of the left nipple-areola complex and suspicious microcalcifications in the lower inner quadrant of the ipsilateral breast on mammography, subsequently diagnosed with nipple melanoma and concomitant ductal carcinoma in situ.

2024-07-25·Cureus

Mammary Paget's Disease Mimicking Benign and Malignant Dermatological Conditions: Clinical Challenges and Diagnostic Considerations

Review

作者: Kołodziej, Faustyna ; NR, Kaushik ; Reza-Soltani, Setareh ; Rezvani, Ali ; Ullah, Muhammad Naqib ; Nr, Kaushik ; Qureshi, Maha R ; Ahmadi, Yasmin ; Scott-Emuakpor, Renee ; Sil-Zavaleta, Susana ; Siddiqui, Humza F ; Nalla, Monica ; Altaf, Sana

Mammary Paget's disease (MPD) or Paget's disease of the breast is a rare dermatological malignancy of the nipple-areolar complex that manifests with a spectrum of symptoms spanning from itching and redness to more severe indications such as breast lump, nipple-areolar complex destruction, or nipple discharge. It is predominantly associated with an underlying ductal carcinoma in situ or invasive ductal carcinoma. MPD often masquerades as other benign and malignant dermatological conditions, including eczema, atopic dermatitis, psoriasis, and squamous and basal cell carcinomas, leading to delayed diagnosis and inappropriate treatment. Only one-third of the patients present with a palpable lump; therefore, advanced age with chronic and unilateral lesions should raise concern for MPD. Our review article presents case reports of MPD imitating other skin conditions and underscores the key findings of clinical features and diagnostic workup to help differentiate the condition. A literature review revealed that studies emphasize caution regarding the sole use of mammography and ultrasound in diagnosing MPD, particularly in cases lacking a palpable lump. This highlights the MRI as a superior and more accurate imaging tool. However, any suspicious lesion must be biopsied to allow histopathological and immunohistochemical examination, since there are some cases where MRI findings were negative in the presence of a biopsy-proven MPD. This highlights the need for clinicians to investigate any suspicious lesion of the nipple or breast using the complete triple assessment approach to exclude an underlying malignancy. It is imperative to establish therapeutic guidelines to approach any nipple lesion to minimize the risk of misdiagnosing any underlying cancer, which can be potentially fatal if left alone.

2024-07-01·Cureus

Mammary Paget's Disease Mimicking Benign and Malignant Dermatological Conditions: Clinical Challenges and Diagnostic Considerations.

Review

作者: Kołodziej, Faustyna ; Reza-Soltani, Setareh ; Rezvani, Ali ; Ullah, Muhammad Naqib ; Nr, Kaushik ; Ahmadi, Yasmin ; Qureshi, Maha R ; Scott-Emuakpor, Renee ; Sil-Zavaleta, Susana ; Siddiqui, Humza F ; Nalla, Monica ; Altaf, Sana