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更新于：2025-05-07

Mammary Paget's Disease

乳腺佩吉特氏病

更新于：2025-05-07

基本信息

别名

Breast Paget Disease、Disease, Mammary Paget、Disease, Mammary Paget's

+ [64]

简介

An intraductal in situ carcinoma of the breast, characterized clinically by eczema-like inflammatory skin changes and histologically by infiltration of the dermis by malignant cells (Paget's cells).

关联

项与乳腺佩吉特氏病相关的药物

Pamidronate Disodium

帕米膦酸二钠

靶点

Bone resorption factor x FDPS

作用机制

骨吸收因子抑制剂 [+1]

在研机构

Hikma Pharmaceuticals USA, Inc. [+2]

原研机构

Novartis Pharma AG

在研适应症

畸形性骨炎 [+3]

非在研适应症

乳腺佩吉特氏病

最高研发阶段批准上市

首次获批国家/地区

美国

首次获批日期1991-10-31

Recombinant Fowlpox-GM-CSF(National Cancer Institute)

靶点-

作用机制-

在研机构-

原研机构

National Cancer Institute

在研适应症-

非在研适应症

膀胱鳞状细胞癌 [+21]

最高研发阶段终止

首次获批国家/地区-

首次获批日期1800-01-20

项与乳腺佩吉特氏病相关的临床试验

ChiCTR2000032336

/ CompletedN/AIIT

IS PREDICTION OF LOCAL RECURRENCE POSSIBLE IN PAGET’S DISEASE OF THE BREAST?

开始日期2020-04-25

申办/合作机构-

ChiCTR1800014979

/ RecruitingN/AIIT

A clinical trials of Rapamycin cream in the treatment of pagets disease

开始日期2018-02-26

申办/合作机构-

RBR-3wfshm

/ Active, not recruitingN/A

Mammillary traumas during breastfeeding and the action of low intensity laser:Randomized Clinical Trial

开始日期2018-01-03

申办/合作机构-

100 项与乳腺佩吉特氏病相关的临床结果

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100 项与乳腺佩吉特氏病相关的转化医学

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0 项与乳腺佩吉特氏病相关的专利（医药）

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519

项与乳腺佩吉特氏病相关的文献（医药）

2025-04-01·Radiology Case Reports

Diagnostic imaging challenges of mammary Paget's disease presenting with subtle clinical and imaging features: A case report

Article

作者: Darmiati, Sawitri ; Heryanto, Andre Elton ; Rustamadji, Primariadewi

Mamary Paget's disease presents with subtle and insidious symptoms leading to late diagnosis that poses medical challenges. This uncommon pathology often has underlying ductal breast cancer, including in situ or invasive breast cancer, which makes early recognition crucial for better prognoses. A 78-year-old postmenopausal woman presented with progressive and persistent eczematous skin lesions of the nipple without breast lumps. Additional imaging procedures revealed subtle findings, but the histopathology and immunohistopathology confirmed Paget's disease. This case highlights the importance of the correlation between clinical findings and the chosen diagnostic method for establishing a definitive diagnosis of mammary Paget's disease.

2025-03-13·Cureus

Insights Into Mammary and Extramammary Paget’s Disease: Diagnosis, Management, and Recent Advances

Review

作者: Sandoval García, Alicia ; Ortuz Lessa, Camila ; López Soto, Katherine ; Brito Brito, Nicolás Ricardo ; Garzón Ortega, Víctor Hugo ; Fernández Varela Gómez, Fernando

Mammary Paget's disease (MPD) and extramammary Paget's disease (EMPD) are rare cutaneous disorders associated with adenocarcinoma, each presenting unique clinical challenges. MPD typically indicates an underlying breast cancer, manifesting as eczematous changes in the nipple-areolar complex. In contrast, EMPD appears as erythematous, scaly plaques in apocrine-gland-rich areas such as the vulva, perianal region, or axilla, with inconsistent links to internal malignancies. These conditions often resemble benign skin diseases, complicating timely diagnosis. Diagnosis involves clinical evaluation, imaging, and histopathological confirmation of Paget cells. Pathogenesis may stem from in situ malignant transformation or migration of cancer cells from distant sites, influenced by molecular pathways like HER2 and PI3K-AKT-mTOR. Treatment varies: MPD often requires mastectomy and systemic therapies, while EMPD is managed with surgical excision (e.g., Mohs surgery), adjusted to disease extent. The prognosis hinges on stage, molecular features, and associated tumors, particularly impacting MPD survival. Recent advances in precision medicine and immunotherapy, especially for EMPD, offer promising directions. This review highlights the distinct features, diagnostic hurdles, treatment strategies, and the essential role of a multidisciplinary approach in improving outcomes.

2024-12-01·Radiology Case Reports

Primary nipple melanoma in a patient with breast cancer: A diagnosis to consider

Article

作者: Antonini, Pietro ; Naro, Federica Di ; Giudice, Lucia ; Incardona, Ludovica Anna ; De Giorgi, Vincenzo ; Vidali, Sofia ; Vezzosi, Vania ; Nori, Jacopo ; Nucci, Elena

Melanoma in situ of the nipple is an uncommon diagnosis, with only a few reports in the literature. Due to the variety of pathologies that can affect the nipple-areola complex, the diagnosis can be challenging. In this case report we describe a patient with cosmetic bilateral breast implants who presented with eczema of the left nipple-areola complex and suspicious microcalcifications in the lower inner quadrant of the ipsilateral breast on mammography, subsequently diagnosed with nipple melanoma and concomitant ductal carcinoma in situ.

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