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更新于：2024-11-01

Dysautonomia Like Disorder

自主神经紊乱

更新于：2024-11-01

基本信息

别名

DYSAUTONOMIA-LIKE DISORDER、Dysautonomia like disorder、Dysautonomia-Like Disorder

+ [1]

简介-

关联

项与自主神经紊乱相关的药物

Clotiazepam

氯噻西泮

靶点

GABAA receptor

作用机制

GABAA receptor激动剂

在研机构

Mitsubishi Tanabe Pharma Corp.

原研机构

Mitsubishi Tanabe Pharma Corp.

在研适应症

焦虑症 [+3]

非在研适应症-

最高研发阶段批准上市

首次获批国家/地区

日本

首次获批日期1988-05-31

Tofisopam

托非索泮

靶点

GABAA receptor

作用机制

GABAA receptor激动剂

在研机构

Mochida Pharmaceutical Co., Ltd.

原研机构-

在研适应症

自主神经紊乱 [+1]

非在研适应症-

最高研发阶段批准上市

首次获批国家/地区

日本

首次获批日期1985-11-05

项与自主神经紊乱相关的临床试验

NCT05638620 / Active, not recruiting临床1期IIT

Evaluating the Effectiveness of Dual Sympathetic Blocks for Patients Experiencing Sympathetically-Mediated Symptoms From Post-Acute Sequelae of SARS-CoV-2 (PASC)

The main purpose of this study is to gather data and assess changes in patient-reported outcomes with the stellate ganglion blocks as treatment for their sympathetically-mediated long COVID symptoms.

开始日期2023-01-03

申办/合作机构

Hudson Medical

100 项与自主神经紊乱相关的临床结果

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100 项与自主神经紊乱相关的转化医学

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0 项与自主神经紊乱相关的专利（医药）

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项与自主神经紊乱相关的文献（医药）

1976-01-01·European Neurology4区 · 医学

A Case of New Dysautonomia-Like Disorder Found in Japan

4区 · 医学

Article

作者: Fujii, K. ; Oura, T. ; Hayashi, A. ; Higa, S. ; Sato, Y. ; Nakagawa, T. ; Suzuki, T.

A case of new dysautonomia-like disorder in a Japanese infant is reported. The patient showed almost all of the essential criteria for the diagnosis of familial dysautonomia. Results of pharmacologic tests and urinary excretion patterns of catecholamines and their metabolites were also compatible with the disorder. But he lacked some important clinical findings, such as lifelong hypolacrimia, skin blotching, excessive sweating and labile blood pressure. Precise observations of clinical features and literatures on non-Jewish cases of familial dysautonomia lent evidence that this case suffered from a new dysautonomia-like disorder.

Human Genome Variation

The case of a patient with MIRAGE syndrome with familial dysautonomia-like symptoms

Article

作者: Tanase-Nakao, Kanako ; Namba, Noriyuki ; Kawashima-Sonoyama, Yuki ; Dohmoto, Tomotsune ; Okuno, Keisuke ; Narumi, Satoshi

AbstractWe describe a case of posthumously diagnosed MIRAGE syndrome (Myelodysplasia, Infection, Restriction of growth, Adrenal hypoplasia, Genital problems, and Enteropathy) in a girl with a new pathogenic SAMD9 variant (p.F437S), who was initially considered to have familial dysautonomia (FD)-like disease due to increased levels of catecholamine metabolites. Functional analyses of F437S-SAMD9 were performed, showing characteristics of disease-causing variants. This new SAMD9 variant (p.F437S) also causes MIRAGE syndrome.