更新于：2024-11-01

Traumatic pancreatitis

创伤性胰腺炎

更新于：2024-11-01

基本信息

别名

PANCREATITIS TRAUMATIC、Traumatic pancreatitis、外傷性膵炎

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简介-

关联

项与创伤性胰腺炎相关的药物

Nafamostat Mesilate

甲磺酸萘莫司他

靶点

Serine protease

作用机制

丝氨酸蛋白酶家族抑制剂

在研机构

江苏杜瑞制药有限公司 [+1]

原研机构

Nichi-Iko Pharmaceutical Co., Ltd.

在研适应症

弥散性血管内凝血 [+2]

非在研适应症

慢性胰腺炎 [+1]

最高研发阶段批准上市

首次获批国家/地区

日本

首次获批日期1989-03-31

项与创伤性胰腺炎相关的临床试验

CTR20160698 / Completed临床1期

注射用甲磺酸萘莫司他人体药代动力学试验

研究健康志愿者单次（10 mg、20 mg、40 mg）和多次（20 mg）给药的药代动力学特征，了解不同剂量甲磺酸萘莫司他在人体内动态变化的规律及其剂量相关性，以及多次连续给药体内蓄积情况，为制定合理临床给药方案提供依据。

开始日期2016-09-14

申办/合作机构

兰州京陇医药科技有限公司

NCT02487225 / Completed临床3期IIT

Pentoxifylline Treatment in Acute Pancreatitis: A Double-Blind Placebo - Controlled Randomized Trial

The purpose of this study was to determine the effects (good and bad) of giving a drug called pentoxifylline to patients with acute pancreatitis.

开始日期2015-05-01

申办/合作机构

Mayo Clinic

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100 项与创伤性胰腺炎相关的临床结果

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100 项与创伤性胰腺炎相关的转化医学

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0 项与创伤性胰腺炎相关的专利（医药）

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230

项与创伤性胰腺炎相关的文献（医药）

2024-02-01·Journal of Cellular and Molecular Medicine

Still water run deep: Therapeutic TP effect of ucMSC‐Ex via regulating mTOR to enhance autophagy

Article

作者: Zhou, Lichen ; Dai, Ruiwu ; Zhao, Zhirong ; Xin, Mei ; Han, Li ; Huang, Qian ; Jiang, Kexin

AbstractOur previous study confirmed that umbilical cord mesenchymal stem cells‐exosomes (ucMSC‐Ex) inhibit apoptosis of pancreatic acinar cells to exert protective effects. However, the relationship between apoptosis and autophagy in traumatic pancreatitis (TP) has rarely been reported. We dissected the transcriptomics after pancreatic trauma and ucMSC‐Ex therapy by high‐throughput sequencing. Additionally, we used rapamycin and MHY1485 to regulate mTOR. HE, inflammatory factors and pancreatic enzymatic assays were used to comprehensively determine the local versus systemic injury level, fluorescence staining and electron microscopy were used to detect the effect of autophagy, and observe the expression levels of autophagy‐related markers at the gene and protein levels. High‐throughput sequencing identified that autophagy played a crucial role in the pathophysiological process of TP and ucMSC‐Ex therapy. The results of electron microscopy, immunofluorescence staining, polymerase chain reaction and western blot suggested that therapeutic effect of ucMSC‐Ex was mediated by activation of autophagy in pancreatic acinar cells through inhibition of mTOR. ucMSC‐Ex can attenuate pancreas injury by inhibiting mTOR to regulate acinar cell autophagy after TP. Future studies will build on the comprehensive sequencing of RNA carried by ucMSC‐Ex to predict and verify specific non‐coding RNA.

2024-01-01·International Journal of Surgery Case Reports

Intrahepatic pancreatic pseudocyst (wayward cyst): A rare presentation of traumatic pancreatitis

作者: Bashya, Bibhav ; Rajbhandari, Shreesti ; Karki, Badal ; Ghimire, Bikal ; Shrestha, Gyaneswhor

INTRODUCTIONCystic lesions in the liver are commonly encountered space-occupying lesions having various etiologies such as simple cysts, malignancies, hydatid cysts, and pancreatic pseudocysts.CASE PRESENTATIONAn eight-year-old girl initially presented with acute abdominal pain, fever, and a cystic lesion in the upper abdomen. Surgical intervention was performed based on an initial diagnosis of an inflammatory cyst. Later, she developed pleural effusion. Further investigations, unveiled a cystic mass arising from the head of the pancreas, and a pancreatico-pleural fistula. Retrospective analysis revealed a history of trauma that started her illness course. Conservative management involving intercostal tube drainage and octreotide infusion resulted in a favorable outcome.DISCUSSIONPancreatic pseudocyst is typically results from pancreatitis or trauma but in rare cases, they can have extended to unusual locations such as the liver. This case highlights the varied presentations and complex interplay of symptoms associated with intrahepatic pseudocysts. The initial oversight of trauma in the patient's history underscore the importance of thorough history-taking for an accurate diagnosis. The complexity of this case emphasize the necessity of a multidisciplinary approach in managing such atypical presentations.CONCLUSIONIntrahepatic pseudocysts, especially those resulting from post-traumatic pancreatic pseudocyst, are uncommon and are not typically included in the differential diagnosis of liver lesions. This case highlights the significance of identifying unusual presentation and thoroughly investigating the patient's medical history to make an accurate diagnosis. A multidisciplinary approach is essential for effective patient management in these complex cases.

2023-09-01·Medical Journal Armed Forces India

Gastrojejunal stoma obstruction due to post-traumatic pancreatitis

作者: Mehta, Sejal ; Adgudwar, Shashank ; Banerjee, J K ; Boralkar, Saurabh

Gastrojejunostomy without gastric resection is performed to bypass the distal stomach or the duodenum. Gastrojejunal stoma (GJ) obstruction is an unusual complication. Pancreatic injuries are usually subtle to identify by different diagnostic imaging modalities or intraoperatively, as the classic features are absent during the first 24 h and even for several days. Symptoms of injury to other intra-abdominal organs or structures commonly mask or supersede that of pancreatic injury, both early and late in the course of trauma. Hence, these injuries are often overlooked. We present a case of gastrojejunal stoma obstruction after a primary repair of traumatic American Association for the Surgery of Trauma" (AAST) grade IV duodenal injury. The surgery included repair of the duodenum over a T-tube, a pyloric occlusion, a retrocolic loop gastrojejunostomy, and feeding jejunostomy. And thereafter, successful management of postoperative complication with adhesiolysis, necrosectomy, and revised antecolic isoperistaltic Roux-en-Y gastrojejunostomy for retrocolic GJ stoma obstruction due to post-traumatic pancreatitis.