更新于：2024-11-01

Lacrimal Duct Obstruction

泪器阻塞

更新于：2024-11-01

基本信息

别名

Blocked lacrimal canaliculus、Blocked tear duct、Canalicular obstruction

+ [55]

简介

Interference with the secretion of tears by the lacrimal glands. Obstruction of the LACRIMAL SAC or NASOLACRIMAL DUCT causing acute or chronic inflammation of the lacrimal sac (DACRYOCYSTITIS). It is caused also in infants by failure of the nasolacrimal duct to open into the inferior meatus and occurs about the third week of life. In adults occlusion may occur spontaneously or after injury or nasal disease. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p250)

关联

项与泪器阻塞相关的药物

Besifloxacin Hydrochloride

盐酸贝西沙星

靶点

Bacterial DNA gyrase x Top II x Topoisomerase IV

作用机制

细菌DNA旋转酶复合体抑制剂 [+2]

在研机构

原研机构

在研适应症

非在研适应症

最高研发阶段批准上市

首次获批国家/地区

美国

首次获批日期2009-05-28

Sodium Pertechnetate (99mTc)

靶点-

作用机制

SPECT

在研机构

Curium US Holdings LLC [+4]

原研机构

PDRadiopharma, Inc.

在研适应症

肿瘤 [+8]

非在研适应症

膀胱输尿管返流

最高研发阶段批准上市

首次获批国家/地区

日本

首次获批日期1973-02-23

106

项与泪器阻塞相关的临床试验

ChiCTR2400084579 / SuspendedN/AIIT

A study on the correlation between differential expression of tear cytokines and the degree of tear sac fibrosis in patients with primary nasolacrimal duct obstruction

开始日期2024-05-27

申办/合作机构-

NCT06346561 / RecruitingN/AIIT

The Efficacy of Dexmedetomidine Versus Labetalol In Providing Controlled Hypotension In Dacryocystorhinostomy SurgeryA Comparative Randomized Prospective Study

The most important symptoms of nasolacrimal duct obstruction are excessive tearing and mucoid discharge.
The proposed treatment in this regard is dacryocystorhinostomy (DCR) surgery. Therefore, hemostasis is of great significance in performing DCR surgery. In this regard, the reduction of controlled hypotension and the control of hemodynamic responses of the body to stress effectively reduce the bleeding volume during surgery.
Hence, there is no enough studies about controlled hypotension in DCR we decided to perform such a comparison between the effect of dexmedetomidine and labetalol in providing controlled hypotension during DCR surgery.

开始日期2024-03-30

申办/合作机构

Sohag University

NCT06226181 / Recruiting临床1期IIT

Amniotic Membrane for External Dacryocystorhinostomy and Comparison of Success Rate With Conventional Surgery for Patients With Nasolacrimal Duct Obstruction

This study aims to compare the success rate of external dacryocystorhinostomy with and without amniotic membranes in patients with nasolacrimal duct obstruction.

开始日期2024-01-01

申办/合作机构-

100 项与泪器阻塞相关的临床结果

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100 项与泪器阻塞相关的转化医学

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0 项与泪器阻塞相关的专利（医药）

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3,056

项与泪器阻塞相关的文献（医药）

2024-12-01·American Journal of Ophthalmology Case Reports

Pediatric dacryolith masquerading as congenital nasolacrimal duct obstruction

Article

作者: Ranjan, Ashish ; Ali, Mohammad Javed ; Pokal, Upasana

PurposeTo report a rare case of a pediatric dacryolith masquerading as congenital nasolacrimal duct obstruction (CNLDO).ObservationsA two-year-old male child presented with history of intermittent epiphora and discharge since the age of six months. Clinical evaluation demonstrated raised tear meniscus height and delayed fluorescein dye disappearance test in the right eye. Lacrimal irrigation of the right eye under general anesthesia demonstrated 90 % regurgitation (subjectively) of mucoid fluid with a hard stop. Nasal endoscopy examination demonstrated a dacryolith obstructing the opening of the nasolacrimal duct (NLD) in the inferior meatus. The dacryolith was teased out of the NLD and following its removal the lacrimal irrigation was freely patent. At six-months post operative follow up, epiphora resolved and the child was asymptomatic.Conclusions and importanceWhile cases of canaliculitis is uncommon in pediatric age group, it is rare to find a NLD dacryolith in a toddler. To the best of the authors' knowledge, there are few prior reports on pediatric NLD dacryolith masquerading as CNLDO in a toddler (1-3 years).

2024-12-01·American Journal of Ophthalmology Case Reports

Pediatric dacryolith masquerading as congenital nasolacrimal duct obstruction

Article

作者: Ranjan, Ashish ; Ali, Mohammad Javed ; Pokal, Upasana

2024-11-01·Indian journal of ophthalmology

Comparative study of the direct closure of surgical incision for external dacryocystorhinostomy using 6-0 Prolene versus Dermabond ®.

Article

作者: Peris-Martínez, Cristina ; Ortega-Evangelio, Leticia

PURPOSEIn this study, we aimed to compare closure of the incision for external dacryocystorhinostomy (ext-DCR) by suturing with 6-0 Prolene versus closure with 2-octyl cyanoacrylate and assess the results in terms of the aesthetic and functional aspects of the scar, operating time, postoperative symptoms and complications, and the economic cost of the two techniques.METHODSSixty-three patients with distal lacrimal obstruction and indication of ext-DCR were initially enrolled in a longitudinal prospective cohort study. Patients underwent ophthalmologic evaluations including lacrimal probing, external examination with photograph, measurement of the surgical wound, timing the cutaneous closure phase of the surgery, recording postoperative wound pain using visual analog scale (VAS), and recording the patient's and clinician's subjective satisfaction with the scar using Patient and Observer Scar Assessment Scale (POSAS) at 6 months postsurgery. The 63 eyes were divided into two groups: the wounds in group 1 were closed with 6-0 Prolene using continuous locking suture and the wounds in group 2 were closed with 2-octyl cyanoacrylate.RESULTSThere was no difference in baseline characteristics (age, sex, and race), and no statistically significant differences were found in wound length, POSAS score, VAS score, or serious complications of the wound between the two groups. There were differences in surgery time and economic cost for group 2 compared to group 1 of -2.39 min and -€5.37/operation, respectively.CONCLUSIONThis is the first study in the literature that compares 6-0 Prolene versus Dermabond ® . The latter one presents advantages compared to Prolene, given that it reduces the length of surgery, reduces costs, and allows for greater flexibility in postoperative follow-up visits.