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更新于：2024-11-01

Facial Hemiatrophy

面部单侧萎缩

更新于：2024-11-01

基本信息

别名

ATROPHY, HEMIFACIAL, ROMBERG、Atrophies, Hemifacial、Atrophies, Progressive Hemifacial

+ [111]

简介

A syndrome characterized by slowly progressive unilateral atrophy of facial subcutaneous fat, muscle tissue, skin, cartilage, and bone. The condition typically progresses over a period of 2-10 years and then stabilizes.

关联

靶点-

作用机制

软骨替代物 [+3]

在研机构

原研机构

在研适应症

非在研适应症

最高研发阶段临床3期

首次获批国家/地区-

首次获批日期1800-01-20

VascoStem

靶点-

作用机制-

在研机构

R Bio Co., Ltd.

原研机构

R Bio Co., Ltd.

在研适应症

面部单侧萎缩 [+1]

非在研适应症-

最高研发阶段临床2期

首次获批国家/地区-

首次获批日期1800-01-20

项与面部单侧萎缩相关的临床试验

ChiCTR2400081791 / RecruitingN/AIIT

Quantitative Analysis of Tissue Defects in Progressive Hemifacial Atrophy Based on Facial Anatomical Zone

开始日期2024-03-12

申办/合作机构-

NCT04769193 / Unknown statusN/A

A Clinical Trial Evaluating the Efficacy of a Skin Cream Targeting Dermal Fat in Improving the Skin Elasticity of Healthy Volunteers

A Clinical Trial Evaluating Efficacy of a Skin Cream Targeting Dermal Fat in Improving the Skin Elasticity of Healthy Volunteers.

开始日期2021-01-27

申办/合作机构-

NCT05610878 / Recruiting临床1期IIT

Supplementation of Autologous Fat Grafts With Curcumin Preconditioned Adipose-Derived Stem Cells in the Treatment of Facial Contour Deformities

The aim of this study is to evaluate the comparison of therapeutic potential of curcumin preconditioned adipose derived stem cells (ASCs) enrichment fat grafting, naïve ASCs enrichment fat grafting and conventional fat grafting to correct facial contour deformities that cause aesthetic complications in patients.

开始日期2020-11-20

申办/合作机构

University of the Punjab

[+3]

100 项与面部单侧萎缩相关的临床结果

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100 项与面部单侧萎缩相关的转化医学

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0 项与面部单侧萎缩相关的专利（医药）

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1,670

项与面部单侧萎缩相关的文献（医药）

2024-12-01·Radiology Case Reports

Parry Romberg syndrome: A case report

Article

作者: Twum, Kwasi Adjepong ; Ankomah, Kwasi ; Amankwa, Adu Tutu ; Otoo, Obed Kojo ; Ashley, Godwin ; Afreh, Yaa Achiaa

Parry Romberg syndrome (PRS) is a rare self-limiting disease, typically occurring in children and young adults, that causes slow progressive atrophy of one-half of the face. It primarily affects the subcutaneous tissue and skin with some cases exhibiting deeper extension to glandular, osseous and muscular structures. Neurologic and ocular involvement is variable. Neuroimaging with computed tomography (CT) scan aids in demonstrating radiological features, assessing disease severity, and detecting neurological and ocular complications. We present a severe case of PRS in a 25-year-old female with right-sided facial asymmetry, diagnosed based on medical history, clinical examination and head CT scan findings.

2024-10-24·Clinical and Experimental Dermatology

Parry–Romberg syndrome following COVID-19 vaccination

Article

作者: De Caux, Deborah ; Akel, Randa

Parry–Romberg syndrome is an uncommon disorder characterized by hemifacial atrophy of the skin. We present an unusual case of COVID-19 vaccine-induced Parry–Romberg syndrome. To our knowledge, no previous cases have been reported.

2024-10-24·Clinical and Experimental Dermatology

A retrospective study of adult patients with Parry–Romberg syndrome

Article

作者: Sandler, Mykayla ; Fedeles, Flavia ; Shah, Nishi ; Tiao, Janice

Parry–Romberg syndrome (PRS), also known as progressive hemifacial atrophy, is characterized by atrophy of the skin and subcutaneous tissue, including muscle, bone and cartilage. PRS is a clinical diagnosis, although supportive imaging and histology may be obtained. We present a case series of 10 adult patients with a diagnosis of PRS seen at Massachusetts General Hospital and Brigham and Women’s Hospital from 2000 to 2021. Nine of 10 patients were women, with a mean (SD) age at onset of 27.3 (12.1) years and a mean (SD) of 12.4 (7.8) years between disease onset and diagnosis. Of the 10 patients, 4 had biopsies with supportive histopathology findings and 7 had positive imaging findings. Patients typically received both medical and surgical treatments.