Compiling Observational Rubrics of Silicea Terra in Paediatric age group as represented in the Synthesis Repertory Treasure edition 2009- RADAR OPUS software verified through clinical cases: An Observational Case Series Study. - NIL

开始日期2025-06-02

申办/合作机构-

CTRI/2025/03/082653

/ Not yet recruiting临床2期IIT

Efficacy of Sadyovamana and Vyaghrijeerakadi Leha in the management of Tamaka Shwasa (Asthma) in children An open labelled single arm clinical trial. - NIL

开始日期2025-05-02

申办/合作机构-

CTR20244600

/ CompletedN/A

布地奈德吸入气雾剂人体药代动力学生物等效性（PK-BE）研究

主要研究目的：以Chiesi GmbH持证的布地奈德吸入气雾剂（规格：200μg/揿）为参比制剂，以鲁南贝特制药有限公司研制的布地奈德吸入气雾剂（规格：200μg/揿）为受试制剂，考察两制剂在空腹状态下单次给药吸收速度和程度的差异，评价两制剂是否具有生物等效性。次要研究目的：观察受试制剂和参比制剂在健康受试者中的安全性。

开始日期2024-12-30

申办/合作机构

鲁南贝特制药有限公司

100 项与轻度持续性哮喘相关的临床结果

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100 项与轻度持续性哮喘相关的转化医学

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0 项与轻度持续性哮喘相关的专利（医药）

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项与轻度持续性哮喘相关的文献（医药）

2025-02-01·Annals of Allergy, Asthma & Immunology

Exacerbation burden in patients treated as intermittent or mild-persistent asthma using short-acting β2-agonist rescue

Article

作者: Lugogo, Njira L ; Gilbert, Ileen A ; Tkacz, Joseph P ; Lanz, Miguel J ; Gandhi, Hitesh N

BACKGROUNDMost people in the United States with asthma use therapies for intermittent/mild-persistent disease; however, exacerbations and death occur in patients with infrequent symptoms or labeled as mild asthma.OBJECTIVETo evaluate relationships between short-acting β₂-agonist (SABA) use, exacerbations, and maintenance adherence in intermittent/mild-persistent asthma.METHODSRetrospective cohort study using US Merative MarketScan administrative claims (January 2010 to December 2017) for patients aged 12 years or older treated as intermittent/mild-persistent asthma. Patients were indexed on a random SABA claim, with 12 months continuous enrollment pre- and post-index. Post-index SABA groups were defined as low (index fill only), medium (2-3 fills), and high (≥4 fills). Severe exacerbations were compared within the treatment, SABA fill, and adherence (medication possession ratio) groups through unadjusted comparison of proportions, χ², and odds ratios (OR [95% CI]); P less than or equal to .05.RESULTSA total of 533,679 patients were included: 68.1% female; mean age (SD) 34.6 (18.3) years; 70.0% intermittent (SABA only) and 30.0% mild-persistent (8.6% low-dose inhaled corticosteroid [ICS]; 21.4% leukotriene modifier [LM]). The proportion of patients with high SABA fills differed among the treatments: SABA only (14.8%), low-dose ICS (37.0%), and LM (25.5%) (P < .001). The proportion experiencing 1 or more exacerbations was higher in SABA only (61.2%) vs low-dose ICS (40.4%) or LM (50.4%): OR (95% CI) 2.32 (2.28-2.37) and 1.55 (1.53-1.57), respectively (both P < .001). The medication possession ratio was less than 50% in 59.3% of patients with mild-persistent asthma; however, adherence was only related to exacerbations in the high SABA group.CONCLUSIONPatients treated as intermittent/mild-persistent asthma rely on SABA and experience exacerbations. Shifting from SABA only to an anti-inflammatory rescue therapy could decrease morbidity.

2024-12-01·Heart Rhythm

Asthma is associated with higher recurrence rates of atrial fibrillation after catheter ablation

Article

作者: Lu, Ree ; Dizon, Jose M ; Saluja, Amardeep S ; Gasmelseed, Ahmed Y ; Garan, Hasan ; Skoll, Devin ; Rubin, Geoffrey A ; Yarmohammadi, Hirad ; Biviano, Angelo ; Wan, Elaine Y

BACKGROUNDAsthma is a known risk factor for atrial fibrillation (AF), the most common sustained arrhythmia. Whereas radiofrequency catheter ablation is effective in treating AF, the impact of asthma and its severity on ablation outcomes has not been previously explored.OBJECTIVEThe purpose of this study was to evaluate the impact of asthma and its severity on AF recurrence after ablation.METHODSIn this single-center retrospective case-control study, 63 case patients with AF and asthma who underwent ablation were matched with 126 controls with AF but without asthma who underwent ablation. Case patients were also compared with a nonablated cohort of patients with asthma. AF recurrence was compared between groups. Univariate and multivariate analyses were conducted to determine associations with recurrence.RESULTSCompared with controls who underwent ablation, patients with asthma, particularly those with severe asthma, had a higher likelihood of AF recurrence after catheter ablation (odds ratio, 3.76 [P = .047] and 5.06 [P = .041], respectively). However, case patients were not more likely to experience adverse outcomes. Multivariate analysis revealed that persistent AF and use of a beta blocker were associated with recurrence. Patients with moderate or severe persistent asthma were more likely than patients with intermittent or mild persistent asthma to have left atrial enlargement (odds ratio, 2.53; P = .009).CONCLUSIONPatients with AF and asthma, particularly those with severe asthma, were more likely than patients with AF but without asthma to have AF recurrence after ablation. Patients with AF and severe asthma were also more likely to have severe left atrial enlargement, a known predictor of recurrence after ablation.

2023-05-01·Computers in biology and medicine

Bioinformatics analysis of ferroptosis-related gene AKR1C3 as a potential biomarker of asthma and its identification in BEAS-2B cells.

Article

作者: Weng, Cuiye ; Song, Jingjing ; Wang, Yufei ; Tong, Yu ; Zhang, Weixi ; Fan, Junwen ; Wang, Lingya ; Wang, Lei ; Lai, Chuqiao

Ferroptosis is a newly discovered type of cell death and has recently been shown to be associated with asthma. However, the relationship between them at the genetic level has not been elucidated via informatics analysis. In this study, bioinformatics analyses are conducted using asthma and ferroptosis datasets to identify candidate ferroptosis-related genes using the R software. Weighted gene co-expression network analysis is performed to identify co-expressed genes. Protein-protein interaction networks, the Kyoto encyclopedia of genes and genomes, and gene ontology enrichment analysis are used to identify the potential functions of the candidate genes. We experimentally validate the results of our analysis using small interfering RNAs and plasmids to silence and upregulate the expression of the candidate gene in human bronchial epithelial cells (BEAS-2B). The ferroptosis signature levels are examined. Bioinformatics analysis of the asthma dataset GDS4896 shows that the level of the aldo-keto reductase family 1 member C3 (AKR1C3) gene in the peripheral blood of patients with severe therapy-resistant asthma and controlled persistent mild asthma (MA) is significantly upregulated. The AUC values for asthma diagnosis and MA are 0.823 and 0.915, respectively. The diagnostic value of AKR1C3 is verified using the GSE64913 dataset. The gene module of AKR1C3 is evident in MA and functions through redox reactions and metabolic processes. Ferroptosis indicators are downregulated by the overexpression of AKR1C3 and upregulated by silencing AKR1C3. The ferroptosis-related gene AKR1C3 can be used as a diagnostic biomarker for asthma, particularly for MA, and regulates ferroptosis in BEAS-2B cells.

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