Study on the Efficacy and Safety of a Therapeutic Strategy of PPH Comparing Early Administration of Human Fibrinogen vs Placebo in Patients Treated With IV Prostaglandins Following Vaginal Delivery
The purpose of the study is to assess the benefits of a therapeutic strategy that associates an early administration of human fibrinogen concentrate in the management of PPH on the reduction of bleeding after the initiation of prostaglandins intravenous infusion, following vaginal delivery.
100 项与 Human fibrinogen concentrate(LFB Biomedicaments) 相关的临床结果
100 项与 Human fibrinogen concentrate(LFB Biomedicaments) 相关的专利（医药）
项与 Human fibrinogen concentrate(LFB Biomedicaments) 相关的文献（医药）
2023-06-09·Journal of clinical pharmacology
Real-World Experience with a Human Fibrinogen Concentrate: Clinical Data From Adult and Pediatric Patients Requiring Fibrinogen For Bleeding Control and Prevention.
作者: Francois Stéphan ; Loriane Gutermann ; Stéphanie Bourget ; Sarah Djabarouti ; Johanna Berdugo ; Yann Fardini ; Pierre Clerson ; Guillaume Hébert ; Chafké Belmokhtar
Human fibrinogen concentrate (Fibryga®, Octapharma AG) received temporary approval for fibrinogen replacement therapy in France (2017), subsequently obtaining full approval for congenital and acquired hypofibrinogenemia. We evaluated real-world use for on-demand treatment of bleeding and prophylaxis to enhance our knowledge on fibrinogen concentrate as an option for fibrinogen replacement. Data was retrospectively collected from adult and pediatric patients with fibrinogen deficiency. Primary endpoint was indication for fibrinogen concentrate use; the secondary endpoint was treatment success for on-demand treatment/perioperative prophylaxis. The study included 150 adult (median [range] age 62 years [18-94]) and 50 pediatric patients (3 years [0.01-17]) with acquired fibrinogen deficiency. Fibrinogen concentrate was administered to 47.3% adults for non-surgical bleeding, 22.7% for surgical bleeding, and 30.0% for perioperative prophylaxis, with 4.0% for surgical bleeding and 96.0% for perioperative prophylaxis in pediatric patients. Cardiac surgeries accounted for 79.5/75.0% perioperative prophylaxis and 82.4/100.0% surgical bleeding cases in adult/pediatric patients, respectively. Mean±SD (median) total fibrinogen doses were 3.06±1.69 g (32.61 mg/kg), 2.09±1.36 g (22.99 mg/kg), and 2.36±1.25 g (29.67 mg/kg) for adult non-surgical bleeding, surgical bleeding, and perioperative prophylaxis; with 0.75±0.35 g (47.64 mg/kg) and 0.83±0.62 g (55.56 mg/kg) for pediatric surgical bleeding and perioperative prophylaxis, respectively. Treatment success in adults was 85.7/97.1/93.3%, and 50.0/87.5% in pediatrics for non-surgical bleeding (adults only), surgical bleeding, and perioperative prophylaxis, respectively. Fibrinogen concentrate demonstrated favorable effectiveness and safety across age groups. This study contributes to evidence supporting fibrinogen concentrate for bleeding control/prevention in real-world clinical practice, particularly for patients with acquired fibrinogen deficiency. This article is protected by copyright. All rights reserved.
2023-06-01·Journal of feline medicine and surgery
Retrospective evaluation of surgical treatment of linear and discrete gastrointestinal foreign bodies in cats: 2009-2021.
作者: Hailey R Gollnick ; Chad W Schmiedt ; Mandy L Wallace ; Brian J Sutherland ; Janet A Grimes
Gastrointestinal foreign bodies (FBs) are an important cause of emergency surgical intervention in cats, but little information exists in the literature evaluating the risks and outcomes in this species. The study purpose was to describe cases of feline FBs and compare perioperative factors and outcomes between linear foreign body (LFB) and discrete foreign body (DFB) surgery in cats.
The medical records from the University of Georgia Veterinary Teaching Hospital were searched for cats that had undergone surgery for FB removal between August 2009 and August 2021. Perioperative data were collected and described. Data were compared between cats with an LFB and cats with a DFB. A binomial probability series was used to estimate the likelihood of postoperative septic peritonitis or mortality in an additional cat in the series.
A total of 56 cats were included in this study; 38 cats had a DFB and 18 had an LFB. No cats developed postoperative septic peritonitis, and all cats survived. The likelihood of postoperative septic peritonitis or mortality in an additional cat was estimated to be <5.2%. Cats with an LFB were found to have a significantly higher body condition score (P = 0.047), albumin (P = 0.025), American Society of Anesthesiologists status (P = 0.027), surgery length (P <0.001) and total cost of visit (P = 0.006) when compared with cats with a DFB. Cats with LFBs were more likely to develop a surgical site infection (SSI; P = 0.007) and be administered postoperative antibiotics (P = 0.017).
CONCLUSIONS AND RELEVANCE:
Cats undergoing surgery for gastrointestinal FBs had a low incidence of postoperative complications. Cats with LFBs had longer surgeries and were more likely to develop postoperative SSIs.
Assessment of Vascular Function in Response to High-Fat and Low-Fat Ground Beef Consumption in Men.
作者: Jason R Lytle ; Sean T Stanelle ; Steven E Martin ; Stephen B Smith ; Dana R Smith ; Stephen F Crouse
Red meat is stigmatized as an unhealthy protein choice; however, its impacts on vascular function have not been evaluated. We aimed to measure the vascular impact of adding either low-fat (~5% fat) ground beef (LFB) or high-fat (~25% fat) ground beef (HFB) to a habitual diet in free-living men. Twenty-three males (39.9 ± 10.8 years, 177.5 ± 6.7 cm, 97.3 ± 25.0 kg) participated in this double-blind crossover study. Assessment of vascular function and aerobic capacity were measured at entry and in the last week of each intervention and washout period. Participants then completed two 5-week dietary interventions (LFB or HFB; 5 patties/week) in a randomized order with a 4-week washout. Data were analyzed via 2 × 2 repeated-measures ANOVA (p < 0.05). The HFB intervention improved FMD relative to all other time points, while lowering systolic (SBP) and diastolic blood pressure (DBP) relative to entry. Neither the HFB nor the LFB altered pulse wave velocity. The addition of either low- or high-fat ground beef did not negatively alter vascular function. In fact, consuming HFB improved FMD and BP values, which may be mediated by lowering LDL-C concentrations.
100 项与 Human fibrinogen concentrate(LFB Biomedicaments) 相关的药物交易