Recombinant human platelet-derived growth factor or urea cream in prevention of multitargeted kinase inhibitor-associated hand foot skin reaction: a randomized controlled trial - NIL

开始日期2024-11-27

申办/合作机构-

NCT06162832 / Recruiting临床2期

Evaluation of Clinical and Radiographic Parameters in Bony Defects Treated With Recombinant Human Platelet-derived Growth Factor in Combination With Allograft

Growth factors are defined as small proteins that trigger a cellular response after binding to cell receptors; Tissue engineering is now clinically applicable in a commercially available system involving the use of recombinant human platelet-derived growth factor.
The objective of this study is to evaluate clinical and radiographic parameters in bone defects treated with platelet-derived growth factor in combination with allograft.
Our hypothesis: Defects treated with DFDBA and rhPDGF-BB have better clinically and radiographic results that the defects treated with DFDBA and saline solution.

开始日期2024-01-10

申办/合作机构

Universidad Autónoma de Nuevo León

[+2]

NCT04786327 / Completed临床2期IIT

Intrabony Defects Management Using Growth Factor Enhanced Matrix Versus Platelet Rich Fibrin Utilizing Minimally Invasive Surgical Technique. A Randomized Clinical and Radiographic Trial.

Twenty-one intra-bony defects in fifteen systemically healthy patients with moderate to severe chronic periodontitis were randomly classified into 3 groups, 7 sites each. Group І treated by MIST alone, group ІІ treated by MIST + ethylenediamine-tetraaceticacid (EDTA) + PRF and group III treated by MIST + EDTA + GEM 21S. The clinical parameters including probing pocket depth (PPD), clinical attachment level (CAL) and bleeding on probing (BOP), were recorded at baseline, 3, 6 and 9 months post-surgery. Cone beam computed tomography (CBCT) was performed at baseline and 9 months post-surgery to evaluate bone level and bone density

开始日期2018-01-01

申办/合作机构

Tanta University

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项与 Growth-factor Enhanced Matrix(ZymoGenetics, Inc.) 相关的文献（医药）

2024-11-01·Tissue Engineering Part C: Methods

Synthetic Bone Blocks Produced by Additive Manufacturing in the Repair of Critical Bone Defects

Article

作者: Muñoz, Eladio ; Pitol-Palin, Leticia ; Novaes, Arthur Belém ; Messora, Michel ; Shibli, Jamil ; Loyola, Ana Carolina ; Okamoto, Roberta ; Scombatti de Souza, Sergio

This study evaluated the efficacy of synthetic bone blocks, composed of hydroxyapatite (HA) or β-tricalcium phosphate (B-TCP), which were produced by additive manufacturing and used for the repair of critical size bone defects (CSDs) in rat calvaria. Sixty rats were divided into five groups (n = 12): blood clot (CONTROL), 3D-printed HA (HA), 3D-printed β-TCP (B-TCP), 3D-printed HA + autologous micrograft (HA+RIG), and 3D-printed β-TCP + autologous micrograft (B-TCP+RIG). CSDs were surgically created in the parietal bone and treated with the respective biomaterials. The animals were euthanized at 30 and 60 days postsurgery for microcomputed tomography (micro-CT) histomorphometric, and immunohistochemical analysis to assess new bone formation. Micro-CT analysis showed that both biomaterials were incorporated into the animals' calvaria. The HA+RIG group, especially at 60 days, exhibited a significant increase in bone formation compared with the control. The use of 3D-printed bioceramics resulted in thinner trabeculae but a higher number of trabeculae compared with the control. Histomorphometric analysis showed bone islands in close contact with the B-TCP and HA blocks at 30 days. The HA blocks (HA and HA+RIG groups) showed statistically higher new bone formation values with further improvement when autologous micrografts were included. Immunohistochemical analysis showed the expression of bone repair proteins. At 30 days, the HA+RIG group had moderate Osteopontin (OPN) staining, indicating that the repair process had started, whereas other groups showed no staining. At 60 days, the HA+RIG group showed slight staining, similar to that of the control. Osteocalcin (OCN) staining, indicating osteoblastic activity, showed moderate expression in the HA and HA+RIG groups at 30 days, with slight expression in the B-TCP and B-TCP+RIG groups. The combination of HA blocks with autologous micrografts significantly enhanced bone repair, suggesting that the presence of progenitor cells and growth factors in the micrografts contributed to the improved outcomes. It was concluded that 3D-printed bone substitute blocks, associated with autologous micrografts, are highly effective in promoting bone repair in CSDs in rat calvaria.

2024-10-01·Journal of Dentistry

Experimental toothpastes containing β-TCP nanoparticles functionalized with fluoride and tin to prevent Erosive Tooth Wear

Article

作者: Garcia, Raíssa Manoel ; Hara, Anderson T ; Scaramucci, Taís ; Silva, Flávia Rodrigues Oliveira ; Lima, Leonardo Custódio ; Viana, Ítallo Emídio Lira ; Weiss, Guilherme Stangler ; Sakae, Letícia Oba

OBJECTIVESThe present study aimed to synthesize toothpastes containing Beta- TriCalcium Phosphate (β-TCP) nanoparticles, functionalized with fluoride and tin, and test their ability to reduce erosive tooth wear (ETW).METHODSToothpastes were synthesized with the following active ingredients: 1100 ppm of fluoride (as sodium fluoride, F^-), 3500 ppm of tin (as stannous chloride, Sn²⁺), and 800 ppm of β-TCP (Sizes a - 20 nm; and b - 100 nm). Enamel specimens were randomly assigned into the following groups (n = 10): 1. Commercial toothpaste; 2. Placebo; 3 F^-; 4. F^- + β-TCP_a; 5. F^- + β-TCP_b; 6. F^- + Sn²⁺; 7. F^- + Sn²⁺ + β-TCP_a and 8. F^- + Sn²⁺ + β-TCP_b. Specimens were subjected to erosion-abrasion cycling. Surface loss (in µm) was measured by optical profilometry. Toothpastes pH and available F^- were also assessed.RESULTSBrushing with placebo toothpaste resulted in higher surface loss than brushing with F^- (p = 0.005) and F^- + β-TCP_b (p = 0.007); however, there was no difference between F^- and F^- + β-TCP_b (p = 1.00). Commercial toothpaste showed no difference from Placebo (p = 0.279). The groups F^-, F^- + β-TCP_a, F^- + β-TCP_b, F^- + Sn²⁺, F^- + Sn²⁺ + β-TCP_a and F^- + Sn²⁺ + β-TCP_b were not different from the commercial toothpaste (p > 0.05). Overall, the addition of β-TCP reduced the amount of available fluoride in the experimental toothpastes. The pH of toothpastes ranged from 4.97 to 6.49.CONCLUSIONSAlthough toothpaste containing β-TCP nanoparticles protected enamel against dental erosion-abrasion, this effect was not superior to the standard fluoride toothpaste (commercial). In addition, the functionalization of β-TCP nanoparticles with fluoride and tin did not enhance their protective effect.CLINICAL SIGNIFICANCEAlthough β-TCP nanoparticles have some potential to control Erosive Tooth Wear, their incorporation into an experimental toothpaste appears to have a protective effect that is similar to a commercial fluoride toothpaste.

2023-08-24·Cureus

Bicalcium Phosphate as an Asset in Regenerative Therapy

Review

作者: Reche, Amit ; Bajaj, Pavan ; Maheshwari, Shefali ; Taori, Tanishka

After a loss of a tooth, alveolar bone resorption is immutable, leaving the area devoid of sufficient bone quality and mass for a successful and satisfactory implant or any other dental treatment. To treat this problem of irreversible bone loss, bone grafting is the primary solution and a well-accepted technique. The use of bone grafting procedures has increased in recent years. This review is about the various bone grafting techniques and best-situated material available currently along with their trump cards and limitations. In the thorough discussion regarding bone grafting materials and their substitutes, one alloplastic material has shown unbeaten and the most satisfactory properties than any other material, "bicalcium phosphate" (BCP). BCP is a mixture of hydroxyapatite (HA) and beta-tricalcium phosphate (B-TCP) usually obtained through sintering calcium-deficient apatite (CDA) at or above 700°C or by other methods such as hydrolysis or precipitation. The review also shows comparative studies done to understand the effect, most adequate balance, and impact of ratios of HA/B-TCP on the properties, structure, and success rate of this material. The objective of the review is to enlighten the principal characteristic of the most likely used bone graft material presently, i.e., BCP. The most impeccable characteristic of BCP is its capability to osteointegrate, which results in a superior interface. This interface depicts a dynamic process that includes physicochemical reactions, crystal-protein interactions, cell and tissue colonization, and bone remodeling. BCP has certain essential properties that could be put forth as its advantage over any other substitute. These properties include bioactivity, osteointegration, osteoinduction, osteogenesis, and biodegradation, which are mostly governed by modifying the HA/B-TCP ratio. Other applications of BCP are feasible, such as in drug administration and scaffolds for tissue engineering.

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骨病	加拿大	ZymoGenetics, Inc.	2007-01-01

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Pubmed \| Int J Periodontics Restorative Dent	N/A	牙龈退缩	15	GEM 21S	遞願醖衊鹹積餘願鑰醖(壓齋窪繭憲製鬱範淵願) = higher in the VISTA group compared with the PPG group 築襯構積壓淵選遞鬱願 (醖構鬱糧憲選遞淵積窪 ) 更多	-	2016-03-01