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截至01月30日15点59分，近期共有 501 本期刊发布了 1080 篇文章，其中血脂相关的文章共 88 篇，覆盖 18 个领域的内容。中国专家参与发表的文章有 30 篇。今日，影响因子最高的文章刊登在 Science (IF: 45.800) 期刊上。
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01Br J Hosp Med (Lond) IF: 01.800脂蛋白(a)水平与2型糖尿病患者外周动脉疾病的显著相关性：一项回顾性研究
Chen, Chao, Lv, Fang, etc.
一项最新的临床研究揭示，在2型糖尿病患者中，血液中的脂蛋白(a)水平升高，可能与一种常见的外周血管并发症——外周动脉疾病的风险增加存在显著关联。
该研究发表在学术期刊British journal of hospital medicine上，题为A Significant Correlation Between Lipoprotein(a) Levels and Peripheral Arterial Disease in Patients With Type 2 Diabetes Mellitus: A Retrospective Study。研究由Chen Chao和Lv Fang共同完成。
为了探究这一关系，研究团队在合肥市第一人民医院进行了一项回顾性分析。研究纳入了从2022年1月到2024年8月期间住院的590名确诊为2型糖尿病的患者作为研究对象。研究人员根据患者入院时检测的脂蛋白(a)浓度，将所有参与者分为低、中、高三个水平组。外周动脉疾病的诊断依据是国际通用的踝臂指数测量，当该指数低于0.9时，即被判定为存在外周动脉疾病。
数据分析结果显示，不同脂蛋白(a)水平组间的外周动脉疾病患病率存在显著差异。具体而言，脂蛋白(a)水平最高的一组患者，其外周动脉疾病的患病率明显高于水平较低的患者组。这一差异具有统计学意义。
在调整了年龄、性别、血压、血脂、血糖控制水平等多种可能混杂因素的影响后，多因素逻辑回归模型的分析结果更加明确了这种关联的强度。与脂蛋白(a)水平最低的一组相比，水平最高的一组患者发生外周动脉疾病的风险增加了约96%，其风险比值达到1.961。此外，分析还发现，脂蛋白(a)水平每升高一个标准差，患病风险相应增加25.7%；而经过对数转换后的脂蛋白(a)每增加一个单位，风险更是上升了80.3%。
研究还通过亚组分析检验了这种关联在不同患者群体中的稳定性。结果表明，无论患者的性别、年龄或是否合并高血压等因素如何，脂蛋白(a)水平与外周动脉疾病风险之间的正相关关系均普遍存在。为了评估脂蛋白(a)作为预测指标的潜力，研究者绘制了受试者工作特征曲线，计算出的曲线下面积为0.622，这表明脂蛋白(a)对于预测2型糖尿病患者是否患有外周动脉疾病具有一定的鉴别能力。
为了更精细地描述两者之间的关系形态，研究者采用了限制性立方样条法进行分析。结果并未发现脂蛋白(a)水平与外周动脉疾病风险之间存在非线性关系的证据，这提示风险可能随着脂蛋白(a)水平的升高而呈现稳定的、连续性的增加趋势。
综上所述，这项回顾性研究提供了证据，表明在2型糖尿病人群中，较高的脂蛋白(a)水平与较高的外周动脉疾病患病风险显著相关。这一发现为临床识别和管理2型糖尿病患者的血管并发症风险提供了一个新的潜在生物标志物视角。
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Br J Hosp Med (Lond) | Volume 87, Issue 1
10.31083/BJHM50381
02JAHA IF: 05.300遗传预测的脂蛋白(a)水平与脑血管疾病风险
Iyas Daghlas, Marios K. Georgakis, Benoit J. Arsenault, Anthony S. Kim, Stephen Burgess, Dipender Gill, etc.
近日，一项题为Genetically Predicted Levels of Lipoprotein(a) and Risk of Cerebrovascular Disease的研究在 Journal of the American Heart Association 期刊上提前在线发表。该研究由 Iyas Daghlas、Marios K. Georgakis 等学者共同完成，旨在利用遗传学方法厘清脂蛋白(a)[Lp(a)]与不同亚型脑血管疾病之间的因果关系。
Lp(a) 是血液中的一种特殊颗粒，已被证实与冠心病风险升高密切相关，是当前降脂药物研发的新热点。然而，其对不同类型脑卒中风险的影响尚未完全明确。为了克服观察性研究中混杂因素和反向因果关系的干扰，本研究采用了孟德尔随机化这一方法。该方法利用与Lp(a)水平密切相关的遗传变异作为“自然随机化”的工具，能够更可靠地推断暴露与结局之间的因果关联。
研究人员选取了两个能强效影响Lp(a)水平的 _LPA_ 基因变异（rs10455872和rs3798220）作为工具，这两个变异共同解释了人体Lp(a)水平36%的个体差异。通过分析大规模遗传学联盟提供的汇总数据，研究者评估了遗传预测的Lp(a)水平（每升高100 nmol/L）与多种脑血管结局之间的关联。
研究的主要发现清晰地指向了Lp(a)致病作用的特异性路径。结果显示，遗传预测的较高Lp(a)水平会显著增加所有缺血性卒中的总体风险。当深入分析缺血性卒中的不同亚型时，关联性出现了明显分化。其中，与大动脉粥样硬化性卒中的关联最为强烈，风险增加了23%。相比之下，与小血管闭塞性（腔隙性）卒中则未发现显著关联。与心源性栓塞性卒中存在较弱的正向关联。
此外，在针对早发性（通常指≤60岁）卒中的分析中，研究者观察到了相似的模式，且Lp(a)与大动脉粥样硬化性卒中的关联强度进一步增大，风险升高了37%。这一发现提示，Lp(a)在年轻人群的动脉粥样硬化性卒中发病中可能扮演着尤为重要的角色。
为了进一步验证和拓展上述发现，研究者还分析了一系列与卒中相关的中间表型。结果同样呈现出具有一致性的模式：遗传预测的高Lp(a)水平与颈动脉斑块的存在显著相关，这直接支持了其促进动脉粥样硬化的作用。同时，研究也发现其与心房颤动风险增加相关，这可能部分解释了其与心源性栓塞性卒中的微弱关联。另一方面，与脑小血管病相关的多个影像学标志物（如白质高信号、腔隙）均未显示出显著关联。
综上所述，这项孟德尔随机化研究提供了强有力的遗传学证据，表明Lp(a)升高是颅内大动脉粥样硬化性缺血性卒中的一个因果风险因素，而其与脑小血管病性卒中无因果关系。这些发现对于未来针对Lp(a)的干预性临床试验具有明确的指导意义，提示应优先考虑将患有动脉粥样硬化性脑血管疾病的个体纳入研究，以评估降低Lp(a)水平对预防此类卒中的潜在益处。
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JAHA | Ahead of Print.
10.1161/JAHA.125.045423
03Frontiers in nutrition IF: 05.100孜然（Cuminum cyminum L.）补充剂对成人代谢综合征患者代谢组分的潜在益处：一项基于GRADE评估的随机对照试验系统评价和荟萃分析
Liu, Man, Wu, Songze, Falahatzadeh, Maryam, etc.
代谢综合征是一组以中心性肥胖、高血糖、血脂异常和高血压为特征的复杂临床症候群，其全球患病率不断上升，寻找安全有效的辅助管理策略成为临床关注的重点。近日，一项发表在Frontiers in nutrition期刊上的系统评价和荟萃分析，评估了传统香料孜然（Cuminum cyminum L.）作为膳食补充剂，对成人代谢紊乱患者代谢综合征关键指标的影响，为该领域提供了新的循证见解。
这项研究由Man Liu、Songze Wu和Maryam Falahatzadeh共同完成，系统检索了截至2025年4月的多个主流医学数据库，最终纳入了9项在伊朗开展的随机对照试验，共涉及531例参与者。研究采用严谨的GRADE方法对证据质量进行评估，旨在综合评价孜然补充剂对空腹血糖、血脂和腰围等核心代谢参数的作用。
荟萃分析结果显示，与安慰剂或对照组相比，补充孜然带来了具有统计学意义的积极变化。具体而言，**孜然补充剂显著降低了参与者的空腹血糖水平**。同时，在血脂谱方面，**孜然显著降低了甘油三酯水平，并提高了对心血管有保护作用的高密度脂蛋白胆固醇水平**。此外，**补充孜然还与腰围的显著减小相关**，这提示其对中心性肥胖可能有改善作用。
研究者进一步通过亚组分析探索了可能影响效果的变量。分析发现，在**年龄超过50岁的参与者**以及**被诊断为2型糖尿病的患者**中，孜然在降低空腹血糖和甘油三酯方面的益处似乎更为突出。有趣的是，**较低剂量的孜然补充（每日低于100毫克）** 在改善空腹血糖和升高高密度脂蛋白胆固醇方面显示出效果。大多数有益效应在**干预持续时间超过8周**的研究中更为明显。
尽管结果令人鼓舞，但研究者也指出了本项分析的局限性。纳入的所有研究均来自伊朗，这可能限制了研究结论在不同人群中的普适性。此外，各研究间存在较高的异质性，部分原因可能在于孜然的补充形式、剂量以及研究人群基线特征的差异。由于报告数据的研究数量不足，该分析未能评估孜然对代谢综合征的另一关键组分——血压的影响。根据GRADE标准，本研究关于空腹血糖、甘油三酯和高密度脂蛋白胆固醇的证据质量被评为“低”，关于腰围的证据质量被评为“中等”。
综上所述，这项荟萃分析表明，孜然补充剂可能作为改善成人代谢综合征患者部分代谢指标的潜在辅助手段。然而，要得出确切的临床推荐结论，未来仍需在不同地区、不同人群中进行更多设计严谨、样本量更大、干预周期更长的随机对照试验予以验证。
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Frontiers in nutrition | Volume 12, Issue
10.3389/fnut.2025.1618108
04Immunology and cell biology IF: 03.000阐释脂质-免疫轴在健康与疾病中的作用
Raeisi, Mortaza, Yousefi, Mehdi, Motavalli, Roza, Hassanzadeh, Ali, Seddighi, Narjes, Mehri, Maghsoud, etc.
近日，一项发表于Immunology and cell biology期刊的综述文章，系统性地梳理了脂质与免疫系统之间复杂而关键的相互作用。这篇由Mortaza Raeisi、Mehdi Yousefi等多位学者共同完成的文章指出，脂质不仅是传统的能量来源或细胞膜的构成部分，更是免疫反应精密调控网络中的核心参与者。该研究阐释了这条长期被忽视的“脂质-免疫轴”如何在维持健康稳态和驱动疾病进程中扮演双重角色。
文章的核心观点在于，脂质对免疫系统的影响是多层次且动态的。从最基本的细胞层面来看，脂质的种类、构成及其代谢过程，深刻影响着包括先天性和适应性免疫在内的各类免疫细胞的发育、分化、活化和功能。更关键的是，脂质本身可以转化为一系列具有强大生物活性的信号分子，例如经典的促炎性二十烷酸类物质，以及近年来备受关注的、能够主动促进炎症消退的消退素和保护素。这些脂质介质共同构成了一个精细的平衡系统，精确指挥着炎症反应的启动、扩大与及时终止。
这种平衡一旦被打破，便与多种重大疾病的发生发展密切相关。文章明确指出，在动脉粥样硬化、肥胖、2型糖尿病以及多种自身免疫性疾病中，普遍存在着脂质代谢的异常。这种异常并非仅仅是生化指标的改变，它直接导致了免疫系统的持续、低度激活，从而推动慢性炎症的进展，形成恶性循环。这为理解这些疾病的共同病理生理机制提供了新的视角。
此外，脂质与免疫的互动战场也延伸到了感染领域。狡猾的病原体，如某些病毒和细菌，进化出了劫持宿主细胞脂质代谢通路的能力。它们通过改变宿主细胞的脂质环境，为自己创造有利的生存空间，并借此削弱或逃避免疫系统的识别与攻击。这一发现揭示了感染性疾病中免疫逃逸的新机制。
基于对脂质-免疫轴作用的深入理解，文章探讨了潜在的治疗新策略。传统的抗炎或免疫抑制疗法往往伴随着显著的副作用。而针对脂质代谢环节进行干预，例如使用他汀类药物调节胆固醇代谢、补充具有抗炎作用的ω-3脂肪酸、或利用人工合成的特异性促消退脂质介质，则有望实现更精准、更生理性的炎症调控，即“调炎”而非“抑炎”。这为开发新一代免疫代谢疗法指明了可能的方向。
最后，该综述也指出了当前研究领域的空白与未来挑战。要完全破译脂质-免疫相互作用的复杂网络，需要整合脂质组学、免疫学和代谢组学等多学科的技术与视角，开展更深入的系统性研究。随着这些研究的推进，我们有望更全面地理解生命活动的调控规律，并为众多难治性炎症和免疫相关疾病带来新的曙光。
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Immunology and cell biology | Ahead of Print.
10.1111/imcb.70076
中国发表（30）
China
Shengwu gongcheng xuebaoVolume 42, Issue 1No.01[Identification of oat GPAT gene family and molecular mechanism of AsGPAT9-1 regulating lipid synthesis]燕麦GPAT基因家族的鉴定及AsGPAT9-1调控脂质合成的分子机制DOI: 10.13345/j.cjb.250714
J Biol Chem IF: 03.900Ahead of Print.No.02Hypoxia-Inducible Factor 1αa Regulates Lipid Metabolism to Coordinate Adipocyte Hypertrophy and Hyperplasia in Grass Carp缺氧诱导因子1αa通过调节脂质代谢协调草鱼脂肪细胞的肥大与增生DOI: 10.1016/j.jbc.2026.111195
Comp Biochem Physiol Part D Genomics Proteomics IF: 02.400Ahead of Print.No.03Genome-wide identification of lipases in the oriental armyworm, Mythimna separata Walker (Lepidoptera: Noctuidae)东方黏虫 Mythimna separata Walker（鳞翅目：夜蛾科）脂肪酶的全基因组鉴定DOI: 10.1016/j.cbd.2026.101761
Journal of thermal biology IF: 02.900Ahead of Print.No.04RSK2 facilitates beige fat formation through thermogenic and glycolytic pathwaysRSK2通过产热和糖酵解途径促进米色脂肪形成DOI: 10.1016/j.jtherbio.2026.104389
Environmental research IF: 07.700Ahead of Print.No.05PM(2.5)-bound nitrated and oxygenated PAHs induced lipid metabolism disorder through different target organsPM2.5结合的硝化和氧化多环芳烃通过不同靶器官诱导脂质代谢紊乱DOI: 10.1016/j.envres.2026.123875
Redox biology IF: 11.900Ahead of Print.No.06Myo1f regulates monocyte adhesion and contributes to atherosclerosis via MRTFA-dependent ITGB2 expressionMyo1f通过MRTFA依赖的ITGB2表达调节单核细胞粘附并促进动脉粥样硬化DOI: 10.1016/j.redox.2026.104049
Redox biology IF: 11.900Ahead of Print.No.07Integrative epidemiology and multi-omics reveal a frailty-associated ACKR1 redox axis linking cadmium exposure to atherosclerosis整合流行病学与多组学揭示虚弱相关的ACKR1氧化还原轴将镉暴露与动脉粥样硬化联系起来DOI: 10.1016/j.redox.2026.104048
BMC nephrology IF: 02.400Ahead of Print.No.08Deciphering the complexity: a case of kidney failure with co-inheritance of COL4A5 and APOE variants解读复杂性：一例共遗传COL4A5与APOE变异的肾脏衰竭病例DOI: 10.1186/s12882-026-04775-7
J Thromb Haemost IF: 05.000Ahead of Print.No.09Exploring the Prognostic Significance of Antiphospholipid Antibody in Acute Myocardial Infarction: Insights from Clinical Study and Mechanism探索抗磷脂抗体在急性心肌梗死中的预后意义：来自临床研究与机制的启示DOI: 10.1016/j.jtha.2025.12.026
J Clin Invest IF: 13.600Ahead of Print.No.10Vascular smooth muscle cell-derived KIF13B protects against atherosclerosis: evidence from humans and mice血管平滑肌细胞来源的KIF13B对动脉粥样硬化具有保护作用：来自人类和小鼠的证据DOI: 10.1172/JCI194175
Journal of neurotrauma IF: 03.800Ahead of Print.No.11Atorvastatin Regulates the Efferocytosis of Macrophages to Promote Hematoma Absorption and Inflammation Resolution in Experimental Subdural Hematoma阿托伐他汀通过调控巨噬细胞胞葬作用促进实验性硬膜下血肿吸收和炎症消退DOI: 10.1177/08977151261415615
Br J Hosp Med (Lond) IF: 01.800Volume 87, Issue 1No.12A Significant Correlation Between Lipoprotein(a) Levels and Peripheral Arterial Disease in Patients With Type 2 Diabetes Mellitus: A Retrospective Study脂蛋白(a)水平与2型糖尿病患者外周动脉疾病的显著相关性：一项回顾性研究DOI: 10.31083/BJHM50381
Br J Hosp Med (Lond) IF: 01.800Volume 87, Issue 1No.13Prognostic Value of the Pan-Immune-Inflammation Value for Predicting Major Adverse Cardiovascular Events Within One Year After Percutaneous Coronary Intervention in Patients With Acute ST-Segment Elevation Myocardial Infarction全系统免疫炎症值对急性ST段抬高型心肌梗死患者经皮冠状动脉介入治疗后一年内主要不良心血管事件的预测价值DOI: 10.31083/BJHM50379
Frontiers in pharmacology IF: 04.800Volume 16, Issue No.14Vulnerable plaques in atherosclerosis: focus on angiogenesis-associated phenotypic crosstalk动脉粥样硬化中的易损斑块：聚焦血管生成相关的表型串扰DOI: 10.3389/fphar.2025.1737140
Frontiers in neurology IF: 02.800Volume 16, Issue No.15A bibliometric analysis of research on cognitive function and carotid atherosclerosis: global trends and hotspots认知功能与颈动脉粥样硬化研究的文献计量分析：全球趋势与热点DOI: 10.3389/fneur.2025.1644172
Annals of Dermatology IF: 01.300Volume 38, Issue 1No.16The SMAD-Pathway Mediates HMGB1-Induced Proliferation and Metastatic Progression in Cutaneous Squamous Cell Carcinoma CellsSMAD通路介导HMGB1诱导的皮肤鳞状细胞癌细胞增殖与转移进展DOI: 10.5021/ad.25.132
World Journal of Cardiology IF: 02.800Volume 18, Issue 1No.17Deciphering Teochew population's genetic protective barrier: Apolipoprotein E- lipoprotein(a) kringle IV type 2 synergy as novel cardioprotective pathway解读潮州人群的遗传保护屏障：载脂蛋白E-脂蛋白(a) Kringle IV 2型协同作用作为新型心脏保护通路DOI: 10.4330/wjc.v18.i1.113327
Food research international IF: 08.000Volume 221, Issue Pt 1No.18Integrated lipidomic and transcriptomic analysis reveals the effect of cold plasma treatment on lipid oxidation in millet during storage脂质组学与转录组学联合分析揭示冷等离子体处理对小米储存期间脂质氧化的影响DOI: 10.1016/j.foodres.2025.117166
World J Clin Oncol IF: 03.200Volume 17, Issue 1No.19Post-treatment triglyceride-glucose index as survival protective factors in patients with esophageal squamous cell carcinoma治疗后甘油三酯-葡萄糖指数作为食管鳞状细胞癌患者的生存保护因素DOI: 10.5306/wjco.v17.i1.113304
Biological Research IF: 04.600Ahead of Print.No.20Vascular smooth muscle cell RNA-binding protein U2AF2 induces copper death by regulating C1qbp expression, delaying development of atherosclerosise血管平滑肌细胞RNA结合蛋白U2AF2通过调控C1qbp表达诱导铜死亡延缓动脉粥样硬化发展DOI: 10.1186/s40659-026-00672-3
Frontiers in medicine IF: 03.000Volume 12, Issue No.21Protective impact of circulating ω-3 PUFAs on sepsis susceptibility through PCSK9 variant: evidence from Mendelian randomization and animal experiments循环ω-3多不饱和脂肪酸通过PCSK9变异对脓毒症易感性的保护作用：来自孟德尔随机化和动物实验的证据DOI: 10.3389/fmed.2025.1701207
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.22Identifying metabolic parameters as key indicators of hyperuricemia and ischemic stroke comorbidity via interpretable Clinlabomics models通过可解释的临床检验组学模型识别代谢参数作为高尿酸血症与缺血性卒中合并症的关键指标DOI: 10.3389/fendo.2025.1737419
Frontiers in nutrition IF: 05.100Volume 12, Issue No.23Potential benefits of Cuminum cyminum L supplementation on components of metabolic syndrome in adults with metabolic disorders: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials孜然（Cuminum cyminum L.）补充剂对成人代谢综合征患者代谢组分的潜在益处：一项基于GRADE评估的随机对照试验系统评价和荟萃分析DOI: 10.3389/fnut.2025.1618108
World Journal of Cardiology IF: 02.800Volume 18, Issue 1No.24Genetic insights into coronary heart disease in the Teochew population: Bridging gaps in precision medicine潮汕人群冠心病遗传学研究：填补精准医疗的空白DOI: 10.4330/wjc.v18.i1.113579
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.25Effects of combined oral contraceptives and metformin on paraoxonase 1 lactonase activity and status in patients with polycystic ovary syndrome and insulin resistance联合口服避孕药和二甲双胍对多囊卵巢综合征合并胰岛素抵抗患者对氧磷酶1内酯酶活性及状态的影响DOI: 10.3389/fendo.2025.1725822
Eur J Med Res IF: 03.400Ahead of Print.No.26The combination of visceral adiposity and triglyceride-glucose indices as predictors of cardiovascular disease incidence in middle-aged and older adults内脏肥胖指标与甘油三酯-葡萄糖指数联合预测中老年人心血管疾病发病风险DOI: 10.1186/s40001-026-03907-x
Biology of sex differences IF: 05.100Ahead of Print.No.27Sex-specific associations between carotid plaque and bone mineral density in patients with type 2 diabetes: a retrospective cross-sectional study2型糖尿病患者颈动脉斑块与骨密度的性别特异性关联：一项回顾性横断面研究DOI: 10.1186/s13293-026-00830-y
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.28Association between elevated C-reactive protein-triglyceride-glucose index and in-hospital major adverse cardiovascular events in acute coronary syndrome patients after percutaneous coronary intervention: a single-center prospective observational study升高的C反应蛋白-甘油三酯-葡萄糖指数与急性冠脉综合征患者经皮冠状动脉介入治疗后院内主要不良心血管事件的关联：一项单中心前瞻性观察性研究DOI: 10.3389/fendo.2025.1745588
Genome biology IF: 09.400Ahead of Print.No.29Genetic associations of circulating plasma proteins with cardiometabolic diseases循环血浆蛋白与心脏代谢性疾病的遗传关联DOI: 10.1186/s13059-026-03962-x
Journal of medical case reports IF: 00.900Ahead of Print.No.30Sitosterolemia due to compound heterozygous mutations in ABCG5: a case reportABCG5基因复合杂合突变所致谷甾醇血症：一例报告DOI: 10.1186/s13256-025-05814-x
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Poultry science IF: 04.200Ahead of Print.No.01Effects of treated walnut green husk on broiler growth performance, gut health, and meat quality处理过的核桃青皮对肉鸡生长性能、肠道健康和肉质的影响DOI: 10.1016/j.psj.2026.106400
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Scientific reports IF: 03.900Ahead of Print.No.03Mechanistic insights into the lipotropic and atheroprotective effects of rosuvastatin-loaded glycerosomes in dyslipidemic rats瑞舒伐他汀甘油体在血脂异常大鼠中的保肝与抗动脉粥样硬化作用机制研究DOI: 10.1038/s41598-025-34918-z
J Sci Med Sport IF: 03.400Ahead of Print.No.04Too much of a good thing: Can high doses of exercise promote chronic low-grade inflammation and cardiovascular risk in competitive athletes?过犹不及：高剂量运动是否会促进竞技运动员的慢性低度炎症和心血管风险？DOI: 10.1016/j.jsams.2026.01.006
Eur J Intern Med IF: 06.100Ahead of Print.No.05Incidence of major adverse cardiovascular events decreases with greater adherence to both Mediterranean and low-fat dietary patterns in secondary prevention patients: a randomized controlled trial在二级预防患者中，更严格遵循地中海或低脂饮食模式均可降低主要不良心血管事件发生率：一项随机对照试验结果DOI: 10.1016/j.ejim.2026.106733
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Arch Gynecol Obstet IF: 02.500Volume 313, Issue 1No.07Risk factors and predictive modeling for occult endometrial cancer in women with atypical hyperplasia: a retrospective study子宫内膜不典型增生女性发生隐匿性癌的危险因素及预测模型构建：一项回顾性研究DOI: 10.1007/s00404-026-08329-y
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BMJ case reports IF: 00.500Volume 19, Issue 1No.09Hypocholesterolaemia in a child with familial hypercholesterolaemia一例家族性高胆固醇血症患儿的低胆固醇血症DOI: 10.1136/bcr-2025-271433
European Heart Journal IF: 35.600Ahead of Print.No.10Peri-operative myocardial infarction/injury after non-cardiac surgery: association between cardiologist evaluation and outcomes非心脏手术后围术期心肌梗死/损伤：心脏病专家评估与结局的关联DOI: 10.1093/eurheartj/ehaf846
Science IF: 45.800Ahead of Print.No.11Targeting modulated vascular smooth muscle cells in atherosclerosis via FAP-directed immunotherapy通过FAP导向的免疫疗法靶向动脉粥样硬化中的调节型血管平滑肌细胞DOI: 10.1126/science.adx1736
Circulation Research IF: 16.200Volume 138, Issue 3No.12When Smell Drives Swell: Olfr2 Fuels Inflammation in AAA嗅以致肿：Olfr2为腹主动脉瘤炎症火上浇油DOI: 10.1161/CIRCRESAHA.125.327969
Stat Methods Med Res IF: 01.900Ahead of Print.No.13Bayesian feature selection in joint models with application to a cardiovascular disease cohort study联合模型中的贝叶斯特征选择及其在心血管疾病队列研究中的应用DOI: 10.1177/09622802251414939
J Clin Invest IF: 13.600Ahead of Print.No.14ADAMTS7 promotes smooth muscle foam cell expansion in atherosclerosisADAMTS7在动脉粥样硬化中促进平滑肌泡沫细胞扩张DOI: 10.1172/JCI187451
Health psychology IF: 03.200Ahead of Print.No.15Prospective links between childhood family income and subclinical atherosclerosis in a sample of young men儿童期家庭收入与年轻男性亚临床动脉粥样硬化的前瞻性关联DOI: 10.1037/hea0001579
Environ Sci Process Impacts IF: 03.900Ahead of Print.No.16A trophic bridge for bioplastic pollution: transstadial retention and systemic toxicity of polylactic acid microplastics from necrophagous flies (Chrysomya megacephala) to secondary consumer beetles (Tribolium castaneum)生物塑料污染的“营养桥接”：聚乳酸微塑料从腐食性苍蝇（大头金蝇）到次级消费者甲虫（赤拟谷盗）的跨龄期残留与系统性毒性DOI: 10.1039/d5em00386e
EJPC IF: 07.500Ahead of Print.No.17Identification of Biomarkers for Predicting New-Onset Atrial Fibrillation: A Systematic Review and Meta-Analysis预测新发心房颤动的生物标志物识别：一项系统回顾与荟萃分析DOI: 10.1093/eurjpc/zwag061
Cardiovascular Research IF: 13.300Ahead of Print.No.18ChemR23 signalling as a potential therapeutic target in atherosclerosis and cardiovascular diseasesChemR23信号作为动脉粥样硬化和心血管疾病的潜在治疗靶点DOI: 10.1093/cvr/cvag037
Age and ageing IF: 07.100Volume 55, Issue 1No.19Vascular-POPS: evidence for a new standard of care in the management of chronic limb-threatening Ischaemia血管-POPS：在管理慢性肢体威胁性缺血中建立新护理标准的证据DOI: 10.1093/ageing/afag003
JAHA IF: 05.300Ahead of Print.No.20Recurrent Symptomatic Hemorrhage in Cerebral Cavernous Malformations After Discontinuation of Atorvastatin or Placebo停用阿托伐他汀或安慰剂后脑海绵状血管畸形症状性出血复发DOI: 10.1161/JAHA.125.046943
Radiol Cardiothorac Imaging IF: 04.200Volume 8, Issue 1No.21Artificial Intelligence-derived Measurements of Myosteatosis from Coronary Artery Calcium CT Scans to Predict COPD: The Multi-Ethnic Study of Atherosclerosis利用冠状动脉钙化CT扫描的人工智能衍生测量评估肌肉脂肪变性以预测慢性阻塞性肺疾病：多民族动脉粥样硬化研究DOI: 10.1148/ryct.250205
CPT Pharmacometrics Syst Pharmacol IF: 03.000Volume 15, Issue 2No.22A QSP Model of Valproic Acid Toxicity in Pediatric and Adult Populations: Implications for Formulation Selection and L-Carnitine Supplementation定量系统药理学模型评估丙戊酸在儿童与成人中的毒性：对制剂选择与左卡尼汀补充的启示DOI: 10.1002/psp4.70200
J Am Nutr Assoc IF: 02.600Ahead of Print.No.23Supplementation With Lactococcus lactis LMG 27352: Lack of Beneficial Effects on Cardiometabolic Risk in Obese Patients Without Concomitant Dietary Intervention-A Randomized, Triple-Blind, Placebo-Controlled Clinical Trial补充Lactococcus lactis LMG 27352：未结合饮食干预对肥胖患者心血管代谢风险缺乏有益影响——一项随机、三盲、安慰剂对照临床试验DOI: 10.1080/27697061.2025.2610805
Cochrane Database Syst Rev IF: 09.400Volume 1, Issue No.24Enteral lipid supplements for the prevention and treatment of parenteral nutrition-associated liver disease in infants肠内脂质补充剂用于预防和治疗婴儿肠外营养相关性肝病DOI: 10.1002/14651858.CD014353.pub2
BMC research notes IF: 01.700Ahead of Print.No.25Lipidomic signatures in lung adenocarcinoma and spontaneous pneumothorax tissues associated with heated tobacco use: a pilot study与使用加热烟草制品相关的肺腺癌及自发性气胸组织中的脂质组学特征：一项初步研究DOI: 10.1186/s13104-026-07633-9
Acta Cardiologica Sinica IF: 01.800Volume 42, Issue 1No.26From ASCOT to Asia: A More Active and Successful Approach in Preventing Cardiovascular Disease从ASCOT到亚洲：预防心血管疾病的更积极、更成功策略DOI: 10.6515/ACS.202601_42(1).20250806A
Folia Medica CracoviensiaVolume 65, Issue 4No.27Health behaviors of young adults in the context of preventing cardiovascular diseases caused by atherosclerosis年轻成人在预防动脉粥样硬化性心血管疾病方面的健康行为DOI: 10.24425/fmc.2025.156703
Folia Medica CracoviensiaVolume 65, Issue 4No.28Computational insights into oxysterols: MD and DFT applications in pharmaceutical research氧固醇的计算洞察：分子动力学与密度泛函理论在药学研究中的应用DOI: 10.24425/fmc.2025.156699
Current opinion in rheumatology IF: 04.300Volume 38, Issue 2No.29Epidemiology and outcomes of rheumatoid arthritis类风湿关节炎的流行病学和结局DOI: 10.1097/BOR.0000000000001142
World Journal of Cardiology IF: 02.800Volume 18, Issue 1No.30Impact of total occlusion of the infarct-related coronary artery on mortality of 2483 patients with acute myocardial infarction罪犯冠状动脉完全闭塞对2483例急性心肌梗死患者死亡率的影响DOI: 10.4330/wjc.v18.i1.111736
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BioMed research international IF: 02.300Volume 2026, Issue No.33Cardiovascular Dysfunction in Polycystic Ovary Syndrome: Mitochondrial and Inflammatory Mechanisms多囊卵巢综合征中的心血管功能障碍：线粒体与炎症机制DOI: 10.1155/bmri/1110229
ATVB IF: 07.400Ahead of Print.No.34Whole-Body Knockout of the AhR (Aryl Hydrocarbon Receptor) Ameliorates Atherosclerosis Due to Altered Lipid Metabolism全身性敲除AhR（芳香烃受体）通过改变脂质代谢改善动脉粥样硬化DOI: 10.1161/ATVBAHA.125.323673
FCVM IF: 02.900Volume 12, Issue No.35Beyond behaviors: do biological intermediates improve lifestyle scoring for blood pressure?超越行为：生物学中间指标能否改善血压生活方式评分？DOI: 10.3389/fcvm.2025.1713086
Res Pharm Sci IF: 02.100Volume 21, Issue 1No.36Association of fatty acid synthase (FASN), ATP-citrate lyase (ACLY), and acyl-coenzyme A synthetase long-chain 4 (ACSL4) expression and human epidermal growth factor receptor 2 (HER2) status with metastasis and survival in breast cancer: a five-year follow-up脂肪酸合酶、ATP-柠檬酸裂解酶及长链脂酰辅酶A合成酶4表达与人类表皮生长因子受体2状态和乳腺癌转移及生存的关系：一项五年随访研究DOI: 10.4103/RPS.RPS_145_25
J Clin Endocrinol Metab IF: 05.100Ahead of Print.No.37Relationship between continuous glucose monitoring and corneal neuropathy in type 2 diabetes持续葡萄糖监测与2型糖尿病患者角膜神经病变的关系DOI: 10.1210/clinem/dgag030
Circulation IF: 38.600Ahead of Print.No.38Wearable-Derived Training Load and Coronary Atherosclerosis in Middle-Aged and Older Athletes and Physically Active Controls: A New Perspective From the Master@Heart Study可穿戴设备衍生的训练负荷与中老年运动员及体力活动对照者冠状动脉粥样硬化的关联：来自Master@Heart研究的新视角DOI: 10.1161/CIRCULATIONAHA.125.077117
ATVB IF: 07.400Ahead of Print.No.39Bmal1 Regulates Vascular Calcification via Noncanonical Circadian PathwayBmal1通过非经典昼夜节律通路调控血管钙化DOI: 10.1161/ATVBAHA.125.324061
World journal of stem cells IF: 03.600Volume 18, Issue 1No.40Extracellular vesicles derived from human amniotic fluid stem cells improve bladder dysfunction in rat model of diabetic atherosclerosis人羊水干细胞来源的细胞外囊泡改善糖尿病动脉粥样硬化大鼠模型的膀胱功能障碍DOI: 10.4252/wjsc.v18.i1.113614
Mediterr J Rheumatol IF: 01.400Volume 36, Issue 4No.41Analysis of Cardiovascular Risk Factors in Patients with Psoriasis: A Cross-Sectional Study银屑病患者心血管危险因素分析：一项横断面研究DOI: 10.31138/mjr.300125.pac
Mediterr J Rheumatol IF: 01.400Volume 36, Issue 4No.42Age, Gender, and Disease Duration as Key Determinants of Comorbidity Burden in Spondyloarthritis: A Multicentre Cross-Sectional Study年龄、性别和病程是脊柱关节炎合并症负担的关键决定因素：一项多中心横断面研究DOI: 10.31138/mjr.230525.dkr
Res Pharm Sci IF: 02.100Volume 21, Issue 1No.43The effect of estradiol and selective estrogen receptor modulators on lipid profile in the ovariectomized rat model雌二醇和选择性雌激素受体调节剂对去卵巢大鼠模型血脂谱的影响DOI: 10.4103/RPS.RPS_216_23
Dental research journalVolume 22, Issue No.44Histopathological comparison of the effect of 5% melatonin gel and 1.2% rosuvastatin gel on bone regeneration in the rat model5%褪黑素凝胶与1.2%瑞舒伐他汀凝胶对大鼠模型骨再生的组织病理学对比研究DOI: 10.4103/drj.drj_680_23
Dental research journalVolume 22, Issue No.45Evidence on pharmacological agents for treating bony defects in chronic periodontitis: A network meta-analysis治疗慢性牙周炎骨缺损的药理学药物证据：一项网络Meta分析DOI: 10.4103/drj.drj_174_25
Res Pharm Sci IF: 02.100Volume 21, Issue 1No.46The combination of rosuvastatin and meloxicam enhances the radiotherapy efficacy of MCF7, T-47D, and MDA-MB-231 breast cancer cell lines瑞舒伐他汀与美洛昔康联用增强MCF7、T-47D及MDA-MB-231乳腺癌细胞系的放疗有效性DOI: 10.4103/RPS.RPS_191_24
Drug Dev Ind Pharm IF: 02.200Ahead of Print.No.47Solubility enhancement of rosuvastatin using co-crystal approach采用共晶技术提高瑞舒伐他汀的溶解度DOI: 10.1080/03639045.2026.2624588
Rev Esp Enferm Dig IF: 04.000Ahead of Print.No.48Detection of coronary artery calcifications with low-dose thoracic computed tomography and cardiovascular events in liver transplant recipients低剂量胸部计算机断层扫描检测肝移植受者冠状动脉钙化与心血管事件的关系DOI: 10.17235/reed.2026.11758/2025
Int J Prev Med IF: 01.500Volume 16, Issue No.49Impact of Anemia on Long-Term Outcomes and Mortality in ST-Segment Elevation Myocardial Infarction Patients: A SEMI-CI Cohort Study贫血对ST段抬高型心肌梗死患者长期预后及死亡率的影响：一项SEMI-CI队列研究DOI: 10.4103/ijpvm.ijpvm_92_24
EHJ-QCCO IF: 04.600Ahead of Print.No.50The Paradox of SMURF-less Outcomes and its Implication for DiabetesSMURF缺失结局的悖论及其对糖尿病的启示DOI: 10.1093/ehjqcco/qcag012
Cell stress IF: 03.000Volume 10, Issue No.51Reversal of Cushing syndrome by antibody-mediated neutralization of ACBP/DBI通过抗体介导的中和ACBP/DBI逆转Cushing综合征DOI: 10.15698/cst2026.01.314
J Clin Endocrinol Metab IF: 05.100Ahead of Print.No.52Metabolic effects of testosterone therapy in transgender and gender diverse individuals with polycystic ovary syndrome睾酮治疗对患有多囊卵巢综合征的跨性别与性别多元化个体的代谢影响DOI: 10.1210/clinem/dgag032
Health science reports IF: 02.100Volume 9, Issue 2No.53Nonalcoholic Fatty Liver Disease Status and Its Associated Factors Among Patients With Type 2 Diabetes Mellitus in Adama Hospital Medical College, South Eastern Ethiopia: A Cross-Sectional Study埃塞俄比亚东南部阿达玛医院医学院2型糖尿病患者非酒精性脂肪肝病状况及其相关因素：一项横断面研究DOI: 10.1002/hsr2.71773
Pak J Biol SciVolume 28, Issue 11No.54First-Degree Family History of Type 2 Diabetes Mellitus Strengthens the Agreement Between MetS-IR and HOMA-IR in Non-Diabetic Adults2型糖尿病直系家族史增强非糖尿病成年人中MetS-IR与HOMA-IR的一致性DOI: 10.3923/pjbs.2025.700.705
Cardiovascular Diabetology IF: 10.600Ahead of Print.No.55Activator protein-1 (AP-1) inhibition prevents endothelial to mesenchymal transition in diabetes-associated atherosclerosis: a translational study激活蛋白-1（AP-1）抑制剂预防糖尿病相关动脉粥样硬化中的内皮间质转化：一项转化研究DOI: 10.1186/s12933-025-03060-5
Clin Exp Dermatol IF: 02.800Ahead of Print.No.56Topical Statins in the Treatment of Porokeratosis: A Systematic Review局部他汀类药物治疗汗孔角化症：一项系统综述DOI: 10.1093/ced/llag038
35Atherosclerosis(AS)动脉粥样硬化
28Triglycerides(TG)甘油三酯
11Hyperlipidemias高脂血症
10Total Cholesterol(TC)总胆固醇
8Statins他汀
6Lipoprotein(a)(Lp(a))脂蛋白a
6Rosuvastatin瑞舒伐他汀
6Hypercholesterolemia高胆固醇血症
5Atorvastatin阿托伐他汀
2Dyslipidemias血脂异常
2Low-Density Lipoprotein Cholesterol(LDL-C)低密度脂蛋白胆固醇
1Hyperlipoproteinemias高脂蛋白血症
1High Density Lipoprotein Cholesterol(HDL-C)高密度脂蛋白胆固醇
1Fluvastatin氟伐他汀
1Simvastatin辛伐他汀
1Lovastatin洛伐他汀
1Evolocumab依洛尤单抗
1Ezetimibe依折麦布
编辑：赵婷
审校：天纳乾坤
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