盐酸安他唑啉(Antazoline Hydrochloride) - 药物靶点：H1 receptor_在研适应症：心律失常，超敏反应_专利_临床

概要

基本信息

药物类型

小分子化药

别名

2-(N-Benzylanilinomethyl)-2-imidazoline、2-(N-Phenyl-N-benzylaminomethyl)imidazoline、4,5-Dihydro-N-phenyl-N-phenylmethyl-1H-imidazole-2-methanamine

+ [2]

靶点

H1 receptor

作用方式

拮抗剂

作用机制

H1 receptor拮抗剂(组胺H1受体拮抗剂)

治疗领域

免疫系统疾病心血管疾病

在研适应症

心律失常超敏反应

非在研适应症-

原研机构

上海中西三维药业有限公司

在研机构

上海中西三维药业有限公司

非在研机构-

权益机构-

最高研发阶段批准上市

首次获批日期-

最高研发阶段(中国)批准上市

特殊审评-

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结构/序列

分子式C17H19N3

InChIKeyREYFJDPCWQRWAA-UHFFFAOYSA-N

CAS号91-75-8

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关联

2

项与盐酸安他唑啉相关的临床试验

NCT05720572

/ Recruiting临床4期IIT

Clinical Efficacy and Safety of Antazoline in Comparison to Propafenone in Conversion of Paroxysmal Atrial Fibrillation to Sinus Rhythm - a Single Center, Randomized, Double-blinded Study (the AnProAF Study).

The purpose of this randomized, double blind, non-inferiority clinical trial was to compare the clinical efficacy and safety of antazoline with propafenone in the rapid conversion of paroxysmal non-valvular atrial fibrillation to sinus rhythm in patients without heart failure

开始日期2019-09-01

申办/合作机构

International Center for Postgraduate Medical Education LLC

NCT01527279

/ Completed临床4期IIT

Clinical Efficacy of Antazoline in Rapid Cardioversion of Paroxysmal Atrial Fibrillation - a Single Centre, Randomized, Double-blind, Placebo-controlled Study (the AnPAF Study)

The purpose of this randomized, double blind, placebo-controlled, superiority clinical trial was to assess clinical efficacy of antazoline in rapid conversion of atrial fibrillation during observation sinus rhythm.

开始日期2012-11-01

申办/合作机构-

100 项与盐酸安他唑啉相关的临床结果

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100 项与盐酸安他唑啉相关的转化医学

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100 项与盐酸安他唑啉相关的专利（医药）

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989

项与盐酸安他唑啉相关的文献（医药）

2025-03-01·Advances in Medical Sciences

Corrigendum to “Effectiveness of antazoline versus amiodarone, flecainide and propafenone in restoring sinus rhythm at the emergency department” [Adv. Med. Sci (2024 Sep) 69(2) 248–255]

作者: Pejska, Michalina ; Homenda, Wojciech ; Daniłowicz-Szymanowicz, Ludmiła ; Kozłowski, Dariusz ; Zdrojewski, Tomasz ; Springer, Janusz

2024-11-01·Journal of Chromatographic Science

Green TLC-Densitometric Method for Simultaneous Determination of Antazoline and Tetryzoline: Application to Pharmaceutical Formulation and Rabbit Aqueous Humor

Article

作者: Hussein, Ola G ; Ahmed, Dina A ; Rostom, Yasmin ; Abdelkawy, Mohamed ; Rezk, Mamdouh R

Abstract Ophthalmic pharmaceutical preparation containing antazoline (ANT) and tetryzoline (TET) is prescribed widely as an over the counter medication for allergic conjunctivitis treatment. Development of a selective, simple and environmentally friendly thin-layer chromatographic method established to determine both ANT and TET in their pure forms, pharmaceutical formulation and spiked aqueous humor samples. By using silica gel plates and means of a developing system consists of ethyl acetate:ethanol (5:5, by volume), the studied drugs separation was achieved, and scanning was carried out at 220.0 nm for the separated bands with a 0.2–18.0 μg/band concentration range for each of ANT and TET. Standard addition technique application was carried out to determine the proposed method validity. Statistical comparison was made between the proposed method and the official methods ANT and TET showing no significant difference concerning accuracy and precision. Furthermore, greenness profile assessment was accomplished by means of four metric tools, namely, analytical greenness, green analytical procedure index, analytical eco-scale and national environmental method index. Highlights

2024-09-01·Veterinary Microbiology

Case-control study to identify the causative agents of ophthalmia and conjunctivitis in goats in Savannakhet province of Lao PDR

Article

作者: Gerber, P F ; Jayasekara, P P ; Theppangna, W ; Walkden-Brown, S W ; Xaikhue, T ; Olmo, L ; Jenkins, C

Pinkeye is a highly contagious disease of goats with different aetiologies. Surveys in Lao PDR have identified eye lesions typical of pinkeye as a common condition, however, this has not been confirmed diagnostically, and the responsible pathogens have not been identified. A matched case-control study was implemented in 70 goat holdings from Savannakhet province, Lao PDR, to detect agents causing pinkeye and conduct phylogenetic analysis of the identified pathogens. Fifty eye swabs from goats with infected eyes (cases) and 50 paired samples from unaffected cohorts (controls) were collected from 25 holdings. Samples were tested using quantitative PCR assays targeting known pinkeye pathogens at the genus and species levels. The prevalence of pathogens in case and control goats was as follows: Mycoplasma conjunctivae (94% and 74% respectively, P = 0.006, OR = 5.5), Chlamydia pecorum (4%, 10%), Moraxella ovis (30%, 30%), Moraxella bovis (0%, 0%) and Moraxella bovoculi (0%, 0%). M. conjunctivae was present in a high proportion of goats in both groups revealing that Lao goats are carriers of M. conjunctivae. However, the mean log₁₀ genome copy number/µL of DNA extract was significantly higher in case goats than control goats (P < 0.05). Thus, M. conjunctivae is likely the principal causative agent of pinkeye in Lao goats with carrier status converting to clinical infection following corneal damage or other causative factors. M. conjunctivae detected in samples from different goats and districts showed low genetic diversity. Identifying the causes of pinkeye in Lao goats will assist in designing appropriate treatment and control strategies.

100 项与盐酸安他唑啉相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D07459	盐酸安他唑啉	R01AC04 R06AX05	DB08799

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
心律失常	中国	上海中西三维药业有限公司	-
超敏反应	中国	上海中西三维药业有限公司	-

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01527279 (AnPAF, Pubmed \| Europace)	临床4期	心房颤动	74	Antazoline	壓積蓋淵築範觸鬱鑰構(選鬱繭齋構範夢積築簾) = 觸齋積襯鏇遞襯衊積築製鏇鑰衊積網窪壓鑰遞 (鹹遞鑰餘醖鏇願築遞觸 )	积极	2017-10-01
				Placebo	壓積蓋淵築範觸鬱鑰構(選鬱繭齋構範夢積築簾) = 鹽獵簾遞鏇糧糧選醖膚製鏇鑰衊積網窪壓鑰遞 (鹹遞鑰餘醖鏇願築遞觸 )
ESC2017	N/A	新发房颤	107	Antazoline	鹹網鬱齋餘襯觸構憲遞(選範簾鏇遞淵積廠齋夢) = 構衊蓋糧積淵構構願遞鑰壓蓋範選築餘窪鑰鑰 (繭鑰窪齋鹹艱築觸繭糧 ) 更多	-	2017-08-28
ESC2016	N/A	-	10	Antazoline	餘膚夢膚簾製顧範鬱鹹(糧淵餘衊鹽觸構廠築憲) = 鬱艱鬱構餘繭淵鹹構夢製網鑰蓋鹹齋獵鬱襯獵 (蓋衊觸鹽獵築願獵醖鬱 ) 更多	-	2016-08-29
				Sotalol	餘膚夢膚簾製顧範鬱鹹(糧淵餘衊鹽觸構廠築憲) = 淵願願構鑰醖膚蓋製築製網鑰蓋鹹齋獵鬱襯獵 (蓋衊觸鹽獵築願獵醖鬱 ) 更多