更新于：2024-11-21
NDI-101150
更新于：2024-11-21
概要
基本信息
非在研机构- |
最高研发阶段临床1/2期 |
首次获批日期- |
最高研发阶段(中国)- |
特殊审评- |
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结构
分子式C27H27FN6O2 |
InChIKeyQOMXZMCZISKNPU-MRXNPFEDSA-N |
CAS号2628486-22-4 |
关联
1
项与 NDI-101150 相关的临床试验A Phase 1/2, Open-label Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Preliminary Antitumor Activity of NDI-101150 Administered as Monotherapy or in Combination With Pembrolizumab in Patients With Solid Tumors
This study is to determine the maximum tolerated dose (MTD) and the recommended Phase 2 dose (RP2D) and to investigate the safety, pharmacokinetics (PK), pharmacodynamics, and preliminary antitumor activity of NDI-101150 given as monotherapy or in combination with pembrolizumab in adult patients with advanced solid tumors.
开始日期2021-11-05 |
申办/合作机构 |
100 项与 NDI-101150 相关的临床结果
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100 项与 NDI-101150 相关的转化医学
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100 项与 NDI-101150 相关的专利（医药）
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24
项与 NDI-101150 相关的新闻（医药）2024-11-07
BOSTON--(
BUSINESS WIRE
)--
Nimbus Therapeutics
, LLC ("Nimbus Therapeutics" or "Nimbus"), a biotechnology company that designs and develops breakthrough medicines for patients through its powerful computational drug discovery engine, today announced the presentation of new clinical and translational data from its ongoing Phase 1/2 trial of NDI-101150, a novel, oral, potent and selective small-molecule hematopoietic progenitor kinase 1 (HPK1) inhibitor, for the treatment of advanced solid tumors. Results will be highlighted in two poster presentations at the Society for Immunotherapy of Cancer (SITC) 39
th
Annual Meeting, taking place November 6-10, 2024 in Houston, Texas.
The Phase 1/2 multicenter, open-label trial (
NCT05128487
) is designed to assess NDI-101150 as a monotherapy (50-200 mg QD dose) and in combination with pembrolizumab (200 mg Q3W) in the treatment of adults with advanced solid tumors. The clinical results being presented at the SITC Annual Meeting include updated safety data from 53 patients in the dose escalation cohorts (n=41 on monotherapy, n=12 on combination therapy) and additional data from 35 patients in the dose expansion cohorts as well as updated efficacy data from 17 response-evaluable patients with renal cell carcinoma (RCC) who received NDI-101150 monotherapy. Results, as of August 12, 2024, showed:
Safety Profile
NDI-101150 was generally well-tolerated with immune-related adverse events supporting the proposed mechanism of action of HPK1 inhibition, which results in immune activation.
Grade ≥3 treatment-related adverse events (TRAEs) occurred in 14% of all patients exposed to NDI-101150 (n=88). The most common TRAEs were nausea, diarrhea, vomiting and fatigue.
Efficacy and Target Engagement
Treatment with NDI-101150 monotherapy resulted in objective responses in 18% (3/17) of response-evaluable RCC patients, including one complete response (CR) and two partial responses (PRs).
A clinical benefit rate (CR + PR + stable disease [SD] ≥6 months) of 29% (5/17) and a disease control rate of 65% (11/17) were observed in response-evaluable RCC patients treated with NDI-101150 monotherapy.
NDI-101150 effectively inhibited its target across multiple dose levels, providing strong pharmacodynamic evidence of the molecule's activity in patients.
Supporting Mechanistic Evidence
Analysis of tumor biopsies showed a more robust presence of immune cells post-treatment, with increased numbers of tumor-infiltrating lymphocytes and dendritic cells in the tumor microenvironment.
Comprehensive gene expression profiling demonstrated broad activation of immune-related pathways, including enhanced interferon response and T cell activation signals.
"These clinical results of NDI-101150 are highly encouraging, particularly in the context of renal cell carcinoma patients who have experienced disease progression on prior checkpoint inhibitors," said Nathalie Franchimont, M.D., Ph.D., Chief Medical Officer of Nimbus. "The objective responses and disease control rates seen thus far with NDI-101150 in heavily pretreated patients as well as the current safety profile support further evaluation of NDI-101150 in the clinic."
"The clinical and translational data package being presented at SITC demonstrates both the therapeutic potential of NDI-101150 and the power of our computational drug discovery engine to design highly selective molecules against challenging targets like HPK1," said Jeb Keiper, M.S., MBA, Chief Executive Officer of Nimbus. "The monotherapy activity we observed is particularly noteworthy, as many second-generation immunotherapy compounds have struggled to show clinical benefit on their own. Together with its safety profile and the immune activation signals we've observed, these data support NDI-101150's potential as a novel oral non-checkpoint immunotherapy option for patients who need new treatment approaches beyond current checkpoint inhibitors."
The abstracts are available in the
Journal for ImmunoTherapy of Cancer
(JITC)
, the official journal of SITC,
here
and the details of the poster presentations are as follows:
Title:
Ongoing Phase 1/2 Trial of the HPK1 Inhibitor NDI-101150 as Monotherapy and in Combination with Pembrolizumab: Clinical Safety Update and Renal Cell Carcinoma (RCC) Efficacy Analysis
Lead Author:
David Sommerhalder, M.D., Director of Clinical Research, NEXT Oncology
Date:
Saturday, November 9, 2024
Time:
9:00 a.m. – 8:30 p.m. CST
Category:
Clinical Trials in Progress
Abstract Number:
682
Title:
Tumor Immune Microenvironment Characterization from Pre- and Post-Dose Tumors Collected from a Phase 1/2 Study of NDI-101150, a Hematopoietic Progenitor Kinase 1 (HPK1) inhibitor
Lead Author:
Scott Daigle, Senior Director, Translational Medicine, Nimbus Therapeutics
Date:
Friday, November 8, 2024
Time:
9:00 a.m. – 7:00 p.m. CST
Category:
Biomarkers, Immune Monitoring and Novel Technologies
Abstract Number:
83
About Nimbus Therapeutics
Nimbus Therapeutics is a clinical-stage, structure-based drug discovery company developing novel small molecule medicines designed to act against well-validated but difficult-to-drug targets implicated in multiple human diseases. The company advances promising research based on a unique strategy that combines leading-edge computational technologies with a tailored array of machine learning-based predictive modeling approaches. Nimbus' pipeline includes a clinical-stage HPK1 inhibitor for the treatment of cancer (NCT05128487), as well as a diverse portfolio of preclinical programs focused on cancer, including a WRN program for MSI-H cancers, autoimmune conditions, and metabolic diseases. The company is headquartered in Boston, Mass. To learn more about Nimbus, please visit
www.nimbustx.com
.
临床结果免疫疗法AACR会议ASCO会议
2024-06-02
·精准药物
进入第二天，壁报也逐步公开，要看的内容也一下子多了起来。昨晚，本来想开个直播，奈何转换视频号之后的主体关注人数尚未达200，不能开播，只好做罢。前两天挖下的这个坑也在逐渐填平，壁报先下载下来慢慢看。这届会议，文章也就再写这一篇了。推荐阅读：摘要集公布｜2024 ASCO值得关注的临床研究由于时间关系，可能在写某些药物研究时想的不是那么周全，各位也都是聪明人，我把数据摆出来大家自己看。其实，之前在前东家时常写药物研究的数据对比分析，包括商务稿，经常把“非头对头”声明先摆出来，其实我是很抵触这几个字的！不是头对头研究为什么不能对比药物疗效了？看看患者基线是否一致、对照药物是否相同，难道临床医生在几个药物之间斟酌选择的时候，都要求有头对头数据才行？药物研究的质量好不好其实从对照药的选择、患者基线特征的分布、最重要的是对照药是否真实反映出历史数据便可判断。比如某个双抗药，比那同靶点的两个单抗药联合治疗效果如何？当然，药物价格更是重要的因素，毕竟我也是穷人很理解没钱拿药的无奈。但我还是觉得，药物应该疗效一致或相似的前提下评价价格，如果一味强调价格，直接告诉患者回家多吃两个“馒头”，岂不更便宜？没有疗效的前提、价格的评价还有何意义？所以，没有利益关系、没有品牌顾虑，自然直抒胸臆，可能存在错误、思考偏颇。大家也可以直接拿证据过来反驳，我也乐然接受，涨知识嘛！ 声明：以下数据请大家看会议摘要，若是患者请遵医嘱。个人观点，仅供参考！1. HPK1本届会议上，来自百济的 BGB15025、Nimbus的NDI-101150和因明生物的PRJ1–3024都有数据披露。但总的来说，截止这三款药物目前的数量，HPK1靶点单药的疗效并没有期待中那样优秀，尽管疗效不是目前评价的重点。早期的研究也是将HPK1推向了一个备受关注的地位，尤其可通过开发HPK1小分子抑制剂来改善免疫疗法，留下了无尽瞎想。不过，这次会议上BGB15025单药和联合替雷利珠单抗也有初步数据显示，有效性方面，BGB15025单药确认和没确认的疾病控制率（DCR）共35%；联合联合替雷利珠单抗ORR为18.4%（含1例CR）、DCR为30.6%。NDI-101150单药，30例单药患者中，2例患者相较基线降低30%以上，1例确认CR。PRJ1–3024的有效性方面，在数据截止日，纳入的30例患者，还有2例研究进行中，包括1例PR。再给出的下列这个图中，也仅有1例PR。2. EGFR国内都有4-5款上市的3代EGFRi了，单臂附条件还不关门？BDTX-1535这个二代摸样的四代种子，继续公布临床数据。在复发性胶质母细胞瘤，数据也不是那么漂亮。在复发性高级别胶质瘤 (HGG)中，数据还需要等待。3. TROP2 ADC国产创新药正在同台竞技，接受考验。ADC的火热，也让这个进程更加迅速，尤其老外拿走权益，临床研究的数据也就更加稳健。近期，吉利德TROP2抗体药物偶联物 Trodelvy 在针对局部晚期或转移性尿路上皮癌患者的验证性 III 期研究中未能达到主要终点，标志着该治疗再次遭遇挫折。III 期 TROPiCS-04 试验将 Trodelvy 与单药化疗进行了对比，单药化疗由医生在已经接受过含铂化疗和抗 PD-(L)1 治疗的转移性尿路上皮癌 (mUC) 患者中选择。该研究未达到意向治疗 (ITT) 人群中总体生存期 (OS) 的主要终点。这届会议上，还有肺癌领域的EVOKE-01 研究数据公布，OS是其主要终点。老外在临床研究设计方面，基线方面大多还算均衡，不会过分调低研究药物相对对照药在响应不足患者上比例。当然，有效性、主要终点在之前就公布了未达终点。EVOKE-01之后，Datopotomab deruxtecan (Dato-DXd)登台，报告了ICARUS-LUNG01研究结果。在报告前端，先回顾了TROPION-Lung01研究。紧接着，研究设计和患者基线主要终点ORRmPFSTROP的表达与治疗效果是否相关呢？此前，印象中，HER3的表达是不是在乳腺癌中是无关的？从结果上看，收益与表达水平无关，但最优有关。紧接着，就是科伦博泰的TROP2 ADC药物SKB264（MK2870）上台。本次公布的是联合PD-L1的OptiTROP-Lung01研究结果。从结果上看，给药频次上去了，数据也好了一些。但是，当然，安全性会不会受影响呢？3级及以上TRAEs多了（54% vs 42.5%），治疗相关SAEs翻倍（22.2% VS 10%）。PPT不放了，没有找的无责来源。当然，上述3个药物这次的数据治疗线级不同、换着基线不同，不可比较。幸运的是，有讨论。作者指出，结果相似，也可以看到，两个研究对照组数据的相似结论4. KARS近日，诺华停止了KRAS G12C肺癌药物Opnurasib（JDQ443）开发，但是，其他家还有很多。其实，无论每一个药物停止研究或者转让权益之时，如果“东家”还在做这个疾病领域，特别是MNC这样的大厂，尤其是权益毫无保留的情况下，要说和药物本身没有关系、药物前景好？MNC的人难道都是傻子不成？KRAS报告太多了，不写了。我也很任性....^_^声明：发表/转载本文仅仅是出于传播信息的需要，并不意味着代表本公众号观点或证实其内容的真实性。据此内容作出的任何判断，后果自负。若有侵权，告知必删！长按关注本公众号 粉丝群/投稿/授权/广告等请联系公众号助手 觉得本文好看，请点这里↓
免疫疗法ASCO会议抗体药物偶联物临床结果
2024-05-26
·药明康德
▎药明康德内容团队编辑本期看点1. Dyne Therapeutics公司治疗杜氏肌营养不良（DMD）等肌肉疾病的潜在“first-in-class”抗体偶联反义寡核苷酸（ASO）疗法的早期临床试验数据积极，可改善患者的肌肉功能。2. 在Orca Bio公司的在研同种异体T细胞免疫疗法Orca-T治疗急性髓系白血病（AML）的1期研究中，患者的一年总生存率达100%。3. iCell Gene Therapeutics公司的BCMA与CD19靶向复合嵌合抗原受体-T（BCMA-CD19 cCAR-T）细胞免疫疗法在早期临床试验中使系统性红斑狼疮（SLE）患者实现了长期无药物缓解。药明康德内容团队整理DYNE-101、DYNE-251：公布1/2期临床试验数据Dyne Therapeutics公司公布了分别用于治疗强直性肌营养不良1型（DM1）和DMD的抗体偶联ASO疗法DYNE-101和DYNE-251的积极1/2期临床试验结果。DYNE-101由与片段抗体（Fab）偶联的反义寡核苷酸组成，Fab与肌肉上高表达的转铁蛋白受体1（TfR1）结合。它旨在实现靶向肌肉组织递送，目的是减少细胞核中的有毒DMPK RNA、释放剪接蛋白、允许正常mRNA处理和正常蛋白翻译，并有可能阻止或逆转疾病进展。在1/2期临床试验ACHIEVE中，DYNE-101（5.4 mg/kg）在第3个月时表现出剂量依赖性剪接校正，剪接校正比例达到27%。此外，DYNE-101改善了患者的肌肉强直、肌肉力量以及多种患者报告的功能性和疲惫指标。DYNE-251由Fab偶联的磷酸二酰胺吗啉寡聚物（PMO）组成。它旨在实现靶向肌肉组织递送，促进外显子51跳跃，使肌肉细胞产生截短、功能性的抗肌萎缩蛋白（dystrophin），目标是停止或逆转疾病进展。在1/2期临床试验DELIVER中，DYNE-251（10 mg/kg）在6个月时将抗肌萎缩蛋白的表达水平提高到接受标准治疗患者的10倍。多种功能性检测也显示出接受DYNE-251治疗患者的功能改善。Orca-T：公布1b期临床试验数据 Orca Bio公司公布了其在研同种异体T细胞免疫疗法Orca-T用于治疗AML患者的1b期临床试验的积极结果。这款细胞疗法由富集的CD34+干细胞，以及通过高精度平台纯化、取材自单倍体匹配供体的特定T细胞亚群组合而成。Orca-Q有潜力改善患者的预后和降低移植物抗宿主疾病（GvHD）风险，并且无需对无法找到人类白细胞抗原（HLA）匹配的患者进行移植后环磷酰胺（PTCy）治疗。此次公布的结果显示，接受Orca-T治疗的37例AML患者中，12个月的无复发生存率和总生存率分别为82.5%和100%，12个月的非复发死亡率为0%。Orca-T在该亚组中的安全性与更大范围的1b期人群一致，没有发现新的安全性信号。Orca-T目前正在美国各大治疗中心进行关键性的3期临床试验评估。BCMA-CD19 cCAR-T：公布1期临床试验数据 iCell Gene Therapeutics宣布其BCMA-CD19 cCAR-T细胞免疫疗法的研究者发起临床试验（IIT）的积极结果。这款由iCell所设计的cCAR-T细胞免疫疗法，在单一结构中表达两种不同且功能齐全的CAR分子，一种靶向B细胞上的CD19分子，另一种靶向浆细胞上的BCMA。鉴于B细胞和长寿浆细胞具有独立的记忆，因此需要同时靶向B细胞和长寿浆细胞以消除所有升高的自身抗体。分析显示，所有接受足量初始剂量cCAR-T治疗的SLE/狼疮性肾炎（LN）患者，在治疗3个月后体内自身抗体呈现阴性，并在随访46个月时，均达到无症状和无药物缓解。ARO-RAGE：公布1/2期临床试验数据Arrowhead Pharmaceuticals公司公布了其用于治疗哮喘等肺部炎症性疾病的RNA干扰（RNAi）疗法ARO-RAGE的最新中期临床数据。高级糖化终产物受体（RAGE）是2型和非2型炎症级联的上游介质，与哮喘和多种炎症疾病的发病机制有关。ARO-RAGE通过RNAi抑制RAGE表达，旨在减少肺上皮细胞中RAGE蛋白的表达，从而有望减少RAGE依赖性炎症通路，以达到降低哮喘患者病情恶化的频率并改善其通气的目的。此次公布的中期结果表明，使用ARO-RAGE治疗后，正常健康受试者（NHV）和轻中度哮喘患者支气管肺泡灌洗液（BALF）和血清中的可溶性RAGE浓度呈剂量依赖性降低。轻度至中度哮喘患者使用两剂ARO-RAGE后，血清中的可溶性RAGE降低了88%，平均最大降幅达77%。此外，该候选疗法的安全性良好，药效学效应持续时间长，有望支持每两个月一次的给药频率。FG-3246：公布1期临床试验的新数据 FibroGen公布了其与Fortis Therapeutics联合开发的潜在“first-in-class”抗体偶联药物（ADC）FG-3246的1期临床试验的新数据。FG-3246旨在治疗转移性去势抵抗性前列腺癌和其他肿瘤类型，其靶向的CD46是一种细胞受体靶点，在前列腺癌和其他肿瘤类型中高度表达，并在大多数正常组织中表达非常有限。FG-3246由抗CD46抗体与抗有丝分裂剂MMAE连接而成，MMAE是一种已经过临床验证的ADC有效载荷。此次公布的结果显示，FG-3246联用恩杂鲁胺使未经生物标志物筛选的患者的中位放射学无进展生存期（PFS）达到10.2个月。此外，FG-3246具有可接受的安全性，不良事件与其他包含细胞毒性药物MMAE作为载荷的ADC一致。TTX-080：公布1b期临床试验数据 Tizona Therapeutics公司公布了其HLA-G靶向抗体TTX-080在转移性结直肠癌（mCRC）和局部晚期/转移性头颈部鳞状细胞癌（mHNSCC）患者中的1b期临床试验数据。TTX-080联用西妥昔单抗对野生型RAS、BRAF、HER2阴性mCRC患者具有抗肿瘤活性，这些患者之前接受过的中位治疗线数为2线（范围为1-5）。患者的中位PFS为24.4周，36周时的无进展生存率为47%。在14例可评估的患者中，4例患者（29%）获得部分缓解（PR），6例患者（43%）保持疾病稳定（SD），这10例（71%）患者的疾病控制了超过90天。TTX-080联用西妥昔单抗可在人乳头瘤病毒（HPV）阴性mHNSCC患者中产生抗肿瘤活性。这些患者之前接受过的中位治疗线数为1线（范围为1-2），所有患者之前都接受过免疫疗法。患者的中位PFS为23.9周，24周时的无进展生存率为43%。在7例可评估的患者中，1例（14%）患者达到了完全缓解（CR），3例（43%）患者达到了PR，1例（14%）患者达到了SD，这5例（71%）患者的疾病控制了超过90天。SON-1010：公布两项1期临床试验的新数据 Sonnet BioTherapeutics公司公布了其在研免疫调节重组蛋白SON-1010的两项1期临床试验的新数据。SON-1010为一重组蛋白，由单链人类IL-12蛋白与和白蛋白结合的抗体单链片段组合而成，具潜力通过刺激产生干扰素γ将像是非小细胞肺癌、黑色素瘤等肿瘤微环境由“冷”转“热”，活化先天免疫与适应性免疫细胞。这些肿瘤的肿瘤微环境中表达SPARC与GP60蛋白。目前，SON-1010研究共招募了61名受试者，患者已接受了25个周期的SON-1010单药治疗或10个周期的SON-1010联用Tecentriq治疗，在任何剂量水平上都未出现剂量限制性毒性。细胞因子数据显示，与重组人IL-12相比，SON-1010的半衰期延长了约10倍，可诱导长时间和可控的干扰素γ反应，且任何剂量下均未发现细胞因子释放综合征的证据。可评估的晚期实体瘤患者中有35%（8/23）在开始给药后的第四个月出现临床获益。Azenosertib：公布1期临床试验数据Zentalis Pharmaceuticals公司公布了新型、选择性口服生物可利用的WEE1抑制剂azenosertib联用吉西他滨治疗复发性或难治性骨肉瘤1期试验的最终结果。WEE1是G1-S和G2-M细胞周期检查点的主调控因子，通过对CDK1和CDK2的负调控来阻止DNA受损细胞的复制。通过抑制WEE1，azenosertib可使细胞周期在存在高水平DNA损伤的情况下继续进行，从而使癌细胞积累DNA损伤并最终死亡。 此次公布的结果显示，azenosertib联用吉西他滨的耐受性良好，与过去类似患者人群的队列相比，接受该组合疗法的患者的无事件生存率（EFS）的提高具有临床意义。前者16周的EFS大约为12%，后者18周时的EFS为39%（11/28）。NDI-101150：公布1/2期临床试验数据 Nimbus Therapeutics公司公布了其小分子HPK1抑制剂NDI-101150的早期临床试验的新数据。临床前研究发现，NDI-101150对HPK1的选择性是MAP4K家族相关蛋白的300多倍，这有望减少脱靶效应。此次公布的结果显示，NDI-101150的单药治疗为30例可评估患者中的5例（16.7%）带来了临床获益，包括1例CR（肾细胞癌）、1例PR（肾细胞癌）和3例SD。3名患有胰腺癌、肾细胞癌或子宫内膜癌的患者表现出了长时间（>6个月）的SD，肾细胞癌患者已保持疾病稳定21个月。此外，NDI-101150的耐受性良好，整体安全性可接受。KN-002：公布1b期临床试验数据 Kinaset Therapeutic公司公布了其口腔吸入式泛JAK抑制剂KN-002的1b期研究的积极结果。KN-002是一种对所有JAK亚型（即JAK1、JAK2、JAK3和TYK2）均有效的均衡抑制剂，目前正作为一种非侵入性抗炎治疗药物进行开发，适用于所有接受中高剂量吸入型糖皮质激素（ICS）或长效β2受体激动剂（LABA）维持治疗但病情控制不佳的嗜酸性粒细胞性和非嗜酸性粒细胞性哮喘患者以及慢性阻塞性肺病患者。KN-002配制成干粉，具有出色的递送效率和化学/物理稳定性。通过吸入进行局部给药，KN-002能够在肺部炎症部位达到治疗浓度，同时最大限度地降低全身暴露水平。这项随机、双盲、安慰剂对照研究报告称，在为未接受过吸入皮质类固醇治疗的轻度哮喘患者进行为期10天、每天剂量≤16 mg的治疗后，未发现安全性或耐受性问题。此外，每天使用一次和两次KN-002可在临床上显著降低部分呼出一氧化氮（FeNO）水平。▲欲了解更多前沿技术在生物医药产业中的应用，请长按扫描上方二维码，即可访问“药明直播间”，观看相关话题的直播讨论与精彩回放参考资料（可上下滑动查看）[1] GC Biopharma/Novel Pharma's Sanfilippo Syndrome Treatment Obtains FDA IND Approval. 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细胞疗法免疫疗法临床结果临床1期信使RNA
100 项与 NDI-101150 相关的药物交易
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研发状态
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 实体瘤 | 临床2期 | 美国 | 2021-11-05 |
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临床结果
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| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
临床1/2期 | 59 | (膚觸積廠窪簾網膚衊繭) = 選顧衊鬱獵鏇鏇憲範鹹 構網憲淵膚淵網鏇鏇窪 (齋醖襯簾鹽顧窪願壓構 ) 更多 | 积极 | 2024-11-05 | |||
临床1期 | 22 | (衊醖繭遞簾鏇製網鑰窪) = 遞築艱鹽網簾範獵範積 衊鏇構蓋簾觸積觸鏇憲 (鏇齋遞積願醖膚選簾窪 ) 更多 | 积极 | 2023-11-02 | |||
临床1期 | - | - | 積窪鏇齋襯衊廠淵積膚(範齋齋夢顧網鏇網淵憲) = 築製積願醖膚顧顧夢壓 淵餘窪築醖襯醖艱廠衊 (餘窪簾繭齋構衊築淵衊 ) | 积极 | 2023-11-02 |
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