LHRH-a is an important hormone treatment in breast cancer especially in high-risk hormone receptor-positive patients or hormone receptor-negative but needing ovarian function protecting. The climacteric symptoms caused by LHRH-a are often and prominent, which is a common clinical problem.

开始日期2017-01-04

申办/合作机构

浙江省肿瘤医院

NCT02952742 / Withdrawn临床2期IIT

Black Cohosh (Actaea Racemosa) for Hot Flashes in Prostate Cancer Patients on Androgen Deprivation Therapy: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial

This is a randomized, placebo-controlled crossover study. Participants will be actively participating in the study for 6 months, and enrolled in the study for up to 1 year. During the first phase of the study, the participants will be randomized into either the placebo group or treatment group for 8 weeks following 1 week of baseline data collection (no treatment). Following this first phase, a no-treatment washout period of at least 3 weeks will be implemented for all participants. After the washout period, the randomized groups will switch from treatment to placebo group, or placebo to treatment group for an additional 8 week period. Hot flash frequency and severity will be documented using a daily hot flash diary and calculated using the Hot Flash Score questionnaire. The impact on quality of life will be documented by weekly Hot Flash Related Daily Interference Scale (HFRDIS) questionnaires.

开始日期2016-11-01

申办/合作机构

Midwestern Regional Medical Center, Inc.

100 项与黑升麻提取物相关的临床结果

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100 项与黑升麻提取物相关的转化医学

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100 项与黑升麻提取物相关的专利（医药）

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308

项与黑升麻提取物相关的文献（医药）

2024-12-31·Gynecological Endocrinology

Transfer of preclinical study data on the influence of cimicifuga racemosa on functional changes in the hippocampus during menopause

Review

作者: Henneicke-von Zepelin, Hans-Heinrich ; Stute, Petra ; Nicken, Petra

Menopausal transition in women involves complex neurobiochemical changes linked to ovarian dysfunction, resulting in symptoms like vasomotor symptoms (VMS), sleep disturbances, anxiety, and cognitive impairments. Hormone replacement therapy is the first-line treatment. However, many women are reluctant to use HRT or have contraindications toward HRT and seek for alternatives. Non-hormonal therapies with extracts of Cimicifuga racemosa rhizomes like the isopropanolic extract (iCR, black cohosh) offer a promising alternative. A preclinical pilot study exploring iCR's effects on gene expression in the hippocampus and hypothalamus of ovarectomized (OVX) rats mimicking menopausal conditions identified important signaling pathways and CNS-based contributions to the multitargeted modes of action of iCR. Especially in the hippocampus, iCR compensated effects of OVX on gene expression profiles. These changes are reflected by the genes AVPR1A, GAL, CALCA, HCRT, PNOC, ESR1, ESR2 and TAC3 contributing to the formation of hot flushes or thermoregulation as well as to secondary effects such as blood pressure, metabolism, hormonal regulation, homeostasis, mood regulation, neuroendocrine modulation, regulation of sleep and arousal, and in learning, memory and cognition. To understand the mechanisms in the brain of estrogen-depressed animals (OVX) and subsequent iCR treatment we combined the results of the pilot study with those of up-to-date literature and tried to transfer the current knowledge to humans during menopausal transition and adaptation. Focus was laid on changes in the hippocampal function, that is disturbed by hormonal fluctuations, but can also be brought back into balance by iCR.

2024-10-01·Physiology & Behavior

Antidepressant-like effects of Cimicifuga dahurica (Turcz.) Maxim. via modulation of monoamine regulatory pathways

Article

作者: Mao, Zhixuan ; Wang, Xiaobo ; Lv, Chongning ; Lu, Jincai ; Yu, Yang ; Zhao, Yudan ; Qin, Rulan

Sheng-ma is recorded in the Compendium of Materia Medica and mainly originates from the rhizomes of Cimicifuga dahurica (Turcz.) Maxim. (CD), Cimicifuga heracleifolia Kom. and Cimicifuga foetida L. The alcoholic extract of Cimicifuga foetida L. (Brand name: Ximingting®) has been approved for the treatment of perimenopausal symptoms accompanying hot flash, depression and anxiety in China. However, there's no further study about the antidepressant-like effects of C. dahurica (CD). The aim of this study is to investigate the antidepressant-like effect of CD extracted by 75% ethanol and its possible mechanisms.The neuro-protective effects of CD on injured PC12 cells induced by corticosterone was measured firstly. Then, forced swim test (FST), tail suspension test (TST), reserpine-induced hypothermia, 5-hydroxytryptophan (5-HTP) induced head twitch response in mice and chronic unpredictable mild stress (CUMS) on sucrose preference tests were executed. Moreover, the potential mechanisms were explored by measuring levels of monoamine neurotransmitter in mice frontal cortex and hippocampus, testing monoamine oxidase enzyme A (MAO-A) activities in the brains of CUMS-exposed mice. Results showed that CD (60, 120 mg/kg) can significantly decreased the immobility period in FST and TST in mice without affecting locomotor activity. CD (30 mg/kg, 60 mg/kg, 120 mg/kg) could significantly counteracted reserpine-induced hypothermia and increased the number of head-twitches in 5-HTP induced head twitch response. It was also found that the monoamine neurotransmitter levels in the hippocampus and frontal cortex were significantly increased in 60 mg/kg and 120 mg/kg CD treated mice. In addition, CD (60 and 120 mg/kg) significantly inhibited MAO-A after 6-week CUMS exposure. CD can effectively produce an antidepressant-like effect, which involved with modulation of monoamine regulatory pathways.

2024-05-01·The Journal of Emergency Medicine

Black Cohosh Interactions with Prescription Medications Associated with Serotonin Toxicity and Rhabdomyolysis: A Case Report

Article

作者: Dernbach, Matthew Robert ; Carpenter, Joseph E ; Carter, George Benjamin ; Shah, Nihar

BACKGROUNDSerotonin toxicity is a well-described phenomenon that is commonly attributed to a variety of drug-drug combinations. Some unregulated herbal supplements have been implicated in the onset of serotonin toxicity, however, there is currently minimal literature available on the potential for black cohosh to contribute to rhabdomyolysis and serotonin toxicity, in spite of its known serotonergic properties.CASE REPORTA middle-aged woman presented to the emergency department with serotonin toxicity and rhabdomyolysis shortly after taking black cohosh supplements in the setting of long-term dual antidepressant use. The serotonin toxicity and rhabdomyolysis resolved with IV fluids, benzodiazepines, and discontinuation of the offending drugs. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: Patients are sometimes not aware of how over-the-counter supplements might interact with their prescription medications. Female patients taking black cohosh to manage hot flashes and menopausal symptoms could be at risk for developing rhabdomyolysis and serotonin toxicity if they are also taking other serotonergic agents.

项与黑升麻提取物相关的新闻（医药）

2024-08-05

·drugs

Botanicals Like Turmeric, Green Tea Are Harming Americans' Livers

MONDAY, Aug. 5, 2024 -- Botanicals like turmeric , green tea and black cohosh may seem benign, but their overuse is being increasingly linked to liver injury. New research suggests that 7% of U.S. adults are using at least one of the six leading botanicals, the equivalent of 15.6 million people. Many are ending up in hospitals for liver toxicity, researchers report. Because there's almost no regulatory oversight over botanicals, chemical tests of products linked to liver crises "show frequent discrepancies between product labels and detected ingredients," noted a team led by Dr. Alisa Likhitsup . She's an assistant professor of gastroenterology at the University of Michigan in Ann Arbor. The researchers focused on the use of six of the most popular botanicals: Turmeric, green tea extract, the Garcinia cambodgia plant, black cohosh, red yeast rice and ashwagandha. Perusing 2017-2021 data on almost 9,700 adults in a federal health database, they found high rates of botanical use. For example, Likhitsup's group estimated that more than 11 million adults regularly take turmeric supplements, often with the notion that it can ease pain or arthritis . That's not too far below the approximately 14.8 million who take an NSAID pain reliever for much the same reasons. Unfortunately, "multiple randomized clinical trials have failed to demonstrate any efficacy of turmeric-containing products in osteoarthritis," and overdoing it on turmeric has been linked to serious liver toxicity, the researchers said. Likewise, over 3 million adults are estimated to be taking another potential liver toxin, green tea extract, usually to help boost energy and aid in weight loss. But again, "multiple studies have failed to demonstrate any objective evidence of weight loss and sustained improvement in mood or energy levels" with products containing the active ingredients in green tea extract, the Michigan team noted. Other claims, many unfounded, are made for other botanicals: Garcinia cambodgia is touted for weight loss, black cohosh for easing hot flashes and ashwagandha to help build muscle. But Likhitsup and colleagues noted that consumers may be overdosing on botanicals, or getting misled by labels that don't reflect the actual ingredients in their supplements. That may be leading to more users ending up in the ER. According to a national database, cases of liver toxicity linked to botanical use, some severe or even fatal, nearly tripled between 2004 and 2014 -- from 7% of cases to 20%. Use of turmeric, green tea extract, Garcinia cambodgia were often implicated. Another study found such cases rising from 12.5% of liver toxicity cases in 2007 to 21.1% by 2015. Who's using these botanicals? According to the new study, the most common consumer is an older (average age about 52) white (75% of users) female (57%), who was typically well-off. People taking botanicals were more likely to be battling some kind of chronic illness, such as arthritis, thyroid disorders or cancer, compared to folks not using the supplements. In two-thirds of cases, people took a botanical while also taking a prescription medicine, the study found. Because of the danger of drug interactions and the threat to liver health, it's crucial that botanical users inform their doctors, Likhitsup's group said. When botanicals are overused, the damage to the liver "can not only be severe, leading to hepatocellular [liver] injury with jaundice, but also fatal, leading to death or liver transplantation," the research team warned. A prior study found that the number of liver transplants required due to botanical overuse has jumped by 70% between 2009 and 2020. The Michigan team believe better regulation and oversight are needed to protect consumers. "Considering widespread and growing popularity of botanical products, we urge government authorities to consider increasing the regulatory oversight on how botanicals are produced, marketed, tested and monitored in the general population," they wrote. The study was published Aug. 5 in the journal JAMA Network Open. Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

2022-08-25

·PRNewswire

Menopausal Hot Flashes Treatment Market Estimated to Rise at CAGR of 6% from 2019 to 2027, TMR Study

Digitalization in healthcare sector, and resultant increase in adoption of high-tech portable and wearable personal thermostat devices for menopausal women generates new revenue streams in the industry Increasing preference for non-pharmacological treatment solutions, supplemented by adoption of cognitive behavior therapy by healthcare providers creates new avenues in the menopausal hot flashes treatment market WILMINGTON, Del., Aug. 25, 2022 /PRNewswire/ -- The products and solutions offered by the leading manufacturers in the menopausal hot flashes treatment market are used to reduce the severity of the temperature dysfunction caused due to changes that happen in gonadal hormones during the period of menopause. The Research study projects that the menopausal hot flashes treatment market is likely to expand at a CAGR of 6 % during the forecast period from 2019 to 2027. Innovations in the healthcare industry complemented by the increasing introduction of new age and high-tech medical devices, are boosting the growth of the menopausal hot flashes treatment market. Along with this, the rising popularity of alternative treatment solutions, including vitamin E, black cohosh, and herbal medicines, is also favoring the expansion of the market. The stakeholders in the menopausal hot flashes treatment market are working towards breaking the silence regarding the menopause, and trying to address the stigma surrounding it, by launching social media campaigns to generate awareness regarding the health issues related to menopause. These social media campaigns, targeted towards digitally literate female population, are also aiding the players in promoting their alternative solutions (such as herbal medicines and non-hormonal drugs) for management of menopausal hot flashes. Get Exclusive PDF Sample Copy of Menopausal Hot Flashes Treatment Market Report – Key Findings of Menopausal Hot Flashes Treatment Market Study Players Developing Treatment Solutions Targeting Thermostat of Brain: Players in the menopausal hot flashes treatment market are making efforts to develop new treatment solutions that can effectively target the thermostat of the brain, in order to reduce the incidence of hot flashes in menopausal women. Advent of Tech-enabled Medical Devices: Healthcare companies in the landscape of the menopausal hot flashes treatment market are introducing new types of portable, as well as wearable devices that can act as personal thermostats for women going through menopause. This trend, bolstered by the increasing number of tech-savvy female population in late 40s, is creating new avenues for growth in the menopausal hot flashes treatment market. Increasing Demand for CBT: Hot flashes experienced by women going through menopause also trigger certain supplementary reactions, such as low levels of productivity in professional environments, as well as disturbances in sleep. While the medications and hormonal drugs can reduce the occurrence of hot flashes, there is still the need to address these comorbid mental health issues. To address these, the medical professionals opt for cognitive behavior therapy. Ask for References – Menopausal Hot Flashes Treatment Market: Key Drivers The increase in the number of elderly female population across the world, along with the increasing incidence of women experiencing hot flashes symptoms during the menopause, is the key driver for the growth of the menopausal hot flashes treatment market The expansion of the menopausal hot flashes treatment market is also supported by a substantial increase in the number of health drives and initiatives, undertaken by a wide number of private, as well as public organizations, for generating awareness regarding women's health Focus of players in the menopausal hot flashes treatment market on developing new and technologically advanced medical solutions and products that feature alternative route of administration is also generating substantial expansion opportunities Menopausal Hot Flashes Treatment Market: Key Players Some of the leading players in the menopausal hot flashes treatment market are Novartis AG, Allergen PLC, Mulan N. V., Merck & Co., Inc., Therapeutics MD, Inc., Pfizer, Inc., Novo Nordisk A/S, Teva Pharmaceutical Industries, Ltd., Hisamitsu Pharmaceutical Co., Inc., and GlaxoSmithKline PLC, among others. Companies in the menopausal hot flashes treatment market are focusing their efforts and investments on extensive research and development activities. Furthermore, leading players in the market are also organizing campaigns and initiatives to address the silence and stigma associated with symptoms of menopause. Make an Enquiry Before Buying – Menopausal Hot Flashes Treatment Market: Segmentation Menopausal Hot Flashes Treatment Market, by Treatment Type Hormonal Treatment Estrogen Progesterone Estrogen-Progesterone Combination Non-hormonal Treatment Antidepressant Paroxetine Fluoxetine Venlafaxine Desvenlafaxine Others Gabapentin Pregabalin Clonidine Alternative Treatment Black Cohosh Vitamin E Herbal Medicines Others Menopausal Hot Flashes Treatment Market, by Distribution Hospital Pharmacies Retail Pharmacies Online Pharmacies Menopausal Hot Flashes Treatment Market, by Region North America Europe Asia Pacific Latin America Middle East & Africa Modernization of healthcare in terms of both infrastructure and services have pushed the healthcare industry to new heights, Stay Updated with Latest Healthcare Research Reports by Transparency Market Research: Vitamin D Testing Market: The global vitamin D testing market is anticipated to reach more than US$ 1.06 Bn by the end of 2031 with a CAGR of 5.8 % from 2022 to 2031. Laboratory Gas Generators Market: The global laboratory gas generators market is anticipated to reach more than US$ 1.27 Bn by the end of 2031 with a CAGR of 11.0% from 2022 to 2031. Animal Genetics Market: The global animal genetics market is anticipated to reach more than US$ 9.1 Bn by the end of 2031 with a CAGR of 6.7% from 2022 to 2031. Soft Tissue Allografts Market: The global soft tissue allografts market is anticipated to reach more than US$ 6.3 Bn by the end of 2031 with a CAGR of 5.5% from 2022 to 2031. PRP and PRF in Cosmetics Market: The global PRP and PRF in cosmetics market is anticipated to exceed US$ 483 Mn by 2031 with a CAGR of 12.6% from 2022 to 2031. Fetal Bovine Serum Market: The global fetal bovine serum market is expected to surpass the value of US$ 1.6 Bn by the end of 2031 with a CAGR of 6.4% from 2021 to 2031. Cell Culture Market: The global cell culture market is expected to reach the value of US$ 27.6 Bn by the end of 2031 with a CAGR of 9% from 2021 to 2031. Molecular Diagnostics Market: The global molecular diagnostics market is expected to reach the value of US$ 37.19 Bn by the end of 2028 with a CAGR of 11.1% from 2021 to 2028. About Transparency Market Research Transparency Market Research, a global market research company registered at Wilmington, Delaware, United States, provides custom research and consulting services. Our exclusive blend of quantitative forecasting and trends analysis provides forward-looking insights for thousands of decision makers. Our experienced team of Analysts, Researchers, and Consultants use proprietary data sources and various tools & techniques to gather and analyze information. Our data repository is continuously updated and revised by a team of research experts, so that it always reflects the latest trends and information. With a broad research and analysis capability, Transparency Market Research employs rigorous primary and secondary research techniques in developing distinctive data sets and research material for business reports. For More Research Insights on Leading Industries, Visit Our YouTube Channel and hit subscribe for Future Update - Contact Rohit Bhisey Transparency Market Research Inc. CORPORATE HEADQUARTER DOWNTOWN, 1000 N. West Street, Suite 1200, Wilmington, Delaware 19801 USA Tel: +1-518-618-1030 USA – Canada Toll Free: 866-552-3453 Website: Blog: Email: [email protected] Logo: SOURCE Transparency Market Research

100 项与黑升麻提取物相关的药物交易

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