Technetium Tc-99m albumin aggregated kit(Technetium Tc-99m albumin aggregated kit)

概要

基本信息

药物类型

诊断用放射药物、蛋白类药物

别名

TECHNETIUM TC-99M ALBUMIN AGGREGATED、TECHNETIUM TC-99M ALBUMIN COLLOID KIT、TECHNETIUM TC-99M ALBUMIN KIT

+ [15]

靶点-

作用机制

SPECT(单光子发射计算机断层成像术增强剂)

治疗领域

呼吸系统疾病

在研适应症

肺部疾病

非在研适应症-

原研机构

Korea University

在研机构

Jubilant Draximage, Inc.初创企业

非在研机构-

最高研发阶段批准上市

首次获批日期

美国 (1987-12-30),

肺部疾病

最高研发阶段(中国)-

特殊审评-

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关联

2

项与 Technetium Tc-99m albumin aggregated kit 相关的临床试验

NCT03821584 / TerminatedN/AIIT

Brain Perfusion Assessment in the Acute Phase of Migraine Aura.

The aim of the study is to determine the proportion of patients with change in brain perfusion during the acute phase of migraine attack with aura.

开始日期2019-03-01

申办/合作机构

Nantes University Hospital

NCT02480413 / CompletedN/AIIT

Evaluation of an Algorithm for Length Based Weight Estimation in Comparison to Already Known Devices Like the Pediatric Emergency Tape (Pädiatrisches Notfalllineal - PNL)

The purpose of this prospective single center study is to investigate if a developed algorithm is more accurate than the pediatric emergency tape (Alpha 1 Werbedesign e.K., Falkenberg, Germany). For this study 500 patients are required to collect anonymized data (length, weight, age, anaesthesia material used during anaesthesia) for achieving a power of 80% during statistical analysis. The main hypothesis ist that the algorithm has a better accuracy than the pediatric emergency tape (53% are in a +/- 10% interval).

开始日期2015-07-01

申办/合作机构-

100 项与 Technetium Tc-99m albumin aggregated kit 相关的临床结果

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100 项与 Technetium Tc-99m albumin aggregated kit 相关的转化医学

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100 项与 Technetium Tc-99m albumin aggregated kit 相关的专利（医药）

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94

项与 Technetium Tc-99m albumin aggregated kit 相关的文献（医药）

2024-09-01·Arthritis & Rheumatology

Antibodies to Malondialdehyde‐Acetaldehyde Adduct Are Associated With Prevalent and Incident Rheumatoid Arthritis–Associated Interstitial Lung Disease in US Veterans

Article

作者: Kunkel, Gary ; Aripova, Nozima ; Hunter, Carlos D ; Monach, Paul A ; Poole, Jill A ; Wysham, Katherine D ; Matson, Scott M ; England, Bryant R ; Roul, Punyasha ; Thiele, Geoffrey M ; Baker, Joshua F ; Kerr, Gail S ; Mikuls, Ted R ; Duryee, Michael J ; Cannon, Grant W ; Yang, Yangyuna ; Ascherman, Dana P

ObjectiveThe objective of this study is to determine the associations of protein‐specific anti–malondialdehyde‐acetaldehyde (MAA) antibodies with prevalent and incident rheumatoid arthritis–interstitial lung disease (RA‐ILD).MethodsWithin a multicenter, prospective cohort of US veterans with RA, RA‐ILD was validated by medical record review of clinical diagnoses, chest imaging, and pathology. Serum antibodies to MAA‐albumin, MAA‐collagen, MAA‐fibrinogen, and MAA‐vimentin (IgA, IgM, and IgG) were measured by a standardized enzyme‐linked immunosorbent assay. Associations of anti‐MAA antibodies with prevalent and incident RA‐ILD were assessed using multivariable regression models adjusting for established RA‐ILD risk factors.ResultsAmong 2,739 participants with RA (88% male, mean age of 64 years), there were 114 with prevalent and 136 with incident RA‐ILD (average time to diagnosis: 6.6 years). Higher IgM anti–MAA‐collagen (per 1 SD: adjusted odds ratio [aOR] 1.28, 95% confidence interval [CI] 1.02–1.61), IgA anti–MAA‐fibrinogen (aOR 1.48, 95% CI 1.14–1.92), and IgA (aOR 1.78, 95% CI 1.34–2.37) and IgG (aOR 1.48, 95% CI 1.14–1.92) anti–MAA‐vimentin antibodies were associated with prevalent RA‐ILD. In incident analyses, higher IgA (per one SD: adjusted hazards ratio [aHR] 1.40, 95% CI 1.11–1.76) and IgM (aHR 1.29, 95% CI 1.04–1.60) anti–MAA‐albumin antibody concentrations were associated with increased ILD risk. Participants with IgA (aHR 2.13, 95% CI 1.16–3.90) or IgM (aHR 1.98, 95% CI 1.08–3.64) anti–MAA‐albumin antibody concentrations in the highest quartile had an approximately two‐fold increased risk of incident RA‐ILD. Across all isotypes, anti–MAA‐fibrinogen, anti–MAA‐collagen, and anti–MAA‐vimentin antibodies were not significantly associated with incident RA‐ILD.ConclusionProtein‐specific anti‐MAA antibodies to collagen, fibrinogen, and vimentin were associated with prevalent RA‐ILD. IgA and IgM anti–MAA‐albumin antibodies were associated with a higher risk of incident RA‐ILD. These findings suggest that MAA modifications and resultant immune responses may contribute to RA‐ILD pathogenesis.

2024-08-01·Clinical Immunology

Macrophage activation and inflammatory priming by anti-MAA antibodies in rheumatoid arthritis

Article

作者: Réthi, Bence ; Grönwall, Caroline ; Afonso, Marcelo ; Sakuraba, Koji ; Cîrciumaru, Alexandra ; Lagutkin, Denis ; Sun, Jitong ; Catrina, Anca I ; Hensvold, Aase ; Filipović, Maša

We studied the effects of rheumatoid arthritis (RA) autoantibodies that target malondialdehyde-acetaldehyde protein adducts (anti-MAA) on inflammation and macrophage functions. We detected a profound reprogramming of gene expressions and the production of chemokines, such as CCL22 and CCL24, in anti-MAA exposed macrophages. Moreover, anti-MAA pretreatment promoted a more inflammatory cytokine profile upon TLR activation. Although anti-MAA are typically multi-reactive, we observed a prominent clonal diversity in inducing macrophage activation. Anti-MAA antibodies were not arthritogenic in mice, but altered a set of cytokine and growth factor encoding genes in the joints. In individuals at risk of RA anti-MAA IgG levels correlated with circulating inflammatory mediators prior to and at arthritis onset. Certain IgG anti-MAA clones may thus contribute to an inflammatory priming of the joint prior to the onset of systemic inflammation via inducing FcγR-mediated macrophage pre-activation and setting the stage for augmented responses to subsequent inflammatory stimuli.

2024-01-01·Environmental Research

A novel method for predicting the emergence of toxicity interaction in ternary mixtures

Article

作者: Zhang, Jing ; Zeng, Jian-Ping ; Zhao, Yuan-Fan ; Hong, Gui-Yun ; Huang, Xian-Huai ; Zhang, Ying ; Zhang, Jin

The environment is teeming with a wide variety of pollutants, but the complexity and diversity of their combinations make it difficult to fully assess their toxicity interaction. A novel toxicity interaction prediction method (TIPM) based on the three-dimensional (3D) surface form of the concentration addition (CA) deviation model (dCA) was proposed to predict the emergence of toxicity interaction in ternary mixtures. Doxycycline hyclate (DH), bromoacetic acid (BAA) and iodoacetic acid (IAA) were used as target pollutants. The toxicity of binary and ternary mixtures designed by the direct equipartition ray design method (EquRay) and the uniform design ray method (UD-Ray) against Escherichia coli (E. coli) was determined by using a time-dependent microplate toxicity analysis (t-MTA) method. The toxicity interaction within mixtures was characterized qualitatively and quantitatively using dCA 3D surface modeling and the emergence of DH-MAA-IAA toxicity interaction was predicted by TIPM. The results showed that the dCA 3D surface model could well characterize the toxicity interactions of the mixtures, and toxicity interaction was closely related to the components' concentration ratio (p_i). TIPM could predict the emergence of DH-MAA-IAA toxicity interactions well based on the relationship. Due the model is only related to the toxicity interactions and p_i value of a mixture, so it can be suggested to predict toxicity interaction within the more complex multicomponent mixtures, which provides a novel approach for the environmental risk assessment and prediction of hazardous substances.

100 项与 Technetium Tc-99m albumin aggregated kit 相关的药物交易

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