采用单中心、随机、开放、三周期部分重复交叉、单次口服给药试验设计，比较空腹和餐后给药条件下华润三九医药股份有限公司生产的布洛肾素那敏片（规格：每片含布洛芬200 mg、盐酸去氧肾上腺素10 mg、马来酸氯苯那敏4 mg）与Glaxosmithkline Consumer Healthcare Holdings US Llc 持证的布洛肾素那敏片（商品名：ADVIL ALLERGY AND CONGESTION RELIEF®，规格：每片含布洛芬200 mg、盐酸去氧肾上腺素10 mg、马来酸氯苯那敏4 mg）在中国健康人群吸收程度和吸收速度的差异。

开始日期-

申办/合作机构

华润三九医药股份有限公司

100 项与马来酸氯苯那敏/布洛芬/盐酸去氧肾上腺素相关的临床结果

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100 项与马来酸氯苯那敏/布洛芬/盐酸去氧肾上腺素相关的转化医学

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100 项与马来酸氯苯那敏/布洛芬/盐酸去氧肾上腺素相关的专利（医药）

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项与马来酸氯苯那敏/布洛芬/盐酸去氧肾上腺素相关的文献（医药）

1985-01-01·Psychopharmacology3区 · 医学

Relative potencies of histamine H1 antagonists as behavioral stimulants in the squirrel monkey

3区 · 医学

Letter

作者: McKearney, James W.

Benzotropine mesylate [132-17-2], promethazine [60-87-7], cyproheptadine [129-03-3], chlorpheniramine maleate [113-92-8], diphenhydramine [58-73-1], pyrilamine maleate [59-33-6], and tripelennamine [91-81-6] injected into squirrel monkeys increased responding under fixed interval schedules.The relative potencies of the drugs were similar to the histaminic H₁ antagonist potencies and not to other possible mechanisms such as inhibition of dopamine uptake, serotonin antagonism, or antimuscarinic effects.

1983-11-01·Journal of Pharmacy and Pharmacology3区 · 医学

Effect of chlorpheniramine, promethazine and cimetidine on human sperm motility in-vitro

3区 · 医学

Article

作者: Turner, Paul ; Thomas, Molly

Neither histamine [51-45-6] nor cimetidine [51481-61-9] at 1-10 mM altered the motility of human sperm.Promethazine [60-87-7] and chlorpheniramine maleate [113-92-8], classical antihistamines, caused concentration-dependent decreases in sperm motility, promethazine being the more potent.Histamine antagonized the promethazine-induced inhibition, but the effect was reduced at higher histamine concentrations

1983-03-01·Journal of Pharmaceutical Sciences3区 · 医学

Estimation of the Extent of Drug-Excipient Interactions Involving Croscarmellose Sodium

3区 · 医学

Article

作者: Krongtong T. Mitrevej ; R. Gary Hollenbeck ; Allan C. Fan

The extent of drug-excipient interactions involving croscarmellose Na [74811-65-7] was estimated by using chlorpheniramine maleate [113-92-8] as the drug.Interactions were electrostatic involving ionized croscarmellose and cations.Any weakly basic drugs at pH >2 and at ≤pK_a of the weak base interacts with the polymer.An equation is given for estimating the percentage of the drug bound to the polymer.The effect of added Na⁺ concentration on the interaction was also investigated.Increases in the Na⁺ concentration decreased the amount of the drug bound.

100 项与马来酸氯苯那敏/布洛芬/盐酸去氧肾上腺素相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	-	R06AB54	-

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
普通感冒	美国	Haleon US Capital LLC	2011-12-21
季节性过敏性鼻炎	美国	Haleon US Capital LLC	2011-12-21
发热	中国	惠氏制药有限公司	2009-05-22
头痛	中国	惠氏制药有限公司	2009-05-22
鼻塞	中国	惠氏制药有限公司	2009-05-22