Papaya Leaf Extract(Papaya Leaf Extract) - 在研适应症：登革热_专利_临床

概要

基本信息

药物类型

中药

别名

Carica Papaya Leaf Extract

靶点-

作用机制-

治疗领域

感染

在研适应症

登革热

非在研适应症-

原研机构-

在研机构

Bangabandhu Sheikh Mujib Medical University

非在研机构-

最高研发阶段临床3期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

2

项与 Papaya Leaf Extract 相关的临床试验

NCT06121934 / Completed临床3期IIT

Efficacy and Safety of Carica Papaya in Dengue Fever: A Randomised Clinical Trial

This will be a placebo-controlled, multicenter-randomized prospective study of CPLE (Carica papaya leaf extract) tabs in dengue patients (WHO-Group A, B). The study will enroll 300 eligible dengue cases into two arms: one arm receiving CPLE 1000mg t.i.d for 5 days and the other group receiving a placebo.
The main question to ask is whether CPLE reduces severe disease progression and increases platelet counts in dengue patients.
The participant will be asked to take orally available CPLE capsules at a dose of 1000 mg (2 capsules, 500mg each) or identical placebo three times a day for 5 days

开始日期2023-10-01

申办/合作机构

Bangabandhu Sheikh Mujib Medical University

NCT05360134 / Unknown statusN/AIIT

Efficacy and Safety of Platelet Augmentation Using Carica Papaya Leaf Extract in Live Donor Liver Transplantation Recipients - a Pilot Randomized Controlled Trial

This project is a pilot randomized controlled trial aimed at investigating the potential of Carica Papaya Leaf Extract, available in a marketed pill formulation, in increasing platelet counts in live donor liver transplant recipients. Carica Papaya leaf extract has shown positive results in increasing platelet counts in various medical conditions such as Dengue, Immune thrombocytopenic purpura and chemotherapy induced thrombocytopenia. Thrombocytopenia i.e. low platelet counts are a common occurrence in patients with chronic liver disease undergoing live donor liver transplant. It has been observed in previous studies that live donor liver transplant recipients who have persistent thrombocytopenia have significantly worse outcomes as compared to patients who have higher platelet counts. Positive results in this study lead to further studies in assessing the impact of platelet augmentation in live donor liver transplant recipients.

开始日期2021-01-01

申办/合作机构

Institute of Liver & Biliary Sciences

100 项与 Papaya Leaf Extract 相关的临床结果

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100 项与 Papaya Leaf Extract 相关的转化医学

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100 项与 Papaya Leaf Extract 相关的专利（医药）

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3

项与 Papaya Leaf Extract 相关的文献（医药）

2022-06-01·Journal of Family Medicine and Primary Care

Effect of doxycycline and doxycycline with carica papaya on thrombocytopenia and leucopenia in acute dengue fever patients

Article

作者: Mangalia, Ravi ; Mathur, Medha ; Kumawat, Dal Chand ; Patyal, Ashish ; Verma, Anjana ; Mehta, Amit ; Pambhar, Vivek ; Mathur, Navgeet

ABSTRACTBackground:Dengue fever is a mosquito borne disease commonly manifest leucopoenia and thrombocytopenia. Dengue fever and its complications like bleeding manifestation can be life threatening. This study was conducted to study the effect of doxycycline and doxycycline with carica papaya on thrombocytopenia and leucopoenia in acute dengue fever patients.Methods:This case control study was conducted amongst the patients suffering from dengue fever with thrombocytopenia. Cases were dengue patients with thrombocytopenia and leucopenia both. Controls were dengue patients with thrombocytopenia with normal leukocyte count. An effect of doxycycline and doxycycline with carica papaya was observed on platelet and leukocyte counts at baseline and first, second, fourth, and seventh day in cases and comparison was done.Results:The maximum improvement in mean platelet count and leukocyte count was observed in doxycycline with carica papaya group followed by doxycycline alone group followed by controls (conservative treatment) in decreasing order on day 4th and 7th day of admission. Reduced hospital stay was also in the same order.Conclusion:The study results indicate that doxycycline and carica papaya are useful modality to improve leucopenia and thrombocytopenia in dengue patients and to minimize hospital stay.

2010-03-01·Tropical Animal Health and Production3区 · 农林科学

A comparative study of the efficacy of piperazine and Carica papaya for the control of helminth parasites in village chickens in Zambia

3区 · 农林科学

Article

作者: Martha N. Musukwa ; Andrew M. Phiri ; Amos Chota ; Felix Haazele ; Isaac K. Phiri ; Chummy Sikalizyo Sikasunge

Village chickens play vital roles in the livelihoods of those people keeping them. Backyard poultry provide a critical source of food and income for people in developing countries (Lans et al. 2007) and so is the case in Zambia. However, their productivity has been hampered by many constraints resulting in low flock sizes (Kusina and Kusina 1999). Among the constraints is the problem of external and internal parasites (Abebe et al. 1997). In Africa, the control of these parasites is limited by the high cost of anthelmintics, their uncertain availability and the increasing frequency of drug resistance (Naidoo et al. 2008). Therefore, possible alternatives such as the use of plant products that function by mechanisms other than those of chemotherapeutics, with the additional advantage of a natural origin have been recommended (Naidoo et al. 2008). Besides, the cost of treatment with alternative traditional methods (herbs) is negligible when compared with the cost of conventional medicines. In addition to being very inexpensive, herbal preparations have good medicinal value (Mbaria et al. 1998). Therefore, in a quest for provision of safe animal products, a number of studies on use of herbal therapy especially in poultry, have been conducted many of which have reported a number of herbal products that are of potential use as therapeutic or prophylactic agents against bacteria (Arshad et al. 2008), protozoa (Nweze and Obiwulu 2009; Naidoo et al. 2008; Arshad et al. 2008) and viruses (Kong et al. 2006). However, only a few herbal products (Lans et al. 2007; Purwati and He 1991) have been reported to be potential antihelmintic agents in poultry. The objective of the current study was to compare the efficacy of Carica papaya latex with that of piperazine in the control of nematode parasites in village chickens as well as assess the effect of treatment on productivity (weight gain). Trop Anim Health Prod DOI 10.1007/s11250-009-9432-6

1969-06-01·Current therapeutic research, clinical and experimental

Effect of treatment with Carica papaya on resolution of edema and ecchymosis following rhinoplasty.

Article

作者: Vallis, C P ; Lund, M H

100 项与 Papaya Leaf Extract 相关的药物交易

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研发状态

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适应症	最高研发状态	国家/地区	公司	日期
登革热	临床3期	孟加拉国	Bangabandhu Sheikh Mujib Medical University	2023-10-01

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临床结果

适应症

分期

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


Pubmed \| Food Chem Toxicol	N/A	妊娠呕吐 \| 创伤和损伤	-	Carica papaya epicarp extracts	鬱願網齋鏇繭築繭醖夢(衊餘齋遞鹹積範夢願窪) = 醖製構選遞範鏇糧網夢繭網蓋範壓壓鹹簾衊艱 (齋壓窪襯觸餘製齋壓鹹 )	-	2008-07-01
				Carica papaya epicarp extracts	鏇築醖顧齋淵襯鏇糧範(壓範鏇繭夢製積觸憲淵) = 積餘壓窪淵觸壓繭糧醖鹹蓋觸憲製齋遞窪鏇淵 (鹹製顧願獵糧鬱鏇鏇餘 ) 更多
Pubmed	N/A	-	-	Carica papaya L.	餘鑰鹹願襯鬱網構遞鏇(鏇壓艱膚鏇壓衊鏇觸積) = The extract treated wounds were found to epithelize faster as compared to controls 鑰齋構繭範範襯網膚窪 (鏇選襯簾觸壓蓋窪齋壓 )	积极	2007-08-01
				Carica papaya L.