Nanocurcumin(Tehran University of Medical Sciences)(Nanocurcumin(Tehran University of Medical Sciences)) - 在研适应症：肿瘤，类风湿关节炎，实体瘤_专利_临床

概要

基本信息

药物类型

小分子化药

别名-

靶点-

作用方式-

作用机制-

治疗领域

肿瘤免疫系统疾病皮肤和肌肉骨骼疾病

在研适应症

肿瘤类风湿关节炎实体瘤

非在研适应症-

原研机构

Tehran University of Medical Sciences

在研机构

JYANT Technologies, Inc.

Tehran University of Medical Sciences

非在研机构-

最高研发阶段临床阶段不明

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

27

项与 Nanocurcumin(Tehran University of Medical Sciences) 相关的临床试验

IRCT20220223054108N3

/ Suspended临床2/3期IIT

Comparison effecte of nanocurcumin and chlorhexidine mouthwash on salivary streptococcus mutans level in fixed orthodontic patients in Gorgan dental clinic

开始日期2025-02-08

申办/合作机构

Gorgan University

IRCT20240721062501N1

/ Recruiting临床3期IIT

An investigation into the efficacy of nano-curcumin for the management of clinical symptoms and the alleviation of gastrointestinal inflammation in children with celiac disease: a pilot randomized controlled trial

开始日期2024-10-22

申办/合作机构

Mashhad University of Medical Sciences

IRCT20170221032698N3

/ Completed临床3期IIT

evaluation of the effect of nano curcumin on anthropometric indices, glycemic markers, lipid parameters, gene expression of CB2R and inflammatory factors in pre-diabetic patients

开始日期2024-06-21

申办/合作机构-

100 项与 Nanocurcumin(Tehran University of Medical Sciences) 相关的临床结果

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100 项与 Nanocurcumin(Tehran University of Medical Sciences) 相关的转化医学

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100 项与 Nanocurcumin(Tehran University of Medical Sciences) 相关的专利（医药）

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290

项与 Nanocurcumin(Tehran University of Medical Sciences) 相关的文献（医药）

2025-03-01·Pharmacological Research

Effects of nanocurcumin supplementation on metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials

Review

作者: Wilar, Gofarana ; Sasaki, Takuya ; Kawahata, Ichiro ; Abdulah, Rizky ; Shigeno, Masanori ; Fukunaga, Kohji ; Suhandi, Cecep

BACKGROUNDMetabolic syndrome (MetS) encompasses metabolic risk factors like elevated blood glucose, abnormal lipid levels, and hypertension. Nanocurcumin, a nanoscale formulation of curcumin, may offer therapeutic benefits for MetS management. This systematic review and meta-analysis evaluates the impact of nanocurcumin supplementation on key MetS parameters.METHODSA systematic literature search identified 20 randomized controlled trials (RCTs) with 1,394 participants. Data were pooled using a random-effects model, and standardized mean differences (SMDs) were calculated for key outcomes.RESULTSNanocurcumin supplementation significantly improved waist circumference (WC) (standardized mean difference (SMD): -0.30cm), fasting blood sugar (FBS) (SMD: -0.34mg/dL), HbA1c (SMD: -0.33%), and quantitative insulin sensitivity check index (QUICKI) score (SMD: 0.73). Lipid profile parameters, including total cholesterol (SMD: -0.18mg/dL), LDL-C (SMD: -0.16mg/dL), and HDL-C (SMD: 0.32mg/dL), also reduced significantly. Improvement in diastolic blood pressure (DBP) (SMD: -0.32mmHg), total antioxidant capacity (TAC) (SMD: 0.44mmol/L), malondialdehyde (MDA) (SMD: -0.37mmol/L), tumor necrosis factor-α (TNF-α) (SMD: -2.30ng/L), interleukin-6 (IL-6) (SMD: -1.07ng/L), and high-sensitivity C-reactive protein (hs-CRP) (SMD: -0.34mg/L) were observed.CONCLUSIONNanocurcumin supplementation significantly improves multiple MetS-related parameters, including anthropometric measures, glycemic control, lipid profile, blood pressure, oxidative stress markers, and inflammatory biomarkers. These findings highlight nanocurcumin's potential as an effective adjunctive therapy for managing MetS. However, the variability in study participant ages, treatment durations, and sample sizes suggests the need for further well-designed RCTs to establish optimal usage guidelines.

2025-03-01·Regenerative Therapy

Nanocurcumin-enhanced zein nanofibers: Advancing macrophage polarization and accelerating wound healing

Article

作者: Fereydouni, Narges ; Astaneh, Mohammad Ebrahim

IntroductionChronic wounds continue to pose a significant global challenge, incurring substantial costs and necessitating extensive research in wound healing. Our previous work involved synthesizing zein nanofibers embedded with 5 %, 10 %, and 15 % nano-curcumin (Zein/nCUR 5, 10, and 15 % NFs), and examining their physicochemical and biological properties. This study aims to explore the potential of these nanofibers in macrophage (MØ) polarization and wound healing.MethodsWe assessed the survival of RAW264.7 cells cultured on Zein/nCUR 5, 10, and 15 % NFs using the MTT assay. To evaluate MØ polarization, we measured the expression of iNOS and Arg-1 genes in MØs cultured on Zein/nCUR 10 % NFs through real-time PCR. Furthermore, we examined the nanofibers' impact on pro-inflammatory cytokine expression (IL-1β, IL-6, TNF-α) in MØs via real-time PCR. The wound healing efficacy of Zein/nCUR 10 % NFs was tested on 54 male rats with full-thickness wounds, with assessments conducted on days 3, 7, and 14. Wound closure, re-epithelialization, and collagen secretion were evaluated through photographic analysis and tissue staining. Statistical analyses were performed using GraphPad Prism 6, with significance set at p < 0.05.ResultsZein/nCUR 10 % NFs significantly enhanced the survival of RAW264.7 cells compared to other groups. They also markedly reduced iNOS expression and increased Arg-1 expression, indicating successful polarization of M1 to M2 MØs. Additionally, these nanofibers decreased the expression of IL-1β, IL-6, and TNF-α, and significantly improved wound closure, re-epithelialization, and collagen deposition compared to control and Zein groups.ConclusionsThis study demonstrates that Zein/nCUR 10 % NFs effectively polarize MØs from M1 to M2, significantly enhancing wound healing, thus offering a promising therapeutic approach for improved wound care.

2025-02-10·Pharmaceutical Nanotechnology

Ameliorating Paraquat-Induced Nephrotoxicity in Rats: Protective Effects of Nanocurcumin on Renal Histology and Molecular Pathways

Article

作者: Rahimi, Mehdi ; Kheiripour, Nejat ; Moghaddam, Davood Ahmadi ; Ranjbar, Akram ; Asl, Sara Soleymani ; Azizi, Zahra ; Sadeghian, Zohre

Background:Paraquat (PQ) is a common herbicide, and its mortality results from injury to several organs, including the kidneys. Nanocurcumin and curcumin have anti-inflammatory and anti-oxidative activities, but their involvement in PQ-induced kidney damage is unclear. Therefore, the goal of our study was to compare nanocurcumin and curcumin in male rats whose kidneys were damaged by PQ.Method:42 eight-week male albino Wistar rats were put into six groups at random as control, control + curcumin, control + nanocurcumin, PQ, PQ + curcumin, PQ + nanocurcumin for 7 days. The kidney tissues and serum were collected at the end of this period. Total antioxidant capacity (TAC), lipid peroxidation (LPO), total thiol Molecule (TTM), urea, creatinine, and blood urea nitrogen (BUN) levels were assessed. The histopathological evaluation of kidney damage was performed at the end of our study. Moreover, the gene expression was assessed by biochemical and Reverse transcription polymerase chain reaction (RT-PCR) analysis.Result:Curcumin and nanocurcumin administration alleviated PQ-induced renal injury, as evidenced by reduced serum creatinine and BUN levels. The levels of antioxidant markers, like TAC and TTM, increased and decreased the levels of oxidative stress indexes like LPO. Furthermore, our result shows up-regulating the expression of nuclear factor-like 2 (Nrf2), NAD (P) H: quinine oxidoreductase 1 (NQO1), Heme oxygenase 1 (HO-1), and down-regulating the expression of Kelchlike ECH-associated protein 1 (Keap-1) in renal tissue.Conclusion:Niosomal curcumin was more advantageous than ordinary curcumin in lowering oxidative stress and renal tissue damage induced by paraquat intoxication.

100 项与 Nanocurcumin(Tehran University of Medical Sciences) 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
类风湿关节炎	临床前	美国	JYANT Technologies, Inc.	2022-01-30
实体瘤	临床前	美国	JYANT Technologies, Inc.	2022-01-30

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


SNMMI2022	N/A	甲状腺癌	90	40 mg nano-curcumin	(選鹽窪糧構願積願顧淵) = 鹹構選鏇鏇醖壓顧壓襯鹹獵壓鹹壓製範鹽鹹廠 (壓窪簾範製簾鏇淵繭齋, 0.58) 更多	积极	2022-08-08
				80 mg nano-curcumin	(選鹽窪糧構願積願顧淵) = 鏇艱選鏇膚鬱範鑰膚構鹹獵壓鹹壓製範鹽鹹廠 (壓窪簾範製簾鏇淵繭齋, 0.85) 更多