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Comparison of therapeutic effect of nigella sativa and corticosterioid in orabase on oral erosive atrophic lichen planus:A randomized triple blind clinical trial

开始日期2640-06-22

申办/合作机构

Mashhad University of Medical Sciences

IRCT20160710028863N24 / SuspendedN/AIIT

Effect of a Physicians Communication Skills Training on Health Outcomes and HealthLiteracy Among Hypertensive Patients: a Randomized Controlled Trial

开始日期2634-11-22

申办/合作机构

Mashhad University of Medical Sciences

IRCT20200306046708N1 / Suspended临床2/3期IIT

Celecoxib added to mood stabilizer for treating acute mania: A randomized, double-blind, placebo-controlled trial

开始日期2633-12-15

申办/合作机构

Mashhad University of Medical Sciences

100 项与 Mashhad University of Medical Sciences 相关的临床结果

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0 项与 Mashhad University of Medical Sciences 相关的专利（医药）

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26,814

项与 Mashhad University of Medical Sciences 相关的文献（医药）

2025-02-01·Non-coding RNA Research

The relationship between microRNAs and COVID-19 complications

Review

作者: Havakhah, Shahrzad ; Besharati, Reza ; Namdar Ahmad Abad, Hasan ; Kebriaei, Abdollah ; Azimian, Amir ; Namdar Ahmadabad, Hasan ; Khosrojerdi, Mahsa

Over the past three years, since the onset of COVID-19, several scientific studies have concentrated on understanding susceptibility to the virus, the progression of the illness, and possible long-term complexity. COVID-19 is broadly recognized with effects on multiple systems in the body, and various factors related to society, medicine, and genetics/epigenetics may contribute to the intensity and results of the disease. Additionally, a SARS-CoV-2 infection can activate pathological activities and expedite the emergence of existing health issues into clinical problems. Forming easily accessible, distinctive, and permeable biomarkers is essential for categorizing patients, preventing the disease, predicting its course, and tailoring treatments for COVID-19 individually. One promising candidate for such biomarkers is microRNAs, which could serve various purposes in understanding diverse forms of COVID-19, including susceptibility, intensity, disease progression, outcomes, and potential therapeutic options. This review provides an overview of the most significant findings related to the involvement of microRNAs in COVID-19 pathogenesis. Furthermore, it explores the function of microRNAs in a broad span of effects that may arise from accompanying or underlying health status. It underscores the value of comprehending how diverse conditions, such as neurological disorders, diabetes, cardiovascular diseases, and obesity, interact with COVID-19.

2025-01-01·Current Drug Therapy

Protective Effect of Statin Therapy in Ankylosing Spondylitis

作者: Abdollahi, Elham ; Tavasolian, Fataneh ; Sahebkar, Amirhossein ; Inman, Robert D.

Ankylosing spondylitis (AS) is a complex autoimmune and auto-inflammatory disorder characterized by a gradual onset that can progress to spinal ankylosis over time. This chronic condition primarily affects the sacroiliac joints and the spine, often extending its influence to peripheral joints and extra-articular organs, including the eyes AS is associated with significant disability, along with comorbidities such as uveitis and inflammatory bowel disease. Moreover, individuals with AS face an elevated risk of mortality due to cardiovascular disease (CVD). This paper explores the potential benefits of statins, known for their anti-inflammatory and immunomodulatory effects, in mitigating AS-related cardiovascular risk and their therapeutic effects on disease activity.

2025-01-01·Gene

Association between IL-6 -174 G/C (rs1800795) and IL-1A -889 C/T (rs1800587) cytokine variants with polycystic ovary syndrome in Iranian women: A case-control study

Article

作者: Pouresmaeili, Farkhondeh ; aarabi, Azadeh ; Farhad Sadr Tabatabaie, Seyed ; Aarabi, Azadeh ; Hosseinpour Golloo, Zahra ; Kholghi Oskooei, Vahid ; Salahshoorifar, Iman ; Vatannejad, Akram

BACKGROUND AND AIMInfertility in women has various causes, one of which is ovulation disorders. Polycystic ovary syndrome (PCOS) affecting ovulation is a complex idiopathic disease in which genetic polymorphisms may be involved. This study aimed to investigate the relationship between IL-6 -174 G/C and IL-1A -889 G/A cytokine polymorphisms with polycystic ovary syndrome in a population of Iranian women.MATERIALS AND METHODSIn this case-control pilot study, 120 PCOS patients (60 infertile, LPI, and 60 women with recurrent pregnancy abortion, LPA) and 60 controls, CTRLs) participated. After genomic DNA extraction from peripheral blood, we investigated for the polymorphisms rs1800795 of the IL-6 -174 and rs1800587 of the IL-1A-889 using specific primers and PCR-RFLP followed by NlaIII enzyme digestion and PCR-ARMS techniques.RESULTSThere was a significant difference in the studied groups in terms of clinical characteristics (p-value < 0.05) except for the levels of HDL and LDL. Regarding demographic and clinical characteristics of patients, a significant correlation was observed between C/G and G/G genotypes of rs1800795 and FBS level (p value = 0.002). Also, rs1800587 showed a substantial relationship between CC and CT genotypes with the level of LH in LPI and the level of FBS in the LPAs (p value = 0.04). There was no significant difference between the frequencies of rs1800795 and frequencies of rs1800587 genotypes in the three studied groups (p value > 0.05).The studied variants were in Hardy-Weinberg equilibrium.CONCLUSIONThe present work showed that rs1800795 and rs1800587 were not directly associated with PCOS in Iranian patients while the SNPs showed an indirect relationship with some factors affecting the disease. However, using genome-wide association analysis is a proper suggestion to obtain more reliable information about the disease's genetic view. To our knowledge, this is the first report that implicates the role of the examined SNPs in an Iranian PCOS population.

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