Amsacrine

周报精选医学文献 近7天周度精选20篇，覆盖重点学科进展 本文支持继续浏览摘要内容；完整摘要、收藏文章、订阅管理等完整功能，请前往小程序「医研日新」。前往小程序查看更多与订阅收藏 1. Chronic Pain Synergizes With High-Fat Diet to Promote Cardiac Injury via c-Jun N-Terminal Kinase 1/Silent Information Regulator 1 Signaling Axis in Apolipoprotein E-Deficient Mice. [Cardiovascular Diseases] Journal of the American Heart Association | 2026-07-31 | IF 5.0 AI在临床实践中，对于合并慢性疼痛的高脂血症患者，需警惕其心脏损伤风险显著增加，JNK1/Sirt1信号通路可能是潜在的治疗靶点。 摘要Both hyperlipidemia and chronic pain were recognized risk factors for cardiac injury, which could lead to cardiovascular diseases. Thirty-two male APOE-/- (apolipoprotein E-deficient) mice (C57BL/6 background, 1 month old) were randomly allocated to 4 groups (n=8/group): Sham group: high-fat diet+sham surgery for 3 months; P1 to P3 groups: high-fat diet +spared nerve injury-induced chronic pain in...查看完整摘要 2. Frequency of therapeutic drug monitoring in inpatient precision depression care and duration of hospitalization. [Major Depressive Disorder] Translational psychiatry | 2026-07-31 | IF 5.8 AI对于重度抑郁症住院患者，至少每两周进行一次治疗药物监测并根据结果及时调整治疗方案，可显著缩短住院时间约21天并降低37%的住院费用。 摘要In psychiatry, therapeutic drug monitoring (TDM) is routinely used to improve treatment safety and efficacy, yet its association with hospitalization duration and cost-effectiveness remains unclear. We hypothesized that the frequency of routinely requested TDM is associated with hospitalization duration. In this retrospective study, patients with major depressive disorder receiving TDM of antidepr...查看完整摘要 3. Identifying Symptom Dynamics and Profiles of Subgroups at Risk for Major Depression and Suicidal Ideation Among Korean Adults: 2-Week Ecological Momentary Assessment Study. [Major Depressive Disorder] JMIR mHealth and uHealth | 2026-07-31 | IF 6.2 AI移动经验取样法(EMA)通过每日实时监测能有效弥补传统回顾性量表的局限性，个体内症状变异性可作为识别抑郁复发风险的重要补充指标。 摘要Traditional clinical assessments in psychiatric research or clinical practice rely on global retrospective self-report depression measures, which do not adequately capture intra- and interindividual variability in depressive symptoms over time and across contexts. This study aimed to (1) assess the sensitivity of mobile ecological momentary assessment (EMA) for monitoring depressive symptoms compa...查看完整摘要 4. Measuring success in HS treatment from the physician's and the patient's perspective. [Hidradenitis Suppurativa] 综述 | Journal of the European Academy of Dermatology and Venereology : JEADV | 2026-07-31 | IF 8.4 AI临床实践中应采用综合评估策略，结合IHS4等动态医生评分与HiSQOL等患者报告结局，同时关注超声等影像学技术揭示的组织损伤，以实现更全面的治疗成功评估。 摘要Hidradenitis suppurativa (HS) is a chronic, debilitating inflammatory skin disease with substantial quality-of-life impact. Accurate measurement of treatment success requires validated instruments capturing both physician-assessed disease activity and patient-reported symptom burden. Despite an expanding toolkit, consensus on defining remission, optimal control, resolution and progression remains ...查看完整摘要 5. Knowing the disease, avoiding the clinic: A surgeon's lived experience with hidradenitis suppurativa. [Hidradenitis Suppurativa] Journal of the European Academy of Dermatology and Venereology : JEADV | 2026-07-31 | IF 8.4 AI此类第一人称疾病叙事研究可揭示医疗从业者作为患者时的独特就医困境，为改善HS等慢性皮肤病患者的临床照护提供重要的人文视角。 6. Mechanisms, Microenvironments, and Models: Understanding Therapeutic Resistance in Glioblastoma. [Glioblastoma] 综述 | International journal of radiation oncology, biology, physics | 2026-04-24 | IF 6.4 AI胶质母细胞瘤治疗失败的核心在于肿瘤异质性与微环境免疫抑制的协同作用，提示未来需结合多组学分析和精准生物标志物驱动的联合策略，而非单一疗法突破。 摘要Glioblastoma (GBM) is the most common and lethal primary malignant brain tumor in adults. Despite aggressive multimodal therapy, including maximal safe resection, radiation therapy, and temozolomide chemotherapy, median survival remains approximately 16 months, and nearly all tumors recur. Over the past 2 decades, numerous therapies that demonstrated promise in preclinical studies have failed to i...查看完整摘要 7. Amsacrine modifies action potential configuration without its prolongation via the blockade of multiple ion currents in canine ventricular cells. [Leukemia] Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie | 2026-07-31 | IF 6.9 AI胺苯丫啶虽不延长APD，但通过多通道抑制改变心脏电生理特征，临床应用时需警惕其在易感患者中的致心律失常风险。 摘要Amsacrine is an antineoplastic agent for acute lymphoblastic leukemia. It contains methanesulfonamide group -similar to hERG/IKr inhibitors like E-4031 and dofetilide-therefore may exert cardiac arrhythmias. Although amsacrine inhibits expressed hERG channels, its effects on native cardiac electrophysiology remain unclear. We investigated the effects of 1 and 10 µM amsacrine on action p...查看完整摘要 8. Modelling targeted therapy efficacy in NRAS mutant conjunctival melanoma. [Melanoma] Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie | 2026-07-31 | IF 6.9 AI对于NRAS突变转移性结膜黑色素瘤患者，离体药物敏感性测试可指导个体化靶向治疗选择，MEK抑制剂可能是具有临床应用前景的治疗策略。 摘要Conjunctival melanoma (CoM) is an ultra-rare ocular melanoma that originates from transformed melanocytes of the conjunctiva. CoM shares a common embryonic cell of origin as cutaneous melanoma and manifests as highly aggressive malignancy. Despite cellular similarity of conjunctival and cutaneous melanoma, the pathogenesis, genetic landscape, response to treatment, and prognosis of these malignanc...查看完整摘要 9. Retraction notice to "The wastewater microbiome: A novel insight for COVID-19 surveillance" [Sci. Total Environ. 764 (2021) 142867]. [COVID-19] Published Erratum | The Science of the total environment | 2026-07-31 | IF 8.2 AI该废水监测研究已被撤稿，其关于COVID-19监测的结论不可信，临床医生不应将此研究作为辅助诊断或流行病学监测的参考依据。 10. Real-world clinical practice and economic burden of seasonal allergic rhinitis in Japan: A nationwide claims database study. [COVID-19] Allergology international : official journal of the Japanese Society of Allergology | 2026-07-31 | IF 6.2 AI日本季节性AR年药物支出达1829亿日元，83%患者依赖门诊诊治，提示基层医疗在AR管理中的核心地位及优化门诊处方的经济价值。 摘要Allergic rhinitis (AR) prevalence is increasing worldwide. However, while information on the economic burden of AR remains limited globally, nationwide data for Japan are similarly scarce. Therefore, we investigated healthcare utilization and prescription drug costs for seasonal AR using a nationwide claims database, primarily focusing on spring AR. This observational study used the National Datab...查看完整摘要 11. Postpandemic Use of Video-Based Psychotherapy Among German Outpatient Psychotherapists: Repeated Cross-Sectional and Partially Longitudinal Survey Study. [COVID-19] Journal of medical Internet research | 2026-07-31 | IF 5.8 AI临床医生应认识到视频心理治疗已成为可用的辅助手段，其选择使用应基于患者个体需求、临床情境及治疗师对远程治疗效果的信心评估，而非技术可得性。 摘要Video-based psychotherapy (VBT) became an essential modality during the COVID-19 pandemic, enabling outpatient care despite social distancing measures. Yet little is known about how usage continued and acceptance evolved after the pandemic. Most existing research is cross-sectional, pandemic-focused, and rarely integrates technology acceptance with clinical process quality and therapist heterogene...查看完整摘要 12. Modeling the public health impact of vaccination with Pfizer-BioNTech COVID-19 vaccine, LP.8.1, 2025-2026 formula in the pediatric population aged 5-17 years at high risk of severe outcomes from COVID-19 in the United States. [COVID-19] Expert review of vaccines | 2026-07-31 | IF 5.5 AI即使当前低接种率（8.6%-8.7%），LP.8.1改良版疫苗已能为高风险儿童群体提供有意义的保护，但将接种率提升至50%可将保护效果放大6倍，临床医生应积极推动高风险儿童完成疫苗接种。 摘要This study evaluated the potential public health impact of receiving Pfizer-BioNTech COVID-19 vaccine, LP.8.1, 2025-2026 formula, in the US pediatric population aged 5-17 years at high risk of severe outcomes from COVID-19. A previously published static decision-tree model was adapted to compare health outcomes with and without vaccination. Demographic, epidemiological, vaccine (effectiveness, vac...查看完整摘要 13. Heterogeneity in the association between APOE ε4 carrier status and dementia risk by modifiable and non-modifiable risk factors. [Dementia] GeroScience | 2026-07-31 | IF 5.3 AI对于携带APOE ε4基因的高风险人群，教育提升和社会支持可能减弱基因相关的痴呆风险，提示针对性的早期干预具有重要临床价值。 摘要Dementia is a major public health challenge, and Apolipoprotein E (APOE) ε4 is strongly associated with all-cause dementia, particularly Alzheimer's disease (AD). We aim to quantify the overall contribution of modifiable lifestyle, adiposity, socioeconomic status (SES), and health conditions occurring before dementia, to the association between ε4 genotype and the development of all-cause dementia...查看完整摘要 14. Association of Weighted Composite Score of Long-Term Variability of Vascular Risk Factors From Childhood With Midlife Cognitive Function: The Bogalusa Heart Study. [Dementia] Journal of the American Heart Association | 2026-07-31 | IF 5.0 AI儿童期至中年持续的血管危险因素波动（尤其是血糖变异性）是中年认知功能下降的重要风险指标，早期监测并稳定这些危险因素可能成为预防认知衰退的关键策略。 摘要Variability in vascular risk factors (VRFs) has been associated with dementia risk. Whether aggregate VRF variability from childhood influences midlife cognitive function (CF) is unclear. Participants of the Bogalusa Heart Study with ≥3 measurements of VRFs (systolic blood pressure, fasting glucose, non-HDL cholesterol, and BMI) from childhood to midlife and one midlife CF assessment were included...查看完整摘要 15. T-type calcium channel blockers: a review of recent advances (2018-2025). [Epilepsy] 综述 | Expert opinion on therapeutic patents | 2026-08-01 | IF 5.4 AIT型钙通道是具有前景的神经系统疾病治疗靶点，开发亚型选择性抑制剂可能是避免泛通道阻滞剂不良反应的关键策略，对癫痫、疼痛和震颤的精准治疗具有重要临床指导价值。 摘要T-type calcium channels are critical for a number of physiological and pathophysiological processes, and are potential molecular targets for antiepileptics, analgesics and drugs that alleviate non-essential tremor. There have been extensive efforts in identifying and developing novel small organic compounds that block the activities of T-type calcium channels. This is reflected in a number of pate...查看完整摘要 16. Chitosan-based hydrogel for intranasal drug delivery; current advances in the brain diseases treatment. [Epilepsy] 综述 | International journal of pharmaceutics | 2026-07-31 | IF 5.2 AI壳聚糖基水凝胶鼻内给药系统为难治性脑部疾病提供了一种无创、便捷的替代治疗途径，尤其适用于需突破血脑屏障的神经退行性疾病，有望显著改善患者依从性。 摘要Neurodegenerative diseases represent a growing health concern that is projected to become more prevalent and affect more people in the upcoming decades. One of the most complicated components of recent neurodegenerative disease therapies is the penetration and delivery of therapeutics to the central nervous system (CNS), which are hindered via the blood-brain barrier (BBB). In response, innovative...查看完整摘要 17. Distinct Theta-gamma network reorganization differentiates hippocampal sclerosis and MRI-negative mesial temporal lobe epilepsy. [Epilepsy] Neurobiology of disease | 2026-07-31 | IF 5.1 AIMTLE患者存在共同的枕-颞theta网络损害，但HS-MTLE与MRI阴性-MTLE呈现截然不同的gamma网络改变模式，这一发现支持基于电生理网络特征进行MTLE精准亚型区分和个体化认知干预。 摘要Temporal lobe epilepsy (TLE), particularly mesial temporal lobe epilepsy (MTLE), often presents with visual working memory (VWM) impairments, with potential heterogeneity between hippocampal sclerosis (HS) and MRI-negative subtypes. However, task-related electrophysiological (EEG) evidence regarding brain network alterations during VWM processing in MTLE remains limited. This study aims to identif...查看完整摘要 18. Parvalbumin interneuron activation rescues both seizures and impaired social novelty in digenic absence epilepsy mice. [Epilepsy] Science advances | 2026-07-31 | IF 11.7 AI该研究证实帕尔瓦蛋白阳性中间神经元是治疗多基因失神癫痫及其社交共病的关键靶点，DREADDs化学遗传学激活策略优于传统抗癫痫药物，提示未来可探索更安全、选择性的干预方法。 摘要Childhood absence epilepsy (CAE) is a common genetic epilepsy with a frequently complex polygenic etiology, for which a genetically tractable animal model is lacking. Current anti-seizure medications fail to address the significant neurocognitive and social comorbidities of CAE, highlighting a critical unmet need for comprehensive therapies and a better understanding of the underlying mechanisms. ...查看完整摘要 19. HLA-dependent association between EBNA1 antibody levels and disability progression in multiple sclerosis. [Multiple Sclerosis] Journal of neurology, neurosurgery, and psychiatry | 2026-07-31 | IF 8.7 AI对于同时携带HLA-A*02:01和DRB1*15:01基因型的MS患者，较高的EBNA1抗体水平可能预示较好的疾病预后，这一发现有助于在特定遗传背景患者中进行风险分层。 摘要Epstein-Barr virus (EBV) is strongly implicated in the development of multiple sclerosis (MS) but whether EBV-related immune responses are also relevant for disease progression after diagnosis remains unclear. We investigated whether Epstein-Barr nuclear antigen 1 (EBNA1) antibody levels are associated with disability progression in MS and whether this association is modified by human leucocyte an...查看完整摘要 20. An integrated in silico approach to identify pyridine-based AChE and BChE inhibitors for Alzheimer's disease. [Alzheimer Disease] Computers in biology and medicine | 2026-05-30 | IF 7.0 AI化合物46和49作为新型吡啶类双靶点胆碱酯酶抑制剂，在结合亲和力和血脑屏障渗透性方面优于现有药物，为AD新药研发提供了具有实验价值的先导化合物。 摘要Among all the neural diseases Alzheimer's disease (AD) represents a major and critical global health challenge, along with limited diseases-altering therapeutic interventions efficacy. This study deploys collective approaches of in silico study which includes molecular docking, ADMET profiling, density functional theory (DFT), and MD simulations simulation to evaluate pyridine-based dual inhibitor...查看完整摘要 在小程序获取完整功能 收藏文章、管理订阅、查看本期完整摘要与个性化内容，请前往小程序「医研日新」。 前往小程序查看更多内容 免责声明：仅供学术交流参考，不构成任何医学建议或诊疗指导