Arginine Butyrate(Arginine Butyrate) - 药物靶点：TK_在研适应症：短肠综合征_专利_临床

概要

基本信息

药物类型

小分子化药

别名

HQK-1004、VX-105

靶点

TK

作用方式

刺激剂

作用机制

thymidine kinase刺激剂(胸苷激酶刺激剂)

治疗领域

消化系统疾病内分泌与代谢疾病其他疾病

在研适应症

短肠综合征

非在研适应症

镰状细胞血症β地中海贫血爱泼斯坦-巴尔病毒阳性淋巴瘤+ [2]

原研机构

Boston University

在研机构

Baxter Healthcare Corp.

非在研机构

Boston UniversityHemaQuest Pharmaceuticals, Inc.

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评孤儿药 (美国)

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结构/序列

分子式C10H22N4O4

InChIKeyHTWPXGKLFMPZHG-WCCKRBBISA-N

CAS号80407-72-3

关联

5

项与 Arginine Butyrate 相关的临床试验

NCT00992732

/ Terminated临床2期

A Phase 2a Open-Label Multi-Center Study Evaluating HQK-1004 Administered With Valganciclovir in Patients With Relapsed or Refractory Epstein-Barr Virus-Positive Lymphoid Malignancies or Lymphoproliferative Disorders

The purpose of this study is to determine if treatment with HQK-1004 and valganciclovir will result in complete or partial responses in patients with EBV-positive lymphoid malignancies or lymphoproliferative disorders.

开始日期2010-05-01

申办/合作机构

HemaQuest Pharmaceuticals, Inc.

NCT00917826

/ Terminated临床2期

A Phase II Trial of Low-Dose Arginine Butyrate and Ganciclovir/Valganciclovir in EBV(+)Lymphoid Malignancies

The purpose of this study is to assess whether administration of Arginine Butyrate + ganciclovir/valganciclovir for up to three 21-day cycles is tolerable, and results in partial or complete responses in patients with EBV(+) lymphoid malignancies.

开始日期2008-09-01

申办/合作机构

HemaQuest Pharmaceuticals, Inc.

[+1]

NCT00006136

/ Completed临床2期IIT

Phase II Study of Arginine Butyrate With or Without Epoetin Alfa in Patients With Thalassemia Intermedia

OBJECTIVES: I. Determine whether arginine butyrate with or without epoetin alfa can stimulate gamma-globin chain production to a degree that decreases anemia and results in hematologic improvement in patients with thalassemia intermedia.
II. Determine whether a proportional increase in gamma-globin synthesis and mRNA and an improvement in nonalfa and alfaglobin chain imbalance by at least 10% over baseline correlate with improved hematologic response in these patients when treated with this regimen.
III. Determine whether a decrease in hemolysis, as assayed by a decrease in LDH, compared to baseline levels correlates with improved hematologic response in these patients when treated with this regimen.
IV. Determine whether any particular genotypes are more responsive than others to this therapy in these patients.
V. Determine whether baseline epoetin alfa levels, gender, and/or baseline reticulocyte counts (or percent circulating nucleated erythroblasts) correlate with improved hematologic response in these patients when treated with this regimen.

开始日期1999-03-01

申办/合作机构

Boston University

100 项与 Arginine Butyrate 相关的临床结果

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100 项与 Arginine Butyrate 相关的转化医学

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100 项与 Arginine Butyrate 相关的专利（医药）

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110,224

项与 Arginine Butyrate 相关的文献（医药）

2025-12-31·INTERNATIONAL JOURNAL OF FOOD PROPERTIES

FTIR characteristics of sweet flour as affected by particle size distribution and in vitro digestibility of gluten-free sweet potato noodles

作者: Mohamed Ahmed, Isam A. ; Aljobair, Moneera O. ; Anees Ur Rehman, Muhammad ; Azeem, Muhammad ; Wadood, Syed Abdul ; Qureshi, Tahir Mahmood ; Ali, Asmahan A.

There is a need to explore the influence of particle size of sweet potato flour on physicochem. properties and in vitro starch digestibility of gluten free sweet potato noodles.The aim of this work was to examine the influence of purple-fleshed sweet potato flour (PFSPF) having different particle size distribution (355 μm to 75μ m) on physicochem. properties and in vitro starch digestibility of gluten-free purple sweet potato noodles.Pasting properties and sugar contents were pos. correlated toward the finest particle fraction.The hardness of noodles was pos. and significantly correlated to the finest particle size fraction.Sweet potato flour (SPF) noodles prepared with particle size of 75 μm retained lower hardness 5.74 N.An abrupt increase in yellowness was observed with decreasing particle size that might be attributed to the reduction of protein.The results of FTIR suggested that with the reduction of particle size, protein and carbohydrates decreased that much associated with crystallization and retrogradation of starch.Among all the amino acids, aspartic acid and glutamic acid were observed to be more abundant, i.e. approx. 13.33 and 29.05‰, resp.In this way, PFSPF with particle size 75 μm exhibited significant application potential for producing gluten free noodles due to high resistant starch and lower hardness.It may be concluded that particle sizes of sweet potato flour influenced pasting properties, textural characteristics, sugar contents, protein contents, amino acid contents, carbohydrate contents of prepared noodles.

2025-12-31·Journal of the International Society of Sports Nutrition

Investigation of the effect of nitrate and L-arginine intake on aerobic, anaerobic performance, balance, agility, and recovery in elite taekwondo athletes

Article

作者: Ozan, Murat ; Buzdağlı, Yusuf ; Kavcı, Zafer ; Savaş, Adem ; Uçar, Halil

BACKGROUND:

Taekwondo is a complex martial art that requires speed, balance, agility, and endurance. This study aims to examine the effects of nitrate and L-arginine supplementation on acute aerobic and anaerobic performance, balance, agility, and recovery in elite taekwondo athletes.

METHOD:

This study was conducted as a double-blind, randomized, crossover study with the participation of 15 experienced taekwondo athletes aged 19.06 ± 0.96 years and 8.93 ± 1.27 years of training experience. Participants visited the laboratory a total of nine times, including a practice session and anthropometric measurements. These visits consisted of eight experimental sessions conducted at 72-hour intervals. The experimental sessions were conducted with nitrate, L-arginine, and a combination of both supplements (NIT*L-ARG) and placebo. Nitrate supplementation was provided by homogenizing fresh spinach (837.40 mg/kg), while L-ARG was given as a single dose of 6 g in powder form three hours before exercise.

RESULTS:

NIT*L-ARG supplementation significantly improved the anaerobic performance of athletes in Wingate peak power and peak power (w/kg) compared to placebo and in mean power compared to NIT, L-ARG, and PLA. In addition, NIT*L-ARG supplementation significantly improved blood lactate levels and agility performance immediately after Wingate and Shuttle run tests.

CONCLUSION:

The combined intake of NIT*L-ARG was found to be effective in improving aerobic, anaerobic, and agility performances as well as fatigue levels of athletes. It was determined that taking NIT and L-ARG supplements alone contributed to the improvement of improving athletes' performance in Wingate mean power values and subsequent fatigue level compared to PLA.

2025-12-01·MOLECULAR BIOLOGY REPORTS

Two different complement Factor B (Bf) alleles of the orangutan major histocompatibility complex (MHC) are also conserved in chimpanzee and humans showing importance in primate immunity

Article

作者: Lledo, Tomás ; Juarez, Ignacio ; Martín-Villa, José Manuel ; Arnaiz-Villena, Antonio ; Vaquero-Yuste, Christian ; Suarez-Trujillo, Fabio

BACKGROUND:

Major Human Histocompatibility complex (MHC or HLA in humans) has been associated to autoimmune diseases. However, only statistical phenomenological and no pathogenetic description has been reached after decades. This shows that MHC single locus association studies are probably useless for HLA/diseases association. Extended HLA (class I and class II genes) haplotypes should also be studied conjointly with class III or complement alleles (complotypes). Complotypes in humans are defined as alleles belonging to C2, C4 and Bf (Factor B) genes/proteins (class III). Also, the placing of MHC class I and class II genes close together with complement genes from at least birds to humans shows existence of a strong selection to gather conjointly these loci that fight microbes, help self-maintenance and avoid autoimmunity. In this paper we aim to study Bf alleles in primates in order to rise again interest to study the role of Bf alleles together with other MHC genes in their physiopathology and evolution.

METHODS:

Orangutan (Pongo pygmaeus, Popy) cell lines RNA from 6 different individuals were retrotranscribed, PCR amplified, cloned and DNA sequenced in order to study Bf alleles.

RESULTS:

A Bf allele identical to that found in chimpanzee (Patr-Bf*A01) and human (rs641153) was found in two of the six studied orangutans: Popy-Bf*A01 and Popy-Bf*A02. This polymorphism is placed in Factor B codon 32 that defines BF*S and Bf*F proteins in man and produce Leu instead of Arg (Bf*S) or Gln (Bf*F). In addition, each new orangutan allele present synonymous differences with each other at codon 25: Popy-Bf*A01 shows ACG while Popy-Bf*A02 bears ACA, both codifying for Thr.

CONCLUSIONS:

The selection for about 15 million years (time gap of evolutionary appearance between orangutan and hominids) shows the importance of this particular allele conservation in immune and self defense in primates. The complotypes (Bf,C2 and C4 loci) alleles together with other MHC class I and Cass II loci alleles are often transmitted in block to the germinal line: this indicates that all specific alleles from the MHC different loci may work together to accomplish MHC functions. All MHC loci alleles should be studied together to unveil their physiopathology and also maintenance of specific alleles (like the one described in this paper) for so long time in evolution should be further studied in Bf and the other neighbouring complement loci (C2 and C4).

100 项与 Arginine Butyrate 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
爱泼斯坦-巴尔病毒阳性淋巴瘤	临床2期	美国	HemaQuest Pharmaceuticals, Inc.	2010-05-01
EBV相关淋巴瘤	临床2期	美国	HemaQuest Pharmaceuticals, Inc.	2008-09-01
镰状细胞血症	临床2期	美国	Boston University	1997-09-01
β地中海贫血	临床2期	美国	Boston University	1997-09-01
下肢溃疡	临床2期	美国	Boston University	1997-09-01
短肠综合征	临床前	美国	Baxter Healthcare Corp.	2023-03-09

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT00004412 (CTgov)	临床2期	β地中海贫血 \| 下肢溃疡 \| 镰状细胞血症	23	Standard local care dressing (Standard Local Care Dressing)	夢壓製壓鏇淵願廠顧願 = 襯顧鏇積醖襯鹹鏇鹹淵鹽鬱蓋夢壓壓餘衊製構 (鹽鬱蓋糧餘選觸構鏇鹹, 網積遞選襯遞糧糧遞蓋 ~ 範艱選繭壓餘淵顧夢鹽) 更多	-	2015-03-31
NCT00004412 (CTgov)	临床2期	β地中海贫血 \| 下肢溃疡 \| 镰状细胞血症	23	Standard local care dressing+Arginine Butyrate (Arginine Butyrate)	夢壓製壓鏇淵願廠顧願 = 窪網簾鹽鏇鹹憲衊顧鬱鹽鬱蓋夢壓壓餘衊製構 (鹽鬱蓋糧餘選觸構鏇鹹, 構夢糧網蓋鏇願艱繭壓 ~ 餘觸鹽醖鏇獵鹹鏇繭觸) 更多	-	2015-03-31
Pubmed \| Br J Haematol	临床2期	下肢溃疡	-	Arginine Butyrate (Standard local care)	簾鹽艱鹽願網夢齋齋遞(夢遞醖蓋選鑰鬱網糧鹽) = 襯齋簾窪衊遞醖衊醖鏇製範壓艱衊憲膚衊築蓋 (膚糧獵鹽鑰網襯繭廠夢 )	-	2010-12-01
Pubmed \| Br J Haematol	临床2期	下肢溃疡	-	Standard care with Arginine Butyrate	簾鹽艱鹽願網夢齋齋遞(夢遞醖蓋選鑰鬱網糧鹽) = 鏇襯淵醖遞網餘膚鏇願製範壓艱衊憲膚衊築蓋 (膚糧獵鹽鑰網襯繭廠夢 )	-	2010-12-01
Pubmed \| Blood	临床1/2期	爱泼斯坦-巴尔病毒相关肿瘤	15	Arginine butyrate	鬱築鏇窪鏇襯遞憲積鹽(鬱壓鑰衊夢廠蓋淵夢簾) = 築齋醖憲齋壓窪築鑰衊膚積選壓鏇範夢壓齋積 (製醖遞襯觸積艱艱淵鏇 )	-	2007-03-15
ASCO2006	临床1/2期	爱泼斯坦-巴尔病毒相关肿瘤	-	Arginine Butyrate	鬱觸糧獵鹹遞襯簾繭願(鹽選觸繭淵鹽衊顧齋醖) = 獵夢簾構鹹醖鹹淵鹹淵壓鹽艱齋製簾選餘淵構 (簾範繭遞鬱鬱鏇糧觸簾 )	-	2006-06-20