Effects of intake of food containing Bifidobacterium animalis subsp. lactis LKM512 and arginine on cognitive function: A randomized, double-blind, placebo-controlled trial

开始日期2026-10-14

申办/合作机构-

NCT07772882

/ Not yet recruiting临床1期IIT

Phase I Study of Supplemental Arginine With Chemotherapy and Immunotherapy in Platinum Resistant Ovarian, Fallopian Tube, and Peritoneal Cancer

This is an open-label, Phase 1 clinical study to evaluate the safety, tolerability, PK profiles, and clinical activity of IV and PO arginine supplementation + SOC chemoimmunotherapy regimens in participants with PROC.

开始日期2026-09-01

申办/合作机构

The University of Alabama at Birmingham

RBR-4y7psfv

/ Not yet recruitingN/AIIT

Effect of a hyperproteic supplement enriched with arginine, glutamine, and HMB on wound healing, body composition, and metabolic markers in individuals with Diabetes-Related Foot Disease: a randomized, controlled, assessor-blinded clinical trial

开始日期2026-08-04

申办/合作机构

Universidade do Estado da Bahia

[+1]

100 项与盐酸L-精氨酸相关的临床结果

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100 项与盐酸L-精氨酸相关的转化医学

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100 项与盐酸L-精氨酸相关的专利（医药）

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76,788

项与盐酸L-精氨酸相关的文献（医药）

2026-12-01·INTERNATIONAL JOURNAL OF PHARMACEUTICS

In situ phase transition to a hydrated ionic liquid-like state: a new application strategy for enhancing topical delivery of potassium 4-methoxysalicylate

Article

作者: Suzuki-Okishima, Anna ; Uyama, Makoto ; Fukuhara, Tadao ; Okamoto, Toru

Hyperpigmented lesions and uneven skin tone are cosmetic concerns caused by excessive melanin deposition. Potassium 4-methoxysalicylate (4MSK) is a widely used active agent for inhibiting melanogenesis; however, its efficacy is constrained by poor skin penetration due to its ionic, highly hydrophilic nature and crystallization on the skin. Ionic liquids (ILs) can suppress crystallization and enhance skin penetration, yet their practical application is limited by high viscosity, poor spreadability, and concerns regarding skin tolerability. Here, we developed an in situ strategy for IL-like amorphous phase formation that overcomes these barriers by decoupling formulation processability from delivery performance. This approach utilizes aqueous mixtures of acidic and basic precursors that undergo counterion exchange as water evaporates, generating an IL phase directly on the skin. Screening of 4-methoxysalicylic acid (4MS) with amino acids identified arginine (Arg) as an effective counterion, yielding a stable IL, [Arg][4MS], with glass transition behavior and reduced crystallinity. Importantly, a formulation-relevant precursor pair-4MSK and arginine hydrochloride-undergoes the same molecular conversion during drying, reproducing the IL-like state without pre-synthesized ILs. This phase transition markedly enhanced skin penetration, increasing human skin permeation to 237% of control and enabling deeper penetration into viable epidermal layers. In a reconstructed human epidermis model, treatment reduced melanin content by 33% without compromising tissue viability. These findings establish in situ IL formation as a viable strategy to combine formulation compatibility with high-performance skin penetration of hydrophilic actives.

2026-11-01·JOURNAL OF PHARMACEUTICAL SCIENCES

Effects of anion excipients on the viscosity of high-concentration mAb solution

Article

作者: Torisu, Tetsuo ; Shibuya, Risa ; Uchiyama, Susumu ; Maruyama, Souhei

High protein concentrations often lead to high viscosity, necessitating reduced solution viscosity. We investigated the effects of eight anionic excipients commonly used in biopharmaceutical formulations on the solution viscosity of high-concentration monoclonal antibodies using three antibodies with different isoelectric points. The three antibodies exhibited attractive or repulsive protein-protein interaction tendencies in histidine buffer without anionic excipients. The effect of adding anionic excipients on solution viscosity differed by interaction tendencies. Preferential interaction coefficients revealed differences in the extent of interaction between individual anionic excipients and antibodies. Comparison with chloride, positioned in the middle of the Hofmeister series, suggested that the observed viscosity behavior could only be partially explained by the previously reported Hofmeister anion effects on solution viscosity. We examined the effects of combining L-arginine with each anionic excipient as a counter anion. Formulations containing L-arginine and other anionic excipients contributed more strongly to reducing solution viscosity than L-arginine hydrochloride. The effects of anionic excipients on viscosity can be understood in terms of protein-protein interactions of an antibody in the presence of anionic excipients; whether anionic excipients strengthen or weaken the intrinsic protein-protein interactions is important, underscoring the key indicator for selecting the optimal anionic excipients when designing high-concentration formulations with lower viscosities.

2026-10-13·JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Arginine Therapy for Sickle Cell Disease Acute Pain Episodes

Article

作者: Brown, Kathleen ; Singh, Nidhi ; Korman, Rawan ; Brousseau, David C. ; Ellison, Angela M. ; Airewele, Gladstone ; Cohen, Daniel ; Wynn, Bridget ; Morris, Claudia R. ; Rees, Chris A. ; Akinsola, Bolanle ; Hatabah, Dunia ; Ahmad, Fahd A. ; Bakshi, Nitya ; Alzraikat, Noor ; Leibovich, Sara ; Denton, Christopher ; Wilkinson, Hagar ; Cruz, Andrea T. ; Chumpitazi, Corrie E. ; Casper, T. Charles ; Coleman, Keli D. ; Jensen, Hailey ; Thompson, Alexis ; Villella, Anthony ; Vichinsky, Elliott ; Dampier, Carlton ; Chang, Todd P. ; Campbell, Andrew D. ; Covelo, Laura ; Fields, Melanie ; Remiker, Allison

Importance:

Acute pain episodes are the leading cause of emergency department visits and hospitalizations for patients with sickle cell disease (SCD), yet US Food and Drug Administration–approved drugs for acute pain episodes are lacking. During acute pain episodes, patients develop acute arginine deficiency associated with longer time to crisis resolution and greater total parenteral opioid use. Multiple single-center, phase 2 randomized clinical trials have shown that arginine is safe, is opioid sparing, improves cardiopulmonary function, and reduces length of hospital stay.

Objective:

To determine the efficacy and safety of intravenous arginine for SCD acute pain episodes.

Design, Setting, and Participants:

Prospective, phase 3, double-blind randomized clinical trial conducted between June 21, 2021, and June 13, 2024, in 10 US children’s hospitals enrolling patients aged 3 to 21 years presenting to the emergency department with SCD acute pain episodes requiring parenteral opioids.

Interventions:

Patients were randomized to receive intravenous arginine (200 mg/kg followed by 100 mg/kg every 8 hours until discharge; n = 129) or saline placebo (n = 142).

Main Outcomes and Measures:

The primary outcome was time to crisis resolution, defined as hours from initial study drug delivery to last intravenous opioid dose. Secondary outcomes included total parenteral opioid use (intravenous morphine equivalents in milligrams per kilogram from first study drug dose to last intravenous opioid dose), pain scores, and patient-reported outcomes.

Results:

Of 274 randomized participants, 271 received study drug; the mean age was 14.3 years (SD, 4.3 years), 51% were male, and 92% were Black. The trial was halted early for futility, as time to crisis resolution was similar in those receiving arginine vs placebo (median, 60.8 hours [IQR, 34.8-109.0 hours] vs 65.8 hours [IQR, 31.1-111.1 hours], respectively; absolute difference, 7.2 hours; 95% CI, −21.6 to 35.9 hours). No significant differences were seen in total parenteral opioid use, pain scores, patient-reported outcomes, or safety events.

Conclusions and Relevance:

Arginine therapy did not shorten time to crisis resolution compared with placebo among children and young adults with SCD acute pain episodes.

Trial Registration:

ClinicalTrials.gov Identifier: NCT04839354

362

项与盐酸L-精氨酸相关的新闻（医药）

2026-10-17

·发酵技术圈

江南大学刘立明教授团队针对工程化谷氨酸棒杆菌与大肠杆菌生产L‑精氨酸及其衍生物领域的研究进展进行系统综述

近期，江南大学生物工程学院刘立明教授课题组针对工程化谷氨酸棒杆菌与大肠杆菌生产L‑精氨酸及其衍生物领域的研究进展进行系统综述，以“Recent advances in the microbial production of L‑arginine and its derivatives using engineering Corynebacterium glutamicum andEscherichia coli”为题正式发表于Biotechnology Advances（IF=12.5）。 L‑精氨酸是一类半必需碱性氨基酸，在食品、饲料、化妆品、医药等多个行业均有广泛应用，同时也是L‑鸟氨酸、L‑瓜氨酸、胍基乙酸、肌酸、腐胺等高附加值化学品的关键生物合成前体。全球L‑精氨酸市场年需求量超30000吨，年均增长率约15%，产业发展前景广阔。微生物发酵是当前L‑精氨酸工业化生产的主流技术，谷氨酸棒杆菌与大肠杆菌是应用最为广泛的两大工业底盘菌株，现有报道最高发酵水平分别达到92.5 g/L、132 g/L。然而，高效L‑精氨酸细胞工厂的构建仍受多重因素制约：关键酶受到严格的反馈抑制、生物合成途径步骤冗长、菌株对ATP与NADPH辅因子依赖性高、发酵过程副产物大量积累、L‑精氨酸分子高含氮量带来巨大氨供体供给压力，同时产物外排转运能力不足，诸多瓶颈共同限制了菌株生产性能与工业化落地。针对上述科学问题，该综述系统梳理两种模式菌株中L‑精氨酸的合成通路与代谢调控机制，归纳总结各类代谢工程改造策略，为L‑精氨酸及其衍生物的高效生物制造提供理论参考与技术思路。 L‑精氨酸及其高价值衍生物的微生物细胞工厂该综述围绕“合成途径与调控机制解析→多维度代谢工程改造策略→现存挑战与未来发展方向”的主线，系统梳理本领域最新研究进展。首先，文章在同一分析框架下，全面对比谷氨酸棒杆菌循环型乙酰回收途径与大肠杆菌线性合成途径的差异，解析二者关键限速酶、转录阻遏系统的分子特征，明确两种底盘菌株固有的代谢特点，提出宿主特异性改造理念：谷氨酸棒杆菌更适合开展抗反馈酶工程、辅因子再生体系优化；大肠杆菌则更侧重转录去阻遏、乙酸溢出消减、生长‑生产耦合动态调控，不能简单套用通用化的通路优化方案。随后，综述从代谢通量限制、副产物积累、产物转运能力、辅因子供给、氨供体供应五个维度解析高产瓶颈，搭建“碳流‑氮流‑能量流‑物流”的整合分析框架，并将现有改造策略归纳为四大模块：强化核心合成途径碳通量、改善前体供给与产物外排、优化胞内ATP/NADPH辅因子供应、提升氨供体可利用性。在解除反馈抑制层面，总结了抗性酶挖掘、蛋白质理性改造、PII信号转导调控等手段；在转录调控层面，对比阻遏蛋白敲除、诱饵转录序列、CRISPRi部分抑制等不同方案的优劣，指出CRISPRi可实现适度去阻遏，兼顾菌体生长与产物合成。针对中心碳代谢，综述阐述α‑酮戊二酸、丙酮酸‑草酰乙酸关键节点的静态调控与生长耦合动态调控策略；在转运系统改造方面，揭示L‑精氨酸外排‑重摄取无效循环现象，提出强化外排蛋白、转运蛋白分子改造、敲除产物重吸收系统的组合改造思路。考虑到L‑精氨酸含氮量高达32.1%的分子特性，文章从氨供体截留、氨合成通路强化、无机铵离子摄取提升三个角度总结氮代谢优化手段；同时分别从“节流、开源、碳流重分配”角度梳理ATP、NADPH辅因子供给优化方法。 L‑精氨酸细胞工厂的系统构建与改造挑战综述最后，当前L‑精氨酸生物制造仍存在三大现实难题：工业发酵环境下菌株高渗、氧化、活性氮胁迫耐受性不足，放大发酵过程普遍出现产量衰减；底物利用能力受限，工业混合糖利用效率有待提升，非粮生物质原料开发不足；面向肌酸、腐胺、胍基乙酸等高附加值衍生物的细胞工厂发展相对滞后，通路效率、辅因子平衡、产物毒性等问题亟待攻克。并展望了工业胁迫耐受性工程、非粮廉价底物开发及高值衍生物合成等未来研究方向，为构建高效、高产的氨基酸细胞工厂提供了新的思路。刘立明教授为本文通讯作者，2022级博士生盛琦为论文第一作者。本项工作得到国家自然科学基金区域联合基金（U25A20618）、江苏省科技重大专项（BG2025045）、江苏省农业科技自主创新资金（CX(23)200）等项目的联合资助。声明：文章来源于江南大学官网，如有侵权请联系删除（识别二维码添加微信） 2026年相关会议推荐【直播10.31-11.1】原料药合成工艺开发、放大优化及CMC开发布局策略专题培训班日程安排【直播10.15-16】生物药下游分离纯化工艺开发及中试放大关键技术专题研讨班【日程安排】发酵培养基设计优化与染菌防控技术装备专题-郑州10.29-31 【日程安排】专业实操演练：2026AI酶生物元件挖掘与实践改造培训班-济南10.30-11.1 【直播10.17-18】iPS细胞全流程生产质量体系IND与IIT双轨落地实施培训实操班【直播10.24-25】运用WorkBuddy在药品注册申报中的应用与实操 ADC抗体偶联药物从IND到BLA的申报流程及策略要点案例分析专题培训班-【直播10.24-25】【直播11.21-22】2026 重组蛋白药物大肠杆菌包涵体表达与纯化实战培训班”的通知——从‘沉淀’到‘活性’的破茧之路发酵技术圈扫/码/关/注/我/们

微生物疗法

2026-10-15

·CVDAILY

全球糖尿病速递（第288期）｜家庭共餐与糖尿病前期、司美格鲁肽与利拉鲁肽、归因于肥胖的疾病负担、儿童肥胖相关多维元素

*本资料仅供医疗卫生专业人士参考，请勿向非医疗卫生专业人士发放截至10月15日15点59分，近期共有 569 本期刊发布了 1113 篇文章，其中糖尿病相关的文章共 289 篇，覆盖 40 个领域的内容。中国专家参与发表的文章有 72 篇。今日，影响因子最高的文章刊登在 The New England Journal of Medicine (IF: 78.500) 期刊上。今日头条 Headlines 01 Journal of diabetes research IF: 03.400 韩国家庭共餐与无糖尿病成人糖尿病前期的关联研究 Eun-Ji Jung, Jae Hyeok Lim, Kui Son Choi, Min Jin Ha, Eun-Cheol Park, etc. 糖尿病前期是一种可逆转但常被忽视的疾病状态，是早期干预的关键窗口。家庭共餐行为可能有助于该阶段的疾病管理。本研究旨在探讨韩国家庭共餐行为与成人糖尿病前期患病率之间的关联。研究分析了2019年至2023年韩国国民健康与营养调查的数据。家庭共餐被定义为每周至少三次与家人共享至少一餐（早餐、午餐或晚餐）。糖尿病前期定义为空腹血糖100-125 mg/dL或糖化血红蛋白（HbA1c）5.7%-6.4%。研究采用性别分层多变量logistic回归分析，并校正了协变量。研究共纳入16,957名无糖尿病的成人，其中男性6,907名，女性10,050名。糖尿病前期患病率在男性中为49.1%，在女性中为42.3%。参与家庭共餐的男性相比不参与的男性，糖尿病前期风险降低16%（比值比[OR]：0.84，95%置信区间[CI]：0.73-0.97）。而在女性中，这种相关性不显著（OR：0.97，95% CI：0.84-1.11）。在男性中，这种相关性在城市居住、较高家庭收入、较高教育水平、白领职业和已婚状态的社会经济亚组中更为明显。研究结论指出，定期参与家庭共餐与韩国无糖尿病成年男性较低的糖尿病前期患病率相关。这一发现可能有助于识别可从针对性生活方式干预中获益的人群亚组，以预防糖尿病。本文由韩玉莲编辑扫描二维码查看源文 Journal of diabetes research | Volume 2026, Issue 1 10.1155/jdr/7457214 02 Frontiers in pharmacology IF: 04.800 司美格鲁肽与利拉鲁肽的适应症特异性不良事件特征：一项FAERS比例失衡分析 Samuel A Fisch, Eitan J Neugut, Nicole Cornet, Daniela Quigee, Alfred I Neugut, Daniel E Freedberg, etc. 一项基于FDA不良事件报告系统（FAERS）的比例失衡分析，比较了司美格鲁肽和利拉鲁肽在2型糖尿病和肥胖适应症下的不良事件特征。研究分析了2021年至2025年第三季度的8,213,105份报告，最终纳入33,259份。结果显示，司美格鲁肽和利拉鲁肽均表现出胃肠道不良事件信号。司美格鲁肽在两种适应症中均显示出胃肠道动力减慢的信号，特别是胃排空受损（2型糖尿病：ROR 8.35，95%CI 1.16-59.97；肥胖：ROR 4.01，95%CI 2.12-7.58）。利拉鲁肽则显示出更严重的胃肠道不良事件信号，包括2型糖尿病中的腹胀（ROR 1.46，95%CI 1.12-1.91）和肥胖中的胰腺炎（ROR 2.90，95%CI 1.91-4.39）。此外，研究还发现司美格鲁肽与缺血性视神经病变（ROR 4.42，95%CI 1.41-13.87）和自杀意念（ROR 5.98，95%CI 1.24-24.19）等信号相关。与二甲双胍和奥利司他相比，GLP-1RA类药物在胃肠道动力障碍和梗阻性事件方面报告比例更高。结论指出，司美格鲁肽和利拉鲁肽均与胃肠道动力减慢相关，但司美格鲁肽的胃肠道不良事件报告更多，而利拉鲁肽的胰腺炎和肝损伤报告更多。缺血性视神经病变和自杀意念等信号需谨慎解读，未来需进一步研究因果关系。本文由韩玉莲编辑扫描二维码查看源文 Frontiers in pharmacology | Volume 17, Issue 10.3389/fphar.2026.1936967 03 Frontiers in public health IF: 03.400 归因于肥胖的糖尿病、高血压和心血管疾病的群体负担：一项在Türkiye开展的社区研究 Banu Ersoy Şen, Meltem Yılmaz, Merve Taştan, etc. 肥胖已成为全球公共卫生大流行，其患病率迅速上升，肥胖相关慢性疾病负担日益加重。尽管肥胖患病率高，但诊断率仍然较低，限制了有效的预防和管理。因此，可靠的区域特异性流行病学数据对于指导公共卫生干预和政策制定至关重要。这项研究旨在调查Türkiye北部Amasya省社区中不同年龄和性别群体的肥胖患病率及其与慢性疾病的关联。研究纳入22,667名成人，其中50.6%为女性，平均年龄46.4±16.1岁。数据收集于2025年6月15日至7月31日期间在实地摊位进行。身高和体重采用标准化程序测量，慢性疾病为自我报告。采用年龄和性别校正的逻辑回归评估肥胖与糖尿病、高血压和心血管疾病的相关性，并进行交互分析，同时计算归因指标。结果显示，肥胖患病率为29.9%，女性高于男性（35.7% vs. 23.9%）。糖尿病、高血压和心血管疾病的患病率分别为12.1%、16.2%和6.6%，在肥胖个体中显著高于非肥胖个体。校正年龄和性别后，肥胖与糖尿病（aOR=2.88，95% CI 2.65-3.14）、高血压（aOR=2.50，95% CI 2.31-2.70）和心血管疾病（aOR=2.29，95% CI 2.05-2.56）的较高风险相关。肥胖的校正后人群归因分数分别为：糖尿病31.5%、高血压25.8%、心血管疾病26.1%。年龄显著修饰肥胖与所有三种慢性疾病的关联，而未观察到与性别的显著交互作用。这项基于社区的研究表明，肥胖高度流行，且与糖尿病、高血压和心血管疾病强相关。这些疾病在群体水平上可归因于肥胖的负担巨大，进一步凸显了肥胖作为重大公共卫生问题的重要性。研究结果支持加强基于证据的策略，通过生活方式改变和基于人群的预防方法来促进健康体重。本文由韩玉莲编辑扫描二维码查看源文 Frontiers in public health | Volume 14, Issue 10.3389/fpubh.2026.1963530 04 Frontiers in nutrition IF: 05.100 中国南方儿童肥胖严重程度相关的多维因素：一项横断面研究 Peifeng Zhuang, Bin Lin, Haiqing Li, Jinlu Zheng, Wenlin Tang, Wenbin Ye, etc. 儿童肥胖已成为全球重大公共卫生挑战。2020年全球约有3890万（5.7%）5岁以下儿童受其影响，对儿童身体、心理及代谢健康产生长期影响。然而，关于饮食、行为、家庭及社会经济等多维度可改变因素与儿童肥胖严重程度之间分级关联的证据仍然有限，尤其是在中国东南部地区。为此，研究人员在中国福建省开展了一项横断面研究，纳入680名学龄儿童（344名男孩和336名女孩，年龄6~16岁）。研究收集了围产期因素、家族体重状况、父母教育水平、膳食摄入、体力活动及睡眠行为等数据，并依据中国国家标准将肥胖严重程度分为四个有序组别，采用有序logistic回归模型估计关联。研究结果显示，出生体重和婴儿喂养方式与肥胖严重程度无显著关联。母亲照护与女孩较低的肥胖风险相关。家族聚集性显著：父亲肥胖（OR 1.93，95% CI 1.20-3.06）和兄弟姐妹肥胖（OR 2.26，95% CI 1.16-4.29）与儿童肥胖风险显著正相关。父母教育水平越低，儿童肥胖严重程度越高。在饮食行为方面，早餐频率随肥胖严重程度增加而逐渐下降。午餐和晚餐中，禽肉、海鲜、蔬菜、水果和豆类的摄入量在各组间显著减少。午餐禽肉摄入与较低肥胖风险显著相关（OR 0.558，95% CI 0.354-0.878）。烧烤、冷饮和膨化食品与肥胖风险增加相关（OR 1.763，95% CI 1.096-2.836）。相比之下，坚果（OR 0.477，95% CI 0.282-0.807）和饼干（OR 0.483，95% CI 0.322-0.723）与较低风险显著相关。在体力活动方面，球类运动（OR 0.457，95% CI 0.227-0.918）和步行（OR 0.368，95% CI 0.180-0.751）与较低肥胖风险显著相关。较晚的就寝时间和较短的睡眠时长与肥胖严重程度相关。研究结论指出，儿童肥胖严重程度与多种因素相关，包括家族体重状况、父母教育水平、膳食多样性、零食模式、体力活动及睡眠行为。这些发现可为以家庭为中心的多层面儿童肥胖预防策略提供参考。本文由韩玉莲编辑扫描二维码查看源文 Frontiers in nutrition | Volume 13, Issue 10.3389/fnut.2026.1942160 中国发表（72） China Journal of chromatography IF: 02.800Volume 1284, Issue No.01Integration multidimensional assessment, bioactivities and chemometrics to study the effect of different drying methods on Trichosanthis Fructus polysaccharides整合多维评估、生物活性和化学计量学方法研究不同干燥方式对瓜蒌多糖的影响DOI: 10.1016/j.jchromb.2026.125318 Trends Endocrinol Metab IF: 12.600Ahead of Print.No.02Hyocholic acid: a primary bile acid regulating lifespan immunometabolism猪胆酸：一种调节寿命免疫代谢的初级胆汁酸DOI: 10.1016/j.tem.2026.09.016 Zhonghua Wei Zhong Bing Ji Jiu Yi XueVolume 38, Issue 9No.03[Correlation between glycemic variability coefficient and sepsis-induced coagulopathy and analysis of risk factors]血糖变异系数与脓毒症诱导凝血病的相关性及危险因素分析DOI: 10.3760/cma.j.cn121430-20260331-00150 Journal of Advanced Research IF: 13.000Ahead of Print.No.04Identifying overlooked factors associated with multidrug-resistant tuberculosis: an ecological study across 201 countries and regions, 1990-2021识别与多重耐药结核病相关的被忽视因素：一项覆盖201个国家和地区、1990-2021年的生态学研究DOI: 10.1016/j.jare.2026.10.028 European journal of pharmacology IF: 04.700Ahead of Print.No.05Effects of Sitagliptin Combined with GTS-21 on Improving Glycemic Control and Diabetic Nephropathy by Anti-Apoptosis in Leprdb/db Mice西格列汀联合GTS-21通过抗凋亡改善Leprdb/db小鼠血糖控制和糖尿病肾病的作用DOI: 10.1016/j.ejphar.2026.179426 Environmental research IF: 07.700Ahead of Print.No.06Association between organophosphate esters and incident type 2 diabetes risk: modification by genetic risk and lifestyle有机磷酸酯与2型糖尿病发病风险的关联：遗传风险与生活方式的修饰作用DOI: 10.1016/j.envres.2026.125923 Diabetes Res Clin Pract IF: 07.400Ahead of Print.No.07Effectiveness of technology-enabled teleophthalmology and emerging retinal imaging techniques for diabetic retinopathy screening: a systematic review and meta-analysis技术赋能的远程眼科和新兴视网膜成像技术在糖尿病视网膜病变筛查中的有效性：系统综述和荟萃分析DOI: 10.1016/j.diabres.2026.113610 Diabetes Res Clin Pract IF: 07.400Ahead of Print.No.08Dapagliflozin and 54-week kidney function in kidney transplant recipients with post-transplant diabetes mellitus: a randomized controlled trial达格列净与肾移植受者移植后糖尿病54周肾功能：一项随机对照试验DOI: 10.1016/j.diabres.2026.113605 Journal of ethnopharmacology IF: 05.400Ahead of Print.No.09Discovery of the mechanism of Huangqi Guizhi Wuwu Decoction in the treatment of Diabetic Peripheral Neuropathy with Qi Deficiency and Blood Stasis based on the dynamic metabolic trajectory analysis基于动态代谢轨迹分析发现黄芪桂枝五物汤治疗气虚血瘀型糖尿病周围神经病变的作用机制DOI: 10.1016/j.jep.2026.122422 Journal of ethnopharmacology IF: 05.400Ahead of Print.No.10Agriophyllum squarrosum oligosaccharides ameliorate inflammation and lipid accumulation in T2DM-induced MASLD via miR-155-regulated PPARγ signaling pathways沙蓬寡糖通过miR-155调控的PPARγ信号通路改善T2DM诱导的MASLD中的炎症和脂质积累DOI: 10.1016/j.jep.2026.122462 Patient education and counseling IF: 03.100Ahead of Print.No.11Exploring doctor-patient communication in glaucoma care: A systematic review探索青光眼诊疗中的医患沟通：一项系统性综述DOI: 10.1016/j.pec.2026.110333 Clinics IF: 02.400Ahead of Print.No.12Earlier onset of type 2 diabetes mellitus as a risk factor for Irvine-Gass syndrome早发2型糖尿病是Irvine-Gass综合征的风险因素DOI: 10.1016/j.clinsp.2026.101204 Comput Med Imaging Graph IF: 04.900Ahead of Print.No.13De-Seg: Advancing OCTA segmentation with multi-scale feature fusion and edge refinementDe-Seg：通过多尺度特征融合和边缘细化推进OCTA分割DOI: 10.1016/j.compmedimag.2026.102825 Comput Biol Chem IF: 03.100Ahead of Print.No.14Integrated expression profiling and structure-based drug discovery identify EGFR as a druggable target and Tripterygium wilfordii phytochemicals as potential therapeutics for autosomal dominant polycystic kidney disease整合表达谱分析与基于结构的药物发现确定EGFR为可成药靶点及雷公藤植物化学物作为常染色体显性多囊肾病的潜在治疗药物DOI: 10.1016/j.compbiolchem.2026.109477 J Biol Chem IF: 03.900Ahead of Print.No.15An m7G tRNA-derived fragment mediated thermogenic activation of brown adipose tissue through post-transcriptional repression of Uqcr10m7G tRNA衍生片段通过转录后抑制Uqcr10介导棕色脂肪组织的产热激活DOI: 10.1016/j.jbc.2026.113640 JHEP reports IF: 07.500Ahead of Print.No.16Spleen stiffness to rule out high-risk varices in advanced chronic liver disease: an individual patient data meta-analysis脾脏硬度用于排除晚期慢性肝病高危静脉曲张：一项个体患者数据荟萃分析DOI: 10.1016/j.jhepr.2026.102066 Current neuropharmacology IF: 05.300Ahead of Print.No.17From Clinical Manifestations to Neural Mechanisms: A Systematic Review of Neurobehavioral Consequences of Pregabalin Misuse and Abuse从临床表现到神经机制：普瑞巴林误用和滥用的神经行为后果的系统综述DOI: 10.2174/011570159X512277260929095531 Journal of Alzheimer's disease IF: 03.100Ahead of Print.No.18Cross-sectional associations of insulin resistance surrogate indices with cognitive disorders and cognitive performance in UK Biobank英国生物样本库中胰岛素抵抗替代指标与认知障碍及认知表现的横断面关联DOI: 10.1177/13872877261494125 Frontiers in nutrition IF: 05.100Volume 13, Issue No.19Correction: Enteral nutrition-related hyperglycemia in critical illness: cascade conceptual model and implications for precision nursing-a systematic review更正：危重症患者肠内营养相关高血糖：级联概念模型及精准护理的意义——一项系统综述DOI: 10.3389/fnut.2026.2000172 Science translational medicine IF: 14.600Volume 18, Issue 871No.20Metabolomic aging and mortality clocks based on ensemble learning identify systemic aging risk across the human life span in 18,476 individuals基于集成学习的代谢组衰老和死亡时钟在18,476名个体中识别人类全生命周期的系统性衰老风险DOI: 10.1126/scitranslmed.adz4815 PloS one IF: 02.600Volume 21, Issue 10No.21Association between the hemoglobin albumin lymphocyte and platelet score and chronic kidney disease: Insights from patient data and animal models血红蛋白、白蛋白、淋巴细胞和血小板评分与慢性肾脏病的关联：来自患者数据和动物模型的见解DOI: 10.1371/journal.pone.0353085 Sleep & breathing IF: 02.000Volume 30, Issue 6No.22Nonlinear age-related differences in clinical profiles of obstructive sleep apnea: a cross-sectional study of 1,508 Chinese patients阻塞性睡眠呼吸暂停临床特征的年龄相关非线性差异：一项针对1508名中国患者的横断面研究DOI: 10.1007/s11325-026-03836-3 Diabetologia IF: 10.200Ahead of Print.No.23Glucose controls metallothionein 1 gene expression in pancreatic islets via a mechanism involving cellular metabolism, granular zinc and the zinc transporter ZnT8 in rat and mouse葡萄糖通过涉及细胞代谢、颗粒锌和锌转运体ZnT8的机制调控大鼠和小鼠胰岛中金属硫蛋白1基因表达DOI: 10.1007/s00125-026-06900-5 Invest Ophthalmol Vis Sci IF: 04.700Volume 67, Issue 12No.24Targeting Endoplasmic Reticulum Stress With Exogenous GDNF Promotes Diabetic Corneal Epithelial and Neural Repair via PI3K/AKT Signaling外源性GDNF通过PI3K/AKT信号通路靶向内质网应激促进糖尿病角膜上皮和神经修复DOI: 10.1167/iovs.67.12.24 Transl Vis Sci Technol IF: 02.600Volume 15, Issue 10No.25FFA-SegGPT: A Two-Stage Cross-Modal AI System to Optimize the Clinical Workflow of Diabetic Retinopathy FFA InterpretationFFA-SegGPT：一种两阶段跨模态人工智能系统，优化糖尿病视网膜病变FFA解读的临床工作流程DOI: 10.1167/tvst.15.10.16 Autism : IF: 05.600Ahead of Print.No.26Disparities in Social Determinants of Health and Health Outcomes Among Autistic Individuals Without Intellectual Disability in Middle-to-Late Adulthood无智力障碍自闭症个体中晚年的健康社会决定因素与健康结局差异DOI: 10.1177/13623613261489847 Burns and trauma IF: 09.600Volume 14, Issue No.27Hydrogel microneedles for chronic wound microenvironment remodeling: from drug delivery to intelligent treatment用于慢性伤口微环境重塑的水凝胶微针：从药物递送到智能治疗DOI: 10.1093/burnst/tkag051 Int J Gen Med IF: 02.000Volume 19, Issue No.28Exploring the Relationship Between Femoral Neck Torsion Angle and Anteversion Angle Through Three-Dimensional Reconstruction in a Fixed Coordinate System通过固定坐标系三维重建探索股骨颈扭转角与前倾角的关系DOI: 10.2147/IJGM.S633691 Int J Gen Med IF: 02.000Volume 19, Issue No.29Recent Advances in the Diagnosis and Management of Gestational Diabetes Mellitus: A Narrative Review妊娠期糖尿病诊断与管理的最新进展：叙述性综述DOI: 10.2147/IJGM.S644149 Diabetes IF: 07.500Ahead of Print.No.30Skeletal Muscle DPT Ameliorates Obesity and Metabolic Dysfunction via the PERK/eIF2α/ATF4-GDF15 Axis骨骼肌DPT通过PERK/eIF2α/ATF4-GDF15轴改善肥胖和代谢功能障碍DOI: 10.2337/db26-0082 Adipocyte IF: 03.100Volume 15, Issue 1No.31The pro-obesity role of G3BP1 through altering adipogenic differentiation in mice via the PI3K/AKT pathwayG3BP1通过PI3K/AKT通路改变小鼠脂肪生成分化促进肥胖的作用DOI: 10.1080/21623945.2026.2743441 Current cancer drug targets IF: 03.500Ahead of Print.No.32Single-Cell Transcriptomics Identifies Fibroblast-Associated Transcriptional Patterns and Candidate Therapeutic Targets in the Comorbidity of Non-Small Cell Lung Cancer and Obesity单细胞转录组学识别非小细胞肺癌与肥胖共病中的成纤维细胞相关转录模式及候选治疗靶点DOI: 10.2174/0115680096497180260909094944 J Pediatr Gastroenterol Nutr IF: 02.600Ahead of Print.No.33The relationship between gut microbiota-friendly diet and the prevalence and severity of asthma in children肠道微生物群友好饮食与儿童哮喘患病率及严重程度的关系DOI: 10.1002/jpn3.70605 Advanced healthcare materials IF: 09.600Ahead of Print.No.34A Bioinspired Nanomedicine for Thermo-Catalytic Reprogramming of Obese Fat一种用于肥胖脂肪热催化重编程的仿生纳米药物DOI: 10.1002/adhm.71832 Frontiers in nutrition IF: 05.100Volume 13, Issue No.35Obesity and thyroid cancer: mechanisms and clinical implications肥胖与甲状腺癌：机制与临床意义DOI: 10.3389/fnut.2026.1887761 Food science & nutrition IF: 03.800Volume 14, Issue 10No.36Maternal Diglyceride Diet Attenuates Selected Metabolic Effects of Maternal High-Fat Feeding in Offspring via Energy Metabolism and Microbiota Modulation母体甘油二酯饮食通过能量代谢和微生物群调节减轻母体高脂喂养对子代的代谢影响DOI: 10.1002/fsn3.72427 Int J Endocrinol IF: 02.300Volume 2026, Issue No.37Link Between the Cardiometabolic Index and Stroke Risk Across Different Glucose Metabolic Status in Chinese Middle-Aged and Older Adults: A Longitudinal Cohort Study中国中老年人群心脏代谢指数与卒中风险的关联：不同糖代谢状态下的纵向队列研究DOI: 10.1155/ije/6169486 Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.38Associations Between Multidimensional Obesity Indices and Diabetic Peripheral Neuropathy and Comparison of Their Discriminative Performance多维肥胖指标与糖尿病周围神经病变的关联及其判别性能比较DOI: 10.2147/DMSO.S634272 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.39Corneal endothelial changes in type 2 diabetes mellitus: a systematic review and meta-analysis with subgroup comparisons by diabetic retinopathy status and disease duration2型糖尿病的角膜内皮变化：按糖尿病视网膜病变状态和病程进行亚组比较的系统综述与荟萃分析DOI: 10.3389/fendo.2026.1982467 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.40Prevalence and risk factors of postmenopausal osteoporosis: a systematic review and meta-analysis based on multivariate logistic regression绝经后骨质疏松症的患病率及危险因素：基于多因素logistic回归的系统评价与meta分析DOI: 10.3389/fendo.2026.1950298 Frontiers in immunology IF: 05.900Volume 17, Issue No.41Diet, hormones, and breast cancer: biomarker-guided assessment of risk and prognosis饮食、激素与乳腺癌：生物标志物引导的风险与预后评估DOI: 10.3389/fimmu.2026.1946846 FCVM IF: 02.900Volume 13, Issue No.42Association between insulin resistance-related indices and cardiovascular disease in patients with atopic dermatitis: mutual validation using real-world and NHANES data胰岛素抵抗相关指数与特应性皮炎患者心血管疾病之间的关联：基于真实世界与NHANES数据的相互验证DOI: 10.3389/fcvm.2026.1903179 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.43Acute glycemic responses to meal-associated alcoholic beverages and ethanol in adults with type 2 diabetes: a systematic review2型糖尿病成人餐时饮用酒精饮料和乙醇的急性血糖反应：一项系统综述DOI: 10.3389/fendo.2026.1967515 Iran J Pharm Res IF: 01.800Volume 25, Issue 1No.44Yishen Xiaoke Formula Delays Renal Fibrosis in Rats with Diabetic Nephropathy by Suppressing the Transforming Growth Factor-Beta 1/Notch Signalling Pathway益肾消渴方通过抑制转化生长因子-β1/Notch信号通路延缓糖尿病肾病大鼠肾脏纤维化DOI: 10.5812/ijpr-171242 Frontiers in fungal biologyVolume 7, Issue No.45Case report: Fatal hematogenous gastrosplenic mucormycosis in an immunocompetent adult following sigmoid perforation, septic shock, and short-term stress glucocorticoids病例报告：免疫健全成人继发于乙状结肠穿孔、脓毒性休克及短期应激性糖皮质激素后的致死性血源性胃脾毛霉病DOI: 10.3389/ffunb.2026.1940494 Frontiers in immunology IF: 05.900Volume 17, Issue No.46X-linked hyper IgM syndrome with a novel CD40-ligand gene mutation suffered from infection of Talaromyces marneffeiX连锁高IgM综合征伴新型CD40配体基因突变患者感染马尔尼菲篮状菌DOI: 10.3389/fimmu.2026.1875082 Frontiers in medicine IF: 03.000Volume 13, Issue No.47Night-to-night sleep variability and all-cause and cardiovascular mortality: a prospective cohort study with a complementary in vitro circadian-disruption experiment夜间睡眠变异性与全因及心血管死亡：一项前瞻性队列研究及补充性体外昼夜节律紊乱实验DOI: 10.3389/fmed.2026.1917205 Frontiers in medicine IF: 03.000Volume 13, Issue No.48Development and validation of a novel metabolic-inflammatory health-related nomogram for predicting in-hospital mortality in older patients with type 2 diabetes mellitus combined with cardiovascular disease新型代谢-炎症健康相关列线图的开发与验证：用于预测老年2型糖尿病合并心血管疾病患者的院内死亡率DOI: 10.3389/fmed.2026.1914467 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.49CFTR variant-associated hereditary pancreatitis complicated by diabetes mellitus: a case report and literature reviewCFTR变异相关遗传性胰腺炎合并糖尿病：一例病例报告及文献综述DOI: 10.3389/fendo.2026.1907178 AME case reports IF: 00.700Volume 10, Issue No.50Classical Hodgkin lymphoma as a second malignancy in a patient with cervical squamous cell carcinoma following chemoradiotherapy: a case report宫颈鳞状细胞癌患者放化疗后发生经典霍奇金淋巴瘤作为第二恶性肿瘤：一例病例报告DOI: 10.21037/acr-2026-0174 Curēus IF: 01.300Volume 18, Issue 9No.51Association Between Left Atrial Volume Index (LAVI) and Glycemic Control (HbA1c) in Patients With Atrial Fibrillation and Type 2 Diabetes Mellitus左心房容积指数与血糖控制在心房颤动合并2型糖尿病患者中的关联DOI: 10.7759/cureus.116179 Frontiers in microbiology IF: 04.500Volume 17, Issue No.52A compartment-resolved framework for microbial sulfur-reactive sulfur signaling in diabetic cardiomyopathy: from gut metabolism to cardiac sulfur responses糖尿病心肌病中微生物硫-反应性硫信号传导的区室解析框架：从肠道代谢到心脏硫响应DOI: 10.3389/fmicb.2026.1966245 J Diabetes Metab Disord IF: 01.600Volume 25, Issue 2No.53The pharmacotherapy for pediatric obesity: insights and challenges from adult weight-loss medications儿童肥胖的药物治疗：来自成人减肥药物的启示与挑战DOI: 10.1007/s40200-026-02110-3 J Diabetes Metab Disord IF: 01.600Volume 25, Issue 2No.54Modulating inflammatory cytokines through acupuncture: Evidence from a systematic review通过针灸调节炎症细胞因子：来自系统综述的证据DOI: 10.1007/s40200-026-02098-w Frontiers in medicine IF: 03.000Volume 13, Issue No.55Respiratory event duration reveals novel phenotypes beyond the apnea-hypopnea index in obstructive sleep apnea呼吸事件持续时间揭示阻塞性睡眠呼吸暂停中超越呼吸暂停低通气指数的新型表型DOI: 10.3389/fmed.2026.1960647 Frontiers in public health IF: 03.400Volume 14, Issue No.56The associations between dynapenic obesity and cognitive disorder in older hypertension patients: a multicenter cross-sectional study老年高血压患者肌少性肥胖与认知障碍的关联：一项多中心横断面研究DOI: 10.3389/fpubh.2026.1893791 Frontiers in nutrition IF: 05.100Volume 13, Issue No.57Multidimensional factors associated with childhood obesity severity in southern China: a cross-sectional study中国南方儿童肥胖严重程度相关的多维因素：一项横断面研究DOI: 10.3389/fnut.2026.1942160 Acta diabetologica IF: 02.900Ahead of Print.No.58Aldosterone–mineralocorticoid receptor signaling and residual cardiorenal risk in type 2 diabetes醛固酮-盐皮质激素受体信号与2型糖尿病残余心肾风险DOI: 10.1007/s00592-026-02811-4 J Transl Med IF: 07.500Volume 24, Issue 1No.59NRF2 activation attenuates obesity-induced adipose inflammation by suppressing STING signaling, with depot-specific regulationNRF2激活通过抑制STING信号减轻肥胖诱导的脂肪炎症，并具有脂肪库特异性调控DOI: 10.1186/s12967-026-08887-4 J Cell Mol Med IF: 04.200Volume 30, Issue 20No.60Application of Panax notoginseng Saponins in Skin Wound Repair: Mechanisms and Research Progress三七总皂苷在皮肤创面修复中的应用：机制与研究进展DOI: 10.1111/jcmm.71381 CCI IF: 01.900Ahead of Print.No.61The Impact of Dual Antiplatelet Therapy on Bleeding and Thrombotic Risks in Diabetic Patients Following Coronary Stent Implantation: A Prospective Study双联抗血小板治疗对冠状动脉支架植入术后糖尿病患者出血与血栓风险的影响：一项前瞻性研究DOI: 10.1002/ccd.70940 European journal of pain IF: 03.400Volume 30, Issue 9No.62Veratramine Alleviates Neuropathic Pain in Male Rats With Chronic Constriction Injury and Inhibits the PI3K/Akt Pathway藜芦胺缓解慢性压迫性损伤雄性大鼠的神经病理性疼痛并抑制PI3K/Akt通路DOI: 10.1002/ejp.70383 J Ocul Pharmacol Ther IF: 02.100Ahead of Print.No.63Ocular Distribution and Metabolite Profiling of Vorolanib in Rats and Its In Vitro Metabolism Using Human Recombinant Enzymes伏罗尼布在大鼠眼部分布及代谢物谱及其利用人重组酶的体外代谢研究DOI: 10.1177/10807683261496831 Biomed Environ Sci IF: 04.100Volume 39, Issue 9No.64Associations of the Triglyceride-glucose Index and Its Obesity-related Indices with Microvascular Complications among Individuals with Type 2 Diabetes: A Prospective Cohort Study甘油三酯-葡萄糖指数及其肥胖相关指数与2型糖尿病患者微血管并发症的关联：一项前瞻性队列研究DOI: 10.3967/bes2026.098 Biomed Environ Sci IF: 04.100Volume 39, Issue 9No.65Dietary Live Microbe Intake and Sarcopenia in Shanghai上海地区膳食活性微生物摄入与肌肉减少症的关联研究DOI: 10.3967/bes2026.095 Biomed Environ Sci IF: 04.100Volume 39, Issue 9No.66A Nationwide Cross-Sectional Study of Chronic Urticaria in Chinese Adults with Cardiometabolic Diseases: Epidemiology, Risk Factors, and Effect on Disease Management中国成人慢性荨麻疹合并心血管代谢疾病的全国横断面研究：流行病学、危险因素及对疾病管理的影响DOI: 10.3967/bes2026.084 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.67Transition-Specific Associations of Cardiometabolic Biomarker Burden With Cardio-Renal-Metabolic Multimorbidity Progression: A Multistate Cohort Study心血管代谢生物标志物负担与心血管-肾脏-代谢多病进展的转变特异性关联：一项多状态队列研究DOI: 10.1111/dom.71427 Advanced healthcare materials IF: 09.600Ahead of Print.No.68Immune‑Friendly Skin Interface Remodeling: Chiral Hydrogels for Diabetic Non-Healing Wound Therapy免疫友好型皮肤界面重塑：手性水凝胶用于糖尿病非愈合性创面治疗DOI: 10.1002/adhm.71842 Nature communications IF: 15.700Volume 17, Issue 1No.69PKM2 AP: a micropeptide inhibits vascular calcification via molecular glue-mediated ubiquitination of PKM2PKM2 AP：一种通过分子胶介导的PKM2泛素化抑制血管钙化的微肽DOI: 10.1038/s41467-026-77693-9 Signal Transduct Target Ther IF: 52.700Volume 11, Issue 1No.70Rhein-induced free fatty acid generation cooperates with silver ions for biofilm-infected diabetic wound healing大黄酸诱导游离脂肪酸生成与银离子协同促进生物膜感染的糖尿病伤口愈合DOI: 10.1038/s41392-026-02869-0 Clinical pharmacokinetics IF: 04.000Ahead of Print.No.71Efsubaglutide Alfa: A Comprehensive Pharmacological Review依苏帕格鲁肽α：综合药理学综述DOI: 10.1007/s40262-026-01713-6 Journal of molecular histology IF: 02.200Volume 57, Issue 6No.72Liraglutide ameliorates obese type 2 diabetes by regulating macrophage cholesterol metabolism and H3K27ac modification to promote M2 polarization and adipocyte thermogenic activation利拉鲁肽通过调控巨噬细胞胆固醇代谢和H3K27ac修饰促进M2极化和脂肪细胞产热激活改善肥胖型2型糖尿病DOI: 10.1007/s10735-026-10993-y 其他发布内容（214） More Published Articles European journal of pharmacology IF: 04.700Ahead of Print.No.01Gut Microbiota-Derived Short-Chain Fatty Acids Mediate the Bone-Protective Effects of Metformin Against Postmenopausal OsteoporosisDOI: 10.1016/j.ejphar.2026.179442 Gynecologic oncology IF: 04.100Ahead of Print.No.02Effects of adjunctive metformin on recurrence-free survival and reproductive outcomes following progestin-based fertility-sparing treatment for endometrial neoplasia: Results from the FELICIA trial, a prospective, randomized, phase IIb trial with blinded central adjudicationDOI: 10.1016/j.ygyno.2026.10.004 The journal of neuroscience : IF: 04.000Volume 46, Issue 41No.03Corticotropin-Releasing Hormone Differentially Modulates GABA and Non-GABA Nucleus Tractus Solitarii Neurons促肾上腺皮质激素释放激素对孤束核GABA与非GABA神经元发挥差异性调控作用DOI: 10.1523/JNEUROSCI.0525-26.2026 Pain medicine case reportsVolume 10, Issue 7No.04Peripheral Nerve Stimulator Implant for Superior Cluneal Neuralgia in Patients with Peripheral Neuropathy: A Case Series周围神经刺激器植入治疗周围神经病患者的上臀神经痛：病例系列https://pubmed.ncbi.nlm.nih.gov/42874086 J Biol Chem IF: 03.900Ahead of Print.No.05ERK-mediated phosphorylation modulates the autolytic processing of the cysteine protease CAPN3ERK介导的磷酸化调节半胱氨酸蛋白酶CAPN3的自溶加工DOI: 10.1016/j.jbc.2026.113638 Biochem Biophys Res Commun IF: 02.200Ahead of Print.No.06Efonidipine inhibiting CYP4A attenuates palmitate-induced hepatocyte lipotoxicity依福地平抑制CYP4A减轻棕榈酸诱导的肝细胞脂毒性DOI: 10.1016/j.bbrc.2026.154723 Res Social Adm Pharm IF: 02.800Ahead of Print.No.07Pharmacists and Ramadan: From education to practice - A mixed methods systematic review药师与斋月：从教育到实践——一项混合方法系统综述DOI: 10.1016/j.sapharm.2026.10.150 Transplantation proceedings IF: 00.800Ahead of Print.No.08Profound Tacrolimus-Induced Catatonic Encephalopathy in a Kidney Transplant Recipient With Mitochondrial Myopathy: A Cautionary Case of Reversible Neurotoxicity线粒体肌病肾移植受者中他克莫司诱导的严重紧张症性脑病：一例可逆性神经毒性的警示病例DOI: 10.1016/j.transproceed.2026.09.022 Diabetic medicine IF: 03.400Ahead of Print.No.09The DePICtion study: Implementing a diabetes classification tool in UK primary care-A qualitative study with primary care staff and patientsDePICtion研究：在英国初级保健中实施糖尿病分类工具——一项针对初级保健工作人员和患者的定性研究DOI: 10.1111/dme.70493 J Atheroscler Thromb IF: 02.800Ahead of Print.No.10Associations of Albuminuria and eGFR with Stiffness Parameter β in Type 2 Diabetes2型糖尿病患者白蛋白尿与估算肾小球滤过率同僵硬度参数β的关联DOI: 10.5551/jat.66371 Endocrine journal IF: 02.100Ahead of Print.No.11Metreleptin improves glucose metabolism and hepatic steatosis in a patient with Werner syndrome and partial lipodystrophy: a case report with review of literature美曲普汀改善Werner综合征合并部分性脂肪萎缩患者的糖代谢和肝脂肪变性：一例病例报告及文献综述DOI: 10.1507/endocrj.EJ26-0235 Diabetic medicine IF: 03.400Ahead of Print.No.12Capability, opportunity and motivation to support adults with type 1 diabetes experiencing fear of hypoglycaemia: A survey of Australian diabetes healthcare professionals支持经历低血糖恐惧的成人1型糖尿病患者的能力、机会和动机：一项针对澳大利亚糖尿病医疗专业人员的调查DOI: 10.1111/dme.70496 Internal medicine IF: 01.100Ahead of Print.No.13Ampullary Neuroendocrine Carcinoma Presenting with Clinically Confirmed Endogenous Hyperinsulinemic Hypoglycemia以临床确诊的内源性高胰岛素性低血糖为表现的壶腹部神经内分泌癌DOI: 10.2169/internalmedicine.7605-26 Diabetic medicine IF: 03.400Ahead of Print.No.14The impact of frailty on glycaemic control in older adults with type 1 diabetes mellitus: An observational study衰弱对老年1型糖尿病患者血糖控制的影响：一项观察性研究DOI: 10.1111/dme.70498 Diabetic medicine IF: 03.400Ahead of Print.No.15Estimating the long-term cost-effectiveness of a free online Diabetes Self-Management Education and Support service in England: Healthy living for people with type 2 diabetes, using a matched cohort study design基于匹配队列研究设计评估英格兰免费在线糖尿病自我管理教育与支持服务的长期成本效果：针对2型糖尿病患者的健康生活项目DOI: 10.1111/dme.70490 BMJ case reports IF: 00.500Volume 19, Issue 10No.16Diabetic ketoacidosis in a patient with renal cell carcinoma on immune checkpoint inhibitor接受免疫检查点抑制剂治疗的肾细胞癌患者发生糖尿病酮症酸中毒DOI: 10.1136/bcr-2025-268141 Enfermeri?a cli?nicaAhead of Print.No.17The role of nurses in shared decision-making in primary care: Qualitative study护士在初级保健共享决策中的作用：定性研究DOI: 10.1016/j.enfcle.2026.502562 Journal of Advanced Research IF: 13.000Ahead of Print.No.18Association between dental pulp necroptosis-related signaling and elodont incisor growth retardation in hyperglycemic rats高血糖大鼠牙髓坏死性凋亡相关信号与持续生长切牙生长迟缓的关联DOI: 10.1016/j.jare.2026.10.027 Appetite IF: 03.800Ahead of Print.No.19Neuroimaging Insights into the Effects of Non-Nutritive Sweeteners on Appetite Regulation: A Systematic Review非营养性甜味剂对食欲调节影响的神经影像学见解：一项系统综述DOI: 10.1016/j.appet.2026.108803 Brain, behavior, and immunity IF: 07.600Ahead of Print.No.20Early post-sepsis innate behavioral changes in aged mice occur independently of detectable neuroinflammation老年小鼠脓毒症后早期先天行为改变独立于可检测的神经炎症DOI: 10.1016/j.bbi.2026.107062 Toxicol Appl Pharmacol IF: 03.400Ahead of Print.No.21High Normal dietary casein attenuates bisphenol A-induced multiorgan toxicity in rats: Preservation of renal integrity, glucose homeostasis, and immune surveillance via modulation of oxidative stress, inflammation, and apoptosis高正常膳食酪蛋白减轻双酚A诱导的大鼠多器官毒性：通过调节氧化应激、炎症和凋亡保护肾脏完整性、葡萄糖稳态和免疫监视DOI: 10.1016/j.taap.2026.118085 Annals of Vascular Surgery IF: 01.600Ahead of Print.No.22"Not so minor" - Digital Amputation as a precursor to Major Amputation and Mortality in an Irish tertiary vascular centre“并非小问题”——趾截肢作为爱尔兰三级血管中心大截肢和死亡的前兆DOI: 10.1016/j.avsg.2026.09.058 Annals of Vascular Surgery IF: 01.600Ahead of Print.No.23THE CLINICAL PROFILE OF RUPTURE: A 19-YEAR CASE-CONTROL STUDY OF ABDOMINAL AORTIC ANEURYSMS破裂的临床特征：一项为期19年的腹主动脉瘤病例对照研究DOI: 10.1016/j.avsg.2026.09.070 Complement Ther Med IF: 03.500Ahead of Print.No.24Pilot, Feasibility, and Acceptability Evaluation of a Mindfulness-Based Intervention with Diabetes Education in Adolescents with Type 1 Diabetes基于正念的干预联合糖尿病教育在1型糖尿病青少年中的试点、可行性和可接受性评估DOI: 10.1016/j.ctim.2026.103451 Diabetes Res Clin Pract IF: 07.400Ahead of Print.No.25Effects of diagnostic thresholds for gestational diabetes on perinatal mental health: Data from the GEMS randomised clinical trial妊娠糖尿病诊断阈值对围产期心理健康的影响：来自GEMS随机临床试验的数据DOI: 10.1016/j.diabres.2026.113590 Photodiagnosis Photodyn Ther IF: 02.600Ahead of Print.No.26Epivascular Glia and Macular Pigment Changes after Faricimab or Aflibercept during the Loading Phase in Diabetic Macular Edema: A Prospective Non-randomized Pilot Study糖尿病性黄斑水肿负荷期使用Faricimab或Aflibercept后血管周围胶质细胞和黃斑色素变化：一项前瞻性非随机初步研究DOI: 10.1016/j.pdpdt.2026.105687 Cornea IF: 02.100Ahead of Print.No.27The Effects of Age on the Presence of Atypical Corneal Nerve Formations年龄对非典型角膜神经结构存在的影响DOI: 10.1097/ICO.0000000000004341 Journal of tissue viability IF: 02.800Ahead of Print.No.28Findings on the efficacy of sonic debridement in chronic wound management - a case series声波清创在慢性伤口管理中的有效性研究——病例系列DOI: 10.1016/j.jtv.2026.101064 Rev Argent Microbiol IF: 02.100Ahead of Print.No.29Antimicrobial resistance and antibiotic therapy in patients with urinary tract infections and asymptomatic bacteriuria: A Peruvian perspective尿路感染与无症状性菌尿患者的抗菌药物耐药性及抗生素治疗：秘鲁视角DOI: 10.1016/j.ram.2026.100760 Clin Neurol Neurosurg IF: 01.600Ahead of Print.No.30Differentiating pituitary metastasis from hypophysitis: A two-center study using conventional MRI and clinical features鉴别垂体转移瘤与垂体炎：基于常规MRI和临床特征的双中心研究DOI: 10.1016/j.clineuro.2026.109662 Diabetes & metabolic syndrome IF: 03.400Ahead of Print.No.31Evaluation of a local healthy moderate carbohydrate (LHMC) diet and structured exercise for diabetes remission in early type 2 diabetes mellitus: A nutrition intervention study from India评估本地健康中等碳水化合物饮食与结构化运动对早期2型糖尿病缓解的作用：一项来自印度的营养干预研究DOI: 10.1016/j.dsx.2026.103487 J Pharmacol Exp Ther IF: 03.800Ahead of Print.No.32Sirtuin 1-microRNA regulatory networks in liver diseases: Mechanistic convergence, cellular senescence, and translational implications肝脏疾病中的Sirtuin 1-微小RNA调控网络：机制汇聚、细胞衰老及转化意义DOI: 10.1016/j.jpet.2026.105031 Injury IF: 02.000Ahead of Print.No.33Association of neighborhood social vulnerability with reoperation after operative treatment of proximal humerus fractures社区社会脆弱性与肱骨近端骨折手术治疗后再手术的关联DOI: 10.1016/j.injury.2026.113769 J Plast Reconstr Aesthet Surg IF: 02.400Ahead of Print.No.34GLP-1 receptor agonist use and postoperative complications after body contouring surgery following massive weight loss减重手术后身体塑形手术中GLP-1受体激动剂使用与术后并发症的关系DOI: 10.1016/j.bjps.2026.09.040 Clin Transl Sci IF: 02.800Volume 19, Issue 10No.35Analysis of Virologic and Clinical Predictors for Hospitalization, Supported by Machine Learning, in a Phase 3 Molnupiravir COVID-19 Treatment Trial在3期molnupiravir COVID-19治疗试验中，通过机器学习支持分析住院的病毒学和临床预测因素DOI: 10.1111/cts.70720 Journal of chromatography IF: 02.800Ahead of Print.No.36Development and validation of qualitative methods for the detection of GLP-1 receptor agonists in serum and dried blood spots by LC-HRMS/MS for doping control purposes用于兴奋剂检测的血清和干血斑中GLP-1受体激动剂的LC-HRMS/MS定性方法的开发与验证DOI: 10.1016/j.jchromb.2026.125326 J Matern Fetal Neonatal Med IF: 01.600Volume 39, Issue 1No.37Characterizing vaginal misoprostol induction in individuals with and without severe obesity严重肥胖与非严重肥胖个体阴道米索前列醇引产的特征分析DOI: 10.1080/14767058.2026.2744004 Surg Obes Relat Dis IF: 03.800Ahead of Print.No.38Clinical outcomes in solid organ transplant recipients undergoing Roux-en-Y gastric bypass surgery: a propensity score-matched study实体器官移植受者接受Roux-en-Y胃旁路手术的临床结局：一项倾向性评分匹配研究DOI: 10.1016/j.soard.2026.09.015 Internal medicine IF: 01.100Ahead of Print.No.39Changes in Gait Speed During a 12-Month Multidisciplinary Obesity Management Program Including Semaglutide: A Real-World Observational Study in Japanese Adults With Musculoskeletal Disorders包含司美格鲁肽的12个月多学科肥胖管理项目期间步速变化：一项针对患有肌肉骨骼疾病的日本成人的真实世界观察性研究DOI: 10.2169/internalmedicine.8145-26 J Obes Metab Syndr IF: 07.900Ahead of Print.No.40Perspectives on Community-Based Pediatric Obesity Prevention and Management Programs in South Korea: A Qualitative Interview Study of School and Local Public Health Center Providers韩国社区儿童肥胖预防与管理项目的视角：对学校和地方公共卫生中心提供者的定性访谈研究DOI: 10.7570/jomes25099 Journal of neuroendocrinology IF: 04.100Volume 38, Issue 10No.41Changes in leptin and melanocortin peptides in cerebrospinal fluid after diet versus bariatric surgery饮食与减重手术后脑脊液中瘦素和黑皮质素肽的变化DOI: 10.1111/jne.70292 Journal of applied gerontology : IF: 02.000Ahead of Print.No.42Beyond BMI: The Role of Abdominal Obesity in Hypertension Risk Among Adults Aged 45 Years and Older in India超越体重指数：腹型肥胖在印度45岁及以上成年人高血压风险中的作用DOI: 10.1177/07334648261497261 Canadian journal of diabetes IF: 02.600Ahead of Print.No.43The Causal Role of Adiponectin in Type 2 Diabetes across Ages and Sexes - An Observational and Mendelian Randomization Study脂联素在2型糖尿病中的因果作用：跨年龄和性别的观察性与孟德尔随机化研究DOI: 10.1016/j.jcjd.2026.09.010 Fish & shellfish immunology IF: 03.900Ahead of Print.No.44A c-Jun N-terminal kinase (JNK) homolog from Macrobrachium rosenbergii participates in immune defense against Aeromonas hydrophila罗氏沼虾c-Jun N末端激酶（JNK）同源物参与抗嗜水气单胞菌的免疫防御DOI: 10.1016/j.fsi.2026.111771 Diabetes Res Clin Pract IF: 07.400Ahead of Print.No.45Capturing human-machine interplay in automated insulin delivery systems through day-to-day variability of the automated correction index (ACI-V%)通过自动校正指数日间变异性（ACI-V%）捕捉自动胰岛素输送系统中的人机交互DOI: 10.1016/j.diabres.2026.113613 Reproductive toxicology IF: 02.800Ahead of Print.No.46Glycerol supplementation attenuates testicular inflammation and miRNA dysregulation in obese rats甘油补充减轻肥胖大鼠的睾丸炎症和微小RNA失调DOI: 10.1016/j.reprotox.2026.109380 Archives of medical research IF: 03.400Ahead of Print.No.47Sex-Specific Neurobehavioral Programming in Offspring by a Maternal High-Fat, Plant-Based Diet: A Central Role of the Hippocampus母体高脂植物性饮食对子代神经行为编程的性别特异性影响：海马的核心作用DOI: 10.1016/j.arcmed.2026.103530 Heart, Lung and Circulation IF: 02.200Ahead of Print.No.48Lipoprotein(a) Reporting by Australian Chemical Pathology Laboratories澳大利亚化学病理实验室的脂蛋白(a)检测报告实践DOI: 10.1016/j.hlc.2026.05.016 The Lancet Psychiatry IF: 24.800Volume 13, Issue 11, Page 905-974, e14No.49Change in HbA1c and weight after initiation of antipsychotic treatment in people with severe mental illness in England: an individual-level interrupted time-series analysis英格兰严重精神疾病患者启动抗精神病药物治疗后糖化血红蛋白和体重的变化：个体水平中断时间序列分析DOI: 10.1016/S2215-0366(26)00274-9 The Lancet Psychiatry IF: 24.800Volume 13, Issue 11, Page 905-974, e14No.50GLP-1 receptor agonist initiation and risk of psychiatric hospitalisation and emergency department presentation in adults with schizophrenia and type 2 diabetes in the USA: an observational cohort study using electronic health records dataGLP-1受体激动剂起始治疗与精神分裂症合并2型糖尿病成人患者精神科住院及急诊就诊风险：基于电子健康记录数据的观察性队列研究DOI: 10.1016/S2215-0366(26)00276-2 The Lancet Psychiatry IF: 24.800Volume 13, Issue 11, Page 905-974, e14No.51Preventing predictable harm in severe mental illness预防严重精神疾病中可预测的伤害DOI: 10.1016/S2215-0366(26)00301-9 EJPC IF: 07.500Ahead of Print.No.52Outcomes in patients with diabetes, atherosclerotic cardiovascular disease, and heart failure treated with tirzepatide or dulaglutide: SURPASS-CVOT analysis合并糖尿病、动脉粥样硬化性心血管疾病和心力衰竭患者接受替尔泊肽或度拉糖肽治疗的结果：SURPASS-CVOT分析DOI: 10.1093/eurjpc/zwag452 Cardiovascular Diabetology IF: 10.600Ahead of Print.No.53Event-anchored piecewise trajectories of the triglyceride-glucose index before and after incident cardiovascular disease: a propensity score-matched longitudinal study from the English Longitudinal Study of Ageing甘油三酯-葡萄糖指数在心血管疾病发病前后的以事件为锚点的分段轨迹：来自英国老龄化纵向研究的倾向评分匹配纵向研究DOI: 10.1186/s12933-026-03387-7 JAMA surgery IF: 14.900Ahead of Print.No.54Bariatric Surgery Is Preventive Medicine减重手术是预防医学DOI: 10.1001/jamasurg.2026.4778 NEJM IF: 78.500Ahead of Print.No.55Continuous Glucose Monitoring in Non–Insulin-Treated Type 2 Diabetes非胰岛素治疗的2型糖尿病中的持续葡萄糖监测DOI: 10.1056/NEJMoa2608571 NEJM IF: 78.500Volume 395, Issue 15No.56Adult Attention Deficit–Hyperactivity Disorder成人注意缺陷多动障碍DOI: 10.1056/NEJMcp2516040 NEJM IF: 78.500Volume 395, Issue 15No.57Setmelanotide for the Treatment of Acquired Hypothalamic ObesitySetmelanotide用于治疗获得性下丘脑性肥胖DOI: 10.1056/NEJMc2610994 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.58Identifying a high-risk CKM syndrome phenotype: association of albuminuria with subclinical hemodynamic alterations via portable noninvasive cardiometer识别高风险心血管-肾脏-代谢综合征表型：白蛋白尿与便携式无创心排量监测仪检测的亚临床血流动力学改变的关联DOI: 10.3389/fendo.2026.1966139 Journal of opioid managementVolume 22, Issue 5No.59Comparison of long-term outcomes between opioid-free and opioid-based anesthesia in head and neck cancer surgeries: A pilot study头颈癌手术中无阿片类麻醉与阿片类麻醉长期结局的比较：一项初步研究DOI: 10.5055/jom.0996 JAMA psychiatry IF: 17.100Ahead of Print.No.60Patient-Reported Changes in Alcohol Use Following Glucagon-Like Peptide-1 Receptor Agonist Initiation胰高血糖素样肽-1受体激动剂启用后患者报告的酒精使用变化DOI: 10.1001/jamapsychiatry.2026.3242 Aesthetic surgery journal / IF: 03.900Ahead of Print.No.61Glucagon-Like Peptide-1 Receptor Agonist-Associated Facial Changes: A Comprehensive Review of Pathophysiology, Clinical Manifestations, Risk Factors, Prevention, and Management胰高血糖素样肽-1受体激动剂相关的面部变化：病理生理学、临床表现、危险因素、预防和管理的综合综述DOI: 10.1093/asj/sjag230 PRiMERVolume 10, Issue No.62Glycemic Outcomes Associated With GLP-1 Receptor Agonist Shortages in Type 2 Diabetes2型糖尿病患者中GLP-1受体激动剂短缺相关的血糖结局DOI: 10.22454/PRiMER.2026.826203 Med J Islam Repub IranVolume 40, Issue No.63Mechanisms of Vestibular System Damage in Diabetes Mellitus: Implications for Benign Paroxysmal Positional Vertigo Pathogenesis and Recurrence糖尿病中前庭系统损伤的机制：对良性阵发性位置性眩晕发病机制和复发的影响DOI: 10.47176/mjiri.40.75 Plant signaling & behavior IF: 03.600Volume 21, Issue 1No.64γ-aminobutyric acid is associated with calcium, reactive oxygen species, and nitric oxide responses and enhanced cadmium tolerance in Salvadora persicaγ-氨基丁酸与钙、活性氧和一氧化氮响应相关并增强Salvadora persica的镉耐受性DOI: 10.1080/15592324.2026.2748062 AME case reports IF: 00.700Volume 10, Issue No.65Thyroid storm revealing suspected evolving autoimmune polyglandular syndrome type 2 with steroid-limited assessment of autoimmune adrenal insufficiency: a case report甲状腺危象揭示疑似进展性自身免疫性多腺体综合征2型伴类固醇限制性自身免疫性肾上腺功能不全评估：一例病例报告DOI: 10.21037/acr-2026-0181 Clinical science IF: 07.700Ahead of Print.No.66Deletion of Nephrocystin-4 Exacerbates Kidney and Cardiac Function in Mice Cardiorenal Syndrome Model via the Interaction with Itch E3 ligaseNephrocystin-4缺失通过与其Itch E3连接酶的相互作用加重小鼠心肾综合征模型中的肾脏和心脏功能DOI: 10.1042/CS20262448 J Mol Neurosci IF: 02.700Volume 76, Issue 4No.67"Morphological, Functional, and Molecular Progression of Blood-Brain Barrier Dysfunction in Alzheimer's Disease"阿尔茨海默病中血脑屏障功能障碍的形态学、功能与分子进展DOI: 10.1007/s12031-026-02610-0 Current pharmaceutical design IF: 02.800Ahead of Print.No.68Emerging Therapeutic Strategies for Graves' Disease: Current Advances and Future PerspectivesGraves病的新兴治疗策略：当前进展与未来展望DOI: 10.2174/0113816128537581261007065942 Brain : IF: 11.700Ahead of Print.No.69Biallelic variants in PIKFYVE cause a hypomyelinating leukodystrophy with endolysosomal dysfunctionPIKFYVE双等位基因变异导致伴内溶酶体功能障碍的低髓鞘性脑白质营养不良DOI: 10.1093/brain/awag355 ACS Pharmacol Transl Sci IF: 03.700Volume 9, Issue 10No.70A Human Glucoregulatory Model for the Rational Design and Evaluation of Diabetes Therapeutics用于糖尿病治疗药物理性设计与评估的人类血糖调控模型DOI: 10.1021/acsptsci.6c00356 ACS Pharmacol Transl Sci IF: 03.700Volume 9, Issue 10No.71Hepatic Overexpression of a Novel Soluble Endogenous Transforming Growth Factor β Type II Receptor-Immunoglobulin G1 Fc Fusion Protein (TβRII-SE/Fc) Attenuates Early Stage Metabolic Dysfunction-Associated Steatotic Liver Disease in Rats肝脏过表达新型可溶性内源性转化生长因子β II型受体-免疫球蛋白G1 Fc融合蛋白（TβRII-SE/Fc）减轻大鼠早期代谢功能障碍相关脂肪性肝病DOI: 10.1021/acsptsci.6c00410 ACS Pharmacol Transl Sci IF: 03.700Volume 9, Issue 10No.72Diabetes-Associated Cognitive Dysfunction: Pathophysiology, Molecular Mechanisms, and Emerging Therapeutic Strategies糖尿病相关认知功能障碍：病理生理学、分子机制与新兴治疗策略DOI: 10.1021/acsptsci.6c00440 Clin Exp Dermatol IF: 02.800Ahead of Print.No.73Prescribed insulin use in type II diabetes mellitus and skin cancer risk: A systematic review 32型糖尿病中处方胰岛素使用与皮肤癌风险：一项系统综述3DOI: 10.1093/ced/llag444 Cancer reports IF: 01.900Volume 9, Issue 10No.74Periprocedural Wound Complication Risks in Cancer Pain Patients Following Targeted Cancer Therapy: A Retrospective Analysis癌症疼痛患者接受靶向癌症治疗后的围手术期伤口并发症风险：一项回顾性分析DOI: 10.1002/cnr2.70664 J Clin Invest IF: 13.600Ahead of Print.No.75Manganese availability determines hepatic insulin sensitivity by enhancing Akt activity锰的可利用性通过增强Akt活性决定肝脏胰岛素敏感性DOI: 10.1172/JCI200951 J Clin Invest IF: 13.600Ahead of Print.No.76SGLT1/2 inhibitor sotagliflozin, but not SGLT2-selective inhibitor empagliflozin, attenuates platelet activation and thrombosisSGLT1/2抑制剂索格列净而非SGLT2选择性抑制剂恩格列净可减弱血小板活化和血栓形成DOI: 10.1172/JCI201899 Salud pública de México IF: 03.100Volume 68, Issue 5 (sept-oct)No.77[Not Available]2025年Ensanut视觉健康模块的方法学设计与范围DOI: 10.21149/18641 JIC IF: 01.400Ahead of Print.No.78Chronic total occlusion percutaneous coronary interventions in dialysis patients透析患者的慢性完全闭塞经皮冠状动脉介入治疗DOI: 10.25270/jic/26.00260 Diabetes care IF: 16.600Ahead of Print.No.79Erratum. Sodium-Glucose Cotransporter 2 Inhibitor Use and Risk of Liver-Related Events in Patients With Type 2 Diabetes: A Meta-analysis of Observational Cohort Studies. Diabetes Care 2025;48:1042-1052勘误。钠-葡萄糖协同转运蛋白2抑制剂使用与2型糖尿病患者肝脏相关事件风险：观察性队列研究的Meta分析。Diabetes Care 2025;48:1042-1052DOI: 10.2337/dc27-er01 Wounds IF: 01.100Volume 38, Issue 9No.80Prospective evaluation of the clinical effectiveness of an innovative catalytic wound care technology创新催化伤口护理技术临床有效性的前瞻性评估DOI: 10.25270/wnds/25122 PLOS pathogens IF: 04.900Ahead of Print.No.81Intranasal HSV‑1 infection drives region‑specific interferon‑dominant microglial remodeling鼻内HSV-1感染驱动区域特异性干扰素主导的小胶质细胞重塑DOI: 10.1371/journal.ppat.1014684 PloS one IF: 02.600Volume 21, Issue 10No.82Subnational spatial co-distribution of tuberculosis and diabetes mellitus across Ghana's 16 regions following administrative reorganisation: An ecological analysis行政重组后加纳16个地区结核病与糖尿病的次国家级空间共分布：一项生态学分析DOI: 10.1371/journal.pone.0354405 PloS one IF: 02.600Volume 21, Issue 10No.83Low diet quality increases the genetic risk of high blood cholesterol levels in Asian Indian adults [CURES - 165]低饮食质量增加亚洲印度成年人高血胆固醇水平的遗传风险 [CURES - 165]DOI: 10.1371/journal.pone.0357182 Gerontology : IF: 03.000Ahead of Print.No.84Local RAGE Inhibition Attenuates Early Diabetic Retinal Pathology in Streptozotocin-Induced Rats局部RAGE抑制减轻链脲佐菌素诱导大鼠的早期糖尿病视网膜病变DOI: 10.1159/ger/acxag008 J Biomol Struct Dyn IF: 02.400Ahead of Print.No.85Structure-dynamics analysis of insulin receptor modulation by plant-derived ligands suggests a potential regulatory role for Asn711植物来源配体调控胰岛素受体的结构动力学分析提示Asn711的潜在调控作用DOI: 10.1080/07391102.2026.2741934 Diabetes care IF: 16.600Ahead of Print.No.86Contemporary Sex-Specific Mortality Risk in Type 1 Diabetes During the Era of Advanced Therapeutic Care当代先进治疗护理时代1型糖尿病的性别特异性死亡风险DOI: 10.2337/dc26-1472 Journal of periodontology IF: 03.800Ahead of Print.No.87Association between xerostomia and peri-implant health: A retrospective cohort study口干症与种植体周围健康之间的关联：一项回顾性队列研究DOI: 10.1002/jper.70192 GeroScience IF: 05.400Ahead of Print.No.88Plasma biomarkers of neurodegeneration and physical performance in older adults老年人神经退行性变的血浆生物标志物与身体表现DOI: 10.1007/s11357-026-02570-8 Clin Rev Allergy Immunol IF: 11.300Volume 69, Issue 1No.89Single-cell Transcriptomics in Autoimmune Diseases: Mechanistic Insights, Cross-disease Convergence, and Translational Challenges in Rheumatoid Arthritis, Systemic Lupus Erythematosus, Type 1 Diabetes, and Multiple Sclerosis自身免疫性疾病中的单细胞转录组学：类风湿关节炎、系统性红斑狼疮、1型糖尿病和多发性硬化中的机制见解、跨疾病趋同及转化挑战DOI: 10.1007/s12016-026-09211-0 J Cardiovasc Surg (Torino) IF: 01.500Ahead of Print.No.90Bailout stenting strategy in complex femoropopliteal lesions: mid-term outcomes with drug-eluting versus bare-metal stents复杂股腘动脉病变的补救性支架策略：药物洗脱支架与裸金属支架的中期结局DOI: 10.23736/S0021-9509.26.13592-7 JACC: Cardiovascular Imaging IF: 15.200Ahead of Print.No.91Bending the Curve: Revealing Population Risk With Quantitative Atherosclerotic Plaque扭转曲线：利用定量动脉粥样硬化斑块揭示人群风险DOI: 10.1016/j.jcmg.2026.09.002 Invest Ophthalmol Vis Sci IF: 04.700Volume 67, Issue 12No.92Neuroprotective and Anti-Inflammatory Effects of SOCS1 Mimetic Peptides in Mouse Diabetic RetinopathySOCS1模拟肽在小鼠糖尿病视网膜病变中的神经保护与抗炎作用DOI: 10.1167/iovs.67.12.21 J Diabetes Sci Technol IF: 03.700Ahead of Print.No.93Redistributing Insulin Pumps for Patients Facing Access Barriers为面临获取障碍的患者重新分配胰岛素泵DOI: 10.1177/19322968261493576 J Diabetes Sci Technol IF: 03.700Ahead of Print.No.94Effectiveness of Continuous Glucose Monitoring in Non-Intensively Managed Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials持续葡萄糖监测在非强化管理的2型糖尿病中的有效性：随机对照试验的系统评价与荟萃分析DOI: 10.1177/19322968261489265 J Diabetes Sci Technol IF: 03.700Ahead of Print.No.95From Clinician-Based Risk Score to Diabetes Complications: Validating the Glycemia Risk Index with the Virtual Diabetes Control and Complications Trial Continuous Glucose Monitoring Data从临床医生风险评分到糖尿病并发症：利用虚拟糖尿病控制与并发症试验的连续葡萄糖监测数据验证血糖风险指数DOI: 10.1177/19322968261489629 J Acquir Immune Defic Syndr IF: 02.900Ahead of Print.No.96Cross-sectional Comparison of the PREVENT and Pooled Cohort Equations for 10-Year Atherosclerotic Cardiovascular Risk Estimates in a U.S. Cohort of Black and Latina Transgender Women with HIVPREVENT与汇总队列方程在美国黑人及拉丁裔跨性别女性HIV感染者中10年动脉粥样硬化性心血管风险估计的横断面比较DOI: 10.1097/QAI.0000000000003985 J Diabetes Sci Technol IF: 03.700Ahead of Print.No.97Performance of a 15-Day Continuous Glucose Monitoring System in Children and Adolescents With Diabetes15天连续血糖监测系统在儿童和青少年糖尿病患者中的性能表现DOI: 10.1177/19322968261493981 Blood Pressure IF: 02.300Ahead of Print.No.98Epidemiology of Uncontrolled and Treatment‑Resistant Hypertension: A Registry‑Based Observational Study未控制高血压与难治性高血压的流行病学：一项基于注册的观察性研究DOI: 10.1080/08037051.2026.2749134 Curr Comput Aided Drug Des IF: 01.600Ahead of Print.No.99In silico and Network Pharmacology Identification of Acacia senegal Phytochemicals as Potential α-Amylase Inhibitors计算机模拟与网络药理学鉴定Acacia senegal植物化学物质作为潜在α-淀粉酶抑制剂DOI: 10.2174/0115734099489718260910060820 Current diabetes reviews IF: 01.900Ahead of Print.No.100Chronotherapeutic and Circadian Rhythm-Based Strategies in Diabetes Management: A Critical Opinion Based on Evidences糖尿病管理中的时间治疗与昼夜节律策略：基于证据的批判性观点DOI: 10.2174/0115733998495346261007070830 Endocrinol Diabetes Metab IF: 02.600Volume 9, Issue 6No.101Real-World Metabolic Improvements in Women With and Without Polyendocrine Metabolic Syndrome via a Multidisciplinary Telehealth Care Platform通过多学科远程医疗平台，患有多内分泌代谢综合征与不患该综合征的女性在真实世界中均获得代谢改善DOI: 10.1002/edm2.70332 Nanoscale IF: 05.100Ahead of Print.No.102Fibroblast-derived exosomes in wound healing and regenerative medicine: mechanisms, therapeutic potential, and clinical perspectives成纤维细胞来源外泌体在伤口愈合与再生医学中的机制、治疗潜力及临床前景DOI: 10.1039/d6nr01426g Geriatr Gerontol Int IF: 02.500Volume 26, Issue 10No.103Comparison of Metabolic Dysfunction-Associated Steatotic Liver Disease Between Individuals With Werner Syndrome and Those With Insulin-Resistant Type 2 Diabetes: Hepatic Steatosis and Fibrosis IndicesWerner综合征患者与胰岛素抵抗型2型糖尿病患者代谢功能障碍相关脂肪性肝病的比较：肝脏脂肪变性和纤维化指标DOI: 10.1111/ggi.70866 Epidemiology and infection IF: 02.200Volume 154, Issue No.104Burden of RSV hospital disease and its comorbidities in adults in Spain (2016-2023)西班牙成人呼吸道合胞病毒住院疾病负担及其合并症（2016-2023年）DOI: 10.1017/S0950268826102076 Endocr Metab Immune Disord Drug Targets IF: 02.000Ahead of Print.No.105Study of Krüppel-like Factor 14 rs4731702 Polymorphism in Type 2 Diabetes MellitusKrüppel样因子14 rs4731702基因多态性与2型糖尿病的研究DOI: 10.2174/0118715303406864260803042753 Current organic synthesis IF: 02.500Ahead of Print.No.106L-Arginine Schiff Bases for Diabetic Wound Healing via Nitric Oxide Synthase Inhibition: Synthesis, In Vitro Activity, and In Silico InsightsL-精氨酸席夫碱通过抑制一氧化氮合酶促进糖尿病伤口愈合：合成、体外活性及计算机模拟研究DOI: 10.2174/0115701794490198260909153846 Phys Chem Chem Phys IF: 02.900Ahead of Print.No.107Delineating the structural distortions in hIAPP protofibrils by rationally designed hexapeptides using computer simulations利用计算机模拟解析理性设计的六肽对hIAPP原纤维的结构破坏作用DOI: 10.1039/d6cp01811d Diabetes Technol Ther IF: 06.300Ahead of Print.No.108Efficacy and Safety of the MiniMed™ Vivera™ Algorithm: Results from a First-in-Human Feasibility TrialMiniMed™ Vivera™算法的有效性与安全性：首次人体可行性试验结果DOI: 10.1177/15209156261496632 Canadian liver journal IF: 01.200Volume 9, Issue 3No.109Cardiometabolic comorbidity and health outcomes of persons with metabolic dysfunction-associated steatotic liver disease (MASLD) in Ontario, Canada加拿大安大略省代谢功能障碍相关脂肪性肝病患者的代谢相关合并症与健康结局DOI: 10.3138/canlivj-2026-0020 Curēus IF: 01.300Volume 18, Issue 9No.110Recurrent Pericarditis With Cardiac Tamponade in a Patient With Systemic Lupus Erythematosus: A Case Report系统性红斑狼疮患者复发性心包炎伴心脏压塞：一例病例报告DOI: 10.7759/cureus.116182 Respir Med Case Rep IF: 00.800Volume 64, Issue No.111Early-onset severe voriconazole-induced liver injury with progressive cholestasis in pulmonary aspergillosis: A case report肺曲霉病患者中伏立康唑诱导的早发性严重肝损伤伴进行性胆汁淤积：一例病例报告DOI: 10.1016/j.rmcr.2026.102522 Curēus IF: 01.300Volume 18, Issue 9No.112Triple Renal Pathology in a Patient With Myeloperoxidase-Associated Vasculitis, Diabetic Nephropathy, and Immunoglobulin A Nephropathy: A Case Report一例髓过氧化物酶相关性血管炎、糖尿病肾病与免疫球蛋白A肾病三重肾脏病理的病例报告DOI: 10.7759/cureus.116188 Current opinion in endocrine and metabolic researchVolume 33, Issue No.113The Evolving Genomic Landscape of Pediatric Papillary Thyroid Cancer儿童甲状腺乳头状癌基因组景观的演变DOI: 10.1016/j.coemr.2023.100483 Drug Des Devel Ther IF: 05.100Volume 20, Issue No.114Oral Obesity Medicines in the Era of Cardiovascular-Kidney-Metabolic Syndrome (CKM): Beyond Weight Loss Toward Disease Modification心血管-肾脏-代谢综合征时代的口服减重药物：超越减重，迈向疾病修饰DOI: 10.2147/DDDT.S637685 Ethnicity & health IF: 02.000Ahead of Print.No.115The association between body mass index and perioperative outcomes by ethnicity and socioeconomic status: a systematic review of systematic reviews体重指数与围手术期结局的关联：基于种族和社会经济地位的系统综述再综述DOI: 10.1080/13557858.2026.2733954 Annals of plastic surgery IF: 01.600Ahead of Print.No.116Impact of Postbariatric Body Contouring Procedures on Patient Body Weight and Metabolism减重术后身体塑形手术对患者体重和代谢的影响DOI: 10.1097/SAP.0000000000004928 Clin Exp Rheumatol IF: 03.300Ahead of Print.No.117Phenotype-based risk stratification for deep vein thrombosis in Behçet's disease: a global 10-year longitudinal study基于表型的白塞病深静脉血栓风险分层：一项全球10年纵向研究DOI: 10.55563/clinexprheumatol/ir8mqc JAMA surgery IF: 14.900Ahead of Print.No.118Bariatric Surgery and Risk of Obesity-Related Cancer by Age and Sex减重手术与肥胖相关癌症风险：年龄和性别的影响DOI: 10.1001/jamasurg.2026.4798 Curr Allergy Asthma Rep IF: 04.600Volume 26, Issue 1No.119Obesity-Related Asthma: Structure and Inflammation肥胖相关哮喘：结构与炎症DOI: 10.1007/s11882-026-01302-4 Brain imaging and behavior IF: 02.400Volume 20, Issue 5No.120The role of neighborhood socioeconomic environment in the association between glycemic control and the developing brain社区社会经济环境在血糖控制与大脑发育关联中的作用DOI: 10.1007/s11682-026-01211-0 Sleep & breathing IF: 02.000Volume 30, Issue 6No.121A dynamic triad: why weight trajectory matters in pediatric obesity, sleep apnea, and metabolic risk动态三联征：为何体重轨迹在儿童肥胖、睡眠呼吸暂停与代谢风险中至关重要DOI: 10.1007/s11325-026-03838-1 Acta diabetologica IF: 02.900Ahead of Print.No.122GLP-1 receptor agonists and hair loss: adverse effect, epiphenomenon, or therapeutic paradox?GLP-1受体激动剂与脱发：不良反应、伴随现象还是治疗悖论？DOI: 10.1007/s00592-026-02812-3 Acta diabetologica IF: 02.900Ahead of Print.No.123Risk of recurrent acute pancreatitis with GLP-1 receptor agonists after prior pancreatitis: a systematic review既往胰腺炎后使用GLP-1受体激动剂复发性急性胰腺炎的风险：一项系统评价DOI: 10.1007/s00592-026-02809-y Acta diabetologica IF: 02.900Ahead of Print.No.124Gestational diabetes mellitus in Italian diabetes clinics: clinical characteristics, screening practices and management from the amd annals registry意大利糖尿病诊所中的妊娠期糖尿病：来自AMD Annals注册中心的临床特征、筛查实践与管理DOI: 10.1007/s00592-026-02816-z Journal of dental research IF: 05.900Ahead of Print.No.125GLP-1 Receptor Agonists in Dentistry: Promise, Pitfalls, and Evidence GapsGLP-1受体激动剂在牙科中的应用：前景、隐患与证据空白DOI: 10.1177/00220345261488338 Small IF: 12.100Ahead of Print.No.126Fenestrated Microneedle Biosensor for Continuous In Vivo Lactate Monitoring in Interstitial Fluid用于连续体内间质液乳酸监测的开窗微针生物传感器DOI: 10.1002/smll.76250 Expert Opin Pharmacother IF: 02.700Ahead of Print.No.127Obesity: oral therapy for those afraid of needles肥胖症：针对恐针患者的口服治疗DOI: 10.1080/14656566.2026.2749645 Current diabetes reviews IF: 01.900Ahead of Print.No.128Gliflozin-Derived SGLT2 Inhibitors: Recent Advances and Future Perspectives in the Management of Type 2 Diabetes格列净衍生的SGLT2抑制剂：2型糖尿病管理的最新进展与未来展望DOI: 10.2174/0115733998505609261006104914 Current drug delivery IF: 03.000Ahead of Print.No.129Pharmacological and Therapeutic Roles of Wild Pistachio and Its Nanoformulations in Endocrine, Metabolic, and Other Diseases: A Comprehensive Review野生开心果及其纳米制剂在内分泌、代谢及其他疾病中的药理与治疗作用：一项综合性综述DOI: 10.2174/0115672018452820261006095941 Strabismus IF: 00.800Ahead of Print.No.130Potocki-Shaffer syndrome associated with Brown syndrome: expansion of the ocular phenotype in a child with an 11p11.2-p11.12 deletionPotocki-Shaffer综合征合并Brown综合征：一例11p11.2-p11.12缺失患儿眼部表型的扩展DOI: 10.1080/09273972.2026.2746025 J Pediatr Gastroenterol Nutr IF: 02.600Ahead of Print.No.131Chronic conditions associated with paediatric onset inflammatory bowel diseases: A population-based study与儿童期起病炎症性肠病相关的慢性疾病：一项基于人群的研究DOI: 10.1002/jpn3.70609 Health Care Women Int IF: 00.900Ahead of Print.No.132Effects of 6- versus 12-week supervised multimodal exercise on health outcomes and adherence in women with obesity: A pilot study6周与12周监督下多模式运动对肥胖女性健康结局和依从性的影响：一项初步研究DOI: 10.1080/07399332.2026.2743908 J Pediatr Endocrinol Metab IF: 01.000Ahead of Print.No.133Fatty liver and adipokines: converging pathways linking insulin resistance to early atherosclerosis in obese children and adolescents脂肪肝与脂肪因子：肥胖儿童和青少年中连接胰岛素抵抗与早期动脉粥样硬化的汇聚通路DOI: 10.1515/jpem-2026-0302 J Clin Pharmacol IF: 02.300Volume 66, Issue 10No.134Mechanistic Prediction of Maternal, Fetal, and Amniotic Fluid Betamethasone Concentrations to Support Dosing Optimization in Pregnancy母体、胎儿及羊水中倍他米松浓度的机制性预测以支持妊娠期给药优化DOI: 10.1002/jcph.70308 J Clin Med Res IF: 02.000Volume 18, Issue 9No.135Common Carotid Artery Extra-Media Thickness as a Marker of Perivascular Obesity and Cardiometabolic Risk in Individuals Without Cardiovascular Disease颈总动脉外膜厚度作为无心血管疾病个体血管周围肥胖和心脏代谢风险的标志物DOI: 10.14740/jocmr6657 Diabetes Metab Syndr Obes IF: 03.000Volume 19, Issue No.136Diabetes Mellitus in Patients with Schizophrenia: A Systematic Review and Meta-Analysis of Prevalence of Types and Risk Factors精神分裂症患者的糖尿病：类型患病率与风险因素的系统综述与荟萃分析DOI: 10.2147/DMSO.S650265 Canadian liver journal IF: 01.200Volume 9, Issue 3No.137Metabolic dysfunction-associated steatotic liver disease assessment and management: Clinical practice guidance from the Canadian Association for the Study of the Liver代谢功能障碍相关脂肪性肝病的评估与管理：加拿大肝病研究学会临床实践指南DOI: 10.3138/canlivj-2026-9-3-guidelines Frontiers in toxicology IF: 04.600Volume 8, Issue No.138Mapping DEHP-induced metabolic dysregulation through multi-omics and systems biology: an adverse outcome pathway network approach通过多组学和系统生物学解析DEHP诱导的代谢失调：有害结局路径网络方法DOI: 10.3389/ftox.2026.1930835 Aesthet Surg J Open Forum IF: 01.900Volume 8, Issue No.139The Impact of Glucagon-Like Peptide-1 Receptor Agonist-Induced Nutritional Deficiencies on Skin Health: A Narrative Review With a Proposed Framework for the Aesthetic Practitioner胰高血糖素样肽-1受体激动剂诱导的营养缺乏对皮肤健康的影响：叙述性综述及为美容从业者提出的框架DOI: 10.1093/asjof/ojag169 Journal of the Endocrine Society IF: 03.100Volume 10, Issue 11No.140Potential links between PCOS/PMOS and Alzheimer disease and related dementias多囊卵巢综合征/多内分泌代谢性卵巢综合征与阿尔茨海默病及相关痴呆的潜在关联DOI: 10.1210/jendso/bvag206 Hepatobiliary Surg Nutr IF: 07.800Volume 15, Issue 5No.141Body mass index and ampulla of Vater cancer incidence and survival: a cohort study of 1.7 million Norwegians体重指数与Vater壶腹癌发病率和生存率：一项170万挪威人的队列研究DOI: 10.21037/hbsn-2024-636 Hepatobiliary Surg Nutr IF: 07.800Volume 15, Issue 5No.142Normal weight, hidden risk: adiposity is a better determinant of liver cancer than body mass index正常体重，隐藏风险：脂肪堆积比体重指数更能决定肝癌风险DOI: 10.21037/hbsn-2026-0411 BMFH IF: 02.900Volume 45, Issue 4No.143Bifidobacterium adolescentis protects the intestinal barrier from obesity-related inflammatory stimuli in association with the nuclear translocation of nuclear factor kappa B青春双歧杆菌通过核因子κB核转位保护肠道屏障免受肥胖相关炎症刺激DOI: 10.12938/bmfh.2026-022 Acta gastroenterológica latinoamericanaVolume 56, Issue 3No.144Glucagon-Like Peptide-1 Receptor Agonist and Gastrointestinal Adverse Effects: A Comprehensive Review胰高血糖素样肽-1受体激动剂与胃肠道不良反应：综合综述DOI: 10.52787/agl.v56i3.690 Int J Womens Health IF: 02.600Volume 18, Issue No.145Burden, Trends, and Future Projections of Polycystic Ovary Syndrome in the Gulf Cooperation Council Countries, 1990-2023, with Projections to 2050: A Global Burden of Disease Study海湾合作委员会国家多囊卵巢综合征的疾病负担、趋势及未来预测（1990-2023年，并预测至2050年）：一项全球疾病负担研究DOI: 10.2147/IJWH.S644317 Przegl?d Menopauzalny IF: 01.700Volume 25, Issue 2No.146Associations between body composition, physical activity, and life satisfaction in perimenopausal women aged 40-50 years: a cross-sectional study40-50岁围绝经期女性体重指数、体力活动与生活满意度的关联：一项横断面研究DOI: 10.5114/pm.2026.163868 BMJ Global Health IF: 06.100Volume 11, Issue 10No.147Estimating the potential health impact of taxing sugar-sweetened drinks in Thailand: a modelling study估算泰国对含糖饮料征税的潜在健康影响：一项建模研究DOI: 10.1136/bmjgh-2025-021625 Nature IF: 48.500Ahead of Print.No.148Artificial intelligence-enabled clinical phenotyping of human brown fat - Nature人工智能赋能的人类棕色脂肪临床表型分析DOI: 10.1038/s41586-026-11162-7 Frontiers in medicine IF: 03.000Volume 13, Issue No.149Cross-modal fusion of OCT and OCT angiography enface for improved diagnostics of diabetic retinopathyOCT与OCTA enface的跨模态融合提升糖尿病视网膜病变诊断效能DOI: 10.3389/fmed.2026.1900570 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.150Investigating the effect of diet-induced prediabetes on the HPA-axis, sympathetic nervous system and endogenous opioids in male Sprague-Dawley rats探究饮食诱导的糖尿病前期对雄性Sprague-Dawley大鼠HPA轴、交感神经系统及内源性阿片系统的影响DOI: 10.3389/fendo.2026.1925577 Frontiers in nephrologyVolume 6, Issue No.151SGLT2 inhibitors as a strategy for volume management in peritoneal dialysis: a case series钠-葡萄糖协同转运蛋白2抑制剂作为腹膜透析容量管理策略：病例系列DOI: 10.3389/fneph.2026.1942462 FCVM IF: 02.900Volume 13, Issue No.152Cardiovascular outcomes of oral incretin-based drugs in type 2 diabetes: a GRADE-assessed meta-analysis of 67,679 patients口服肠促胰素类药物在2型糖尿病中的心血管结局：一项纳入67,679例患者的GRADE评估荟萃分析DOI: 10.3389/fcvm.2026.1884895 Med J Islam Repub IranVolume 40, Issue No.153Latent Class Analysis for Clustering Iranian Individuals Based on Cardiovascular Risk Factors基于心血管危险因素对伊朗个体进行聚类分析的潜在类别分析DOI: 10.47176/mjiri.40.88 3 biotech IF: 02.900Volume 16, Issue 11No.154Machine learning-driven discovery of TGFBR1 inhibitors from Mangifera indica for Atorvastatin-based antidiabetic therapy机器学习驱动的芒果中TGFBR1抑制剂发现及其用于基于阿托伐他汀的降糖治疗DOI: 10.1007/s13205-026-05088-0 JCEM case reportsVolume 4, Issue 11No.155Aortic coarctation and McArdle disease in histiocytosis-lymphadenopathy plus syndrome: expanding the SLC29A3 spectrum组织细胞增生症-淋巴结病附加综合征中的主动脉缩窄与McArdle病：扩展SLC29A3谱系DOI: 10.1210/jcemcr/luag289 JCEM case reportsVolume 4, Issue 11No.156Hypoinsulinemic hypoglycemia with hemihypertrophy in a Filipino infant: management in a resource-limited setting一例菲律宾婴儿低胰岛素性低血糖伴偏身肥大：资源有限环境下的管理DOI: 10.1210/jcemcr/luag231 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.157Commentary: Pembrolizumab-induced type-1 diabetes mellitus: clinical characteristics, therapeutic strategies, and prognosis from a retrospective analysis of 43 published cases评论：帕博利珠单抗诱导的1型糖尿病——基于43例已发表病例回顾性分析的临床特征、治疗策略与预后DOI: 10.3389/fendo.2026.1986405 Frontiers in nutrition IF: 05.100Volume 13, Issue No.158Comparative accuracy of automated carbohydrate estimation using NutriDish and ChatGPT-5 against dietitian-derived reference valuesNutriDish与ChatGPT-5自动估算碳水化合物的准确性比较：以营养师推导的参考值为基准DOI: 10.3389/fnut.2026.1927840 Med J Islam Repub IranVolume 40, Issue No.159Introducing Prostaglandin Endoperoxide Synthase-2 as a Remarkable Player in the Development of Gastroesophageal Reflux Disease前列腺素内过氧化物合酶-2在胃食管反流病发展中的重要作用DOI: 10.47176/mjiri.40.78 Indian journal of orthopaedics IF: 01.100Volume 60, Issue 10No.160Predictors of Non-union in Subtrochanteric Femur Fractures: A Multivariate Logistic Regression Analysis股骨转子下骨折不愈合的预测因素：多因素Logistic回归分析DOI: 10.1007/s43465-026-01882-3 Curēus IF: 01.300Volume 18, Issue 9No.161Predictive Factors for Diabetes Insipidus and Syndrome of Inappropriate Secretion of Antidiuretic Hormone After Transsphenoidal Surgery for Pituitary Adenoma垂体腺瘤经蝶手术后尿崩症与抗利尿激素不适当分泌综合征的预测因素DOI: 10.7759/cureus.116176 Med J Islam Repub IranVolume 40, Issue No.162Diabetes Status and the Association Between a Coronary Artery Disease Polygenic Risk Score and Incident Coronary Artery Disease in an Iranian Prospective Cohort糖尿病状态与伊朗前瞻性队列中冠状动脉疾病多基因风险评分及新发冠状动脉疾病之间的关联DOI: 10.47176/mjiri.40.89 AME case reports IF: 00.700Volume 10, Issue No.163Where did the iron go?-a case report of a patient with severe iron deficiency anemia despite parenteral and oral iron supplementation due to semaglutide application铁去哪儿了？——一例因应用司美格鲁肽导致尽管接受肠外和口服铁补充仍出现严重缺铁性贫血患者的病例报告DOI: 10.21037/acr-2026-0027 Indian journal of orthopaedics IF: 01.100Volume 60, Issue 10No.164Occurrence and Determinants of Periprosthetic Fractures of the Femur During Intraoperative and Post-operative Period in Patients Undergoing Hip Arthroplasty: A Prospective Cohort Study髋关节置换术患者术中及术后股骨假体周围骨折的发生率及决定因素：一项前瞻性队列研究DOI: 10.1007/s43465-026-01808-z JCEM case reportsVolume 4, Issue 11No.165Primary adrenal small cell neuroendocrine carcinoma in a patient with sarcoidosis and synchronous colon adenocarcinoma结节病合并同步升结肠腺癌患者中原发性肾上腺小细胞神经内分泌癌一例DOI: 10.1210/jcemcr/luag313 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.166The CKM-GDM multi-organ precision model: reframing gestational diabetes as an early cardiovascular-kidney-metabolic event in Southeast AsiaCKM-GDM多器官精准模型：将妊娠期糖尿病重新定义为东南亚地区早期心血管-肾脏-代谢事件DOI: 10.3389/fendo.2026.1949130 FCVM IF: 02.900Volume 13, Issue No.167Effect of rosuvastatin and ezetimibe therapy on LDL-cholesterol reduction and non-invasive arterial injury markers in children with heterozygous familial hypercholesterolemia: a prospective, open-label, randomized study瑞舒伐他汀与依折麦布治疗对杂合子家族性高胆固醇血症儿童低密度脂蛋白胆固醇降低及无创动脉损伤标志物的影响：一项前瞻性、开放标签、随机研究DOI: 10.3389/fcvm.2026.1933757 Indian journal of orthopaedics IF: 01.100Volume 60, Issue 10No.168Body Mass Index-Related Changes in Tibial Morphology: Considerations for Intramedullary Nailing体重指数相关的胫骨形态变化：髓内钉置入的考量DOI: 10.1007/s43465-026-01921-z Int J Hypertens IF: 01.700Volume 2026, Issue No.169From Adiposity to Diastolic Dysfunction: The Integrated Role of Epicardial Fat, Autonomic Dysregulation, and Morning Blood Pressure Surge in Obesity从肥胖到舒张功能障碍：心外膜脂肪、自主神经失调与晨峰血压在肥胖中的整合作用DOI: 10.1155/ijhy/8528281 J Diabetes Metab Disord IF: 01.600Volume 25, Issue 2No.170The hepato-thyroid axis in male obesity: unraveling inter-organ crosstalk through non-invasive biomarkers男性肥胖中的肝-甲状腺轴：通过无创生物标志物揭示器官间串扰DOI: 10.1007/s40200-026-02107-y Frontiers in pharmacology IF: 04.800Volume 17, Issue No.171The role of sitagliptin in modifying metabolic, hormonal and clinical parameters in polycystic ovarian syndrome patients: a randomized controlled trial西格列汀对多囊卵巢综合征患者代谢、激素及临床指标的影响：一项随机对照试验DOI: 10.3389/fphar.2026.1822226 AME case reports IF: 00.700Volume 10, Issue No.172Urogenital abscess with a complex etiology: a case report复杂病因的泌尿生殖系统脓肿：一例病例报告DOI: 10.21037/acr-2026-0132 Frontiers in Nuclear MedicineVolume 6, Issue No.173Absolute stress myocardial blood flow is reduced in patients with prior cardiac disease despite normal perfusion and ejection fraction on rubidium-82 PET: an Arabian Gulf cohort阿拉伯湾队列研究：既往心脏病患者尽管灌注和射血分数正常，但绝对负荷心肌血流量降低：一项铷-82 PET研究DOI: 10.3389/fnume.2026.1957482 N Am Spine Soc J IF: 02.500Volume 28, Issue No.174GLP-1 receptor agonists in elective spine surgery: a systematic review of fusion outcomes, perioperative safety, and procedure-specific risk胰高血糖素样肽-1受体激动剂在择期脊柱手术中的应用：融合结局、围手术期安全性和手术特异性风险的系统综述DOI: 10.1016/j.xnsj.2026.100942 DEN open IF: 01.500Volume 7, Issue 1No.175Evaluating a Modified American Society of Anesthesiologists Physical Status-Based Sedation Management System for Pancreatobiliary Endoscopy: A Prospective Feasibility Study评估基于改良美国麻醉医师协会体能状态分级的胰胆内镜镇静管理系统：一项前瞻性可行性研究DOI: 10.1002/deo2.70445 Afr J Reprod Health IF: 01.000Volume 30, Issue 19No.176Maternal risk factors for hypertension in pregnancy: A quantitative study on the role of demographics, obesity, and healthcare compliance妊娠期高血压的母体风险因素：关于人口统计学、肥胖和医疗依从性作用的定量研究DOI: 10.29063/ajrh2026/v30i19.7 Frontiers in immunology IF: 05.900Volume 17, Issue No.177Saccharomyces boulardii reduces food intake and attenuates weight gain in diet-induced obese mice: links to gut microbial, metabolic, and immune remodeling布拉氏酵母菌减少饮食诱导肥胖小鼠的进食量并减轻体重增长：与肠道微生物、代谢及免疫重塑的关联DOI: 10.3389/fimmu.2026.1925200 Hypertension Research IF: 04.600Ahead of Print.No.178Pre-pregnancy BMI and hypertensive disorders of pregnancy in Japan: population burden and simulated BMI reduction scenarios for preconception and interpregnancy care日本孕前体重指数与妊娠期高血压疾病：人群负担及孕前和孕期保健中模拟体重指数降低情景DOI: 10.1038/s41440-026-02847-7 Arthritis & rheumatology IF: 10.900Ahead of Print.No.179Higher risk of Long COVID among patients with autoimmune rheumatic diseases and immunomodulatory therapy: a retrospective cohort analysis of national US data自身免疫性风湿病患者和免疫调节治疗中Long COVID风险更高：一项基于美国国家数据的回顾性队列分析DOI: 10.1002/art.70361 Nutrition journal IF: 03.800Volume 25, Issue 1No.180Intake of ultra-processed foods in Sweden and its association with diet quality and weight status: cross-sectional analyses from three national dietary surveys瑞典超加工食品摄入及其与膳食质量和体重状况的关联：来自三项全国膳食调查的横断面分析DOI: 10.1186/s12937-026-01408-5 Dermatology and therapy IF: 04.200Ahead of Print.No.181Obesity and Early Biologic Failure in Psoriasis: An Italian Multicentre Retrospective Cohort Study肥胖与银屑病早期生物制剂治疗失败：一项意大利多中心回顾性队列研究DOI: 10.1007/s13555-026-01956-y J Gen Intern Med IF: 04.200Ahead of Print.No.182Self-Reported Obesity Medicine Competence, Knowledge, and Attitudes Among US Medical Students: An Eight-School Pre- vs. Post-Intervention Study美国医学生自我报告的肥胖医学能力、知识和态度：一项八所学校干预前后研究DOI: 10.1007/s11606-026-10913-6 Eur Arch Psychiatry Clin Neurosci IF: 03.700Ahead of Print.No.183Testing whether prolactin and glucose associations differ by sex检验催乳素与血糖的关联是否存在性别差异DOI: 10.1007/s00406-026-02406-8 Communications biology IF: 05.100Volume 9, Issue 1No.184KCNQ1 disruption alters human neuronal development through mitochondrial and insulin signalling pathwaysKCNQ1缺失通过线粒体和胰岛素信号通路改变人类神经元发育DOI: 10.1038/s42003-026-11111-0 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.185Reappraising the Role of GH/IGF-I Axis and β-Cell Failure: Insights From Two Genetic Syndromes重新评估GH/IGF-I轴与β细胞衰竭的作用：来自两种遗传综合征的启示DOI: 10.1111/dom.71386 Proteomics IF: 03.900Ahead of Print.No.186Meet the Editorial Team. An Interview With Prof David Greening, Associate Editor, Proteomics, Baker Heart and Diabetes Institute, Melbourne, Australia认识编辑团队：专访澳大利亚墨尔本贝克心脏与糖尿病研究所蛋白质组学副主编David Greening教授DOI: 10.1002/pmic.70191 Crit Rev Ther Drug Carrier Syst IF: 02.500Volume 43, Issue 3No.187Stimuli-Responsive Wound Management: A Focus on Innovative pH-Driven Healing Systems刺激响应性伤口管理：聚焦创新的pH驱动愈合系统DOI: 10.1615/CritRevTherDrugCarrierSyst.2026058031 Nepal J Ophthalmol IF: 00.200Volume 17, Issue 34No.188Corneal Endothelial Morphology in Type II Diabetic versus Non-Diabetic Individuals using Specular Microscopy使用镜面显微镜比较II型糖尿病患者与非糖尿病个体的角膜内皮形态DOI: 10.3126/nepjoph.v17i34.74598 Arthroscopy : IF: 05.400Ahead of Print.No.189Arthroscopic Bankart Repair Is Associated With Lower 90-Day Emergency Department Use Than Open Repair, With Smoking, Medicaid Insurance, and Depression as Additional Independent Predictors关节镜Bankart修复术相比开放修复术与更低的90天急诊使用相关，吸烟、Medicaid保险和抑郁是额外的独立预测因素DOI: 10.1002/arj.70639 Nepal J Ophthalmol IF: 00.200Volume 18, Issue 35No.190Severity of Primary Open Angle Glaucoma at First Presentation and Associated Factors in Tertiary Hospital三级医院中原发性开角型青光眼首次就诊时的严重程度及相关因素DOI: 10.3126/nepjoph.v18i35.82846 Egyptian Journal of ImmunologyVolume 33, Issue 4No.191Impact of probiotic supplementation on serum klotho levels and inflammatory status in patients with diabetic kidney disease补充益生菌对糖尿病肾病患者血清klotho水平及炎症状态的影响DOI: 10.55133/eji.330404 IUBMB life IF: 03.200Volume 78, Issue 10No.192The Receptor for Advanced Glycation End Products: Regulation and Implications in Metabolic Diseases晚期糖基化终产物受体：在代谢性疾病中的调控与意义DOI: 10.1002/iub.70137 Can J Public Health IF: 02.600Ahead of Print.No.193Self-reported impact of the sugar-sweetened beverage tax on consumer attitudes among adults in Newfoundland and Labrador: A comparison with other Canadian provinces in 2021 and 2022含糖饮料税对Newfoundland and Labrador成年人消费者态度自我报告影响的比较研究：2021年和2022年与加拿大其他省份的对比DOI: 10.17269/s41997-026-01259-x European journal of pediatrics IF: 02.600Volume 185, Issue 11No.194Exercise management in pediatric type 1 diabetes: a multicenter study of healthcare professionals' perspectives儿童1型糖尿病的运动管理：一项关于医疗保健专业人员观点的多中心研究DOI: 10.1007/s00431-026-07472-7 Prostate Cancer Prostatic Dis IF: 05.800Ahead of Print.No.195Fracture risk and fracture risk factor assessment among men at prostate cancer diagnosis前列腺癌诊断时男性的骨折风险及骨折风险因素评估DOI: 10.1038/s41391-026-01151-2 J Gen Intern Med IF: 04.200Ahead of Print.No.196Representation of the LGBTQIA+ Patient Community in Cardiovascular Disease Clinical GuidelinesLGBTQIA+患者群体在心血管疾病临床指南中的代表性DOI: 10.1007/s11606-026-10857-x Nepal J Ophthalmol IF: 00.200Volume 17, Issue 34No.197Real-world Outcomes and Predictors of Vision Loss after Panretinal Photocoagulation for Diabetic Retinopathy: Five-year Follow-up全视网膜光凝治疗糖尿病视网膜病变后的真实世界结局与视力丧失预测因素：五年随访DOI: 10.3126/nepjoph.v17i34.86992 Nepal J Ophthalmol IF: 00.200Volume 17, Issue 34No.198Awareness, Knowledge, and Practice on Retinal Diseases at High-altitude of Nepal尼泊尔高海拔地区视网膜疾病的意识、知识与实践DOI: 10.3126/nepjoph.v17i34.68246 Epidemiology and infection IF: 02.200Volume 154, Issue No.199Presence of post-COVID-19 condition in six ethnic groups in Amsterdam, the Netherlands: a retrospectively reconstructed time interval approach荷兰阿姆斯特丹六个族裔群体中COVID-19后状况的存在情况：一项回顾性重建时间间隔方法研究DOI: 10.1017/S095026882610199X Biomed Environ Sci IF: 04.100Volume 39, Issue 9No.200Long-term National Trends in the Prevalence of Type 2 Diabetes Mellitus and the Association with Social Determinants of Health in Korean Adults, 2007-20242007-2024年韩国成人2型糖尿病患病率的长期全国趋势及其与社会健康决定因素的关联DOI: 10.3967/bes2026.090 Toxicol Mech Methods IF: 02.700Ahead of Print.No.201Molecular Toxicological Mechanisms of Pharmaceutical Nitrosamines: DNA Damage, Metabolic Activation, Carcinogenesis, and Advanced Analytical Detection Strategies药物亚硝胺的分子毒理学机制：DNA损伤、代谢活化、致癌作用及先进分析检测策略DOI: 10.1080/15376516.2026.2749670 BMC pharmacology & toxicology IF: 02.700Volume 27, Issue 1No.202Correction to: In vitro comparative quality evaluation of different brands of metformin hydrochloride tablets available in Mekelle City, Tigray Regional State, Ethiopia更正：埃塞俄比亚提格雷州默克莱市市售不同品牌盐酸二甲双胍片的体外质量比较评价DOI: 10.1186/s40360-026-01202-3 Nepal J Ophthalmol IF: 00.200Volume 17, Issue 34No.203Evaluation of Optical Coherence Tomography Angiography Parameters following Intravitreal Ranibizumab Biosimilar in Diabetic Macular Oedema玻璃体腔注射雷珠单抗生物类似药治疗糖尿病性黄斑水肿后光学相干断层扫描血管成像参数的评估DOI: 10.3126/nepjoph.v17i34.69532 Nepal J Ophthalmol IF: 00.200Volume 18, Issue 35No.204Retinal Nerve Fibre Layer and Ganglion Cell Complex Thickness in Diabetes Mellitus without Diabetic Retinopathy无糖尿病视网膜病变的糖尿病患者视网膜神经纤维层和神经节细胞复合体厚度研究DOI: 10.3126/nepjoph.v18i35.75209 Nepal J Ophthalmol IF: 00.200Volume 18, Issue 35No.205Visual Outcomes of Ranibizumab Versus Bevacizumab in Diabetic Retinopathy: An Analytical Study雷珠单抗与贝伐珠单抗治疗糖尿病视网膜病变的视觉结局：一项分析性研究DOI: 10.3126/nepjoph.v18i35.82606 J Long Term Eff Med ImplantsVolume 36, Issue 2No.206Influence of Metabolic Syndrome on Peri-Implant Tissue Health and Disease: A Comparative Evaluation of Clinical, Radiographic, and Red Complex Microbiological Parameters代谢综合征对种植体周围组织健康与疾病的影响：临床、影像学和红色复合体微生物学参数的比较评估DOI: 10.1615/JLongTermEffMedImplants.2025061104 J Microbiol Biotechnol IF: 03.100Volume 36, Issue No.207Isolation and Characterization of Levilactobacillus brevis FBL-3 from Godeulppaegi Kimchi and Screening of Medium Components for γ-Aminobutyric Acid Production从Godeulppaegi Kimchi中分离鉴定Levilactobacillus brevis FBL-3及产γ-氨基丁酸培养基组分筛选DOI: 10.4014/jmb.2608.08011 BMC endocrine disorders IF: 03.300Volume 26, Issue 1No.208Levothyroxine dose requirements, oral bioavailability and gut microbiome enterotype dynamics during the early post-bariatric period: a single-centre, prospective, cohort study减重手术后早期左甲状腺素剂量需求、口服生物利用度及肠道微生物组肠型动态：一项单中心、前瞻性、队列研究DOI: 10.1186/s12902-026-02599-y J Long Term Eff Med ImplantsVolume 36, Issue 2No.209Harnessing the Therapeutic Potential of Locally Delivered 1% Metformin Gel for Modulation of Clinical and Inflammatory Parameters in Peri-Implantitis Disease: A Prospective Clinical Evaluation利用局部递送1%二甲双胍凝胶调节种植体周围炎临床和炎症参数的治疗潜力：一项前瞻性临床评估DOI: 10.1615/JLongTermEffMedImplants.2025062172 Chemistry & biodiversity IF: 02.500Volume 23, Issue 10No.210Bioactive Compounds and Antidiabetic Properties of Launaea mucronata Hydroethanolic Extract: Phytochemical and Pharmacological InsightsLaunaea mucronata 氢乙醇提取物的生物活性化合物与抗糖尿病特性：植物化学与药理学见解DOI: 10.1002/cbdv.71780 Acta neuropsychiatrica IF: 02.500Volume 38, Issue No.211Effects of glucagon-like peptide-1 (GLP-1) mono-agonists on reward processing in animal models: a systematic review胰高血糖素样肽-1（GLP-1）单激动剂对动物模型奖赏加工的影响：一项系统综述DOI: 10.1017/neu.2026.10097 Alzheimer's & dementia IF: 11.100Volume 22, Issue 10No.212Sphingolipid and ceramide associations with tau pathology vary across diverse ethnoracial groups in postmortem brain tissue死后脑组织中鞘脂和神经酰胺与tau病理的关联在不同种族群体中存在差异DOI: 10.1002/alz.71690 Expert Opin Pharmacother IF: 02.700Ahead of Print.No.213Pharmacotherapy for MASLD/MASH: approved therapies, drug repurposing, and emerging mechanism-based candidatesMASLD/MASH的药物治疗：已获批疗法、药物重定位及新兴机制候选药物DOI: 10.1080/14656566.2026.2749643 J Clin Endocrinol Metab IF: 05.100Ahead of Print.No.214Iopanoic Acid in Severe Thyrotoxicosis: Rediscovering an Effective Therapy碘番酸在严重甲状腺毒症中的应用：重新发现一种有效疗法DOI: 10.1210/clinem/dgag421 204 Diabetes Mellitus(DM) 糖尿病 95 Obesity 肥胖症 54 Insulin 胰岛素 29 Type 2 diabetes mellitus(T2DM) 2型糖尿病 16 Semaglutide 司美格鲁肽 15 Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA) 胰高血糖素样肽-1受体激动剂 12 Diabetic Retinopathy 糖尿病视网膜病 9 Metformin 二甲双胍 7 Tirzepatide 替尔泊肽 7 Metabolic Syndrome 代谢综合征 5 Liraglutide 利拉鲁肽 4 Type 1 diabetes mellitus(T1DM) 1型糖尿病 4 Hypoglycemic Agents 降糖药 4 Diabetic Foot 糖尿病足 4 Diabetes Complications 糖尿病并发症 3 Diabetic acidosis 糖尿病性酸中毒 3 Sotagliflozin 索格列净 3 Dapagliflozin 达格列净 3 Pregabalin 普瑞巴林 3 Diabetic Peripheral Neuropathy(PDN) 糖尿病周围神经病变 3 Gestational Diabetes Mellitus(GDM) 妊娠糖尿病 3 Dulaglutide 度拉糖肽 3 gamma-Aminobutyric Acid(GABA) γ-氨基丁酸 2 Exenatide 艾塞那肽 2 Gastrointestinal lipase inhibitor 胃肠道脂肪酶抑制剂 2 Orlistat 奥利司他 2 Empagliflozin 恩格列净 2 Sitagliptin 西他列汀 1 Diabetic Cardiomyopathies 糖尿病心肌病 1 Ertugliflozin 艾托格列净 1 Bexagliflozin 贝沙格列净 1 Canagliflozin 卡格列净 1 Alzheimer Disease and Diabetes Mellitus 阿尔茨海默病与糖尿病 1 Mazdutide 玛仕度肽 1 Orforglipron 奥氟格列隆 1 Diabetic Kidney Disease(DKD) 糖尿病肾脏病 1 Diabetic Neuropathies 糖尿病性神经病变 1 Dipeptidyl-Peptidase IV Inhibitors(DPP-4i) 二肽基肽酶-4抑制剂 1 Lixisenatide 利司那肽 1 Gabapentin 加巴喷丁编辑：韩玉莲审校：韩玉莲

临床结果

2026-10-15

·皮下递送观察

全球含rHuPH20皮下共制剂处方盘点——已上市单抗的辅料策略

前言 News Today 单抗等生物药正从静脉输注加速转向皮下注射，但皮下透明质酸屏障限制了大体积给药。重组人透明质酸酶（rHuPH20）可短暂降解皮下透明质酸，提高组织通透性，使大体积药物在数分钟内完成皮下递送。本文聚焦含rHuPH20的已上市皮下共制剂，系统梳理其处方组成与辅料策略，以期为生物制剂的皮下开发提供参考。 01 rHuPH20：平台化的皮下渗透增强剂 rHuPH20在皮下共制剂中展现出明显的“平台化”特征，表1总结了透明质酸酶辅助的皮下单克隆抗体（mAb）产品，列出了各产品（瓶装或预充式注射器）中mAb浓度和rHuPH20含量。数据表明，大多数皮下注射用单克隆抗体产品的 rHuPH20 浓度高度一致，均为2,000 U/mL，且可支持的抗体浓度范围较广（120–200 mg/mL）。单次给药时，高活性透明质酸酶可使大体积药物在数分钟内实现皮下递送 [1]。表1. 皮下注射mAb+ rHuPH20产品的剂量比较[1] rHuPH20能够暂时降解皮下空间中的透明质酸，显著增加组织通透性，允许给予更大体积的溶液，而不会影响患者舒适度或注射可行性。图1展示了使用rHuPH20的mAb给药体积与注射时间的关系趋势。如图所示，最大抗体剂量约1800 mg（15 mL， 120 mg/mL）在约8分钟内完成注射。总体而言，这些药物与rHuPH20组合的剂量（mg）、注射体积（mL）和注射时间（分钟）取决于装置构型和制剂黏度。图1. 使用rHuPH20的mAb注射时间和剂量体积比较[1] 02 皮下生物制剂的辅料策略分析高剂量生物制剂的皮下递送主要有三种策略：高浓度-小体积，低浓度-大体积，高浓度-大体积。历史上，高浓度-小体积因与预充式注射器、自动注射器等传统给药装置相容性良好而更受青睐；但近年来，趋势正日益转向高浓度-大体积配方。辅料的选择对于保障高浓度mAb制剂的稳定性、可制造性及可注射性至关重要，图2总结了蛋白浓度≥100 mg/mL 的商业化高浓度皮下生物制剂在开发过程中辅料策略的演变。图2. 高剂量皮下生物制剂辅料策略的演变 [1] 注：Histidine buffer：组氨酸缓冲剂；Citrate Buffer：柠檬酸盐缓冲剂；Acetate Buffer：醋酸盐缓冲剂；Phosphate Buffer：磷酸盐缓冲剂；Sucrose：蔗糖；Sorbitol：山梨醇；Mannitol：甘露醇；Trehalose：海藻糖；Histidine：组氨酸；Arginine：精氨酸；Proline：脯氨酸；Methionine：甲硫氨酸；Glycine：甘氨酸；Polysorbate 80：聚山梨酯80；Polysorbate 20：聚山梨酯20；Poloxamer 188：泊洛沙姆188 缓冲剂组氨酸已成为皮下生物制剂最常用的缓冲剂，其次是醋酸盐缓冲剂。组氨酸在pH 5.5–6.5范围内提供有效的缓冲能力，该范围对大多数mAb的稳定性最为理想。同时，它能稳定蛋白质并抑制聚集，取代了早期简单的磷酸盐体系——后者缓冲效果较差或在某些高浓度条件下存在更高的沉淀风险；市售产品数据也证实了这一点：在38种处方中，组氨酸使用频率最高，pH主要集中在5.0–6.9 [1]。柠檬酸盐因可能增加注射痛，不作为优选缓冲体系 [2]。黏度调节剂黏度升高会增加蛋白质聚集风险，并限制其通过常用细口径针头进行注射。为应对这一局限，通常采用精氨酸、氯化钠等辅料降黏。精氨酸作为蛋白质-蛋白质相互作用的调节剂，可屏蔽或削弱导致黏度升高的单克隆抗体分子间的吸引力。精氨酸最早用于奥马珠单抗制剂，后也用于贝利尤单抗、萨特利珠单抗等高浓度制剂 [1]。稳定剂蔗糖因非还原性、高溶解度以及稳定性能优异，成为常用的稳定剂之一，尤其适用于液体制剂，如阿利西尤单抗、美泊利珠单抗和度普利尤单抗；同时，它也是常用的渗透压调节剂[1]。此外，海藻糖作为稳定剂在已上市产品中占比也较高 [2]。表面活性剂聚山梨酯80较常用，如用于戈利木单抗、依洛尤单抗、美泊利珠单抗，但人们担心其可能降解产生过氧化物，进而氧化敏感的单克隆抗体残基，因此制剂开发者转向使用聚山梨酯20，后者已被用于奥马珠单抗、阿利西尤单抗、布罗达鲁单抗和沙利鲁单抗。此外，泊洛沙姆188在防止振荡诱导聚集方面表现优异，正日益被视为生物制药配方中有价值的替代选择 [1]。等渗调节剂等渗调节剂被选择性地用于确保生理相容性，如山梨醇和氯化钠，渗透压的调整对于保证制剂稳定性、可注射性和患者舒适度至关重要。蔗糖是最常用的等渗调节剂，见于52.8%的产品中；精氨酸在某些配方中可能发挥双重作用，它既作为降低黏度的成分，又作为调节渗透压的物质 [1]。设备兼容性在现代生物药开发中，辅料策略必须考虑与初级包装的相容性。聚山梨酯等表面活性剂可防止蛋白质吸附至注射器材料，并降低其与PFS和AI中硅油相互作用而引发聚集的风险。此外，需严格控制制剂pH和离子强度，以避免玻璃注射器中的微量元素（如钨）浸出，导致药物不稳定。因此，组氨酸、精氨酸等辅料不仅因其稳定特性受到重视，也因其能保障药械组合产品的长期安全性 [1]。 03 已上市含rHuPH20皮下共制剂处方实例表2汇总了含rHuPH20皮下共制剂的处方组成。这些制剂大多采用组氨酸盐缓冲体系；稳定剂方面，L-甲硫氨酸为标配，并添加海藻糖或蔗糖。L-甲硫氨酸几乎出现于所有已批准的rHuPH20共制剂中，提示其对维持rHuPH20稳定性具有重要价值 [2]。 rHuPH20与多种辅料相容性良好，包括氨基酸（L-组氨酸、L-甲硫氨酸、L-精氨酸）、糖和多元醇（海藻糖、山梨醇、蔗糖）、表面活性剂（聚山梨酯20、聚山梨酯80）及缓冲剂（组氨酸盐、醋酸盐）。表2. 含rHuPH20皮下共制剂的处方组成（根据说明书及公开资料整理） 04 总结含rHuPH20的皮下共制剂中，rHuPH20通常以2000 U/mL为平台浓度，采用组氨酸缓冲体系，以L-甲硫氨酸为稳定剂，并加入糖/多元醇和表面活性剂，实现大体积、高剂量mAb的皮下递送；其处方兼顾稳定性、可注射性与药械兼容性，可为生物制剂皮下开发提供参考。 [ END ] . REF: [1] Ghosh, Indrajit, et al. “Subcutaneous Drug Delivery of High Concentration Antibody Products - Part 2: Formulation, Device Options, and Clinical Bridging Strategies for Patient-Centric Commercial Presentations.” mAbs, vol. 18, no. 1, Dec. 2026, p. 2680773, https://doi.org/10.1080/19420862.2026.2680773. [2] Guo, Jeremy, et al. “An Industry Perspective on Hyaluronidase Co-Formulated Biopharmaceutics.” Journal of Controlled Release : Official Journal of the Controlled Release Society, vol. 381, May 2025, p. 113573, https://doi.org/10.1016/j.jconrel.2025.02.069. 免责声明本文内容系基于公开资料与学术文献的整理汇总，作者仅为信息传播之目的进行客观陈述，不保证所涉信息（包括但不限于数据、结论、预测）的绝对准确、完整或最新，亦不对因依赖本文信息而引发的任何直接或间接损失承担责任。本文仅供专业人员参考学习，文中提及的技术路线及产品信息仅为学术性介绍，不构成任何商业推荐、用药建议、临床决策依据或投资建议，亦不构成对任何公司证券的购买邀约或邀请。本文可能包含前瞻性陈述（包括但不限于对业务战略、未来运营、研发进展、临床试验结果、商业化前景及财务表现等方面的描述），此类陈述系作者基于当前预期、假设与预测作出，涉及已知及未知的风险及不确定性，实际结果可能与前瞻性陈述所明示或暗示的结果存在重大差异。基于上述原因，作者不承担更新或修订任何前瞻性陈述的义务。文中引用的图表/原文版权归原文献作者所有，如有侵权内容，请联系删除。

100 项与盐酸L-精氨酸相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D01126	盐酸L-精氨酸	V04CD	DB00125

研发状态

批准上市

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
高氨血症	日本	Yoshindo, Inc.	1999-09-22
高氨血症	日本	AY Pharmaceuticals Co Ltd.	1999-09-22
垂体性侏儒症	美国	Pharmacia & Upjohn, Inc.	1973-02-28

未上市

10 条进展最快的记录,

后查看更多信息

适应症	最高研发状态	国家/地区	公司	日期
1型糖尿病	临床阶段不明	美国	Pfizer Inc.	2005-12-01
2型糖尿病	临床阶段不明	美国	Pfizer Inc.	2005-12-01

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT04839354 (Pubmed \| JAMA)	临床3期	镰状细胞血症	271	Arginine	積糧淵網鬱製製鏇醖構(憲遞製構憲網鏇膚築齋) = 構淵襯襯簾窪壓簾淵窪獵製網願網餘糧廠積淵 (獵憲醖艱鹽網繭艱壓鏇, 34.8 ~ 109.0)	不佳	2026-10-13
				Placebo	積糧淵網鬱製製鏇醖構(憲遞製構憲網鏇膚築齋) = 齋憲憲衊範積淵鹽夢獵獵製網願網餘糧廠積淵 (獵憲醖艱鹽網繭艱壓鏇, 31.1 ~ 111.1)
NCT02447874 \| NCT02536170 (Pubmed \| Pediatr Blood Cancer)	N/A	镰状细胞血症 Secretory phospholipase A 2	105	Arginine therapy	鑰糧鹽簾衊衊願鑰糧艱(窪鑰醖製製鏇廠鹹鬱遞) = 範淵製衊膚鏇壓網繭糧繭鏇淵齋糧構窪膚齋鬱 (窪糧製鹹蓋憲鑰網糧夢 ) 更多	积极	2026-10-01
				Placebo	鑰糧鹽簾衊衊願鑰糧艱(窪鑰醖製製鏇廠鹹鬱遞) = 觸淵製繭壓鹹餘艱齋選繭鏇淵齋糧構窪膚齋鬱 (窪糧製鹹蓋憲鑰網糧夢 ) 更多
NCT04839354 (STArT, ASH2025)	临床3期	镰状细胞血症	271	Arginine	範餘選蓋膚簾鑰衊膚餘(鬱鬱簾鏇構餘壓鑰鏇獵) = 鬱構築鏇顧網膚襯糧窪艱鹽膚鹽衊鑰衊觸壓鹽 (顧憲鹽製築淵淵獵顧廠, 80.0) 更多	不佳	2025-12-06
				Placebo	範餘選蓋膚簾鑰衊膚餘(鬱鬱簾鏇構餘壓鑰鏇獵) = 蓋築網簾鬱襯願繭窪鏇艱鹽膚鹽衊鑰衊觸壓鹽 (顧憲鹽製築淵淵獵顧廠, 152.0) 更多
NCT04839354 (STArT, CTgov)	临床3期	镰状细胞血症	271	L-Arginine Hydrochloride (L-Arginine Hydrochloride)	淵襯醖鏇醖鏇醖鏇齋膚(衊壓蓋遞廠衊範淵夢餘) = 顧壓鑰淵廠淵遞範餘壓遞糧積醖壓艱網蓋憲鬱 (夢構製製願襯衊鬱鏇構, 79.6) 更多	-	2025-07-30
				Normal saline (Placebo)	淵襯醖鏇醖鏇醖鏇齋膚(衊壓蓋遞廠衊範淵夢餘) = 醖壓築積繭壓鏇餘齋淵遞糧積醖壓艱網蓋憲鬱 (夢構製製願襯衊鬱鏇構, 152.2) 更多
NCT01607879 (CTgov)	临床2期	前列腺癌 \| 局限性前列腺癌 \| 前列腺腺癌	48	Standard of care ADT + (HMB + arginine + glutamine) (Standard of Care ADT + (HMB + AG))	構鹹範鏇蓋鹹遞膚觸網(窪艱艱願蓋鏇獵獵觸壓) = 顧積鑰餘衊鹽醖繭網襯淵壓餘築獵糧襯壓觸願 (壓齋鏇廠築遞觸築積窪, 8.66) 更多	-	2023-09-22
				Standard of care ADT (Standard of Care ADT)	構鹹範鏇蓋鹹遞膚觸網(窪艱艱願蓋鏇獵獵觸壓) = 醖製膚鹹糧願襯積餘襯淵壓餘築獵糧襯壓觸願 (壓齋鏇廠築遞觸築積窪, 7.39) 更多
NCT01105130 (CTgov)	临床2期	毒性 \| 前列腺癌 \| 勃起功能障碍	140	Placebo (Arm I - Placebo)	選製憲鏇蓋製鹹蓋鑰鹹(憲糧憲夢壓壓積繭艱夢) = 鹽衊網鹹醖鹽膚製衊遞鬱蓋餘願鹽簾襯網蓋築 (窪窪齋憲顧壓壓齋襯衊, 1.09) 更多	-	2015-07-21
				Placebo+Oral L-Arginine (Arm II - Low Dose)	選製憲鏇蓋製鹹蓋鑰鹹(憲糧憲夢壓壓積繭艱夢) = 獵襯醖壓顧窪鬱醖網醖鬱蓋餘願鹽簾襯網蓋築 (窪窪齋憲顧壓壓齋襯衊, 1.13) 更多
NCT00345605 (CTgov)	临床2期	精氨基琥珀酸尿	12	Arginine+Buphenyl (Low-dose Arginine Plus Buphenyl)	壓夢襯鬱齋簾願獵選餘(憲壓夢艱鏇艱遞衊遞襯) = 鹹獵艱廠壓簾淵窪觸繭蓋膚繭選選製範衊鬱鑰 (選獵艱鑰鏇艱壓顧膚糧, 10.9) 更多	-	2014-11-05
				Arginine (High Dose Arginine Alone)	壓夢襯鬱齋簾願獵選餘(憲壓夢艱鏇艱遞衊遞襯) = 鹹鬱壓製襯糧糧鏇襯糧蓋膚繭選選製範衊鬱鑰 (選獵艱鑰鏇艱壓顧膚糧, 15.7) 更多
NCT00513617 (Arginine, CTgov)	临床2期	镰状细胞血症	128	Arginine (Low Dose)	淵壓廠範艱衊膚鹽鏇鹽(鏇觸壓觸築鹹製艱築構) = 製淵獵衊夢膚鬱築淵衊構願壓獵鏇鑰網鹽顧壓 (遞壓衊憲獵艱製網蓋艱, 0.2341) 更多	-	2009-08-04
				Arginine (High Dose)	淵壓廠範艱衊膚鹽鏇鹽(鏇觸壓觸築鹹製艱築構) = 網蓋顧選淵艱夢齋顧顧構願壓獵鏇鑰網鹽顧壓 (遞壓衊憲獵艱製網蓋艱, 0.3028) 更多
ASCO2008	临床2期	黑色素瘤	22	ADI-PEG20	襯網鑰願廠遞襯觸顧壓(壓選觸積製蓋構艱願夢) = 獵衊廠選憲遞鬱齋蓋蓋願鬱願襯壓鬱顧憲蓋遞 (遞積積襯製鑰夢鬱襯鏇 )	-	2008-05-20