Aspergilol I(Aspergilol I) - 药物靶点：细菌群体感应蛋白_专利_临床

概要

基本信息

药物类型

小分子化药

别名-

靶点

细菌群体感应蛋白

作用方式

抑制剂

作用机制

细菌群体感应蛋白抑制剂

治疗领域-

在研适应症-

非在研适应症-

原研机构

在研机构

非在研机构-

权益机构-

最高研发阶段药物发现

首次获批日期-

最高研发阶段(中国)药物发现

特殊审评-

关联

100 项与 Aspergilol I 相关的临床结果

登录后查看更多信息

100 项与 Aspergilol I 相关的转化医学

登录后查看更多信息

100 项与 Aspergilol I 相关的专利（医药）

登录后查看更多信息

1

项与 Aspergilol I 相关的文献（医药）

NATURAL PRODUCT RESEARCH

Ganodermanic acid, a new steroidal compound derived from the marine fungus Aspergillu s sp. ZJUT223

Article

作者: Yang, Si ; Shan, Weiguang ; Zhan, Shijie ; Wang, Rong ; Lin, Yuhao ; Chen, Xiaoxiao ; Ying, Youmin ; Liu, Jinli

A new steroid ganodermanic acid (1) and seventeen known compounds 2-18 were isolated from the marine fungus Aspergillus sp. ZJUT223. Extensive spectroscopic data (1D/2D NMR and HR-ESI-MS) established the planar structure of 1. Its stereochemistry was assigned using NOESY, density functional theory (DFT)-calculated NMR with DP4+ analysis, and calculated electrical circular dichroism (ECD). In the quorum sensing (QS) inhibition assay, aspergilol I (17) dose-dependently inhibited violacein production in Chromobacterium violaceum CV026, suggesting that it interfered with quorum sensing signalling in this reporter strain. This is the first report of aspergilol I (17) as a potential quorum sensing inhibitor.

100 项与 Aspergilol I 相关的药物交易

登录后查看更多信息