更新于：2024-11-01

Droperidol/Fentanyl Citrate

氟哌利多/芬太尼

更新于：2024-11-01

概要

概要

基本信息

药物类型

小分子化药

别名

Innovar

靶点

D2 receptor x μ opioid receptor

作用机制

D2 receptor拮抗剂(多巴胺D2受体拮抗剂)、μ opioid receptor激动剂(μ-阿片受体激动剂)

治疗领域-

在研适应症-

非在研适应症-

原研机构

Akorn Operating Co. LLC

在研机构-

非在研机构

Akorn Operating Co. LLC

最高研发阶段撤市

首次获批日期

美国 (1982-01-01)

最高研发阶段(中国)-

特殊审评-

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结构

分子式C28H36N2O8

InChIKeyIVLVTNPOHDFFCJ-UHFFFAOYSA-N

CAS号990-73-8

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关联

100 项与氟哌利多/芬太尼相关的临床结果

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100 项与氟哌利多/芬太尼相关的转化医学

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100 项与氟哌利多/芬太尼相关的专利（医药）

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106

项与氟哌利多/芬太尼相关的文献（医药）

2011-04-01·Zhongguo zhen jiu = Chinese acupuncture & moxibustion

[Effects of magnetic auricular point-sticking on adjuvant anesthesia and postoperative recovery of body function].

Article

作者: Wanlai, Si-qi ; Li, Wan-yao ; Cui, Song-sheng ; Zhao, Wei-xian ; Li, Wan-shan

OBJECTIVETo prove analgesia and sedative effect of adjuvant anesthesia with magnetic auricular point-sticking on abdominal gynecological operation and its effect on postoperative recovery of body function.METHODSNinety-two patients with abdominal gynecological operation were randomly divided into 3 groups. The auricular point-sticking group (APS group, n=31) was pasted and pressed by plasters with magnetic beads at bilateral Shenmen, Pizhixia (subcortex), Zigong (uterus) and Penqiang (pelvic cavity), etc. the night before operation. The placebo group (n=31) was pasted by plasters without magnetic beads. The blank group (n=30) was given no intervention. The mental and gastrointestinal functional changes before and 3 days after the operation were observed.RESULTSAs compared with those in the control group and the blank group, the postoperative score of Self rating Anxiety Scale (SAS) was less (25.5 +/- 0.81 vs. 28.9 +/- 3.19, 28.3 +/- 2.36, both P < 0.01), with lower-dose of Innovar [(2.5 + 1.1) mL vs. (3.4 + 1.8) mL, (3.2 + 1.6) mL, both P < 0.05], earlier exsufflation after the operation [(34.2 + 12.1) h vs. (46.3 + 10.9) h, (43.2 + 14.8) h, both P < 0.01] and higher level serum of beta-endorphin before and after the operation in the APS group (all P < 0.05).CONCLUSIONThe magnetic auricular point-sticking has sedative, analgesic and function-regulating effects on the abdominal gynecological operation.

1999-01-01·Acta Oto-Laryngologica4区 · 医学

Innovar Treatment for Meniere's Disease

4区 · 医学

Article

作者: Gates, G A

Patients with intractable vertigo due to clinical Meniere's disease were offered treatment with Innovar, a neurolept analgesic. The patients were from a single clinical practice, had failed conventional dietary and medical treatment and were eligible on clinical grounds for endolymphatic sac surgery. After a follow-up of 2-8 years, 58% of patients had long-lasting relief of vertigo. Hearing was not affected. Risk factors for a favorable response were male gender, fluctuating hearing, and early stage of the disorder. Innovar is a safe, cost-effective second-line therapy for patients with Meniere's disease who have failed conventional first-line medical therapy.

1991-02-01·Acta Anaesthesiologica Scandinavica4区 · 医学

Hemodynamic and catecholamine response to isoflurane versus droperidol in complement to fentanyl anaesthesia

4区 · 医学

Article

作者: K. McGee ; J. L. Bourgain ; E. Comoy ; J. Truffa‐Bachi ; F. Tandonnet

Droperidol (0.03 mg X kg‐1 to 0.25 mg X kg‐1) with fentanyl has been reported to be less efficient than volatile agents in the prevention of haemodynamic responses to surgery. The aim of this study was to investigate the use of high‐dose droperidol in complement to fentanyl in comparison with isoflurane and fentanyl anaesthesia. Thirty patients undergoing laryngectomy were studied. Systolic blood pressure (SBP), heart rate (HR) and plasma catecholamines were analysed both during anaesthesia and during recovery. During surgery, SBP epinephrine (E) levels did not change in either group. HR was slightly lower during droperidol fentanyl anaesthesia. Norepinephrine (NE) levels were significantly higher in the droperidol group than in the isoflurane group (P <0.05). During recovery, in both groups, SBP increased by 20% whereas E levels increased by 65%. NE levels increased post‐operatively in both groups, but this rise was significantly higher in the droperidol group (P <0.01). It is concluded that the two techniques contribute to the haemodynamic stability during surgery, but do not prevent haemodynamic instability during recovery.

100 项与氟哌利多/芬太尼相关的药物交易

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