Our study is the first to use genipin, a naturally occurring collagen cross-linking agent, as a therapeutic agent to treat superficial digital flexor tendon (SDFT) injuries in horses. The promising approach of intratendinous genipin injection and tendon mechanical enhancement could be a viable alternative to current therapies for SDFT injuries.

开始日期2016-06-28

申办/合作机构

University of Zurich

100 项与京尼平相关的临床结果

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100 项与京尼平相关的转化医学

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100 项与京尼平相关的专利（医药）

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项与京尼平相关的文献（医药）

2024-12-01·International Journal of Biological Macromolecules

Genipin-crosslinked hydrogels for food and biomedical applications: A scientometric review

Review

作者: Wang, Jing-Wen ; Tao, Xing-Ru ; Hui, Yu-Yu ; Zhao, Mei-Na ; Xu, Dong ; Gao, Kai ; Zhang, Wei

Genipin, a precursor of dietary blue pigment, is a promising alternative for industrial applications in food and health. Due to its ability to simultaneously satisfy biosafety requirements and provide crosslinking effects, genipin has attracted considerable attention for food and biomedical applications. In this review, we attempt to shed light on the progress in genipin research using scientometrics. Based on this scientometric discovery, we reviewed the use of genipin-crosslinked films for fruit packaging in food science. Genipin-crosslinked hydrogels used for drug delivery include natural, chemical, and protein delivery systems. Genipin-crosslinked hydrogels for tissue engineering primarily include materials used for tissue regeneration and repair. Genipin-crosslinked hydrogels are used in wound dressings and wound closure. This review provides a scientometric perspective to facilitate future research and development of genipin for food science, drug delivery, tissue engineering, and wound healing.

2024-11-01·International Journal of Biological Macromolecules

A multifunctional polyacrylonitrile fibers/alginate-based hydrogel loaded with chamomile extract and silver sulfadiazine for full-thickness wound healing

Article

作者: Najmoddin, Najmeh ; Moshfeghi, Tahereh ; Hosseinzadeh, Leila ; Arkan, Elham

Most conventional wound dressings do not meet the clinical requisites owing to their limited multifunctionality. Herein, a bilayer wound dressing containing both hydrogel and fibrous structures with multifunctional features was developed for effective skin rehabilitation. Sodium alginate (SA)/gelatin (Gel) hydrogel comprising Matricaria chamomilla L extract and silver sulfadiazine (AgSD) drug as antibacterial agents was cross-linked using genipin and CaCl₂. Then, the surface of the hydrogel was covered by electrospun polyacrylonitrile (PAN) nanofibers to fabricate a bilayer dressing. FESEM images revealed formation of continuous, smooth, and bead-free PAN nanofibers with excellent compatibility between hydrogel and fibers. The bilayer wound dressing exhibited satisfactory mechanical virtues including elastic modulus (2.4 ± 0.2 MPa), tensile strength (6.2 ± 0.5 MPa) and elongation at break (21.8 ± 1 %) as well as suitable swelling ratio. Such bilayer dressing revealed biodegradability, cytocompatibility and effective antibacterial performance against gram positive and gram negative strains. Release kinetics of AgSD drug followed a Fickian diffusion mechanism, ensuring sustained drug release. In vivo studies demonstrated bilayer dressing could promote rate of wound closure, re-epithelialization and collagen deposition, facilitating the replacement of damaged skin with healthy tissue. Such engineered wound dressing has a high potency for inducing skin repair and could be used in skin tissue engineering.

2024-11-01·Food and Chemical Toxicology

Limited uptake of [14C]Gardenia Blue administered orally in male and female rats and mice.

Article

作者: Hayashi, Shim-Mo ; Hayashi, Shim-mo ; Ishibashi, Ryo ; Fennell, Timothy R ; Black, Sherry R. ; Elkins, Phyllis ; Snyder, Rodney ; Koyanagi, Mihoko ; Black, Sherry R ; Fennell, Timothy R.

Gardenia blue (GB), a widely used plant-derived food color is prepared by reaction of genipin, the aglycone of geniposide, with protein hydrolysate. Recent animal studies investigating GB toxicity have indicated blue coloration in the gastrointestinal tract, kidneys and mesenteric lymph nodes in rodents following dietary administration. This study investigated the uptake and disposition of [¹⁴C]GB in male and female rats and mice administered 100 or 1000 mg/kg by gavage. [¹⁴C]GB was prepared by reaction of [2-¹⁴C]genipin with soy protein hydrolysate. Following administration in rats, ¹⁴C was eliminated primarily in feces (89-97% of administered dose), exhaled volatile organic chemical (VOC) and CO₂ traps contained no radioactivity, and urine contained 0.2-0.4 %. In bile-duct-cannulated rats (100 mg/kg [¹⁴C]GB), 0.25% of dose was recovered in bile, and in urine, 0.5%. The percent of the dose absorbed was 0.9%, based on radioactivity in urine, bile, and carcass minus digestive tract contents. The highest level of radioactivity in tissues was in kidney; however renal recovery was low, with only 0.02-0.04% of the dose recovered in kidney. Repeated dosing indicated that ¹⁴C accumulated in kidney, and was slowly removed following cessation of dosing, consistent with previous studies, in the absence of any functional or histopathological changes.

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适应症	最高研发状态	国家/地区	公司	日期
肌腱损伤	临床3期	瑞士	University of Zurich	2016-06-28

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


SNMMI2015	N/A	-	-	Metformin	糧廠鏇夢鏇遞網糧蓋壓(簾築繭餘顧獵願鏇簾齋) = 淵齋鹹顧鑰醖壓簾鏇繭鹹範願選網餘觸齋淵鏇 (鹹壓艱壓顧觸構選範壓 ) 更多	-	2015-05-15
				Genipin	遞積構範製淵獵窪淵網(築襯構鑰齋夢窪襯衊糧) = 顧構醖齋鑰鑰艱窪鹹觸繭糧齋網選餘顧遞艱構 (鹹築醖蓋鑰鹽夢艱觸襯, 9.8) 更多