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更新于：2025-03-06
Metformin Hydrochloride
盐酸二甲双胍
更新于：2025-03-06
概要
基本信息
简介盐酸二甲双胍，商品名为GLUCOPHAGE，用于治疗2型糖尿病。它于1957年在法国首次获批，现在由Bristol Myers Squibb公司生产。GLUCOPHAGE通过激活PRKAB1，帮助改善10岁及以上成人和儿童患者的血糖控制，配合饮食和运动使用。该药物属于双胍类药物，通常用作辅助疗法，帮助管理2型糖尿病患者的血糖水平。 |
药物类型 小分子化药 |
别名 Meiformin Hydrochloride、Metformin hydrochloride (JP17/USP)、Metformin Hydrochlorride + [67] |
靶点 |
作用机制 PRKAB1激活剂(腺苷酸活化蛋白激酶亚基β1激活剂) |
非在研适应症 |
最高研发阶段批准上市 |
首次获批日期 中国 (1992-01-01), |
最高研发阶段(中国)批准上市 |
特殊审评优先审评 (中国) |
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结构/序列
分子式C4H12ClN5 |
InChIKeyOETHQSJEHLVLGH-UHFFFAOYSA-N |
CAS号1115-70-4 |
关联
1,835
项与 盐酸二甲双胍 相关的临床试验NCT05910554
Investigation of the Efficacy of Metformin Therapy on Pulmonary Sarcoidosis Phase II Randomized, Double-blind, Placebo-controlled Trial
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Efficacy and safety of Curcuma longa either alone or in combination with metformin on glycemic status in prediabetes population: A Randomized, double-blinded, double-dummy, placebo-controlled, factorial design trial - NIL
NCT04836910
The Change in Microbiome Following Treatment of Women With Polycystic Ovaries
100 项与 盐酸二甲双胍 相关的临床结果
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100 项与 盐酸二甲双胍 相关的转化医学
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100 项与 盐酸二甲双胍 相关的专利（医药）
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28,452
项与 盐酸二甲双胍 相关的文献（医药）2025-12-25Oriental Journal of Chemistry
Quantitative UV-Spectrophotometric Method for the Analysis of Teneligliptin HBr and Metformin HCl in Pharmaceutical Dosage form: Development and Validation
作者: Gahtori, Archana ; Khanduri, Praveen
This study developed a UV-spectrophotometric method for the simultaneous quantification of Metformin HCl and Teneligliptin HBr. Both active pharmaceutical ingredients were found to be soluble in 0.1N sulfuric acid, which was thus chosen as the solvent for analysis. The maximum absorption wavelengths for Metformin HCl and Teneligliptin HBr were identified at 220 nm and 240 nm, respectively. Standard stock solutions were prepared, and samples from commercially available tablets were accurately measured and dissolved for testing. Method validation included evaluations of linearity, precision (intra-day and inter-day), accuracy, robustness, as well as detection (LOD) and quantification limits (LOQ). The method exhibited strong precision and accuracy, with %RSD values less than 2%. Both LOD and LOQ demonstrated sufficient sensitivity, and the method proved effective for analyzing commercial formulations, achieving compliance levels of 99.20% for Metformin and 102.00% for Teneligliptin.
2025-06-01BIOMATERIALS
Magnesium peroxide-based biomimetic nanoigniter degrades extracellular matrix to awake T cell-mediated cancer immunotherapy
Article
作者: Fang, Yixuan ; Fu, Yanan ; Peng, Zhangwen ; Yi, Yunfei ; Tang, Jia ; Wang, Tianqi ; Hao, Huisong ; Sun, Shengjie ; Wu, Meiying ; Wen, Yingfei ; Wen, Simin
As the elite force of our immune system, T cells play a determining role in the effectiveness of cancer immunotherapy. However, the clever tumor cells construct a strong immunosuppressive tumor microenvironment (TME) fortress to resist the attack of T cells. Herein, a magnesium peroxide (MP)-based biomimetic nanoigniter loaded with doxorubicin (DOX) and metformin (MET) is rationally designed (D/M-MP@LM) to awake T cell-mediated cancer immunotherapy via comprehensively destroying the strong TME fortress. The nanoigniter not only effectively initiate CD8+ T cell-mediated immune response by promoting the presentation of tumor antigens, but also greatly facilitate the infiltration of T cells by degrading rigid extracellular matrix (ECM). More importantly, the nanoigniter significantly augment the effector functions of infiltrated CD8+ T cells by Mg2+-mediated metalloimmunotherapy and avoid the exhaustion of CD8+ T cells by improving the acidic TME. Thus, the nanoigniter comprehensively awakes T cells and achieves remarkable tumor inhibition efficacy.
2025-04-13ANALYTICAL LETTERS
Influence of the Capillary Design and Conditions upon the Transmission Efficiency of a Portable Ion Trap Mass Spectrometer
作者: Hong, Huanhuan ; Chen, La ; Wen, Luhong ; Li, Gangqiang ; Kuang, Lvying ; Huang, Zhixiang
The capillary is a widely used atm. pressure interface in mass spectrometers that may be heated to enhance the desolvation of ions.In this study, the ion transmission efficiency of a portable ion trap mass spectrometer was investigated using capillaries with different inner diameters and temperatures, different vacuum pressures, and different ion optics designs.Due to the incomplete desolvation and the space charge effect inside the miniature ion funnel, the increase of ion intensities with the inner diameter of the capillary leveled off when the inner diameter of the capillary was larger than 0.37 mm.With the increase of capillary temperature, the ion intensities first increase due to better desolvation and then decrease due to greater diffusion loss.The optimal temperature of the capillary increases with the inner diameter of the capillary and the mass-to-charge ratio of ion.In addition, the pressures of different vacuum stages also exerted remarkable effects on the sensitivity of the portable mass spectrometer.From the perspective of instrument miniaturization, optimal transmission efficiency can be obtained when the first-stage vacuum pressure is maintained from 4 to 6 mbar.For a capillary with an inner diameter of 0.37 mm, the background of mass spectrum can be significantly reduced by replacing the pinhole behind the ion funnel with an off-axis skimmer.
研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 糖尿病 | 美国 | 2004-04-27 | |
| 2型糖尿病 | 中国 | 1992-01-01 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 浸润性乳腺癌 | 临床3期 | 美国 | 2024-12-16 | |
| 慢性病 | 临床3期 | 美国 | 2020-07-29 | |
| 胰岛素抵抗 | 临床3期 | 美国 | 2020-07-29 | |
| 获得性免疫缺陷综合征 | 临床3期 | 美国 | 2019-02-01 | |
| 非典型增生 | 临床3期 | 美国 | 2015-11-23 | |
| 乳腺增生 | 临床3期 | 美国 | 2015-11-23 | |
| 非浸润性导管内癌 | 临床3期 | 美国 | 2015-11-23 | |
| 子宫内膜透明细胞癌 | 临床3期 | 美国 | 2014-03-17 | |
| 子宫内膜未分化癌 | 临床3期 | 美国 | 2014-03-17 | |
| 复发性子宫内膜癌 | 临床3期 | 美国 | 2014-03-17 |
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临床结果
临床结果
适应症
分期
评价
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临床2期 | 23 | (High Dose Metformin) | 繭築壓衊艱願選膚網壓(積願積窪鹽簾廠齋選淵) = 觸積觸鏇鏇繭壓醖憲鹽 襯壓鬱遞鏇蓋衊廠醖襯 (構艱獵糧範壓鬱選範糧, 襯醖獵構製蓋鏇網廠顧 ~ 憲膚簾選遞構獵鹹艱築) 更多 | - | 2025-02-21 | ||
(Low Dose Metformin) | 繭築壓衊艱願選膚網壓(積願積窪鹽簾廠齋選淵) = 範製憲構獵糧獵齋憲夢 襯壓鬱遞鏇蓋衊廠醖襯 (構艱獵糧範壓鬱選範糧, 鑰積範廠襯齋觸膚觸醖 ~ 構餘壓鏇構構鹽構衊願) 更多 | ||||||
临床2期 | 14 | (Treatment Group) | 憲餘網衊窪餘糧餘襯繭(夢願鑰衊鹹積鏇繭餘鏇) = 構壓遞鹹襯鏇選積鬱壓 築齋膚糧鏇遞遞選衊繭 (齋廠鏇築築蓋淵淵製遞, 簾夢襯網齋積艱夢齋憲 ~ 壓壓築積鏇窪繭鏇顧構) 更多 | - | 2025-02-18 | ||
Placebo (Placebo Group) | 憲餘網衊窪餘糧餘襯繭(夢願鑰衊鹹積鏇繭餘鏇) = 餘糧糧衊壓範願網壓廠 築齋膚糧鏇遞遞選衊繭 (齋廠鏇築築蓋淵淵製遞, 簾鬱製襯餘憲網遞鏇餘 ~ 鏇夢繭繭壓網築衊鏇選) 更多 | ||||||
临床2期 | 41 | (Metformin Only) | 襯襯鏇衊糧選鹽膚鏇獵(顧衊衊顧壓築鹹鹽鹹窪) = 網觸窪範鏇選遞夢鹽鹽 鏇鹹廠齋範鹹蓋鏇醖糧 (醖獵醖窪蓋遞鑰憲獵壓, 膚選蓋壓願範積構鬱襯 ~ 觸築築簾餘鏇簾製廠築) 更多 | - | 2025-02-03 | ||
OPC (OPC Only) | 襯襯鏇衊糧選鹽膚鏇獵(顧衊衊顧壓築鹹鹽鹹窪) = 積範築獵醖艱憲餘鹽選 鏇鹹廠齋範鹹蓋鏇醖糧 (醖獵醖窪蓋遞鑰憲獵壓, 廠選選窪願鹽襯觸鏇顧 ~ 範範選鬱襯願膚壓製窪) 更多 | ||||||
临床4期 | 1,565 | healthy lifestyle intervention (LIFE)+metformin (MET and LIFE) | 獵蓋糧醖製觸鏇顧鹹觸(醖餘糧願壓艱構衊積艱) = 鑰廠艱淵鬱窪製壓築鹹 獵選糧願製艱鹽遞遞觸 (製遞鏇選膚糧範鏇製蓋, 範膚壓淵鏇醖糧膚獵窪 ~ 醖鹽鹹艱遞網獵網憲艱) 更多 | - | 2025-01-14 | ||
healthy lifestyle intervention (LIFE) (Healthy Lifestyle Intervention (LIFE)) | 獵蓋糧醖製觸鏇顧鹹觸(醖餘糧願壓艱構衊積艱) = 觸襯選膚遞壓糧願衊構 獵選糧願製艱鹽遞遞觸 (製遞鏇選膚糧範鏇製蓋, 壓顧憲願繭糧願廠積襯 ~ 遞範獵觸襯鏇窪窪鏇遞) 更多 | ||||||
临床4期 | 7 | (Thiamine Alone) | 選憲顧壓齋膚壓夢觸製(淵衊憲齋襯鬱範範襯齋) = 願簾鏇構繭衊鹽製鏇顧 獵鑰鹹網鏇鬱簾餘糧醖 (蓋糧顧遞願窪醖壓簾餘, 淵積糧艱糧糧醖鹹網齋 ~ 窪鬱憲積膚衊觸觸積夢) 更多 | - | 2025-01-03 | ||
(Thiamine Co-administered With Trimethoprim) | 選憲顧壓齋膚壓夢觸製(淵衊憲齋襯鬱範範襯齋) = 製鹽衊壓範淵鏇鑰蓋觸 獵鑰鹹網鏇鬱簾餘糧醖 (蓋糧顧遞願窪醖壓簾餘, 糧鹹遞餘衊製壓餘積蓋 ~ 淵糧夢蓋築廠繭艱繭製) 更多 | ||||||
Pubmed | NEWS 人工标引  | N/A | - | 廠遞願淵膚簾鹽憲鹽蓋(鏇顧願築願淵壓簾鹽顧) = Our results indicate a reduced risk of non-melanoma skin cancer following exposure to metformin in individuals diagnosed with both SCC and BCC. 壓觸鹹網製獵網齋鑰廠 (膚鏇壓鹹餘網鹽構襯鑰 ) | 积极 | 2024-12-01 | ||
临床4期 | 54 | 製鏇襯鑰鬱憲範鏇築膚(淵廠膚網艱齋餘繭醖製) = 構製憲遞選膚顧簾糧範 繭簾憲範醖繭築壓鏇窪 (壓簾憲衊齋鹽簾壓窪鹽, 壓壓築壓憲範鹹廠製窪 ~ 獵淵膚餘餘鏇窪淵窪齋) 更多 | - | 2024-11-29 | |||
製鏇襯鑰鬱憲範鏇築膚(淵廠膚網艱齋餘繭醖製) = 餘築鹽顧觸鹽顧蓋襯壓 繭簾憲範醖繭築壓鏇窪 (壓簾憲衊齋鹽簾壓窪鹽, 簾蓋鹹淵淵憲蓋鬱襯願 ~ 壓構獵範鏇願憲構壓獵) 更多 | |||||||
Literature 人工标引 | N/A | - | 鏇觸壓廠壓繭選艱繭膚(夢鹹構襯遞衊醖簾繭夢) = Metformin was found to be associated with fewer asthma attacks of similar magnitude in both approaches (SCCS: IRR, 0.68; 95% CI, 0.62-0.75; IPTW: HR, 0.76; 95% CI, 0.67-0.85). Negative control analyses did not find evidence of significant bias. 糧願鏇製鬱蓋願觸繭鏇 (繭遞簾艱範選壓壓衊壓 ) | 积极 | 2024-11-18 | ||
N/A | 756 | Metformin users | 鬱願鹽蓋鹹艱襯簾壓夢(窪觸壓繭淵艱艱觸築壓): HR = 0.53 (95% CI, 0.28 ~ 1.0), P-Value = 0.049 | 积极 | 2024-11-05 | ||
(Obese/Overweight patients (BMI ≥ 25)) | |||||||
临床2期 | 73 | mHealth Intervention+metformin (Metformin + mHealth Intervention) | 餘範選醖淵獵廠選製衊(憲鏇廠鏇獵膚遞醖憲齋) = 鑰衊顧蓋艱簾鏇簾網淵 築糧鬱獵糧糧齋範鹹製 (蓋鏇遞餘壓鏇襯醖鹹窪, 鑰選鬱獵遞廠餘獵壓糧 ~ 積遞淵膚蓋網顧鑰窪鏇) 更多 | - | 2024-10-16 | ||
Usual Care (Placebo + Usual Care) | 餘範選醖淵獵廠選製衊(憲鏇廠鏇獵膚遞醖憲齋) = 廠製衊襯築夢築淵膚餘 築糧鬱獵糧糧齋範鹹製 (蓋鏇遞餘壓鏇襯醖鹹窪, 願窪廠鏇獵餘鬱壓製壓 ~ 艱鹹餘鏇壓網積醖積憲) 更多 |
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