A Phase 2, Randomized, Observer-Blinded Study to Evaluate the Safety and Immunogenicity of a SARS-CoV-2 rS Nanoparticle and Quadrivalent Hemagglutinin Nanoparticle Influenza Combination Vaccine With Matrix-M™ Adjuvant in Healthy Participants ≥ 50 to ≤ 80 Years of Age

This is a randomized, observer-blinded, Phase 2 study evaluating the safety and immunogenicity of a severe acute respiratory syndrome coronavirus 2 (SARSCoV2) recombinant spike (rS) (SARS-CoV-2 rS) nanoparticle and quadrivalent hemagglutinin (HA) nanoparticle influenza vaccine (qNIV) combination vaccine with Matrix-M™ adjuvant; this combination vaccine.

开始日期2022-12-30

申办/合作机构

Novavax, Inc.

NCT04120194 / Completed临床3期

A Phase 3, Randomized, Observer-blinded, Active-controlled Trial to Evaluate Immunogenicity & Safety of a Recombinant Quadrivalent Nanoparticle Influenza Vaccine (Quad-NIV) With Matrix-M1™ Adjuvant Against Fluzone® Quadrivalent in Clinically Stable Adults ≥ 65 Years of Age

A Phase 3, randomized, observer-blinded, active-controlled trial to evaluate the immunogenicity and safety of a recombinant quadrivalent nanoparticle influenza vaccine with Matrix-M1 adjuvant (NanoFlu) compared with a licensed quadrivalent inactivated influenza vaccine in adults ≥ 65 years of age. Both vaccines were formulated with the 4 influenza strains recommended for the 2019-20 Northern hemisphere influenza season. 2654 subjects were enrolled and randomized into 1 of 2 treatment groups to receive either NanoFlu or active comparator. Subjects were followed for approximately 1 year following injection; with primary immunogenicity analyses based on Day 28 sera. This trial was conducted in the United States at approximately 19 clinical sites.

开始日期2019-10-14

申办/合作机构

Novavax, Inc.

NCT03293498 / Completed临床1/2期

A Phase 1/2, Randomized, Observer-Blinded, Active-Controlled Trials to Evaluate the Safety and Immunogenicity of a Recombinant Trivalent Nanoparticle Influenza Vaccine With Matrix-M1 Adjuvant (NanoFlu) in Healthy Older Adults

This was a Phase 1/2, randomized, observer-blinded, active-controlled trial to assess the Safety and Tolerability of a Recombinant Trivalent Nanoparticle Influenza Vaccine (Tri-NIV) with Matrix M1™ Adjuvant in Healthy Older Adults ≥ 60 Years of Age

开始日期2017-09-18

申办/合作机构

Novavax, Inc.

100 项与 Seasonal influenza nanoparticle vaccine (Novavax) 相关的临床结果

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100 项与 Seasonal influenza nanoparticle vaccine (Novavax) 相关的转化医学

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100 项与 Seasonal influenza nanoparticle vaccine (Novavax) 相关的专利（医药）

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项与 Seasonal influenza nanoparticle vaccine (Novavax) 相关的文献（医药）

2024-12-31·Expert Review of Vaccines

Unpacking adverse events and associations post COVID-19 vaccination: a deep dive into vaccine adverse event reporting system data

Article

作者: Li, Yiming ; Chen, Yong ; Li, Jianfu ; Tao, Cui ; Dang, Yifang ; Tao, Wei ; Lundin, Sori K

INTRODUCTIONThe rapid development of COVID-19 vaccines has provided crucial tools for pandemic control, but the occurrence of vaccine-related adverse events (AEs) underscores the need for comprehensive monitoring.METHODSThis study analyzed the Vaccine Adverse Event Reporting System (VAERS) data from 2020-2022 using statistical methods such as zero-truncated Poisson regression and logistic regression to assess associations with age, gender groups, and vaccine manufacturers.RESULTSLogistic regression identified 26 System Organ Classes (SOCs) significantly associated with age and gender. Females displayed especially higher odds in SOC 19 (Pregnancy, puerperium and perinatal conditions), while males had higher odds in SOC 25 (Surgical and medical procedures). Older adults (>65) were more prone to symptoms like Cardiac disorders, whereas those aged 18-65 showed susceptibility to AEs like Skin and subcutaneous tissue disorders. Moderna and Pfizer vaccines induced fewer SOC symptoms compared to Janssen and Novavax. The zero-truncated Poisson regression model estimated an average of 4.243 symptoms per individual.CONCLUSIONThese findings offer vital insights into vaccine safety, guiding evidence-based vaccination strategies and monitoring programs for precise and effective outcomes.

2024-03-19·Journal of Virology

Prototype and BA.5 protein nanoparticle vaccines protect against Omicron BA.5 variant in Syrian hamsters

Article

作者: Smith, Gale ; Scheaffer, Suzanne M ; Joshi, Astha ; Boon, Adrianus C M ; Patel, Nita ; Guebre-Xabier, Mimi ; Bricker, Traci L ; Diamond, Michael S ; Soudani, Nadia

ABSTRACTThe emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with greater transmissibility or immune evasion properties has jeopardized the existing vaccine and antibody-based countermeasures. Here, we evaluated the efficacy of boosting pre-immune hamsters with protein nanoparticle vaccines (Novavax, Inc.) containing recombinant Prototype (Wuhan-1) or BA.5 S proteins against a challenge with the Omicron BA.5 variant of SARS-CoV-2. Serum antibody binding and neutralization titers were quantified before challenge, and viral loads were measured 3 days after challenge. Boosting with Prototype or BA.5 vaccine induced similar antibody binding responses against ancestral Wuhan-1 or BA.5 S proteins, and neutralizing activity of Omicron BA.1 and BA.5 variants. One and three months after vaccine boosting, hamsters were challenged with the Omicron BA.5 variant. Prototype and BA.5 vaccine-boosted hamsters had reduced viral infection in the nasal washes, nasal turbinates, and lungs compared to unvaccinated animals. Although no significant differences in virus load were detected between the Prototype and BA.5 vaccine-boosted animals, fewer breakthrough infections were detected in the BA.5-vaccinated hamsters. Thus, immunity induced by Prototype or BA.5 S protein nanoparticle vaccine boosting can protect against the Omicron BA.5 variant in the Syrian hamster model.IMPORTANCEAs SARS-CoV-2 continues to evolve, there may be a need to update the vaccines to match the newly emerging variants. Here, we compared the protective efficacy of the updated BA.5 and the original Wuhan-1 COVID-19 vaccine against a challenge with the BA.5 Omicron variant of SARS-CoV-2 in hamsters. Both vaccines induced similar levels of neutralizing antibodies against multiple variants of SARS-CoV-2. One and three months after the final immunization, hamsters were challenged with BA.5. No differences in protection against the BA.5 variant virus were observed between the two vaccines, although fewer breakthrough infections were detected in the BA.5-vaccinated hamsters. Together, our data show that both protein nanoparticle vaccines are effective against the BA.5 variant of SARS-CoV-2 but given the increased number of breakthrough infections and continued evolution, it is important to update the COVID-19 vaccine for long-term protection.

2024-03-01·ImmunoHorizons

SARS-CoV-2 Vaccine-Elicited Immunity after B Cell Depletion in Multiple Sclerosis

Article

作者: Moreno, Miguel Guerrero ; Klarquist, Jared ; Evans, Courtney ; Kedl, Ross M ; Haakonsen, Nicola ; Miller, Todd M ; Bowhay, Emily ; Ghosh, Tusharkanti ; Borko, Tyler L ; Ghosh, Debashis ; Fleischer, Chelsie L ; van Bokhoven, Adrie ; Rester, Cody ; Deane, Kevin D ; Cabrera-Martinez, Berenice ; Huey, Leah ; Selva, Sean ; Mayher, Ariana ; Baxter, Ryan M ; Jordan, Kimberly R ; Hsieh, Elena W Y ; Knight, Vijaya ; McWilliams, Jennifer ; Piquet, Amanda L

AbstractThe impact of B cell deficiency on the humoral and cellular responses to SARS-CoV2 mRNA vaccination remains a challenging and significant clinical management question. We evaluated vaccine-elicited serological and cellular responses in 1) healthy individuals who were pre-exposed to SARS-CoV-2 (n = 21), 2) healthy individuals who received a homologous booster (mRNA, n = 19; or Novavax, n = 19), and 3) persons with multiple sclerosis on B cell depletion therapy (MS-αCD20) receiving mRNA homologous boosting (n = 36). Pre-exposure increased humoral and CD4 T cellular responses in immunocompetent individuals. Novavax homologous boosting induced a significantly more robust serological response than mRNA boosting. MS-α CD20 had an intact IgA mucosal response and an enhanced CD8 T cell response to mRNA boosting compared with immunocompetent individuals. This enhanced cellular response was characterized by the expansion of only effector, not memory, T cells. The enhancement of CD8 T cells in the setting of B cell depletion suggests a regulatory mechanism between B and CD8 T cell vaccine responses.

项与 Seasonal influenza nanoparticle vaccine (Novavax) 相关的新闻（医药）

2024-05-11

·同写意

妥协与低头，当一家明星biotech“丢掉”野望

同写意20岁庆！第五届全球生物医药前沿技术大会报名开启！“意”同创新，穿越周期。7月中旬，苏州金鸡湖畔，让我们与“新药写意人”一起为中国医药创新“同写意”！在生物科技的竞技场中，没有梦想的玩家就像是失去了灵魂的咸鱼，徒有其表而缺乏内在的活力。伴随着资本市场的潮起潮落，许多生物技术公司的真实写照或许正是如此。然而，要实现从平凡到卓越的跨越，从来都不是一条容易的道路。Novavax的发展历程为我们提供了宝贵的启示。在新冠疫苗之前，这家成立了30多年的公司尚未有产品成功上市，屡遭挫折。新冠疫情的爆发为Novavax带来了绝佳的逆袭机会。凭借在抗原设计和佐剂技术上的深厚积累，Novavax在新冠疫苗的研发竞赛中占据了一席之地，吸引了市场的目光。然而，由于自身战略和执行层面的局限，Novavax在这场疫苗研发竞赛中起了个大早，赶了个晚集。在mRNA疫苗的快速崛起和病毒变异的双重挑战下，Novavax最终陷入了困境。面对现实，Novavax不得不做出选择，与赛诺菲携手合作。5月10日，Novavax宣布与赛诺菲建立合作伙伴关系，将其新冠疫苗和流感疫苗等关键产品线的商业化权益转让给赛诺菲；同时赛诺菲也将利用Novavax的核心技术——佐剂，来研发新的疫苗。通过这笔交易，Novavax获得了5亿美元的首期付款，为自己赢得了宝贵的喘息空间。与赛诺菲合作的消息传出后，Novavax盘前股价暴涨超100%。看来，相比明星biotech逆风翻盘的剧本，还是傍MNC大腿的故事，更得人心。1输给现实在新冠疫苗研发竞赛中，Novavax也曾一马当先。2020年初，Novavax几乎在第一时间宣布投入新冠疫苗的研发。从最开始的进度来看，Moderna于2020年8月启动3期临床，而Novavax首个3期临床于同年12月开启，进度相差并没有那么大。但遗憾的是，直到2022年7月，在经历了漫长的临床试验和监管审批之后，Novavax的重组蛋白疫苗才获得了FDA的紧急使用授权。此时，距离mRNA疫苗上市已经过去了一年零七个月。Novavax面临的是，毒株变异和被mRNA疫苗抢占先机的局面。而之所以出现这个局面，与公司及其管理层的“能力”密不可分。一方面，管理层战略失误，延缓了获批节点。在早期临床方面，Novavax错误地将试验地点选择在了南非而不是美国。南非是新冠疫情最严重的地区之一，理论上在当地开始试验能够获得较好的效果，但Novavax直到2021年6月才拿到期中分析数据，并没有实现后来居上。更重要的是，在后续的上市推进中，Novavax因缺乏美国本地的试验，而无法得到批复。其在美国重新进行关键的3期试验进度更为落后，导致一步慢步步慢，最终申报上市节奏明显落后。另一方面，不成熟的制备流程管理，导致产能成为制约Novavax的最大因素。在Novavax开始着手进行量产时，原本已经与美国CDMO公司Emergent BioSolutions签约，但却由于先行获批的强生抢走了CDMO公司的疫苗产能，导致Novavax只能另寻他家。后来，Novavax只能选择日本富士集团美国子公司Diosynth Biotechnologies做CDMO代工，又委托印度血清研究所SII进行抗原生产，而佐剂则主要来自于北欧的丹麦和瑞典。Novavax一个疫苗的生产就需要动用三个大洲数个国家的协同生产才能完成，这对于刚刚步入规模化生产的Novavax来说无疑是一大难题。再加上当时全球生物材料紧缺，类似于无菌培养的滤材和培养皿都处于断货之中，这就导致在2021上半年，Novavax几乎处于停产状态。尽管成立已久，但由于一直未有产业化经验，使得Novavax在这一次新冠风口下暴露出诸多如初创企业般的不成熟。这使得其落后不少，最终遗憾败北。2鲜明反差Novavax在疫情中投入了大量的人力、财力，面对需求突然消失的“新冠悬崖”，不可避免陷入了困境。现金极速消耗。2021年，Novavax账上现金余额高达15.15亿美元，截至2023年末只剩下5.69亿美元。并且，公司还背负近5.7亿美元的债务。不得已，公司只能持续裁员，断臂求生。市值更是急剧缩水。巅峰时期，Novavax市值一度飙至285亿美金，如今的公司市值只剩下6亿美金……没有对比就没有伤害。同样作为一家biotech，伴上辉瑞大腿的BioNTech，与Novavax形成了鲜明的反差。BioNtech和Moderna的疫苗几乎是前后脚面市。Moderna的疫苗效果更强，销量却远不如BioNtech。原因在于，BioNtech背靠大药企辉瑞的资源。这也使得，BioNtech虽然同样面临“新冠悬崖”，但处境却与Novavax截然相反。得益于新冠疫苗的积累，BioNtech账上现金余额仍然高达116亿美元，这给予其转型带来更多可能。如今的BioNTech在抗肿瘤的路上越走越远。一方面，BioNtech在大力引进早期肿瘤管线。去年以来，BioNTech相继与普米斯生物、道尔生物、映恩生物等国内外biotech牵手，在ADC、双抗等热门领域落子。另一方面，BioNTech预计收获期将近。根据最新的一季报，公司预计2026年公司的首个肿瘤管线将会获批，正式在市场亮相。到 2030 年，该公司预计将获得10个获批的癌症适应症。不管“饼”能否实现，但BioNTech最新市值仍达到218.85亿美金。这意味着，这家biotech已经成功借助新冠疫情的机遇，完成了跃迁，也为自己赢得了足够的腾挪空间。Novavax则在生存线上徘徊，也失去了成为biopharma的机会。而其将现有临床管线全部授权出去，也意味着，自己需要重头来过。3重头来过Novavax与BioNTech的遭遇，在海外或许并不会令人感到意外。毕竟，“铁打的大药企，流水的biotech”是常态。大药企是资源集中模式，生产场地、设施这些固定设施优势逐步累积，药物的临床试验团队、销售团队资源会逐步聚集，最终形成带来决定性优势。所以大药企能够实现一种正向循环，药企的规模越大，在药物后期研发、推广成本反而越低，资源优势还会日益增厚，药物的销售情况也更好。而biotech虽然在研发端有优势，但是在药物的临床开发和后续商业化过程中，biotech面对的挑战也并不容易克服。这并不是意味着biotech彻底没有跃迁的机会，只能说非常渺茫。也正因此，海外药企通常形成了“biotech负责研发、大药厂负责销售”的生态格局。如今，经历过毒打的Novavax，或许也选择向现实低头。5月10日，Novavax宣布与四大疫苗巨头之一的赛诺菲达成战略合作协议。在该合作协议中，赛诺菲将全权负责任何包含其流感疫苗和新冠疫苗的组合疫苗的开发和商业化。并且，赛诺菲将利用Novavax的旗舰疫苗技术Matrix-M佐剂来开发新的疫苗产品。为此，赛诺菲将向Novavax支付5亿美元的预付款，并在达成开发、监管和上市里程碑时支付高达7亿美元的额外款项。这笔交易的总价值大约是Novavax目前市值的两倍。也就是说，Novavax通过技术授权的方式，傍上了赛诺菲大腿。以后，研发、商业化将会在赛诺菲的助力下开展。这也使得，Novavax短暂度过了经营危机。Novavax CEO表示，通过与赛诺菲这样的世界领导者达成的协议，不仅在商业化方面，而且在开发方面，将大大增加更快地推出多种新疫苗的机会。不管Novavax能否成功，它的经历，无疑给所有梦想快速成为biopharma的biotech，上了生动的一课。不是所有biotech，都能成为bigpharma。当然，也不是所有的biotech都需要成为bigpharma。【转载声明】本文转载自“氨基观察”微信公众号。更多优质内容，欢迎关注↓↓↓

疫苗临床3期信使RNA引进/卖出临床2期

2024-03-02

·药事纵横

大跌26%！mRNA疫苗巨头公布2023财报，营收降50%

声明：因水平有限，错误不可避免，或有些信息非最及时，欢迎留言指出。本文仅作医疗健康相关药物介绍，非治疗方案推荐（若涉及）;本文不构成任何投资建议。当新冠疫苗逐渐失去热度和市场，mRNA疫苗公司的收入也在下降。2月28日，mRNA疫苗三大巨头之一的Novavax公布2023财报：全年营收9.84亿美元，同比下降50%；研发费用为7.38亿美元，净亏损达5.45亿美元（2022年为6.58亿美元）。其中Q4营收2.91，同比下降18%。截至2023年12月31日，该公司现金、现金等价物和限制性现金总计5.84亿美元。预计2024年总收入为8~10亿美元。受此消息影响，Novavax当日股价大跌26%，目前市值为7.1512亿美元。值得注意的是，Novavax的COVID-19-流感联合疫苗的3 期试验将于2024年下半年完成，且有望于 2026 年上市推出，从而加快扩大公司研发管线。Novavax未来研发计划：Novavax研发管线：对于mRNA疫苗公司来说，由于COVID-19疫苗销量减少，2023年是艰难的一年。同为mRNA疫苗巨头的Moderna ，2023年营收68.48亿美元，同比下降64.45%；净利润亏损47.14亿美元，相比2022年，亏损扩大156.37%。目前，Moderna总市值约为367.6亿美元，近一年市值蒸发约200亿美元。参考资料：https://ir.novavax.com/press-releases/2024-02-28-Novavax-Reports-Fourth-Quarter-and-Full-Year-2023-Financial-Results-and-Operational-Highlights

财报疫苗信使RNA

2024-02-27

·Business Wire

Global H3N2 infection Drug Pipeline Landscape Report 2024: Insights on 15+ Companies and 20+ Pipeline Drugs - ResearchAndMarkets.com

DUBLIN--( BUSINESS WIRE )--The "H3N2 infection - Pipeline Insight, 2024" drug pipelines has been added to ResearchAndMarkets.com's offering. This report provides comprehensive insights about 15+ companies and 20+ pipeline drugs in H3N2 infection pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space. The report outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the H3N2 infection pipeline landscape is provided which includes the disease overview and H3N2 infection treatment guidelines. The assessment part of the report embraces, in depth H3N2 infection commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, H3N2 infection collaborations, licensing, mergers and acquisition, funding, designations and other product related details. Report Highlights The companies and academics are working to assess challenges and seek opportunities that could influence H3N2 infection R&D. The therapies under development are focused on novel approaches to treat/improve H3N2 infection. H3N2 infection Emerging Drugs Chapters This segment of the H3N2 infection report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, II/III I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases. H3N2 infection Emerging Drugs mRNA-1083: Moderna Therapeutics mRNA-1083 is under development for the prevention of influenza virus infection caused by influenza A/H1N1, A/H3N2, and influenza B/Yamagata and B/Victoria strains and coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in 18 to 79 years of age group. It is a combination vaccine of mRNA-1283, which encodes Receptor Binding Doman (RBD) and N-Terminal Domain (NTD) of the spike protein and mRNA-1010, which encodes hemagglutinin (HA) glycoproteins of influenza A/H1N1, A/H3N2, and influenza B/Yamagata and B/Victoria-lineages. It is administered through intramuscular route in the form of sterile liquid for injection. Currently, the drug is in Phase III stage of its clinical trial for the treatment H3N2 infection. CD-388: Cidara therapeutics CD-388 is under development of the treatment and prevention of influenza virus A, seasonal influenza, pandemic influenza and influenza virus B infections. The drug candidate is a second generation, anti-viral Fc conjugate (AVC). It comprises of two moieties attached through a chemical linker. One is a targeting moiety (TM) that recognizes cell surface target and another is an effector moiety (EM) that is recognized by the immune system. It is administered through intramuscular and subcutaneous route. Currently, the drug is in Phase II stage of its clinical trial for the treatment of H3N2 infection. PF-07845104: Pfizer PF-07845104 is a prophylactic saRNA Vaccine developed by Pfizer. Its therapeutics area include infectious respiratory diseases. Currently, the drug is in phase I stage of its clinical trial for the treatment of H3N2 infection. H3N2 infection: Therapeutic Assessment Major Players in H3N2 infection There are approx. 15+ key companies which are developing the therapies for H3N2 infection. The companies which have their H3N2 infection drug candidates in the most advanced stage, i.e. Phase III include, Moderna Therapeutics. Phases Late stage products (Phase III) Mid-stage products (Phase II) Early-stage product (Phase I) along with the details of Pre-clinical and Discovery stage candidates Discontinued & Inactive candidates Route of Administration Products have been categorized under various ROAs such as Intravenous Subcutaneous Oral Intramuscular Molecule Type Products have been categorized under various Molecule types such as Monoclonal antibody Small molecule Peptide Product Type H3N2 infection Report Insights H3N2 infection Pipeline Analysis Therapeutic Assessment Unmet Needs Impact of Drugs H3N2 infection Report Assessment Pipeline Product Profiles Therapeutic Assessment Pipeline Assessment Inactive drugs assessment Unmet Needs Key Players Novartis Vaccines PDS Biotechnology Corporation Sanofi Moderna Therapeutics Pfizer Cidara therapeutics GRDG SCIENECES FluGen Inc. Barinthus Biotherapeutics Key Products NanoFlu PDS0202 MRT-5400 mRNA 1083 PF-07845104 CD 388 Equivir H3N2 M2SR influenza vaccine MVA-NP+M1 For more information about this drug pipelines report visit https://www.researchandmarkets.com/r/kiulgc About ResearchAndMarkets.com ResearchAndMarkets.com is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends.

临床2期疫苗临床3期临床1期

100 项与 Seasonal influenza nanoparticle vaccine (Novavax) 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
流感病毒感染	药物发现	美国	Novavax, Inc.	2019-10-14

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03293498 (CTgov)	临床1/2期	流感病毒感染	330	Fluzone+Tri-NIV Vaccine (Group A- Participants Received Low Dose Tri-NIV Vaccine at Day 0 and Received Fluzone HD at Day 21)	艱範餘廠鹹壓淵鑰壓鬱(簾簾鏇鏇齋鬱積遞鬱構) = 範遞範糧選顧膚構膚鏇鏇膚膚築製糧構夢顧網 (製廠鹽窪築積獵積繭膚, 獵襯製襯鹽齋蓋鏇壓築 ~ 膚鏇範膚簾築鏇獵築範) 更多	-	2022-12-21
				Fluzone+Tri-NIV Vaccine (Group B- Participants Received High Dose Tri-NIV Vaccine at Day 0 and Received Fluzone HD at Day 21)	艱範餘廠鹹壓淵鑰壓鬱(簾簾鏇鏇齋鬱積遞鬱構) = 積鏇鑰壓窪醖艱鏇網選鏇膚膚築製糧構夢顧網 (製廠鹽窪築積獵積繭膚, 遞鏇構選範願網製遞蓋 ~ 衊鬱遞遞壓構製糧積觸) 更多
NCT04120194 (CTgov)	临床3期	流感病毒感染	2,654	NanoFlu (NanoFlu)	夢衊範廠鹹蓋壓築餘廠(鬱膚繭觸網廠衊積夢鹹) = 鑰繭齋繭艱艱鹽壓餘艱繭鏇遞壓鬱獵憲製蓋憲 (蓋顧遞鹹淵繭製築構襯, 鑰獵築夢餘鏇壓糧廠淵 ~ 築網鬱簾膚鑰窪糧網鹽) 更多	-	2023-05-06
				Fluzone Quadrivalent (Fluzone Quadrivalent)	夢衊範廠鹹蓋壓築餘廠(鬱膚繭觸網廠衊積夢鹹) = 範憲繭遞繭淵製膚淵範繭鏇遞壓鬱獵憲製蓋憲 (蓋顧遞鹹淵繭製築構襯, 蓋構艱憲築簾鹹蓋積壓 ~ 觸構獵鹹鏇蓋衊廠遞遞) 更多