Squaric acid dibutyl ester(Squarex)(Squaric acid dibutyl ester(Squarex))

概要

基本信息

药物类型

小分子化药

别名

Quadratic-acid-dibutylester、SADBE、Squaric acid dibutyl ester

+ [4]

靶点-

作用方式

调节剂

作用机制

免疫调节剂

治疗领域

感染口颌疾病皮肤和肌肉骨骼疾病

在研适应症-

非在研适应症

唇疱疹

原研机构

Squarex

在研机构-

非在研机构

Squarex

权益机构-

最高研发阶段终止临床2期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C12H18O4

InChIKeyXBRWELTXMQSEIN-UHFFFAOYSA-N

CAS号2892-62-8

关联

7

项与 Squaric acid dibutyl ester(Squarex) 相关的临床试验

NCT05535738

/ Recruiting临床2/3期IIT

Biologics and Blistering - Using a Contact Dermatitis Model With Biologic Medications to Study Skin Inflammation Through Suction Blistering

The purpose of this study is to answer: how do inflammation and anti-inflammatory skin therapies work in the skin? Inflammation is a protective response from the body's immune system to injury, disease, or irritation. It is a process by which your body's white blood cells and the things they make protect you from infection from outside invaders such as bacteria and viruses.

开始日期2022-11-15

申办/合作机构

Massachusetts Institute of Technology

NCT05414266

/ Unknown status早期临床1期IIT

A Randomized, Placebo Controlled Single Site Study Evaluating Efficacy of Topical Squaric Acid Dibutyl Ester in Children and Adolescents With Alopecia Areata

The purpose of this study is to evaluate the efficacy and tolerability of squaric acid dibutylester (SADBE) in children and adolescents with alopecia areata (AA) and to evaluate effect of squaric acid dibutyl ester on patient-centered outcomes and payer relevant measures to assess treatment benefit from the patient perspective and to demonstrate value

开始日期2022-08-15

申办/合作机构

University of Texas Health Science Center at Houston

NCT04999631

/ Not yet recruiting早期临床1期IIT

Neoadjuvant Squaric Acid Dibutylester Treatment of Melanocytes in Congenital Melanocytic Nevi

A study to evaluate the safety and efficacy topical squaric acid dibutylester (SADBE) for the neoadjuvant treatment of congenital melanocytic nevi (CMN).

开始日期2022-01-01

申办/合作机构

The General Hospital Corp.

100 项与 Squaric acid dibutyl ester(Squarex) 相关的临床结果

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100 项与 Squaric acid dibutyl ester(Squarex) 相关的转化医学

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100 项与 Squaric acid dibutyl ester(Squarex) 相关的专利（医药）

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303

项与 Squaric acid dibutyl ester(Squarex) 相关的文献（医药）

2025-05-01·Journal of Investigative Dermatology

Single-Cell RNA Sequencing Reveals Molecular Signatures that Distinguish Allergic from Irritant Contact Dermatitis

Article

作者: Wang, Yuqing ; Martinez, Nuria ; Harris, John E. ; Harris, John E ; Ko, Wei-Che C. ; Frisoli, Michael L ; Frisoli, Michael L. ; Garber, Manuel ; Afshari, Khashayar ; Ko, Wei-Che C

Allergic contact dermatitis (ACD) is a pruritic skin disease caused by environmental chemicals that induce cell-mediated skin inflammation within susceptible individuals. Irritant contact dermatitis (ICD) is caused by direct damage to the skin barrier by environmental insults. Diagnosis can be challenging because both types of contact dermatitis can appear similar by visual examination, and histopathological analysis does not reliably distinguish ACD from ICD. To discover specific biomarkers of ACD and ICD, we characterized the transcriptomic and proteomic changes that occur within the skin during each type of contact dermatitis. We induced ACD and ICD in healthy human volunteers and sampled skin using a nonscarring suction blister biopsy method that collects interstitial fluid and cellular infiltrate. Single-cell RNA sequencing analysis revealed that cell-specific transcriptome differences rather than cell-type proportions best distinguished ACD from ICD. Allergy-specific genes were associated with upregulation of IFNG, and cell signaling network analysis implicated several other genes such as IL4, despite their low expression levels. We validated transcriptomic differences with proteomic assays on blister fluid and trained a logistic regression model on skin interstitial fluid proteins that could distinguish ACD from ICD and healthy control skin with 93% sensitivity and 93% specificity.

2025-03-03·ChemBioChem

Hydrophobic Domain Modulation of Chemical Responsiveness in a Bolaamphiphile‐Based Supramolecular Monomer

Article

作者: Fehér, Bence ; van Zwol, Suzanne ; Voets, Ilja K. ; Vittala, Sandeepa K. ; Kieltyka, Roxanne E. ; Liu, Tingxian

AbstractSelf‐immolative chemistries that respond in an irreversible manner to external stimuli are highly attractive to permanently degrade filamentous supramolecular biomaterials. Within the monomer, a balance needs to be struck between its capacity to be supramolecularly polymerized and degraded at an appropriate rate for a given application. Herein, we unravel the structure‐property‐function relationships of a library of squaramide‐based bolaamphiphiles bearing a central disulfide‐based self‐immolative spacer to construct supramolecular polymers responsive to chemical stimuli in aqueous solutions. We examine the impact of changing the alkyl domain length (2 to 12 methylene units) on the formation of supramolecular filaments and their rate of degradation in response to a biological antioxidant, glutathione. A minimum of an octyl spacer is required to robustly form supramolecular polymers that can be irreversibly degraded through a cyclization‐elimination reaction of the self‐immolative spacer triggered by thiol‐disulfide exchange. Further increasing the peripheral alkyl chain length to a decyl spacer increases the ordered packing of the amphiphiles, hindering their chemical degradation. This study provides a framework to design chemically responsive filamentous supramolecular polymers based on bolaamphiphiles that can be irreversibly degraded in aqueous solutions for their eventual application as biomedical materials.

2024-12-31·Journal of Dermatological Treatment

Alopecia areata treatment with baricitinib: different relapse phenotypes

Article

作者: Vitale, Pasquale ; Lacarrubba, Francesco ; Dall’Oglio, Federica ; Nasca, Maria Rita ; Micali, Giuseppe

A 28-yr-old woman with a history of AA universalis since 5 years of age with transient response to different AA treatments, including intralesional corticosteroids, contact immunotherapy with squaric acid dibutylester (SAdBe), cyclosporine, and methotrexate.Laboratory investigations were unremarkable, showing only mild anemia.Trichoscopy, showing black dots and exclamation mark hairs, and histopathol. confirmed the diagnosis of active AA.A 43-yr-old woman with severe AA (SALt = 70) occurred 2 years earlier.A 52-yr-old woman with severe AA (SALt = 90) occurred 2 years earlier unresponsive to previous treatments with systemic corticosteroids and methotrexate.Our observations confirm that AA relapses may occur during baricitinib treatment.Interestingly, hair loss developed either within the regrowth area as seen in Cases 1 and 3 or in a healthy area previously unaffected as in Case 2, confirming two different presentation phenotypes.

100 项与 Squaric acid dibutyl ester(Squarex) 相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	-	-	DB12223

研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
唇疱疹	临床2期	美国	Squarex	2018-03-12

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT02965781 (P2a, CTgov)	临床1/2期	唇疱疹	139	Placebo (Placebo Application (DMSO Only-No SADBE))	衊餘網網糧選製鏇鏇廠(糧膚衊積淵鑰簾齋簾夢) = 積製遞鏇艱淵醖淵壓壓艱夢範淵齋顧築淵觸顧 (鬱獵壓衊範鬱顧鹹範壓, 鬱糧襯夢獵網餘範製獵 ~ 鑰選積獵選夢壓觸顧獵) 更多	-	2021-11-02
				SADBE (Two SADBE Applications)	衊餘網網糧選製鏇鏇廠(糧膚衊積淵鑰簾齋簾夢) = 淵衊願願窪顧壓艱網簾艱夢範淵齋顧築淵觸顧 (鬱獵壓衊範鬱顧鹹範壓, 鹹鏇淵獵構願遞膚衊鑰 ~ 遞築壓鹹選壓積窪築積) 更多
NCT03521479 (CTgov)	临床2期	唇疱疹	40	Squaric Acid Dibutyl Ester (Group A)	遞鑰網鑰夢築鑰艱築鹹(糧獵鑰蓋鹽鏇積鹹餘夢) = 襯網淵壓選簾夢網壓網壓夢選衊蓋廠鬱遞鬱選 (構製鹽齋壓遞觸襯醖齋, 遞蓋襯夢構鹽窪選鏇淵 ~ 獵遞壓夢齋艱鹽願壓築) 更多	-	2021-06-15
				Squaric Acid Dibutyl Ester (Group B)	遞鑰網鑰夢築鑰艱築鹹(糧獵鑰蓋鹽鏇積鹹餘夢) = 壓蓋鏇糧鏇壓襯選憲網壓夢選衊蓋廠鬱遞鬱選 (構製鹽齋壓遞觸襯醖齋, 繭鬱窪積鹽製醖顧築製 ~ 壓願製窪構廠選構繭衊) 更多
NCT01971385 (Squarex, CTgov)	临床1期	唇疱疹	54	Squaric Acid solution (2% Squaric Acid Sensitization)	繭選鏇壓餘繭夢餘壓淵(遞艱簾艱鬱鹹獵壓築鬱) = 選窪獵鬱鹹繭網醖餘鹽積鏇繭鬱糧醖鑰範蓋蓋 (壓鑰廠製襯襯壓網艱鹹, 餘艱淵構膚夢簾築鹹顧 ~ 餘獵壓繭齋顧壓鹽願齋)	-	2017-10-02
				Placebo solution (Placebo Solution)	繭選鏇壓餘繭夢餘壓淵(遞艱簾艱鬱鹹獵壓築鬱) = 餘鑰齋艱鬱繭蓋艱壓獵積鏇繭鬱糧醖鑰範蓋蓋 (壓鑰廠製襯襯壓網艱鹹, 淵觸糧構觸製網鬱簾網 ~ 鏇齋遞構憲觸獵鏇構顧) 更多