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更新于：2025-05-16
Alanylglutamine
丙氨酰谷氨酰胺
更新于：2025-05-16
概要
基本信息
权益机构- |
最高研发阶段批准上市 |
首次获批日期 德国 (1995-04-01) |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国) |
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结构/序列
分子式C8H15N3O4 |
InChIKeyHJCMDXDYPOUFDY-WHFBIAKZSA-N |
CAS号39537-23-0 |
关联
26
项与 丙氨酰谷氨酰胺 相关的临床试验PACTR202303692483097
Efficacy of Perioperative Infusion of N (2)-L-alanyl-L-glutamine in Glycemic Control for Patients With Uncontrolled Diabetes Mellitus Presented for Urgent Coronary Artery Bypass Surgery: Randomized Control Trial
ISRCTN13489936
The ameliorative potential of L-alanyl L-glutamine dipeptide in colon cancer patients receiving modified FOLFOX-6 regarding the incidence of diarrhea, the treatment response, and patients’ survival: a randomized controlled trial
NCT05586646
Effect of IV Alanyl Glutamine on Healing of Pressure Ulcers in Critically Ill Patients
100 项与 丙氨酰谷氨酰胺 相关的临床结果
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100 项与 丙氨酰谷氨酰胺 相关的转化医学
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100 项与 丙氨酰谷氨酰胺 相关的专利（医药）
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974
项与 丙氨酰谷氨酰胺 相关的文献（医药）2025-05-01Analytical and Bioanalytical Chemistry
Leveraging the potential of 1.0-mm i.d. columns in UHPLC-HRMS-based untargeted metabolomics
Article
作者: Tonon, Giovanni ; Salviati, Emanuela ; Basilicata, Manuela Giovanna ; La Gioia, Danila ; Botrugno, Oronza A ; Sommella, Eduardo ; Felici, Claudia ; Campiglia, Pietro
Abstract:
Untargeted metabolomics UHPLC-HRMS workflows typically employ narrowbore 2.1-mm inner diameter (i.d.) columns. However, the wide concentration range of the metabolome and the need to often analyze small sample amounts poses challenges to these approaches. Reducing the column diameter could be a potential solution. Herein, we evaluated the performance of a microbore 1.0-mm i.d. setup compared to the 2.1-mm i.d. benchmark for untargeted metabolomics. The 1.0-mm i.d. setup was implemented on a micro-UHPLC system, while the 2.1-mm i.d. on a standard UHPLC, both coupled to quadrupole-orbitrap HRMS. On polar standard metabolites, a sensitivity gain with an average 3.8-fold increase over the 2.1-mm i.d., along with lower LOD (LODavg 1.48 ng/mL vs. 6.18 ng/mL) and LOQ (LOQavg 4.94 ng/mL vs. 20.60 ng/mL), was observed. The microbore method detected and quantified all metabolites at LLOQ with respect to 2.1, also demonstrating good repeatability with lower CV% for retention times (0.29% vs. 0.63%) and peak areas (4.65% vs. 7.27%). The analysis of various samples, in both RP and HILIC modes, including different plasma volumes, dried blood spots (DBS), and colorectal cancer (CRC) patient-derived organoids (PDOs), in full scan-data dependent mode (FS-DDA) reported a significant increase in MS1 and MS2 features, as well as MS/MS spectral matches by 38.95%, 39.26%, and 18.23%, respectively. These findings demonstrate that 1.0-mm i.d. columns in UHPLC-HRMS could be a potential strategy to enhance coverage for low-amount samples while maintaining the same analytical throughput and robustness of 2.1-mm i.d. formats, with reduced solvent consumption.
2025-05-01POULTRY SCIENCE
Exploring the effects of feeding methods on the growth and meat flavor of Wenchang chicken
Article
作者: Zheng, Xinli ; Xu, Tieshan ; Xiao, Zhepeng ; Jiang, Qicheng ; Gu, Lihong ; Xu, Chaohua
Wenchang chicken, renowned for its high-quality meat, is the economic meat breed in Hainan Province, China. This study compared cage-rearing (CR) and free-range (FR) groups in terms of growth performance, slaughter performance, meat quality, IMP (inosine monophosphate) content, AAs, FAs, serum lipid metabolites, and transcriptomic and metabolomic analyses. The CR group showed increased body weight, live weight, and abdominal fat but lower leg muscle percentage and breast muscle redness, suggesting flavor differences. CR chickens had higher IMP, threonine (Thr), and pentadecanoic, oleic, and linoleic acids, while glutamate (Glu) and alpha-linolenic acid were lower compared to FR. Glycine was elevated, but histidine, myristic, and tricosanoic acids were lower in CR leg muscle. Serum analysis revealed higher total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), lipoprotein lipase (LPL), hormone-sensitive lipase (HSL), fatty acid synthase (FAS), thyroid-stimulating hormone (TSH), leptin (LEP), and adiponectin (ADP) in the CR group. Transcriptomic and metabolomic studies identified 252 differentially expressed genes and 34 metabolites linked to metabolic pathways. In summary, CR system can improve production performance, FR system is considered more flavorful. The results can act as a theoretical basis for selecting a suitable rearing method for this unique breed.
2025-04-01JOURNAL OF NUTRITION
Clostridioides difficile Infection in Aged Mice Decreases Memory Function, Which Can Be Protected with Alanyl-Glutamine Supplementation
Article
作者: Whitt, Caroline C ; Tora, Ayesha E ; Warren, Cirle A ; Yang, Suemin E ; Costa, Deiziane Vs ; Shin, Jae Hyun ; Goldbeck, Sophia M
BACKGROUND:
Adults aged >65 face a higher risk of both Clostridioides difficile infection (CDI) and dementia. CDI in the elderly may exacerbate functional and cognitive impairments. Current CDI treatment options are limited. Alanyl-glutamine (AQ) is a dipeptide shown to decrease C. difficile toxin effects in vitro and in vivo.
OBJECTIVES:
We tested the potential benefits of AQ on the clinical outcomes and cognitive impairment in the aged mouse model of CDI treated at various timings of AQ and vancomycin treatment.
METHODS:
C57BL/6 retired breeder (9 mo) and aged (18 mo) mice were treated with AQ-supplemented water as a 2-wk pretreatment or continuously. The mice underwent a standard CDI protocol (VPI10463) and were treated, or not, with vancomycin. Disease severity was tracked for 14 d, then novel object recognition (NOR) tests for acute memory were performed. Hippocampal tissues were assayed for molecular markers.
RESULTS:
NOR testing confirmed CDI-induced cognitive impairment (P = 0.0352). AQ pretreatment had mild neuroprotective effects during CDI. Mice treated with vancomycin and continuous AQ had better clinical scores and better memory performance than vancomycin controls (P = 0.0286). Continuous AQ treatment, when used alone or paired with vancomycin, offered protection against CDI-induced cognitive impairment. The mechanism of CDI-induced memory impairment remains unclear, but infected mice had elevated synaptobrevin-2 (P = 0.0396) and neural cell adhesion molecule (P = 0.008) compared with uninfected controls on day 14 post infection.
CONCLUSIONS:
Our findings suggest that neuroinflammation and memory loss occur during CDI, which may be ameliorated by AQ supplementation. AQ supplementation may have both neurological and intestinal protective effects during CDI treatment.
100 项与 丙氨酰谷氨酰胺 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 谷氨酰胺缺乏症 | 中国 | 1999-04-03 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 终末期肾脏病 | 临床2期 | 奥地利 | 2022-03-16 | |
| 腹膜炎 | 临床2期 | 奥地利 | 2014-06-02 | |
| 膳食补充剂 | 临床1期 | 中国 | - | |
| 膳食补充剂 | 临床1期 | 中国 | - | |
| 辐射引起的溃疡性口腔粘膜炎 | 临床前 | 美国 | 2018-07-10 | |
| 辐射引起的溃疡性口腔粘膜炎 | 临床前 | 日本 | 2018-07-10 | |
| 腹膜纤维变性 | 临床前 | 荷兰 | 2015-11-03 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床3期 | 60 | (Glutamine) | 製繭鑰簾廠窪製衊築淵(顧憲淵願膚衊鏇鏇鬱鏇) = 顧鹹獵範製衊醖憲獵憲 積醖鏇壓窪網餘鹹積夢 (餘壓積廠顧蓋製艱糧積, 製鑰衊築網夢鹹遞廠簾 ~ 淵簾窪繭壓糧鹹繭遞鬱) 更多 | - | 2023-11-13 | ||
Placebo (Control) | 製繭鑰簾廠窪製衊築淵(顧憲淵願膚衊鏇鏇鬱鏇) = 遞觸構膚淵鑰糧廠壓醖 積醖鏇壓窪網餘鹹積夢 (餘壓積廠顧蓋製艱糧積, 憲選簾鹹範淵窪襯築鑰 ~ 淵遞廠餘夢鑰獵淵齋願) 更多 | ||||||
临床2期 | 7 | 壓鏇鏇顧廠窪鏇鹹範鏇 = 鑰窪鹽夢鏇築願壓壓鬱 窪願鏇糧鏇醖夢齋鹽觸 (製鏇窪積網簾簾襯鏇範, 膚糧獵網鏇艱鹹餘網艱 ~ 醖齋餘選齋鑰醖選憲顧) 更多 | - | 2022-06-07 | |||
N/A | - | - | (Peritoneal Dialysis Fluid (PDF)) | 餘壓願蓋構憲衊廠願鏇(齋願遞觸獵築獵艱鏇選) = 艱窪獵襯夢窪廠鑰壓遞 醖鬱齋繭窪製製餘網積 (糧壓鑰醖鹹夢積糧願餘 ) | - | 2017-05-26 | |
Peritoneal Dialysis Fluid (PDF) + Alanyl-Glutamine (AlaGln) | 餘壓願蓋構憲衊廠願鏇(齋願遞觸獵築獵艱鏇選) = 膚廠選廠築衊繭構艱遞 醖鬱齋繭窪製製餘網積 (糧壓鑰醖鹹夢積糧願餘 ) | ||||||
N/A | 腹膜透析相关性腹膜炎 peritoneal leukocyte immuno-competence | peritoneal leukocyte transcriptome status | 6 | (Standard PD fluid (Physioneal40 3.86%, Baxter)) | 遞鬱醖觸窪膚鹽齋遞窪(醖獵繭鹹膚鹹選醖淵鏇) = 鹹願積選積遞艱製壓製 鹹鑰構壓顧鏇選鏇窪遞 (鏇構壓觸壓鑰廠積醖遞 ) | 积极 | 2015-11-03 | |
AlaGln-supplemented PD fluid | 遞鬱醖觸窪膚鹽齋遞窪(醖獵繭鹹膚鹹選醖淵鏇) = 選襯積築齋艱廠窪鏇襯 鹹鑰構壓顧鏇選鏇窪遞 (鏇構壓觸壓鑰廠積醖遞 ) | ||||||
临床3期 | 150 | (Glutamine Dipeptide) | 簾顧襯餘鹽顧願觸觸鏇 = 鹽鑰願蓋餘衊獵夢膚襯 襯鬱繭鹽範鏇構簾廠遞 (遞糧選遞鬱鹹獵鏇鏇壓, 鬱繭蓋鬱壓淵夢壓膚衊 ~ 壓夢餘餘蓋鏇選餘顧顧) 更多 | - | 2014-02-13 | ||
15% Clinisol (Standard) | 簾顧襯餘鹽顧願觸觸鏇 = 艱鑰構鬱築網繭憲顧簾 襯鬱繭鹽範鏇構簾廠遞 (遞糧選遞鬱鹹獵鏇鏇壓, 觸夢鹽蓋鑰鹹網夢鬱襯 ~ 觸糧衊築範鹹憲糧廠夢) 更多 |
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