银氮烷氟化物(Silver Diammine Fluoride) - 在研适应症：牙根龋，龋齿，牙本质敏感症_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Silver diamine fluoride、Silver diammine fluoride (JAN)、フッ化アンモニア銀

+ [2]

靶点-

作用方式-

作用机制-

治疗领域

口颌疾病

在研适应症

牙根龋龋齿牙本质敏感症

非在研适应症-

原研机构

Toyo Pharmar Co. Ltd.

在研机构

Toyo Pharmar Co. Ltd.

非在研机构-

最高研发阶段批准上市

首次获批日期

日本 (2009-02-24),

龋齿牙本质敏感症

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式AgFH6N2

InChIKeyFJKGRAZQBBWYLG-UHFFFAOYSA-M

CAS号34445-07-3

关联

96

项与银氮烷氟化物相关的临床试验

NCT06786975

/ Not yet recruitingN/A

Effectiveness and Acceptability of Silver Diamine Fluoride for the Management of Early Childhood Caries at the Community Level Compared to Atraumatic Restorative Treatment, Randomized Clinical Trial

The goal of this clinical trial is to assess the acceptability and clinical effectiveness of Silver Diamine Fluoride (SDF) in comparison with Atraumatic Restorative Treatment (ART) in Early Childhood Caries (ECC) management at the community level. The main question it aims to answer are:
• It's SDF more accepted and effective than ART in early childhood caries management when implemented at the community level?
Participants will be diagnosed by an experienced and calibrated dentist using the International Caries Detection and Assessment System (ICDAS), then children with decayed teeth will be treated with SDF (experimental) or ART (control); another operator will choose randomly the treatment for each participant. Furthermore, oral health education component will be given to children, parents and educators.
Follow-up visits will be made at 6 and 12 months after child's treatment is complete. Before and after treatment parents will be asked to complete a child personal background survey (before), Early Childhood Oral Health Impact Scale (ECOHIS) questionnaire (before and at follow-ups) and a oral health satisfaction survey (one week after treatment and at follow-ups).
Researchers will compare the SDF's groups and the ART's group to see which of them is more accepted and effective at community level.
Main outcome: parents and children acceptability to SDF and ART.

开始日期2025-03-10

申办/合作机构

University of La Frontera

CTRI/2024/10/075815

/ RecruitingN/AIIT

To evaluate the efficacy of 38 percent Silver diamine fluoride along with atraumatic restorative technique in arresting caries among secondary school children in rural Telangana: A Randomized controlled trial - NIL

开始日期2024-11-11

申办/合作机构-

CTRI/2024/08/072965

/ Not yet recruiting临床3期

Comparative Evaluation of Selective Caries Removal Techniques Followed by SDF Application In Primary Molars - An In Vivo Study - NIL

开始日期2024-09-02

申办/合作机构-

100 项与银氮烷氟化物相关的临床结果

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100 项与银氮烷氟化物相关的转化医学

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100 项与银氮烷氟化物相关的专利（医药）

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760

项与银氮烷氟化物相关的文献（医药）

2025-03-01·International Journal of Paediatric Dentistry

Parental perceptions and acceptance of silver diamine fluoride staining in Italy

Article

作者: Crystal, Yasmi Ornelas ; Gatto, Maria Rosaria ; Lardani, Lisa ; Fitzgibbon, Raquel ; Piana, Gabriela ; Guinot Jimeno, Francisco ; Cappiello, Maria Chiara ; Bagattoni, Simone

AbstractBackgroundParental perceptions of staining due to silver diamine fluoride (SDF) could affect its utilization in paediatric dentistry. This study represents the second part of a wider project focused on SDF esthetic acceptability among Italian parents.AimTo evaluate parental acceptance of SDF staining in Italy and to assess whether the parent's level of acceptance depends on location, child's behavior, or demographic background.DesignA cross‐sectional study was conducted among Italian parents of children attending two university dental clinics. We used a validated Italian version of the questionnaire “Parental Perceptions of Silver Diamine Fluoride Dental Color Changes.”ResultsTwo hundred and thirty‐four parents took part in the survey. Of parents, 65.4% considered the staining on posterior teeth esthetically “acceptable” or “somewhat acceptable,” and 19.3% on anterior teeth (p = .001). In a scenario of positive cooperation, 48.5% of parents were “somewhat likely” or “very likely” to choose SDF to treat posterior teeth, and 17.6% on anterior teeth (p = .001). Level of acceptance increased as the difficulty the child would experience to receive conventional treatment increased.ConclusionStaining on posterior teeth is more acceptable to parents than staining on anterior teeth. Level of acceptance on anterior teeth increases when sedation or general anesthesia is the alternative for the child.

2025-02-01·European Archives of Paediatric Dentistry

Effects of glutathione and potassium iodide on silver diamine fluoride application on remineralisation and colour change in dentine caries of primary teeth: an in vitro study

Article

作者: Olmez, A ; Cömert, H ; Olmez, A. ; Cömert, H.

PURPOSEThe aim of this study is to compare the effect of GSH (reduced glutathione) and KI (potassium iodide) on SDF (silver diamine fluoride) discolouration and dentine remineralisation.METHODSSixteen primary molars were utilised, yielding 4 dentine specimens each. Three specimens per tooth were allocated: one as a control and the others to experimental groups. Initial microhardness measurements were taken from one remaining dentine specimen per tooth. Subsequently, all groups underwent exposure to a demineralisation solution. Colorimetry assessed specimen colour, and post-second microhardness measurements on demineralised specimens, treatments were administered as follows: group 1 (control, n = 16): 38% SDF, group 2 (n = 16): 38% SDF followed by KI, group 3 (n = 16): 38% SDF with 5% GSH added by weight. Following pH cycling across all groups, colorimetry reassessed 48 dentine specimens. Final microhardness measurements ensued, followed by statistical analysis. Normality was checked via Shapiro-Wilk, and homogeneity via Levene's test. Independent samples t test compared normally distributed groups; Mann-Whitney U compared non-normally distributed groups. ANOVA compared means of normally distributed groups, and Kruskal-Wallis for non-normally distributed ones. Repeated measures ANOVA compared dependent groups with normal distribution, and Friedman test for non-normal. Post hoc Bonferroni analyses identified significant differences. IBM SPSS 25 was used to conduct analyses.RESULTSThe mean ΔE* values for SDF and SDF + GSH groups were significantly higher than those of the SDF + KI group (p < 0.05). Significant differences in L* values during final colour measurement were noted between the SDF + KI group and both SDF and SDF + GSH groups (p < 0.05). Although mean remineralisation microhardness measurements were higher than mean demineralisation microhardness measurements in all groups, statistical significance was observed only in the SDF and SDF + KI groups (p < 0.05).CONCLUSIONThe study found that the addition of 5% GSH by weight to SDF does not significantly affect discolouration. Moreover, the addition of 5% GSH to the SDF solution may have a minor impact on the remineralisation potential of SDF. The application of KI after SDF reduces discolouration and does not affect the expected remineralisation process.

2025-01-23·Oral health & preventive dentistry

The Effect of Silver Diamine Fluoride Combined with Potassium Iodide and Sodium Fluoride on the Remineralisation of Hydroxyapatite.

Article

作者: Tao, Liming ; Chen, Haoran ; Ma, Yan ; He, Yan

PURPOSETo compare remineralisation efficacy between silver diamine fluoride (SDF) combined with potassium iodide (KI) and sodium fluoride (NaF) varnish using hydroxyapatite (HAP) artificial white spot lesions (AWSLs) demineralisation model.MATERIALS AND METHODSA total of 25 HAP disks was randomly divided into five groups (n = 5): baseline, AWSLs, deionized water (DW), SDF-KI or F-varnish. After AWSLs were developed, the specimen was treated with either deionized water, SDF-KI or F-varnish. These specimens were then subjected to pH-cycling for 7 days. The remineralisation potential was assessed by measuring changes in Vickers hardness (VHN). Morphological and compositional analyses were conducted using scanning electron microscopy (SEM), energy dispersive x-ray (EDX), x-ray diffraction (XRD), and Fourier-transform infrared spectroscopy (FTIR). Ion-selective electrodes (ISE) were utilised to measure calcium and fluoride release.RESULTSSDF-KI treatment demonstrated statistically significant remineralisation potential in restoring VHN values vs baseline levels (p 0.001). SEM, EDX, and XRD analyses confirmed the mineral deposits to indicate remineralisation. The uptake of calcium was higher in SDF-KI than in F-varnish (p = 0.011). The fluorapatite (FAP) and fluoride-substituted apatite formation were validated by FTIR and XRD analyses.CONCLUSIONSDF-KI and F-varnish applications are both effective in promoting remineralisation on HAP disks. The application of SDF-KI affected the physicochemical and mechanical properties of demineralised HAP. The SDF-KI showed more formation of fluoride-substituted apatite and is effective in the hardening of demineralised HAP.

2

项与银氮烷氟化物相关的新闻（医药）

2024-01-03

·Business Wire

MouthWatch Marks 2023 a Year of Virtual-First Care Innovation and Leading Intraoral Photography Growth

METUCHEN, N.J.--( BUSINESS WIRE )--MouthWatch, LLC, an industry leader in teledentistry solutions and dental intraoral cameras , is marking 2023 as a year defined by its commitment to continuous innovation, development of new technology solutions, and helping dental professionals increase access to care, improve oral health, and deliver excellence in patient experience. “As we reflect on 2023 and look ahead to 2024 and beyond, we are so proud of what we have accomplished, grateful for the recognition we have received, and excited about the growing role MouthWatch solutions play in addressing the needs of today’s patients, healthcare professionals, and organizations focused on patient health,” said Brant Herman, Founder and Chief Executive Officer of MouthWatch and Dentistry One . 2023 was an exciting year for MouthWatch, as it continued to bring new and exciting solutions to the marketplace: Virtual Care Innovation: MouthWatch launched Dentistry.One; a virtual-first dental care network built to break down barriers to oral health care, address the expectations of today’s modern healthcare consumers, the need for greater efficiency in healthcare, and the proven connection between good oral health and overall health. Dentistry.One features on-demand dental consultations, personalized care coordination, and oral health coaching for prioritizing oral health. Congressional Briefing : Mr. Herman joined other distinguished leaders in dental innovation at a Congressional Briefing in Washington, D.C., hosted by the Dental Trade Alliance, to share insights and experience about how teledentistry and artificial intelligence can improve both access to dental care and patient outcomes. Founder Recognition: Mr. Herman was named among NJBIZ Magazine’s “2023 People to Watch in Healthcare.” He was also named by the American Mobile and Teledentistry Alliance as one of the "Top 50 Teledentistry Leaders to Know in 2023," along with three other company Directors. Leadership Team Growth: New leadership roles were created to ensure continued growth and success of MouthWatch and Dentistry One: Carolyn Brown, DDS: Dr. Brown assumed the role of Chief Dental Officer at Dentistry One. She first joined MouthWatch in 2022 as Chief Health Innovation Officer, a position she continues to hold. Dr. Brown is nationally recognized for her focus on helping individuals and organizations achieve growth, improve health outcomes, leverage digital innovation, and bridge the gap across the medical-dental divide. She was instrumental in helping to launch Dentistry.One. Dr. Brown’s training at Dartmouth during the early days of value-based care and ACO formation is invaluable in the understanding of big data, diagnostic codes, healthtech, and risk-based partnerships. Previously, Dr. Brown has held academic positions at two dental schools, with over $20 million in research-related grant funding, and was amongst the first in the country to explore new models of dental care, including mobile and teledentistry. Sharity Ludwig, EPDH, MS: Ms. Ludwig joined Dentistry One as Senior Director of Clinical Operations. In this pivotal role, she oversees the development and implementation of innovative clinical strategies and processes for ensuring a seamless Dentistry One Provider-Patient experience. Prior to joining Dentistry One, Ms. Ludwig worked for 12+ years in various roles at DentaQuest, the largest Medicaid dental benefits administrator in the US. Her primary role was responsible for collaborating with clinical providers and operations management to develop and implement non-traditional services and care models across more than 70 practices and 200 providers. She played a key role in developing high-value clinical business opportunities and defining strategic and tactical objectives to oversee community-based care coupled with integrated care models for physical, behavioral, and oral health systems. Ms. Ludwig, in addition to dental care administration, treated at-risk patient populations as a clinical dental hygienist in both a federally qualified health center and private practice. Her background also includes coordinating dental services among various public and private dentistry stakeholders for a public health department and serving as project director for a Phase 3 randomized clinical trial of silver diamine fluoride. Susan Vassallo: Ms. Vassallo was promoted to Director of Marketing for MouthWatch and Dentistry One. In this role, she is responsible for driving visibility for the company’s products, services, and solutions to help ensure their sustained success. Ms. Vassallo brings over two decades of leadership experience in marketing communications and brand management to the company. Prior to joining MouthWatch and Dentistry One, her work in creating and deploying marketing communications strategies and initiatives contributed to growing a $1.5 billion national healthcare distributor into a multi-billion-dollar global Fortune 500 health solutions company serving dental and medical practitioners. Ms. Vassallo is passionate about raising awareness for important health topics and uncovering opportunities to increase access to care. Product Awards: The MouthWatch Intraoral Camera continued its winning streak by taking a 2023 Dentaltown Magazine Townie Choice Award in its category for the fourth consecutive year. In addition, the dental industry online forum and community, Nifty Thrifty Dentists, awarded the MouthWatch Intraoral Camera with a best product award based on its value and performance. The company’s newest product, The MouthWatch Plus+ HD Intraoral Camera was recognized with three separate awards by Dentistry Today Magazine : “Top 50 Technology Products,” “Readers’ Choice Top 100 Products,” and “Top Innovative Products.” “The success we achieved during 2023 was possible because of the outstanding expertise of the MouthWatch and Dentistry One team and the deep commitment we share to improve oral health and help our customers achieve their goals,” said Mr. Herman. “We look forward to taking on 2024 and beyond with the same vigor and enthusiasm we experienced this past year.” About MouthWatch, LLC MouthWatch, LLC, is a leader in developing digital technology solutions that drive success for dental professionals, improve oral health care, and enhance the overall patient experience. Headquartered in Metuchen, New Jersey, MouthWatch is widely known for its intraoral cameras that help engage patients in treatment planning through high-quality, affordable imaging technology, and its TeleDent software that provides practices and organizations with a teledentistry option to engage patients with providers remotely. MouthWatch launched Dentistry.One, a virtual-first care network that addresses the expectations of today’s modern healthcare consumers, the need for greater efficiency in healthcare, and the proven connection between good oral health and total health. Dentistry.One features on-demand dental consultations, personalized care coordination, and oral health coaching for prioritizing oral health. MouthWatch hardware and software are in use at over 40,000 practices, over 40 leading Dental Service Organizations (DSOs), and over 100 dental and hygiene schools. The company has been recognized three times in the Inc. 5000. For more information, visit mouthwatch.com . or dentistry.one .

高管变更临床3期

2023-02-10

·Science Daily

School dental program prevents 80 percent of cavities with one-time, non-invasive treatment

In a study of nearly 3,000 schoolchildren, silver diamine fluoride -- a liquid that is brushed onto the surface of teeth to prevent cavities or keep them from worsening -- was as effective against cavities as dental sealants, the standard of care. A single dose of either topical treatment given in elementary schools prevented roughly 80% of cavities and kept 50% of cavities from worsening when children were seen two years later. In a study of nearly 3,000 schoolchildren, silver diamine fluoride -- a liquid that is brushed onto the surface of teeth to prevent cavities or keep them from worsening -- was as effective against cavities as dental sealants, the standard of care. A single dose of either topical treatment given in elementary schools prevented roughly 80% of cavities and kept 50% of cavities from worsening when children were seen two years later. The findings, published in JAMA Network Open, offer an efficient and cost-effective approach to improving children's oral health through school-based care. Dental cavities are the most common chronic disease in children, and kids from low-income families are twice as likely to have cavities as those from higher-income families. Without proper and timely intervention, cavities can lead to severe infections, reduce children's quality of life, and are associated with lower student academic performance and school attendance. But getting kids to a dentist for the recommended twice-yearly visits can be challenging, especially when parents need to take time off of work. To reduce the barriers to seeing a dentist, some basic dental services can be offered in schools, especially those serving children from low-income families. For example, the Centers for Disease Control and Prevention recommends and funds school sealant programs. In 2017, NYU College of Dentistry researchers received funding from the Patient-Centered Outcomes Research Institute (PCORI) to run the nation's largest school-based cavity prevention study, which they named CariedAway. CariedAway is a randomized trial comparing the effectiveness of two cavity-prevention techniques: a "simple" treatment using silver diamine fluoride (SDF) and fluoride varnish, and a "complex" treatment using traditional glass ionomer sealants and fluoride varnish. Both are non-invasive and applied to the surface of teeth to prevent and arrest cavities in children, but for the same time and cost, providers can treat more children with the simpler SDF therapy. The study included 2,998 children in kindergarten through third grade at 47 New York City schools. The schools -- which serve a racially diverse group of students, most of whom are from low-income families -- were randomized to receive either the simple or complex treatment. Upon visiting each school, the clinical research team -- which included a supervising dentist, dental hygienists, registered nurses, and assistants -- did baseline exams to measure any tooth decay, and then applied fluoride varnish and either sealants or SDF, depending on whether the school was assigned to receive the complex or simple treatment. The initial visits took place in 2019 and early 2020, and were paused when the COVID-19 pandemic temporarily closed New York City schools and halted all school-based care. Two years later, schools allowed the clinical research team to resume, and they returned to each school for follow-up visits. The researchers found that both the simple and complex treatments were successful: just one cavity prevention treatment prevented more than 80% of cavities (81% for SDF and 82% for sealants) and stopped half of cavities from progressing (56% for SDF and 46% for sealants). "Without prevention, dental cavities grow continuously if not treated. One CariedAway cavity prevention treatment, provided just before schools closed during the pandemic, was remarkably effective over the following two-year period," said Richard Niederman, DMD, professor in the Department of Epidemiology & Health Promotion at NYU College of Dentistry, co-principal investigator of CariedAway, and the study's senior author. "I know of no other dental preventive intervention that had this great a beneficial impact across the pandemic." While the limited availability of trained dental professionals can pose challenges for school sealant programs, as sealants are applied by a dentist or dental hygienist, SDF may be an attractive alternative, as it can also be applied by nurses -- a workforce already in place in many schools. "Our results support the use of SDF for cavity prevention in school-based oral health programs and offer an opportunity for expanding access to critical oral health care," said Ryan Richard Ruff, MPH, PhD, associate professor in the Department of Epidemiology & Health Promotion at NYU College of Dentistry, co-principal investigator of CariedAway and the study's first author. Tamarinda Barry-Godín, DDS, MPH, was a study co-author. This research was funded by the Patient-Centered Outcomes Research Institute (award PCS-1609-36824).

临床结果

100 项与银氮烷氟化物相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D01502	-	A01AA	-

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
牙根龋	日本	Toyo Pharmar Co. Ltd.	2009-09-25
龋齿	日本	Toyo Pharmar Co. Ltd.	2009-02-24
牙本质敏感症	日本	Toyo Pharmar Co. Ltd.	2009-02-24

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03649659 (CTgov)	临床3期	龋齿	830	Silver Diamine Fluoride (Silver Diamine Fluoride (SDF))	願繭觸淵鏇蓋顧選窪遞(壓選壓獵夢選憲衊繭網) = 醖餘糧簾繭襯蓋鏇鹽鏇齋醖鏇襯鹹獵夢壓繭糧 (繭鏇製獵廠簾鑰壓醖齋, 簾夢廠齋糧獵觸獵衊選 ~ 製網齋襯衊鹽壓製夢遞) 更多	-	2025-01-07
				Placebo (Placebo)	願繭觸淵鏇蓋顧選窪遞(壓選壓獵夢選憲衊繭網) = 窪製醖壓構願獵選範鬱齋醖鏇襯鹹獵夢壓繭糧 (繭鏇製獵廠簾鑰壓醖齋, 選築窪齋衊鏇獵醖餘構 ~ 蓋範鹹淵觸夢齋顧範繭) 更多
NCT04054635 (Pubmed \| BMC Oral Health)	N/A	龋齿	-	silver diamine fluoride (38% SDF and 5% NaFV at one-month intervals)	憲顧淵蓋憲網憲鏇衊製(憲艱選繭鹹艱艱壓選廠) = 鑰艱遞顧襯繭糧鏇獵顧鹹願鹹構衊膚獵鹹蓋網 (膚壓獵艱鑰獵網選鏇醖 )	积极	2024-09-04
				silver diamine fluoride (38% SDF and 5% NaFV at four-month intervals)	憲顧淵蓋憲網憲鏇衊製(憲艱選繭鹹艱艱壓選廠) = 範範蓋餘膚蓋膚衊壓築鹹願鹹構衊膚獵鹹蓋網 (膚壓獵艱鑰獵網選鏇醖 )
NCT05761041 (Pubmed \| BMC Oral Health)	临床3期	龋齿	165	silver diamine fluoride (38% SDF solution)	築鹽鏇淵鏇糧選積築網(範獵築顧網窪顧窪構選) = 艱鑰願廠糧鹽簾鏇鹽夢積願遞顧鬱鬱簾鹹鏇醖 (鏇鹽鑰夢積醖醖壓願築 ) 更多	积极	2023-10-04
				silver diamine fluoride (5% NaF varnish + MI)	築鹽鏇淵鏇糧選積築網(範獵築顧網窪顧窪構選) = 網齋簾衊構艱網鬱顧鬱積願遞顧鬱鬱簾鹹鏇醖 (鏇鹽鑰夢積醖醖壓願築 ) 更多
Pubmed \| Dent Med Probl	N/A	龋齿	190	38% silver diamine fluoride (Atraumatic Restorative Treatment (ART))	鏇窪積鑰選製顧繭鹹壓(顧鑰壓夢蓋壓築鏇範鹽) = 築醖構鹹齋遞遞鑰壓艱簾鬱獵築襯淵鹽淵築窪 (觸繭繭蓋鹹築壓窪網網 )	积极	2022-04-29
NCT04186663 (CTgov)	临床2期	龋齿	59	Silver Diamine Fluoride	窪鏇網觸艱獵憲鹹艱構(鹹築構築簾鹹積選構構) = 製網構憲蓋顧製糧壓願積願觸獵鏇糧鏇選獵鬱 (鹹醖鬱淵範鏇鬱選觸積, 醖繭襯觸夢遞淵醖鏇襯 ~ 範窪選顧築選鏇憲夢蓋) 更多	-	2022-03-10
NCT02601833 (Pubmed \| JDR Clin Trans Res)	临床3期	龋齿	98	38% SDF	鑰襯蓋憲糧範遞衊夢鬱(壓繭窪膚範構簾齋獵積) = 鑰廠鹹網構衊憲糧網膚範願憲選範製糧遞醖餘 (構繭窪觸夢鏇鹹窪遞糧 ) 更多	不佳	2022-02-04
				38% SDF (Restorative Treatment)	鑰襯蓋憲糧範遞衊夢鬱(壓繭窪膚範構簾齋獵積) = 網齋觸膚餘衊鹹憲顧鹽範願憲選範製糧遞醖餘 (構繭窪觸夢鏇鹹窪遞糧 ) 更多
NCT03186261 (CTgov)	临床3期	龋齿	44	Nano silver fluoride solution (Nano Silver Fluoride Solution)	構憲鹹鹽糧窪獵製獵鏇(選獵醖窪繭齋選簾觸範) = 廠廠淵觸廠構餘衊鑰鹹築艱襯鹹顧獵選憲築顧 (顧鑰構膚觸夢衊襯淵窪, 憲獵蓋廠衊願鑰壓膚衊 ~ 鑰範鏇蓋簾齋繭醖鑰鹽) 更多	-	2021-09-16
				Cavity Cleanser (Cavity Cleanser)	構憲鹹鹽糧窪獵製獵鏇(選獵醖窪繭齋選簾觸範) = 鏇範遞齋積醖淵積壓衊築艱襯鹹顧獵選憲築顧 (顧鑰構膚觸夢衊襯淵窪, 夢壓膚憲觸鹽積簾廠齋 ~ 遞夢願鏇憲繭願醖遞艱) 更多
NCT04184271 (CTgov)	临床2期	龋齿	16	38% silver diamine fluoride	醖構繭網窪艱蓋廠醖網(繭憲築餘夢夢鹹憲醖鏇) = 遞觸遞網壓範築範夢願膚廠觸糧壓膚製網製蓋 (簾糧廠衊淵範觸觸鹹淵, 鏇鏇夢齋顧選繭鹹憲糧 ~ 糧製餘築衊壓顧製艱築) 更多	-	2020-08-14
NCT02536040 (CTgov)	临床3期	龋齿	66	38% diammine silver fluoride (38% Diamine Silver Fluoride)	鹽製遞壓鏇壓鹽鏇遞憲(鹽繭獵網艱鹽範醖範醖) = 醖艱餘選淵顧夢簾廠顧範齋蓋構繭簾積衊鬱願 (簾網廠鹹鏇衊簾獵憲糧, 顧範蓋築膚餘獵鏇簾艱 ~ 窪淵憲範觸鑰壓繭餘鹹) 更多	-	2020-01-23
				Water (Water)	鹽製遞壓鏇壓鹽鏇遞憲(鹽繭獵網艱鹽範醖範醖) = 鹹築鏇艱遞獵範鹽範選範齋蓋構繭簾積衊鬱願 (簾網廠鹹鏇衊簾獵憲糧, 獵憲簾壓範憲製糧壓壓 ~ 醖餘餘鏇窪範鏇構獵膚) 更多
NCT02360124 (CTgov)	临床2/3期	牙根龋	323	Water as placebo (Control)	遞範鑰醖網選鑰衊鹽餘(觸築鹽艱壓膚鑰憲願鹽) = 壓築憲窪窪鬱顧蓋糧糧膚窪遞獵衊壓窪窪觸蓋 (蓋觸襯製襯醖範製鏇顧, 窪壓鏇壓膚獵壓鹹艱壓 ~ 衊製簾顧窪構鹹膚鑰範) 更多	-	2016-05-19
				silver diammine fluoride (Silver Diammine Fluoride)	遞範鑰醖網選鑰衊鹽餘(觸築鹽艱壓膚鑰憲願鹽) = 壓窪憲繭壓鹽觸觸醖鏇膚窪遞獵衊壓窪窪觸蓋 (蓋觸襯製襯醖範製鏇顧, 衊築積窪顧襯觸餘齋糧 ~ 蓋積範積鹹簾糧襯鹹鏇) 更多