预约演示
更新于：2025-01-26
Silver Diammine Fluoride
银氮烷氟化物
更新于：2025-01-26
概要
基本信息
非在研机构- |
最高研发阶段批准上市 |
最高研发阶段(中国)- |
特殊审评- |
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结构/序列
分子式AgFH6N2 |
InChIKeyFJKGRAZQBBWYLG-UHFFFAOYSA-M |
CAS号34445-07-3 |
关联
83
项与 银氮烷氟化物 相关的临床试验CTRI/2024/10/075815
To evaluate the efficacy of 38 percent Silver diamine fluoride along with atraumatic restorative technique in arresting caries among secondary school children in rural Telangana: A Randomized controlled trial - NIL
开始日期2024-11-11 |
申办/合作机构- |
CTRI/2024/08/072862
To assess the effectiveness of silver diamine fluoride application with delayed glass ionomer cement restoration in dentinal caries of differently abled children An in-vivo study - Nil
开始日期2024-09-02 |
申办/合作机构- |
CTRI/2024/08/072965
Comparative Evaluation of Selective Caries Removal Techniques Followed by SDF Application In Primary Molars - An In Vivo Study - NIL
开始日期2024-09-02 |
申办/合作机构- |
100 项与 银氮烷氟化物 相关的临床结果
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100 项与 银氮烷氟化物 相关的转化医学
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100 项与 银氮烷氟化物 相关的专利（医药）
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875
项与 银氮烷氟化物 相关的文献（医药）2025-01-10·BRITISH DENTAL JOURNAL
Silver diamine fluoride and war-affected children
Letter
作者: Albujeer, A ; Khoshnevisan, M H
2025-01-01·DENTAL MATERIALS
The preventive effect of silver diamine fluoride-modified salivary pellicle on dental erosion
Article
作者: Lam, Walter Yu Hang ; Chu, Chun Hung ; Chawhuaveang, Darren Dhananthat ; Yu, Ollie Yiru
OBJECTIVE:
To investigate the preventive effect of silver diamine fluoride (SDF) modified salivary pellicle (SP) against dental erosion.
METHODS:
Enamel and dentin blocks allocated into 4 groups (n = 30 each). Blocks in Group SDF+SP were treated with SDF and SP. Blocks in Group SDF were treated with SDF. Blocks in Group DW+SP were treated with deionized water (DW) and SP. Blocks in Group DW were treated with DW. The blocks were subjected to an erosive challenge at pH 3.2 for 2 mins, 5 times per day for 14 days. Salivary pellicle morphology was assessed by atomic force microscopy (AFM). Crystal characteristics, percentage microhardness loss (%SMHL), surface loss, and surface morphology were assessed by X-ray diffraction (XRD), microhardness test, profilometry, and scanning electron microscopy (SEM), respectively.
RESULTS:
AFM revealed a modified pellicle morphology in Group SDF+SP. XRD of both blocks revealed hydroxyapatite, silver chloride, silver phosphate, and silver fluoride in Groups SDF+SP and SDF. Fluoroapatite was found in Group SDF+SP only. %SMHL ( ± Standard deviation in %) of Groups SDF+SP, SDF, DW+SP, and DW were 33.4 ± 2.2, 38.6 ± 2.2, 50.3 ± 2.2, and 58.3 ± 2.4 in enamel and 16.1 ± 2.2, 19.7 ± 2.1, 32.8 ± 2.1, and 39.0 ± 2.3 in dentin, respectively. The presence of SDF and SP reduced %SMHL in both blocks (p < 0.001). The surface loss ( ± Standard deviation in μm) of Groups SDF+SP, SDF, DW+SP, and DW were 3.6 ± 0.7, 4.1 ± 0.4, 5.3 ± 0.5, and 7.0 ± 0.6 in enamel and 5.4 ± 0.6, 6.1 ± 0.5, 9.1 ± 0.7, and 9.2 ± 0.5 in dentin, respectively. The presence of SDF and SP reduced surface loss in enamel and dentin blocks (p = 0.031 and p = 0.002, respectively). SEM showed enamel surface remained relatively smooth and partially dentinal tubule occlusion on dentin blocks in Groups SDF+SP and SDF.
CONCLUSION:
SDF had a positively synergistic effect with SP. SDF-modified salivary pellicle provided a superior protective effect against dental erosion.
2025-01-01·JDR Clinical & Translational Research
Tooth Discoloration from 2 Silver Fluorides Used in Adults with Special Needs: A Randomized Trial
Article
作者: Fu, D. ; See, L. ; Ha, D.H. ; Walsh, L.J. ; Zafar, S. ; Lopez Silva, C.
Background::
Discoloration of carious lesions after application of silver diamine fluoride lowers patient acceptance and limits its wider use for caries arrest.
Objective::
To assess lesion and tooth color changes from 2 novel silver fluoride (AgF) products and its relationship to caries activity (clinical visuo-tactile scores) and bacterial load (using laser fluorescence with the DIAGNOdent).
Methods::
A split-mouth design was followed, with matched smooth surface carious lesions in the same arch in adults with special needs randomized for 1-min treatments with AgF/potassium iodide (KI) (Riva Star Aqua, SDI) and AgF/stannous fluoride (SnF2) (Caries Status Disclosing Solution; Whiteley). Standardized images taken at baseline, immediately postoperatively, and at 3-mo review were subjected to digital image analysis to calculate delta-E and to track changes in luminosity of carious lesions.
Results::
Twelve participants were recruited in the study. A total of 56 teeth (28 pairs) were included. Significantly greater changes were seen in treated lesions than in the adjacent noncarious natural tooth structure, both immediately after treatment and at the 3-mo review ( P < 0.0001). Color change and caries activity were not affected by tooth type, tooth location, plaque status, salivary status, or special needs condition. AgF/SnF2 caused transitory darkening immediately on application, while AgF/KI caused the immediate formation of yellow deposits (silver iodide). Both products caused significant darkening of treated lesions at 3 mo ( P = 0.0009; P = 0.0361), with no differences between them ( P = 0.506). Responding lesions showed larger and more perceptible color changes immediately after either AgF application ( P = 0.002; P = 0.024).
Conclusions::
Both AgF products were highly effective for caries arrest in this patient population. Despite minor differences in the appearance of treated lesions at the time of application, both products lead to similar darkening of treated sites at 3 mo.
Knowledge Transfer Statement::
This study shows the usefulness of silver fluoride used in conjunction with potassium iodide or stannous fluoride for achieving caries arrest in smooth surface lesions in adults with special needs. Patients need to be informed that long-term staining of the lesion occurs with both, similar to silver diamine fluoride.
2
项与 银氮烷氟化物 相关的新闻（医药）2024-01-03
METUCHEN, N.J.--(
BUSINESS WIRE
)--MouthWatch, LLC, an industry leader in teledentistry solutions and dental
intraoral cameras
, is marking 2023 as a year defined by its commitment to continuous innovation, development of new technology solutions, and helping dental professionals increase access to care, improve oral health, and deliver excellence in patient experience.
“As we reflect on 2023 and look ahead to 2024 and beyond, we are so proud of what we have accomplished, grateful for the recognition we have received, and excited about the growing role MouthWatch solutions play in addressing the needs of today’s patients, healthcare professionals, and organizations focused on patient health,” said Brant Herman, Founder and Chief Executive Officer of
MouthWatch
and
Dentistry One
.
2023 was an exciting year for MouthWatch, as it continued to bring new and exciting solutions to the marketplace:
Virtual Care Innovation:
MouthWatch launched Dentistry.One; a
virtual-first dental care
network built to break down barriers to oral health care, address the expectations of today’s modern healthcare consumers, the need for greater efficiency in healthcare, and the proven connection between good oral health and overall health. Dentistry.One features on-demand dental consultations, personalized care coordination, and oral health coaching for prioritizing oral health.
Congressional Briefing
: Mr. Herman joined other distinguished leaders in dental innovation at a Congressional Briefing in Washington, D.C., hosted by the Dental Trade Alliance, to share insights and experience about how teledentistry and artificial intelligence can improve both access to dental care and patient outcomes.
Founder Recognition:
Mr. Herman was named among NJBIZ Magazine’s “2023 People to Watch in Healthcare.” He was also named by the American Mobile and Teledentistry Alliance as one of the "Top 50 Teledentistry Leaders to Know in 2023," along with three other company Directors.
Leadership Team Growth:
New leadership roles were created to ensure continued growth and success of MouthWatch and Dentistry One:
Carolyn Brown, DDS:
Dr. Brown assumed the role of Chief Dental Officer at Dentistry One. She first joined MouthWatch in 2022 as Chief Health Innovation Officer, a position she continues to hold.
Dr. Brown is nationally recognized for her focus on helping individuals and organizations achieve growth, improve health outcomes, leverage digital innovation, and bridge the gap across the medical-dental divide. She was instrumental in helping to launch Dentistry.One.
Dr. Brown’s training at Dartmouth during the early days of value-based care and ACO formation is invaluable in the understanding of big data, diagnostic codes, healthtech, and risk-based partnerships. Previously, Dr. Brown has held academic positions at two dental schools, with over $20 million in research-related grant funding, and was amongst the first in the country to explore new models of dental care, including mobile and teledentistry.
Sharity Ludwig, EPDH, MS:
Ms. Ludwig joined Dentistry One as
Senior Director of Clinical Operations. In this pivotal role, she oversees the development and implementation of innovative clinical strategies and processes for ensuring a seamless Dentistry One Provider-Patient experience.
Prior to joining Dentistry One, Ms. Ludwig worked for 12+ years in various roles at DentaQuest, the largest Medicaid dental benefits administrator in the US. Her primary role was responsible for collaborating with clinical providers and operations management to develop and implement non-traditional services and care models across more than 70 practices and 200 providers. She played a key role in developing high-value clinical business opportunities and defining strategic and tactical objectives to oversee community-based care coupled with integrated care models for physical, behavioral, and oral health systems.
Ms. Ludwig, in addition to dental care administration, treated at-risk patient populations as a clinical dental hygienist in both a federally qualified health center and private practice. Her background also includes coordinating dental services among various public and private dentistry stakeholders for a public health department and serving as project director for a Phase 3 randomized clinical trial of silver diamine fluoride.
Susan Vassallo:
Ms. Vassallo was promoted to Director of Marketing for MouthWatch and Dentistry One. In this role, she is responsible for driving visibility for the company’s products, services, and solutions to help ensure their sustained success.
Ms. Vassallo brings over two decades of leadership experience in marketing communications and brand management to the company. Prior to joining MouthWatch and Dentistry One, her work in creating and deploying marketing communications strategies and initiatives contributed to growing a $1.5 billion national healthcare distributor into a multi-billion-dollar global Fortune 500 health solutions company serving dental and medical practitioners.
Ms. Vassallo is passionate about raising awareness for important health topics and uncovering opportunities to increase access to care.
Product Awards:
The MouthWatch Intraoral Camera continued its winning streak by taking a 2023
Dentaltown Magazine Townie Choice Award
in its category for the fourth consecutive year.
In addition, the dental industry online forum and community,
Nifty Thrifty Dentists,
awarded the MouthWatch Intraoral Camera with a best product award based on its value and performance.
The company’s newest product, The MouthWatch Plus+ HD Intraoral Camera was recognized with three separate awards by
Dentistry Today Magazine
: “Top 50 Technology Products,” “Readers’ Choice Top 100 Products,” and “Top Innovative Products.”
“The success we achieved during 2023 was possible because of the outstanding expertise of the MouthWatch and Dentistry One team and the deep commitment we share to improve oral health and help our customers achieve their goals,” said Mr. Herman. “We look forward to taking on 2024 and beyond with the same vigor and enthusiasm we experienced this past year.”
About MouthWatch, LLC
MouthWatch, LLC, is a leader in developing digital technology solutions that drive success for dental professionals, improve oral health care, and enhance the overall patient experience.
Headquartered in Metuchen, New Jersey, MouthWatch is widely known for its intraoral cameras that help engage patients in treatment planning through high-quality, affordable imaging technology, and its TeleDent software that provides practices and organizations with a teledentistry option to engage patients with providers remotely.
MouthWatch launched Dentistry.One, a virtual-first care network that addresses the expectations of today’s modern healthcare consumers, the need for greater efficiency in healthcare, and the proven connection between good oral health and total health. Dentistry.One features on-demand dental consultations, personalized care coordination, and oral health coaching for prioritizing oral health.
MouthWatch hardware and software are in use at over 40,000 practices, over 40 leading Dental Service Organizations (DSOs), and over 100 dental and hygiene schools. The company has been recognized three times in the Inc. 5000.
For more information, visit
mouthwatch.com
. or
dentistry.one
.
高管变更临床3期
2023-02-10
In a study of nearly 3,000 schoolchildren, silver diamine fluoride -- a liquid that is brushed onto the surface of teeth to prevent cavities or keep them from worsening -- was as effective against cavities as dental sealants, the standard of care. A single dose of either topical treatment given in elementary schools prevented roughly 80% of cavities and kept 50% of cavities from worsening when children were seen two years later.
In a study of nearly 3,000 schoolchildren, silver diamine fluoride -- a liquid that is brushed onto the surface of teeth to prevent cavities or keep them from worsening -- was as effective against cavities as dental sealants, the standard of care. A single dose of either topical treatment given in elementary schools prevented roughly 80% of cavities and kept 50% of cavities from worsening when children were seen two years later.
The findings, published in JAMA Network Open, offer an efficient and cost-effective approach to improving children's oral health through school-based care.
Dental cavities are the most common chronic disease in children, and kids from low-income families are twice as likely to have cavities as those from higher-income families. Without proper and timely intervention, cavities can lead to severe infections, reduce children's quality of life, and are associated with lower student academic performance and school attendance. But getting kids to a dentist for the recommended twice-yearly visits can be challenging, especially when parents need to take time off of work.
To reduce the barriers to seeing a dentist, some basic dental services can be offered in schools, especially those serving children from low-income families. For example, the Centers for Disease Control and Prevention recommends and funds school sealant programs. In 2017, NYU College of Dentistry researchers received funding from the Patient-Centered Outcomes Research Institute (PCORI) to run the nation's largest school-based cavity prevention study, which they named CariedAway.
CariedAway is a randomized trial comparing the effectiveness of two cavity-prevention techniques: a "simple" treatment using silver diamine fluoride (SDF) and fluoride varnish, and a "complex" treatment using traditional glass ionomer sealants and fluoride varnish. Both are non-invasive and applied to the surface of teeth to prevent and arrest cavities in children, but for the same time and cost, providers can treat more children with the simpler SDF therapy.
The study included 2,998 children in kindergarten through third grade at 47 New York City schools. The schools -- which serve a racially diverse group of students, most of whom are from low-income families -- were randomized to receive either the simple or complex treatment.
Upon visiting each school, the clinical research team -- which included a supervising dentist, dental hygienists, registered nurses, and assistants -- did baseline exams to measure any tooth decay, and then applied fluoride varnish and either sealants or SDF, depending on whether the school was assigned to receive the complex or simple treatment.
The initial visits took place in 2019 and early 2020, and were paused when the COVID-19 pandemic temporarily closed New York City schools and halted all school-based care. Two years later, schools allowed the clinical research team to resume, and they returned to each school for follow-up visits.
The researchers found that both the simple and complex treatments were successful: just one cavity prevention treatment prevented more than 80% of cavities (81% for SDF and 82% for sealants) and stopped half of cavities from progressing (56% for SDF and 46% for sealants).
"Without prevention, dental cavities grow continuously if not treated. One CariedAway cavity prevention treatment, provided just before schools closed during the pandemic, was remarkably effective over the following two-year period," said Richard Niederman, DMD, professor in the Department of Epidemiology & Health Promotion at NYU College of Dentistry, co-principal investigator of CariedAway, and the study's senior author. "I know of no other dental preventive intervention that had this great a beneficial impact across the pandemic."
While the limited availability of trained dental professionals can pose challenges for school sealant programs, as sealants are applied by a dentist or dental hygienist, SDF may be an attractive alternative, as it can also be applied by nurses -- a workforce already in place in many schools.
"Our results support the use of SDF for cavity prevention in school-based oral health programs and offer an opportunity for expanding access to critical oral health care," said Ryan Richard Ruff, MPH, PhD, associate professor in the Department of Epidemiology & Health Promotion at NYU College of Dentistry, co-principal investigator of CariedAway and the study's first author.
Tamarinda Barry-Godín, DDS, MPH, was a study co-author. This research was funded by the Patient-Centered Outcomes Research Institute (award PCS-1609-36824).
临床结果
100 项与 银氮烷氟化物 相关的药物交易
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研发状态
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 牙根龋 | 日本 | 2009-09-25 | |
| 龋齿 | 日本 | 2009-02-24 | |
| 牙本质敏感症 | 日本 | 2009-02-24 |
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临床结果
临床结果
适应症
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| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
临床3期 | 830 | (Silver Diamine Fluoride (SDF)) | 獵廠積膚願蓋餘繭鹹餘(網範觸餘範築製衊選廠) = 壓顧顧壓餘顧鏇衊糧顧 鏇築選廠壓簾醖鬱獵鑰 (簾製餘選醖窪構壓築鹹, 鹹醖醖顧觸壓醖鏇範淵 ~ 餘鬱夢網願鏇製簾餘願) 更多 | - | 2025-01-07 | ||
Placebo (Placebo) | 獵廠積膚願蓋餘繭鹹餘(網範觸餘範築製衊選廠) = 範構鹹鹽蓋簾範鹹顧繭 鏇築選廠壓簾醖鬱獵鑰 (簾製餘選醖窪構壓築鹹, 艱遞窪膚艱夢築艱糧鹹 ~ 鹽糧鑰獵齋憲襯壓鏇簾) 更多 | ||||||
临床3期 | 165 | (38% SDF solution) | 鹹窪簾繭壓鏇獵醖築壓(窪艱選鹽壓觸築積願餘) = 鹹壓獵鑰築網構遞選觸 鏇糧鹽蓋齋糧夢艱範窪 (衊夢壓遞鑰蓋積齋鬱襯 ) 更多 | 积极 | 2023-10-04 | ||
(5% NaF varnish + MI) | 鹹窪簾繭壓鏇獵醖築壓(窪艱選鹽壓觸築積願餘) = 選餘夢願鏇膚顧獵鑰築 鏇糧鹽蓋齋糧夢艱範窪 (衊夢壓遞鑰蓋積齋鬱襯 ) 更多 | ||||||
N/A | 190 | (Atraumatic Restorative Treatment (ART)) | 鹹鑰齋鹹築遞襯觸壓繭(選鏇選構鹹壓廠選醖蓋) = 網鑰衊膚網齋淵積膚襯 廠蓋窪遞鬱窪積齋蓋夢 (簾艱廠觸廠餘積窪選艱 ) | 积极 | 2022-04-29 | ||
临床2期 | 59 | 鬱齋選繭網網餘遞蓋簾(範製糧憲齋製齋壓遞廠) = 製廠憲網衊鹹艱願觸觸 選蓋壓壓範壓遞網鏇鹹 (築選蓋襯鹹壓鹽鹹壓鏇, 願觸憲構憲廠鏇願獵襯 ~ 醖獵廠觸鹹鏇糧淵鏇夢) 更多 | - | 2022-03-10 | |||
临床3期 | 44 | (Nano Silver Fluoride Solution) | 窪獵鬱艱顧襯淵壓鹹鑰(積餘鹽獵鏇淵鏇繭鹽鏇) = 醖選齋鹽餘醖顧鏇鏇衊 構築齋鹹淵蓋鏇鹹鹽憲 (繭製網齋遞憲衊醖積簾, 膚膚鑰築積製鬱糧顧顧 ~ 襯鹹夢遞鏇網網艱鏇構) 更多 | - | 2021-09-16 | ||
(Cavity Cleanser) | 窪獵鬱艱顧襯淵壓鹹鑰(積餘鹽獵鏇淵鏇繭鹽鏇) = 簾艱膚繭願遞餘鑰構壓 構築齋鹹淵蓋鏇鹹鹽憲 (繭製網齋遞憲衊醖積簾, 鹹製選獵艱範積膚構壓 ~ 獵餘築製襯網積範鑰餘) 更多 | ||||||
临床2期 | 16 | 糧選簾憲鬱鏇顧艱壓糧(製範鹽鹽醖蓋淵襯構構) = 選艱衊構壓積鬱艱餘壓 壓鏇窪艱鬱積襯齋鏇範 (憲膚蓋壓憲襯淵積觸齋, 淵衊窪範醖鬱構襯顧膚 ~ 繭淵蓋鬱積鏇壓膚築鏇) 更多 | - | 2020-08-14 | |||
临床3期 | 66 | (38% Diamine Silver Fluoride) | 鹽鏇襯製鏇築構衊遞廠(醖遞選願範鬱襯蓋糧繭) = 製選糧鹹選鹹廠構鹽遞 網鏇醖醖構衊糧網淵餘 (鹹鑰築選觸鹽餘繭範獵, 獵鹹廠積窪襯簾範遞鑰 ~ 顧鹽願網築選夢蓋齋構) 更多 | - | 2020-01-23 | ||
Water (Water) | 鹽鏇襯製鏇築構衊遞廠(醖遞選願範鬱襯蓋糧繭) = 網窪製範願淵願醖壓淵 網鏇醖醖構衊糧網淵餘 (鹹鑰築選觸鹽餘繭範獵, 壓鹹廠網鏇艱憲廠膚願 ~ 範醖簾網選膚蓋窪鬱廠) 更多 | ||||||
临床2/3期 | 323 | Water as placebo (Control) | 鏇醖鏇淵鑰繭鏇醖遞積(艱壓構膚鏇淵齋鹹蓋齋) = 鏇艱鹽鑰鑰壓襯積膚鹽 淵網齋淵壓齋願顧選鹹 (艱鑰鏇鹹遞獵窪範獵繭, 選廠夢淵積糧願觸顧構 ~ 齋簾糧夢膚餘鬱繭製憲) 更多 | - | 2016-05-19 | ||
(Silver Diammine Fluoride) | 鏇醖鏇淵鑰繭鏇醖遞積(艱壓構膚鏇淵齋鹹蓋齋) = 醖醖鏇襯製醖遞膚淵艱 淵網齋淵壓齋願顧選鹹 (艱鑰鏇鹹遞獵窪範獵繭, 觸淵鹹鹹衊鏇壓獵膚窪 ~ 鏇鹽膚廠齋願鏇觸積膚) 更多 |
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