Hepatitis B DNA vaccine(Guangzhou Baiyunshan Bai Di Bio-technology Co., Ltd.)

在完成Ⅱa期、Ⅱb期临床试验的基础上，评价治疗性双质粒HBV DNA疫苗治疗HBeAg未发生血清学转换的慢性乙型肝炎的有效性和安全性。

In order to study the immunotherapeutic effects of electroporation (EP)-mediated dual-plasmids Hepatitis B Virus DNA vaccine, the investigators plan to conduct a double-blind, randomized, placebo-controlled trial, approved by Chinese State Food and Drug Administration with written informed consent from each chronic hepatitis B (CHB) patients with baseline ALT more than 2 times the ULN, for whom antiviral treatment is indicated and who were under the simultaneous lamivudine (LAM) chemotherapy.