N-butyl-2-cyanoacrylate(N-butyl-2-cyanoacrylate)

概要

基本信息

药物类型

小分子化药

别名

Histoacryl

靶点-

作用机制-

治疗领域

消化系统疾病肿瘤感染+ [3]

在研适应症-

非在研适应症

脓肿龋齿食管胃静脉曲张+ [2]

原研机构-

在研机构-

非在研机构

Mansoura University

Tanta University

最高研发阶段无进展临床3期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

6

项与 N-butyl-2-cyanoacrylate 相关的临床试验

CTRI/2024/05/068011 / Not yet recruiting临床4期IIT

Evaluation of the effectiveness of n-butyl-2-cyanoacrylate tissue glue versus black braided silk suture as a wound closure agent for minor oral surgical procedures – A split mouth randomized controlled trial. - NIL

开始日期2024-06-01

申办/合作机构-

ChiCTR2400080913 / Suspended早期临床1期IIT

The effects of endoscopic conventional treatment and conventional treatment combined with Histoacryl glue on the rate of rebleeding in patients with acute nonvariceal upper gastrointestinal bleeding combined with coronary artery disease:A prospective randomized controlled study

开始日期2024-02-20

申办/合作机构-

CTRI/2023/10/058734 / Recruiting临床2期IIT

Post pancreatectomy hemorrhage afterusing N-butyl-2-cyanoacrylate glue on pancreatic stump in pancreaticoduodenectomy – A pilot study - Nil

开始日期2023-10-23

申办/合作机构-

100 项与 N-butyl-2-cyanoacrylate 相关的临床结果

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100 项与 N-butyl-2-cyanoacrylate 相关的转化医学

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100 项与 N-butyl-2-cyanoacrylate 相关的专利（医药）

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890

项与 N-butyl-2-cyanoacrylate 相关的文献（医药）

2024-12-01·Radiology Case Reports

Middle meningeal artery embolization for organized chronic subdural hematoma combined with minimal evacuation surgery: Two case reports

Article

作者: Kajikawa, Ryuichiro ; Kadono, Yoshinori ; Kishima, Haruhiko ; Tsuzuki, Takashi

Organized chronic subdural hematoma (OCSDH) is a rare condition lacking standardized treatment protocols. Middle meningeal artery (MMA) embolization has recently demonstrated promising outcomes in managing chronic subdural hematoma (CSDH). We present 2 cases of OCSDH treated with endovascular embolization and minimal evacuation surgery. The first case involved an 83-year-old male with a history of left CSDH drainage, admitted urgently due to right hemiplegia and dysarthria. CT scans confirmed recurrent CSDH. A small craniotomy was performed to decompress the thick hematoma, followed by drain placement. Postoperative magnetic resonance imaging (MRI) indicated OCSDH. Seven days later, MMA embolization with 25% n-butyl-2-cyanoacrylate (NBCA) was performed under local anesthesia. The patient's symptoms improved, and the hematoma resolved within 6 months without recurrence. The second case involved a 76-year-old male with right CSDH and thrombocytopenia (platelet count of 19,000/µL), diagnosed with immune thrombocytopenia. MRI indicated OCSDH. Due to the risk associated with craniotomy, a burr hole perforation and MMA embolization were planned, accompanied by a platelet transfusion. Left MMA embolization with 20% NBCA was performed, followed by burr hole enlargement for decompression and drain placement. The patient's symptoms improved postoperatively, and his platelet count stabilized with steroid therapy and thrombopoietin. The hematoma resolved within 3 months without recurrence. These cases indicate that MMA embolization combined with small craniotomy or perforation may be an effective treatment strategy for OCSDH.

2024-12-01·Endoscopy

Endoscopic glue injection therapy with N-butyl-2-cyanoacrylate for bleeding from isolated large rectal varices

Article

作者: Takita, Masahiro ; Kashida, Hiroshi ; Matsui, Shigenaga ; Kudo, Masatoshi

2024-12-01·Radiology Case Reports

Embolization of a type 2 endoleak using a micropuncture introducer set and a triple-coaxial system through the deep iliac circumflex artery via the ipsilateral femoral artery

Article

作者: Maruchi, Yuki ; Takehara, Yumi ; Saga, Toshinobu ; Shimohira, Masashi ; Ozaki, Shinichi ; Nakano, Yuta ; Ikeda, Shuji ; Suzuki, Kojiro ; Narita, Akiko ; Taniguchi, Marino ; Okada, Hiroaki

An 83-year-old man underwent embolization for a type 2 endoleak following endovascular aortic repair for an abdominal aortic aneurysm. The type 2 endoleak originated from the left iliac circumflex artery, which was located very close to the puncture site in the left femoral artery. This proximity made the embolization procedure challenging; however, by employing a combination of a micropuncture introducer set and a triple-coaxial system, embolization with N-butyl-2-cyanoacrylate was successfully achieved.

100 项与 N-butyl-2-cyanoacrylate 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
食管胃静脉曲张	临床3期	埃及	Tanta University	2016-01-01
脓肿	临床3期	埃及	Mansoura University	2008-08-31
龋齿	临床3期	埃及	Mansoura University	2008-08-31
藏毛性窦道	临床3期	埃及	Mansoura University	2008-08-31
手术伤口	临床3期	埃及	Mansoura University	2008-08-31

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


ARVO2016	N/A	-	-	N-Butyl-2-Cyanoacrylate glue	鏇鏇衊願鑰網憲壓衊鹽(繭選夢蓋鏇膚鑰夢糧範) = 鹹網簾鬱襯獵窪鬱鹹襯壓獵選鑰選齋繭簾糧願 (廠獵廠顧鹽觸範觸壓醖, ± 44.5)	-	2016-09-01
ARVO2013	N/A	眼睑下垂	22	Histoacryl	(夢齋壓夢遞顧衊艱鹽鹹) = 艱築廠壓夢鏇製願繭願襯觸遞鏇鏇觸壓願憲製 (鏇簾鑰鬱獵觸壓壓鑰選 )	-	2013-06-01
Pubmed \| Am J Gastroenterol	N/A	出血性胃底静脉曲张	-	N-Butyl-2-Cyanoacrylate (Histoacryl) Glue Injections	醖膚構艱廠構製觸艱構(選壓構選選鹽顧遞夢簾) = 蓋襯膚壓窪壓觸繭壓製窪鹹膚齋醖廠網餘製蓋 (襯鏇蓋觸製鑰獵鏇衊鏇 ) 更多	-	2003-12-01
Pubmed \| Am J Gastroenterol	N/A	出血性胃底静脉曲张	-	N-Butyl-2-Cyanoacrylate (Histoacryl) Glue Injections	壓鹹選壓餘願鑰衊襯憲(鹽鏇製淵齋蓋餘網糧鹹) = 製遞願憲憲顧選鏇壓淵鑰選窪遞艱顧鹽壓觸憲 (廠願窪鹽範構齋願選糧 ) 更多	-	2003-12-01
Pubmed \| Gastrointest Endosc	N/A	出血性胃底静脉曲张	90	N-butyl-2-cyanoacrylate (Histoacryl)	網顧鑰製選淵積積艱鹽(觸製鬱構憲鹽築醖膚餘) = 願膚憲築膚構齋簾膚願鹹壓衊網網淵夢觸觸齋 (簾齋繭構鏇餘簾製壓鬱 ) 更多	-	2000-08-01