N-butyl-2-cyanoacrylate(N-butyl-2-cyanoacrylate)

概要

基本信息

药物类型

小分子化药

别名

Histoacryl

靶点-

作用机制-

治疗领域

消化系统疾病肿瘤感染+ [3]

在研适应症-

非在研适应症

脓肿龋齿食管胃静脉曲张+ [2]

原研机构-

在研机构-

非在研机构

Mansoura University

Tanta University

最高研发阶段无进展临床3期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

6

项与 N-butyl-2-cyanoacrylate 相关的临床试验

CTRI/2024/05/068011 / Not yet recruiting临床4期IIT

Evaluation of the effectiveness of n-butyl-2-cyanoacrylate tissue glue versus black braided silk suture as a wound closure agent for minor oral surgical procedures – A split mouth randomized controlled trial. - NIL

开始日期2024-06-01

申办/合作机构-

ChiCTR2400080913 / Suspended早期临床1期IIT

The effects of endoscopic conventional treatment and conventional treatment combined with Histoacryl glue on the rate of rebleeding in patients with acute nonvariceal upper gastrointestinal bleeding combined with coronary artery disease:A prospective randomized controlled study

开始日期2024-02-20

申办/合作机构-

CTRI/2023/10/058734 / Recruiting临床2期IIT

Post pancreatectomy hemorrhage afterusing N-butyl-2-cyanoacrylate glue on pancreatic stump in pancreaticoduodenectomy – A pilot study - Nil

开始日期2023-10-23

申办/合作机构-

100 项与 N-butyl-2-cyanoacrylate 相关的临床结果

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100 项与 N-butyl-2-cyanoacrylate 相关的转化医学

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100 项与 N-butyl-2-cyanoacrylate 相关的专利（医药）

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893

项与 N-butyl-2-cyanoacrylate 相关的文献（医药）

2025-01-01·Radiology Case Reports

Navigating complexity and sealing the threat: Ultrasound and CT guided percutaneous glue embolization of bronchial artery pseudoaneurysm with challenging anatomy

Article

作者: Patton, Andrew ; Jogi, Ravi Muli ; Hylands, Annabel

Bronchial artery aneurysms are a rare vascular pathology, however bronchial artery pseudoaneurysms are even less commonly observed with minimal cases available in the literature. They are often associated with conditions such as lung infections or malignancies and are typically managed with endovascular embolization. However, complex vascular anatomy may render endovascular approaches unsuitable. Both pathologies require prompt diagnosis and management due to the risk of rupture and subsequent bleeding. This case report aims to describe the diagnosis and successful percutaneous treatment of a bronchial artery pseudoaneurysm of a 59-year-old female patient who presented with hemoptysis on the background of cavitating lung disease secondary to aspergillus colonization. The patient underwent successful percutaneous glue embolization opposed to the typical endovascular approach due to difficult anatomy, leading to complete resolution of the hemoptysis. This case report highlights the importance of US-guided direct percutaneous embolization of a bronchial artery pseudoaneurysm with the use of n-butyl-2-cyanoacrylate as a safe and effective treatment option when endovascular therapy cannot be performed.

2025-01-01·Annals of Vascular Surgery

Clinical Application of n-Butyl-2- Cyanoacrylate (NBCA) in the Transarterial Embolization for Type I/II Endoleak During and After EVAR Surgery

Article

作者: Wang, Qi-Bin ; Wang, Xu ; Jiang, Li-Ping ; Ren, Luo-Yi ; Zhang, Hong-Mei

BACKGROUNDExploring the effectiveness and safety of n-butyl-2-cyanoacrylate (NBCA) in the transarterial embolization for common endoleak during and after endovascular repair of aortic aneurysm (EVAR).METHODSA total of 226 patients with abdominal aortic aneurysm (AAA) were treated with EVAR in 4 years from August 2019 to February 2023, including 46 patients with ruptured aneurysms (rAAA). 37 cases, 28 nonruptured AAA patients and 9 rAAA patients, developed endoleak during EVAR surgery and follow-up period and were then treated with NBCA for transarterial embolization. A follow-up was done for at least 6 months to observe its clinical efficacy and adverse reactions.RESULTSAmong 37 cases of endoleak, there were 8 cases of primary type Ia endoleak and one case of primary right type Ib endoleak in the rAAA group, one case of primary type Ib endoleak, 2 cases of secondary type Ia endoleak, and 25 cases of postoperative type II endoleak in the nonruptured AAA group. Three patients with primary type Ia endoleak were treated with coil-assisted NBCA in the rAAA group, while the remaining 34 patients with type I and type II endoleaks were treated with NBCA alone. All transarterial embolization achieved technical success, and the endoleak disappeared. Postoperative hospitalization observation showed that 3 cases of patients in the rAAA group who experienced primary type Ia endoleak during emergency EVAR surgery died within 4 days after surgery due to hemorrhagic shock and multiple organ failure. Two patients experienced non-AAA-related deaths during the follow-up period.CONCLUSIONSTransarterial embolization with NBCA for the treatment of primary and secondary endoleak is a safe and effective method. It can achieve more dense embolization of the aneurysm sac and more complex endoleaks embolization. And, it showed a low recurrence rate of endoleak and the incidence of perioperative complications after surgery, which is worthy of clinical promotion and application. Even in emergency EVAR combined with primary type I endoleak treatment in rAAA patients, patients can still benefit.

2024-12-01·Radiology Case Reports

Embolization of a type 2 endoleak using a micropuncture introducer set and a triple-coaxial system through the deep iliac circumflex artery via the ipsilateral femoral artery

Article

作者: Maruchi, Yuki ; Takehara, Yumi ; Saga, Toshinobu ; Shimohira, Masashi ; Ozaki, Shinichi ; Nakano, Yuta ; Ikeda, Shuji ; Suzuki, Kojiro ; Narita, Akiko ; Taniguchi, Marino ; Okada, Hiroaki

An 83-year-old man underwent embolization for a type 2 endoleak following endovascular aortic repair for an abdominal aortic aneurysm. The type 2 endoleak originated from the left iliac circumflex artery, which was located very close to the puncture site in the left femoral artery. This proximity made the embolization procedure challenging; however, by employing a combination of a micropuncture introducer set and a triple-coaxial system, embolization with N-butyl-2-cyanoacrylate was successfully achieved.

100 项与 N-butyl-2-cyanoacrylate 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
食管胃静脉曲张	临床3期	埃及	Tanta University	2016-01-01
脓肿	临床3期	埃及	Mansoura University	2008-08-31
龋齿	临床3期	埃及	Mansoura University	2008-08-31
藏毛性窦道	临床3期	埃及	Mansoura University	2008-08-31
手术伤口	临床3期	埃及	Mansoura University	2008-08-31

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


UEGW	N/A	食管胃静脉曲张	-	N-2-Butyl Cyanoacrylate (Group 1 (G1))	遞鏇簾鹽鹹遞選顧製顧(憲觸壓齋範網糧膚淵夢) = Minor complications were observed in 38.7% in the G2( N=12) and 29.5%cases in the G1(N=12). Major complications were seen in 9.7% in the G2(N=3), including a case of pulmonary embolism and in 2.3%,in the G1 (N=1) represented by a single case of spontaneous bacterial peritonitis. 觸壓艱鹽遞願膚觸壓廠 (鬱壓鹹醖積鹽網廠網遞 ) 更多	-	2019-10-01
UEGW	N/A	食管胃静脉曲张	-	N-2-Butyl Cyanoacrylate (Group 2 (G2))		-	2019-10-01
ARVO2016	N/A	-	-	N-Butyl-2-Cyanoacrylate glue	鏇製廠範壓簾鬱壓遞廠(鑰積憲遞築鹹築積餘蓋) = 願艱顧選夢簾窪簾鏇製選範膚繭築鑰鹽膚鬱齋 (壓廠願鬱衊顧糧獵觸繭, ± 44.5)	-	2016-09-01
ARVO2013	N/A	眼睑下垂	22	Histoacryl	(顧願餘膚夢夢淵簾範窪) = 選壓鹹膚選範窪簾簾衊蓋鑰蓋窪鬱壓窪鑰觸淵 (築糧艱鹹餘製窪獵鏇觸 )	-	2013-06-01
Pubmed \| Am J Gastroenterol	N/A	出血性胃底静脉曲张	-	N-Butyl-2-Cyanoacrylate (Histoacryl) Glue Injections	積憲餘鏇構鏇遞艱衊繭(齋窪築憲網壓夢觸窪鏇) = 鑰築繭廠簾鹽鑰願顧積廠積糧壓遞鹽壓醖艱遞 (獵膚襯鏇鑰齋廠壓蓋選 ) 更多	-	2003-12-01
Pubmed \| Am J Gastroenterol	N/A	出血性胃底静脉曲张	-	N-Butyl-2-Cyanoacrylate (Histoacryl) Glue Injections	廠觸餘壓選艱艱襯繭蓋(獵鹹製蓋鑰醖憲觸鹽廠) = 範鹽廠夢鹽衊淵範鏇積壓顧壓襯餘網膚鹹築廠 (夢鑰積鬱窪願窪膚夢選 ) 更多	-	2003-12-01
Pubmed \| Gastrointest Endosc	N/A	出血性胃底静脉曲张	90	N-butyl-2-cyanoacrylate (Histoacryl)	願積選鏇壓製製範鹽夢(積壓蓋艱衊廠廠築衊夢) = 艱餘壓醖衊積壓鑰築糧蓋壓顧蓋顧壓願製網鏇 (餘鹽壓蓋構繭憲蓋襯鏇 ) 更多	-	2000-08-01