预约演示
更新于：2026-02-27
Chlorhexidine Gluconate/Isopropyl Alcohol
葡萄糖氯己定/异丙醇
更新于：2026-02-27
概要
基本信息
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (2000-07-14), |
最高研发阶段(中国)- |
特殊审评- |
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结构/序列
分子式C3H8O |
InChIKeyKFZMGEQAYNKOFK-UHFFFAOYSA-N |
CAS号67-63-0 |
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关联
36
项与 葡萄糖氯己定/异丙醇 相关的临床试验NCT04756154
Assessment of the Antimicrobial Efficacy of 3M™ SoluPrep™ Preoperative Skin Preparation Against Resident Human Skin Flora on the Inguinal Region
NCT04218110
Preoperative Skin Preparation Study Following ASTM E1173 Methods to Evaluate the Antimicrobial Capabilities of Four Test Substances
NCT03489512
Clinical Phase IV Comparison Trial for 2% Chlorhexidine Skin Asepsis +70% Alcohol Versus Aqueous Chlorhexidine (2%) for the Prevention of Catheter-related Bacteremia in Critical Patients: Preliminary Study
100 项与 葡萄糖氯己定/异丙醇 相关的临床结果
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100 项与 葡萄糖氯己定/异丙醇 相关的转化医学
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100 项与 葡萄糖氯己定/异丙醇 相关的专利（医药）
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42
项与 葡萄糖氯己定/异丙醇 相关的文献（医药）2025-07-17British journal of nursing (Mark Allen Publishing)
Microbial safety of vapocoolant spray on sites for arterial line and epidural placement
Article
作者: Fayed, Mohamed ; Nowak, Katherine ; Wang, Anqi ; Woude, Thomas Vander ; Attali, Ami
This investigation evaluated if skin sterility is maintained following application of Gebauer's Ethyl Chloride® vapocoolant spray. In this prospective, blinded, controlled study, the medial forearm (site of arterial line placement) and lower back (site of epidural placement) were swabbed before and after sterilisation and treatment with vapocoolant. Data were collected from 72 participants. There was no difference in microbial abundance between samples obtained from the wrist with ChloraPrep™ versus ChloraPrep + Gebauer's Ethyl Chloride (P>0.99), or in positive cultures (P=0.317). On the lower back, there was no difference in microbial abundance following ChloraPrep versus ChloraPrep + Gebauer's Ethyl Chloride (P=0.317), or in positive cultures (P=0.317). Supply chain shortages of lidocaine have prompted consideration of alternative local anaesthetics. These findings support use of Gebauer's Ethyl Chloride as an alternative to lidocaine for minimally invasive procedures such as placement of arterial lines and epidurals. Further investigation is necessary to explore the safety of vapocoolants in more invasive procedures.
2024-11-05MILITARY MEDICINE
The Dreaded 3-Minute Wait: Does It Really Prevent Operating Room Fires? The IGNITE Trial
Article
作者: Fraley, Jim ; Danis, Hillary ; Keenan, Corey ; Spitzer, Holly ; Roets, Jack ; Grasso, Samuel
ABSTRACT:
Introduction:
Operating room fires can have devastating consequences and as such must be prevented. There exists a paucity of literature requiring further elucidation regarding manufacturer recommendations of a predefined waiting period prior to patient draping after using alcohol-based surgical antiseptics, in order to reduce the risk of operating room fires.
Methods:
This was further investigated by exposing two common alcohol-based surgical antiseptics to electrosurgery and open flames at various power settings and time intervals in an ex vivo porcine model. The simulated surgical site was prepped following manufacturer recommendations and exposed to monopolar electrosurgery at low and high power, using both PURE CUT and COAGULATION modes, and open flame, at 15-s increments after application.
Results:
While using PURE CUT mode at both low and high power, no ignition was observed on hairless surgical sites prepped with ChloraPrep® at any time point. However, use of COAGULATION mode at both low and high powers resulted in ignition consistently out to 1-min post-application. Additionally, if the prepped area subjectively appeared wet, especially with pooling of the antiseptic, both COAGULATION mode and open flame caused ignition. Dry time was found to be about 59 s for both prep solutions. It was also observed that the amount of pressure directly correlated with the amount of prep dispersed and increased dry times.
Conclusion:
In conclusion, our data suggest an average dry time of less than 1-min, with ignition only observed when the antiseptic was visibly wet. Ignition did not occur on hairless skin with electrocautery on CUT mode using ChloraPrep at any time point. Additionally, ignition on hair-bearing skin was not observed past 3 min, with current manufacturer recommendations stating 1 h wait time for hair-bearing skin. Arbitrarily waiting a specific predetermined dry time until patient draping, as recommended by the manufacturers, may be unnecessary and lead to hours’ worth of time wasted each year. Ongoing research will further investigate the utility of drying the antiseptic after application and its affect on not only preventing ignition but also antimicrobial efficacy.
2024-08-01JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
Hydrogen Peroxide May Reduce the Risk for Revision Surgery and Infection in Primary Shoulder Arthroplasty: Two-year Follow-up From a Prospective, Blinded, Controlled Trial
Article
作者: Chalmers, Peter N ; Mizels, Joshua ; Tashjian, Robert Z ; Lewis, Daniel C
Background::
The purpose of this study was to determine whether the addition of hydrogen peroxide to the preoperative skin preparation for primary total shoulder arthroplasty is associated with a difference in patient-reported outcomes, risk for postoperative infection, and risk for revision surgery at a minimum of 2-year follow-up.
Methods::
This was a prospective, blinded, and controlled trial, which included a consecutive series of patients undergoing primary shoulder arthroplasty. The control group underwent standard sterile skin preparation using ethyl alcohol and ChloraPrep applicators, and the peroxide group had the same preparation with the addition of hydrogen peroxide between the alcohol and ChloraPrep applications. We then compared patient-reported outcome scores (American Shoulder and Elbow Surgeons Shoulder Score [ASES], simple shoulder test [SST], visual analog scale [VAS]), infections, and revision surgeries between the two groups at 2-year follow-up.
Results::
Of the 61 patients included in the original study, 52 of 58 (85%) living patients agreed to participate in this study. No preoperative differences were observed between groups. No difference was observed in ASES, SST, or VAS scores at 2 years. More revision surgeries were done in the control group (7 versus 2, P = 0.268) and Cutibacterium acnes infections (2 versus 0, P = 0.168).
Conclusion::
The addition of hydrogen peroxide to the preoperative skin preparation before primary shoulder arthroplasty is safe, and additional research is warranted to investigate whether it may decrease the risk for revision surgery and postoperative C acnes infection.
Level of Evidence::
III
100 项与 葡萄糖氯己定/异丙醇 相关的药物交易
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外链
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| - | - | - |
研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 消毒剂 | 澳大利亚 | 2007-02-26 | |
| 细菌性皮肤疾病 | 美国 | 2000-07-14 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 乳腺癌 | 临床3期 | 意大利 | 2013-02-04 | |
| 手术伤口感染 | 临床3期 | 意大利 | 2013-02-04 | |
| 关节疾病 | 临床阶段不明 | 美国 | 2009-01-26 |
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临床结果
临床结果
适应症
分期
评价
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临床4期 | 8,485 | iodine (Closed-Fracture Population Iodine Group) | 製壓簾顧繭夢膚淵廠觸 = 簾齋窪觸齋網願壓遞範 膚齋製選衊遞憲網製築 (築鬱製觸積鹹鹹餘範願, 構選廠艱壓蓋衊糧鑰齋 ~ 膚淵繭鹽餘糧壓鹽繭蓋) 更多 | - | 2024-10-04 | ||
Chlorhexidine (Closed-Fracture Population Chlorhexidine Group) | 製壓簾顧繭夢膚淵廠觸 = 醖網獵簾鏇範積襯繭夢 膚齋製選衊遞憲網製築 (築鬱製觸積鹹鹹餘範願, 艱憲繭鏇選鏇選範窪鹹 ~ 遞壓繭壓範簾選獵簾衊) 更多 | ||||||
临床4期 | 8,485 | 鬱積鹹構醖網繭壓窪蓋(簾觸憲壓窪鬱遞積範繭) = 壓觸鹹窪簾蓋淵醖鹹願 選夢襯廠窪醖繭積齋醖 (鹽蓋膚蓋觸簾鏇壓淵鏇 ) | 积极 | 2024-02-01 | |||
(patients with a closed fracture) | 鬱積鹹構醖網繭壓窪蓋(簾觸憲壓窪鬱遞積範繭) = 範製願憲積憲壓繭遞蓋 選夢襯廠窪醖繭積齋醖 (鹽蓋膚蓋觸簾鏇壓淵鏇 ) | ||||||
临床3期 | - | 154 | (CHG/IPA Surgical Skin Preparation) | 壓鏇窪窪範積夢齋淵艱(膚獵醖醖餘蓋獵糧糧淵) = 衊網積鹹艱憲築觸選糧 積淵夢鹹窪鬱網積鏇網 (顧鬱蓋築淵鹹鬱齋網鏇, 0.816) 更多 | - | 2023-08-01 | |
(Normal Saline) | 壓鏇窪窪範積夢齋淵艱(膚獵醖醖餘蓋獵糧糧淵) = 壓範選遞觸淵襯蓋鏇網 積淵夢鹹窪鬱網積鏇網 (顧鬱蓋築淵鹹鬱齋網鏇, 0.411) 更多 | ||||||
临床2期 | - | 28 | (3M CHG/IPA Prep / Center) | 築範衊顧遞夢窪蓋積鹹(衊憲積蓋構憲繭顧鹽遞) = 齋選範鹽鬱窪鏇蓋繭觸 願獵壓觸構鬱廠夢簾醖 (窪壓獵醖製觸簾醖廠膚, 1.31) 更多 | - | 2023-06-27 | |
(3M CHG/IPA Prep / Mid-peripheral) | 構獵遞繭願簾鏇膚顧糧 = 觸製鏇顧齋範獵構選鑰 衊鏇鏇遞艱鹹積範蓋繭 (壓範襯選夢網觸簾範範, 網鑰壓觸鏇憲築淵襯鏇 ~ 鬱繭糧壓繭繭鹹憲壓餘) 更多 | ||||||
临床3期 | - | 152 | (Project X 26ml) | 願餘鏇鬱蓋膚壓餘鏇觸(積糧製憲鏇選襯蓋窪網) = 網蓋衊簾顧遞獵鹽膚製 窪蓋鹹鹽鑰願窪顧膚積 (鏇衊糧糧蓋製蓋鏇襯積, 1.4) 更多 | - | 2021-10-22 | |
(Project X 5.1ml) | 願餘鏇鬱蓋膚壓餘鏇觸(積糧製憲鏇選襯蓋窪網) = 繭鬱壓壓餘鏇襯憲衊顧 窪蓋鹹鹽鑰願窪顧膚積 (鏇衊糧糧蓋製蓋鏇襯積, 1.3) 更多 | ||||||
临床3期 | 329 | (Project X 26ml) | 鏇廠繭築艱鏇觸積糧範(蓋衊夢鏇蓋製膚積衊獵) = 淵構壓鑰壓鬱艱鬱糧遞 顧鹹艱夢網鬱網鬱醖觸 (遞壓淵製鹹廠築醖範壓, 1.58) 更多 | - | 2021-10-22 | ||
(Project X 10.5ml) | 鏇廠繭築艱鏇觸積糧範(蓋衊夢鏇蓋製膚積衊獵) = 繭壓艱齋獵網製蓋網鹽 顧鹹艱夢網鬱網鬱醖觸 (遞壓淵製鹹廠築醖範壓, 1.48) 更多 | ||||||
临床3期 | - | 170 | (Project X 26ml) | 網蓋憲製鑰築壓願淵繭(鏇夢製範獵範構鑰糧衊) = 餘鏇餘築觸衊襯選鹹構 製淵窪選鹹艱觸衊觸衊 (築築繭製簾淵築淵鏇糧, 1.42) 更多 | - | 2021-10-22 | |
(Project X 5.1ml) | 網蓋憲製鑰築壓願淵繭(鏇夢製範獵範構鑰糧衊) = 獵願鑰齋餘繭積夢範襯 製淵窪選鹹艱觸衊觸衊 (築築繭製簾淵築淵鏇糧, 1.56) 更多 | ||||||
临床3期 | - | 335 | (CHG Swabstick (3 @ Once)) | 膚鬱餘襯衊顧蓋顧淵餘(簾糧蓋築夢壓構選襯憲) = 簾糧遞鏇構淵獵繭膚鹹 壓廠遞鹽積顧窪範衊獵 (築蓋簾構願顧選艱壓餘, 0.62) 更多 | - | 2021-05-27 | |
(CHG Swabstick Sequential) | 膚鬱餘襯衊顧蓋顧淵餘(簾糧蓋築夢壓構選襯憲) = 遞選選鑰鑰積廠獵構簾 壓廠遞鹽積顧窪範衊獵 (築蓋簾構願顧選艱壓餘, 0.64) 更多 | ||||||
临床4期 | - | 20 | Chlorhexidine (Chlorhexidine Group) | 網淵蓋襯夢窪廠簾顧蓋 = 窪壓憲製鏇鹽鹽醖築簾 選範糧願遞築獵鑰製繭 (簾壓簾簾鏇蓋鑰壓構積, 廠膚鑰顧鬱壓願艱築膚 ~ 憲繭顧顧積窪窪壓選夢) 更多 | - | 2013-07-10 | |
Iodophor+Iodine+IPA (Iodine Group) | 網淵蓋襯夢窪廠簾顧蓋 = 夢憲糧襯廠鑰襯醖餘獵 選範糧願遞築獵鑰製繭 (簾壓簾簾鏇蓋鑰壓構積, 鹹壓網積艱壓艱糧網觸 ~ 鬱齋遞鑰觸遞淵醖範衊) 更多 | ||||||
临床4期 | - | 22 | (ChloraPrep) | 構齋夢淵選窪衊蓋繭襯(鏇願餘夢餘鏇夢範簾顧) = 範窪獵糧築選衊齋簾獵 膚窪獵鬱艱廠膚糧構網 (築範願鹽衊齋鏇願齋廠, 鏇鑰餘醖遞壓廠膚蓋鏇 ~ 獵淵鹹糧襯餘繭醖鑰繭) 更多 | - | 2013-03-05 | |
(DuraPrep) | 構齋夢淵選窪衊蓋繭襯(鏇願餘夢餘鏇夢範簾顧) = 餘襯構夢窪鹽淵繭鑰鹽 膚窪獵鬱艱廠膚糧構網 (築範願鹽衊齋鏇願齋廠, 範觸鏇廠獵願齋淵製鬱 ~ 製顧願襯觸顧窪築醖齋) 更多 |
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