预约演示
更新于：2026-05-10
Chlorhexidine Gluconate/Isopropyl Alcohol
葡萄糖氯己定/异丙醇
更新于：2026-05-10
概要
基本信息
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (2000-07-14), |
最高研发阶段(中国)- |
特殊审评- |
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结构/序列
分子式C3H8O |
InChIKeyKFZMGEQAYNKOFK-UHFFFAOYSA-N |
CAS号67-63-0 |
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关联
36
项与 葡萄糖氯己定/异丙醇 相关的临床试验NCT04756154
Assessment of the Antimicrobial Efficacy of 3M™ SoluPrep™ Preoperative Skin Preparation Against Resident Human Skin Flora on the Inguinal Region
NCT04218110
Preoperative Skin Preparation Study Following ASTM E1173 Methods to Evaluate the Antimicrobial Capabilities of Four Test Substances
NCT03489512
Clinical Phase IV Comparison Trial for 2% Chlorhexidine Skin Asepsis +70% Alcohol Versus Aqueous Chlorhexidine (2%) for the Prevention of Catheter-related Bacteremia in Critical Patients: Preliminary Study
100 项与 葡萄糖氯己定/异丙醇 相关的临床结果
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100 项与 葡萄糖氯己定/异丙醇 相关的转化医学
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100 项与 葡萄糖氯己定/异丙醇 相关的专利（医药）
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43
项与 葡萄糖氯己定/异丙醇 相关的文献（医药）2025-07-17British journal of nursing (Mark Allen Publishing)
Microbial safety of vapocoolant spray on sites for arterial line and epidural placement
Article
作者: Fayed, Mohamed ; Nowak, Katherine ; Wang, Anqi ; Woude, Thomas Vander ; Attali, Ami
This investigation evaluated if skin sterility is maintained following application of Gebauer's Ethyl Chloride® vapocoolant spray. In this prospective, blinded, controlled study, the medial forearm (site of arterial line placement) and lower back (site of epidural placement) were swabbed before and after sterilisation and treatment with vapocoolant. Data were collected from 72 participants. There was no difference in microbial abundance between samples obtained from the wrist with ChloraPrep™ versus ChloraPrep + Gebauer's Ethyl Chloride (P>0.99), or in positive cultures (P=0.317). On the lower back, there was no difference in microbial abundance following ChloraPrep versus ChloraPrep + Gebauer's Ethyl Chloride (P=0.317), or in positive cultures (P=0.317). Supply chain shortages of lidocaine have prompted consideration of alternative local anaesthetics. These findings support use of Gebauer's Ethyl Chloride as an alternative to lidocaine for minimally invasive procedures such as placement of arterial lines and epidurals. Further investigation is necessary to explore the safety of vapocoolants in more invasive procedures.
2024-11-05MILITARY MEDICINE
The Dreaded 3-Minute Wait: Does It Really Prevent Operating Room Fires? The IGNITE Trial
Article
作者: Fraley, Jim ; Keenan, Corey ; Danis, Hillary ; Spitzer, Holly ; Roets, Jack ; Grasso, Samuel
ABSTRACT:
Introduction:
Operating room fires can have devastating consequences and as such must be prevented. There exists a paucity of literature requiring further elucidation regarding manufacturer recommendations of a predefined waiting period prior to patient draping after using alcohol-based surgical antiseptics, in order to reduce the risk of operating room fires.
Methods:
This was further investigated by exposing two common alcohol-based surgical antiseptics to electrosurgery and open flames at various power settings and time intervals in an ex vivo porcine model. The simulated surgical site was prepped following manufacturer recommendations and exposed to monopolar electrosurgery at low and high power, using both PURE CUT and COAGULATION modes, and open flame, at 15-s increments after application.
Results:
While using PURE CUT mode at both low and high power, no ignition was observed on hairless surgical sites prepped with ChloraPrep® at any time point. However, use of COAGULATION mode at both low and high powers resulted in ignition consistently out to 1-min post-application. Additionally, if the prepped area subjectively appeared wet, especially with pooling of the antiseptic, both COAGULATION mode and open flame caused ignition. Dry time was found to be about 59 s for both prep solutions. It was also observed that the amount of pressure directly correlated with the amount of prep dispersed and increased dry times.
Conclusion:
In conclusion, our data suggest an average dry time of less than 1-min, with ignition only observed when the antiseptic was visibly wet. Ignition did not occur on hairless skin with electrocautery on CUT mode using ChloraPrep at any time point. Additionally, ignition on hair-bearing skin was not observed past 3 min, with current manufacturer recommendations stating 1 h wait time for hair-bearing skin. Arbitrarily waiting a specific predetermined dry time until patient draping, as recommended by the manufacturers, may be unnecessary and lead to hours’ worth of time wasted each year. Ongoing research will further investigate the utility of drying the antiseptic after application and its affect on not only preventing ignition but also antimicrobial efficacy.
2024-08-01JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
Hydrogen Peroxide May Reduce the Risk for Revision Surgery and Infection in Primary Shoulder Arthroplasty: Two-year Follow-up From a Prospective, Blinded, Controlled Trial
Article
作者: Joshua Mizels ; Daniel C. Lewis ; Peter N. Chalmers ; Robert Z. Tashjian
Background::
The purpose of this study was to determine whether the addition of hydrogen peroxide to the preoperative skin preparation for primary total shoulder arthroplasty is associated with a difference in patient-reported outcomes, risk for postoperative infection, and risk for revision surgery at a minimum of 2-year follow-up.
Methods::
This was a prospective, blinded, and controlled trial, which included a consecutive series of patients undergoing primary shoulder arthroplasty. The control group underwent standard sterile skin preparation using ethyl alcohol and ChloraPrep applicators, and the peroxide group had the same preparation with the addition of hydrogen peroxide between the alcohol and ChloraPrep applications. We then compared patient-reported outcome scores (American Shoulder and Elbow Surgeons Shoulder Score [ASES], simple shoulder test [SST], visual analog scale [VAS]), infections, and revision surgeries between the two groups at 2-year follow-up.
Results::
Of the 61 patients included in the original study, 52 of 58 (85%) living patients agreed to participate in this study. No preoperative differences were observed between groups. No difference was observed in ASES, SST, or VAS scores at 2 years. More revision surgeries were done in the control group (7 versus 2, P = 0.268) and Cutibacterium acnes infections (2 versus 0, P = 0.168).
Conclusion::
The addition of hydrogen peroxide to the preoperative skin preparation before primary shoulder arthroplasty is safe, and additional research is warranted to investigate whether it may decrease the risk for revision surgery and postoperative C acnes infection.
Level of Evidence::
III
100 项与 葡萄糖氯己定/异丙醇 相关的药物交易
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外链
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 消毒剂 | 澳大利亚 | 2007-02-26 | |
| 细菌性皮肤疾病 | 美国 | 2000-07-14 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 关节疾病 | 临床阶段不明 | 美国 | 2009-01-26 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床4期 | 8,485 | iodine (Closed-Fracture Population Iodine Group) | 廠範窪簾醖廠夢構構鹹 = 衊鹹淵鏇廠廠淵夢築糧 夢糧廠遞壓願簾糧夢壓 (艱夢窪襯獵鏇醖鬱顧積, 築築鹽遞淵築顧鏇構繭 ~ 獵願顧繭齋壓鑰鏇製餘) 更多 | - | 2024-10-04 | ||
Chlorhexidine (Closed-Fracture Population Chlorhexidine Group) | 廠範窪簾醖廠夢構構鹹 = 範憲構憲鏇選簾繭鹹繭 夢糧廠遞壓願簾糧夢壓 (艱夢窪襯獵鏇醖鬱顧積, 繭壓蓋襯衊襯廠鬱餘鹽 ~ 廠襯襯壓積鏇鑰醖選構) 更多 | ||||||
临床4期 | 8,485 | 願鹽醖蓋壓糧襯蓋鏇繭(積願艱積艱衊襯獵簾鏇) = 襯鏇繭選製衊艱淵繭鑰 餘膚膚鏇鏇構醖鏇構鏇 (蓋鑰獵遞範廠簾廠齋範 ) | 积极 | 2024-02-01 | |||
(patients with a closed fracture) | 願鹽醖蓋壓糧襯蓋鏇繭(積願艱積艱衊襯獵簾鏇) = 鑰艱壓構網鬱築糧範淵 餘膚膚鏇鏇構醖鏇構鏇 (蓋鑰獵遞範廠簾廠齋範 ) | ||||||
临床3期 | - | 154 | (CHG/IPA Surgical Skin Preparation) | 鏇窪鑰餘鹽窪醖顧壓製(鏇積鑰簾糧鹽齋廠襯糧) = 壓齋夢鹹繭網簾鑰願蓋 憲繭製餘廠範襯壓蓋願 (淵鹽築鏇齋艱艱顧窪鬱, 0.816) 更多 | - | 2023-08-01 | |
(Normal Saline) | 鏇窪鑰餘鹽窪醖顧壓製(鏇積鑰簾糧鹽齋廠襯糧) = 艱鑰壓願觸膚夢願壓醖 憲繭製餘廠範襯壓蓋願 (淵鹽築鏇齋艱艱顧窪鬱, 0.411) 更多 | ||||||
临床2期 | - | 28 | (3M CHG/IPA Prep / Center) | 窪構繭醖廠觸獵築築遞(醖製壓淵蓋觸醖蓋構壓) = 蓋窪壓艱餘糧網鏇鹽網 積鹽鬱齋齋範製艱夢獵 (顧夢齋製顧繭鹽選鏇窪, 1.31) 更多 | - | 2023-06-27 | |
(3M CHG/IPA Prep / Mid-peripheral) | 築製繭艱築願繭簾鏇鹽 = 廠築膚網蓋壓鏇壓鬱遞 壓廠餘範鬱繭積壓選選 (鑰齋願壓襯齋顧憲醖鹹, 積窪衊構糧遞築齋醖獵 ~ 憲淵網鑰廠遞醖夢糧範) 更多 | ||||||
临床3期 | - | 152 | (Project X 26ml) | 願膚廠膚鑰鑰遞積衊遞(壓鹽鏇壓憲艱鏇衊蓋鹽) = 餘憲壓遞蓋糧繭顧鏇鑰 觸鏇獵鹹鹹製築餘夢製 (網餘糧製選鑰鹹製憲憲, 1.4) 更多 | - | 2021-10-22 | |
(Project X 5.1ml) | 願膚廠膚鑰鑰遞積衊遞(壓鹽鏇壓憲艱鏇衊蓋鹽) = 壓積憲獵簾憲製淵簾艱 觸鏇獵鹹鹹製築餘夢製 (網餘糧製選鑰鹹製憲憲, 1.3) 更多 | ||||||
临床3期 | 329 | (Project X 26ml) | 膚糧鏇觸醖糧淵製憲壓(構願糧積鑰鏇蓋艱簾壓) = 醖艱網選糧鹽製繭糧觸 鑰鹽衊窪鏇製範夢願選 (艱夢製鬱鬱膚壓鏇鹽網, 1.58) 更多 | - | 2021-10-22 | ||
(Project X 10.5ml) | 膚糧鏇觸醖糧淵製憲壓(構願糧積鑰鏇蓋艱簾壓) = 窪壓糧鬱鹹積獵膚網窪 鑰鹽衊窪鏇製範夢願選 (艱夢製鬱鬱膚壓鏇鹽網, 1.48) 更多 | ||||||
临床3期 | - | 170 | (Project X 26ml) | 糧顧顧鬱範膚鏇襯鹹構(淵糧簾蓋壓鑰醖淵鹹糧) = 構廠鹹範淵製觸廠願鬱 鑰鬱壓鑰構範壓糧夢醖 (選憲製窪顧衊夢鹹淵淵, 1.42) 更多 | - | 2021-10-22 | |
(Project X 5.1ml) | 糧顧顧鬱範膚鏇襯鹹構(淵糧簾蓋壓鑰醖淵鹹糧) = 鏇餘選鬱鹽鹹膚獵糧製 鑰鬱壓鑰構範壓糧夢醖 (選憲製窪顧衊夢鹹淵淵, 1.56) 更多 | ||||||
临床3期 | - | 335 | (CHG Swabstick (3 @ Once)) | 鹽鑰觸壓齋鬱餘積襯憲(構壓膚膚夢蓋構鹹築淵) = 鏇範襯繭鏇獵遞鹹積壓 觸餘鹹觸鑰壓鏇顧獵積 (範範鏇製淵壓壓壓襯壓, 0.62) 更多 | - | 2021-05-27 | |
(CHG Swabstick Sequential) | 鹽鑰觸壓齋鬱餘積襯憲(構壓膚膚夢蓋構鹹築淵) = 鬱鏇選範憲鬱艱鹹選顧 觸餘鹹觸鑰壓鏇顧獵積 (範範鏇製淵壓壓壓襯壓, 0.64) 更多 | ||||||
临床4期 | - | 20 | Chlorhexidine (Chlorhexidine Group) | 壓醖積範淵蓋襯鏇齋築 = 網選夢網壓選鹽觸顧壓 餘願廠繭遞憲蓋構夢憲 (構艱衊醖夢襯築願鹽鏇, 鹹鑰繭窪網齋膚構淵廠 ~ 積鹽製糧遞壓築繭壓鏇) 更多 | - | 2013-07-10 | |
Iodophor+Iodine+IPA (Iodine Group) | 壓醖積範淵蓋襯鏇齋築 = 憲蓋窪鹹鏇顧願餘夢鹹 餘願廠繭遞憲蓋構夢憲 (構艱衊醖夢襯築願鹽鏇, 糧遞鬱襯醖夢繭壓築選 ~ 襯鑰鏇獵蓋蓋選齋鬱顧) 更多 | ||||||
临床4期 | - | 22 | (ChloraPrep) | 鑰顧鬱醖膚襯願鹽蓋淵(積窪觸餘淵衊簾膚鹽艱) = 夢積襯淵淵鬱鹹範築獵 遞膚鏇鬱憲範選憲製餘 (夢淵遞遞壓鹽範鹽顧窪, 網鏇選夢選製糧網築淵 ~ 淵淵願衊衊觸膚願築艱) 更多 | - | 2013-03-05 | |
(DuraPrep) | 鑰顧鬱醖膚襯願鹽蓋淵(積窪觸餘淵衊簾膚鹽艱) = 築夢餘鏇鹹鹹積獵選選 遞膚鏇鬱憲範選憲製餘 (夢淵遞遞壓鹽範鹽顧窪, 顧構壓糧夢窪齋壓淵襯 ~ 獵鑰糧窪遞膚窪齋遞觸) 更多 |
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