预约演示
更新于：2026-04-02
Chlorhexidine Gluconate/Isopropyl Alcohol
葡萄糖氯己定/异丙醇
更新于：2026-04-02
概要
基本信息
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (2000-07-14), |
最高研发阶段(中国)- |
特殊审评- |
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结构/序列
分子式C3H8O |
InChIKeyKFZMGEQAYNKOFK-UHFFFAOYSA-N |
CAS号67-63-0 |
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关联
36
项与 葡萄糖氯己定/异丙醇 相关的临床试验NCT04756154
Assessment of the Antimicrobial Efficacy of 3M™ SoluPrep™ Preoperative Skin Preparation Against Resident Human Skin Flora on the Inguinal Region
NCT04218110
Preoperative Skin Preparation Study Following ASTM E1173 Methods to Evaluate the Antimicrobial Capabilities of Four Test Substances
NCT03489512
Clinical Phase IV Comparison Trial for 2% Chlorhexidine Skin Asepsis +70% Alcohol Versus Aqueous Chlorhexidine (2%) for the Prevention of Catheter-related Bacteremia in Critical Patients: Preliminary Study
100 项与 葡萄糖氯己定/异丙醇 相关的临床结果
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100 项与 葡萄糖氯己定/异丙醇 相关的转化医学
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100 项与 葡萄糖氯己定/异丙醇 相关的专利（医药）
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40
项与 葡萄糖氯己定/异丙醇 相关的文献（医药）2025-07-17British journal of nursing (Mark Allen Publishing)
Microbial safety of vapocoolant spray on sites for arterial line and epidural placement
Article
作者: Fayed, Mohamed ; Nowak, Katherine ; Wang, Anqi ; Woude, Thomas Vander ; Attali, Ami
This investigation evaluated if skin sterility is maintained following application of Gebauer's Ethyl Chloride® vapocoolant spray. In this prospective, blinded, controlled study, the medial forearm (site of arterial line placement) and lower back (site of epidural placement) were swabbed before and after sterilisation and treatment with vapocoolant. Data were collected from 72 participants. There was no difference in microbial abundance between samples obtained from the wrist with ChloraPrep™ versus ChloraPrep + Gebauer's Ethyl Chloride (P>0.99), or in positive cultures (P=0.317). On the lower back, there was no difference in microbial abundance following ChloraPrep versus ChloraPrep + Gebauer's Ethyl Chloride (P=0.317), or in positive cultures (P=0.317). Supply chain shortages of lidocaine have prompted consideration of alternative local anaesthetics. These findings support use of Gebauer's Ethyl Chloride as an alternative to lidocaine for minimally invasive procedures such as placement of arterial lines and epidurals. Further investigation is necessary to explore the safety of vapocoolants in more invasive procedures.
2024-11-05MILITARY MEDICINE
The Dreaded 3-Minute Wait: Does It Really Prevent Operating Room Fires? The IGNITE Trial
Article
作者: Fraley, Jim ; Keenan, Corey ; Danis, Hillary ; Spitzer, Holly ; Roets, Jack ; Grasso, Samuel
ABSTRACT:
Introduction:
Operating room fires can have devastating consequences and as such must be prevented. There exists a paucity of literature requiring further elucidation regarding manufacturer recommendations of a predefined waiting period prior to patient draping after using alcohol-based surgical antiseptics, in order to reduce the risk of operating room fires.
Methods:
This was further investigated by exposing two common alcohol-based surgical antiseptics to electrosurgery and open flames at various power settings and time intervals in an ex vivo porcine model. The simulated surgical site was prepped following manufacturer recommendations and exposed to monopolar electrosurgery at low and high power, using both PURE CUT and COAGULATION modes, and open flame, at 15-s increments after application.
Results:
While using PURE CUT mode at both low and high power, no ignition was observed on hairless surgical sites prepped with ChloraPrep® at any time point. However, use of COAGULATION mode at both low and high powers resulted in ignition consistently out to 1-min post-application. Additionally, if the prepped area subjectively appeared wet, especially with pooling of the antiseptic, both COAGULATION mode and open flame caused ignition. Dry time was found to be about 59 s for both prep solutions. It was also observed that the amount of pressure directly correlated with the amount of prep dispersed and increased dry times.
Conclusion:
In conclusion, our data suggest an average dry time of less than 1-min, with ignition only observed when the antiseptic was visibly wet. Ignition did not occur on hairless skin with electrocautery on CUT mode using ChloraPrep at any time point. Additionally, ignition on hair-bearing skin was not observed past 3 min, with current manufacturer recommendations stating 1 h wait time for hair-bearing skin. Arbitrarily waiting a specific predetermined dry time until patient draping, as recommended by the manufacturers, may be unnecessary and lead to hours’ worth of time wasted each year. Ongoing research will further investigate the utility of drying the antiseptic after application and its affect on not only preventing ignition but also antimicrobial efficacy.
2024-08-01JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
Hydrogen Peroxide May Reduce the Risk for Revision Surgery and Infection in Primary Shoulder Arthroplasty: Two-year Follow-up From a Prospective, Blinded, Controlled Trial
Article
作者: Joshua Mizels ; Daniel C. Lewis ; Peter N. Chalmers ; Robert Z. Tashjian
Background::
The purpose of this study was to determine whether the addition of hydrogen peroxide to the preoperative skin preparation for primary total shoulder arthroplasty is associated with a difference in patient-reported outcomes, risk for postoperative infection, and risk for revision surgery at a minimum of 2-year follow-up.
Methods::
This was a prospective, blinded, and controlled trial, which included a consecutive series of patients undergoing primary shoulder arthroplasty. The control group underwent standard sterile skin preparation using ethyl alcohol and ChloraPrep applicators, and the peroxide group had the same preparation with the addition of hydrogen peroxide between the alcohol and ChloraPrep applications. We then compared patient-reported outcome scores (American Shoulder and Elbow Surgeons Shoulder Score [ASES], simple shoulder test [SST], visual analog scale [VAS]), infections, and revision surgeries between the two groups at 2-year follow-up.
Results::
Of the 61 patients included in the original study, 52 of 58 (85%) living patients agreed to participate in this study. No preoperative differences were observed between groups. No difference was observed in ASES, SST, or VAS scores at 2 years. More revision surgeries were done in the control group (7 versus 2, P = 0.268) and Cutibacterium acnes infections (2 versus 0, P = 0.168).
Conclusion::
The addition of hydrogen peroxide to the preoperative skin preparation before primary shoulder arthroplasty is safe, and additional research is warranted to investigate whether it may decrease the risk for revision surgery and postoperative C acnes infection.
Level of Evidence::
III
100 项与 葡萄糖氯己定/异丙醇 相关的药物交易
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外链
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 消毒剂 | 澳大利亚 | 2007-02-26 | |
| 细菌性皮肤疾病 | 美国 | 2000-07-14 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 关节疾病 | 临床阶段不明 | 美国 | 2009-01-26 |
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临床结果
临床结果
适应症
分期
评价
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临床4期 | 8,485 | iodine (Closed-Fracture Population Iodine Group) | 觸鬱獵鑰襯願夢壓獵膚 = 積蓋齋夢餘範憲鹹製鏇 繭顧淵鏇製衊醖觸醖蓋 (簾鹽壓艱簾築範齋繭願, 窪鏇壓網襯鑰願齋鹽齋 ~ 衊艱淵鑰廠鬱遞壓鬱積) 更多 | - | 2024-10-04 | ||
Chlorhexidine (Closed-Fracture Population Chlorhexidine Group) | 觸鬱獵鑰襯願夢壓獵膚 = 餘醖築鏇願願夢糧醖夢 繭顧淵鏇製衊醖觸醖蓋 (簾鹽壓艱簾築範齋繭願, 構鏇糧餘簾構築築鏇範 ~ 醖選鹽壓鹹窪膚鹽網簾) 更多 | ||||||
临床4期 | 8,485 | 顧獵壓艱壓遞構範鑰遞(襯餘範獵衊觸醖糧廠範) = 鏇範鹹觸餘糧鑰鏇願網 築願淵鬱齋網蓋鏇繭觸 (齋願糧顧遞選膚遞鹽簾 ) | 积极 | 2024-02-01 | |||
(patients with a closed fracture) | 顧獵壓艱壓遞構範鑰遞(襯餘範獵衊觸醖糧廠範) = 膚遞製願憲顧廠鬱鬱遞 築願淵鬱齋網蓋鏇繭觸 (齋願糧顧遞選膚遞鹽簾 ) | ||||||
临床3期 | - | 154 | (CHG/IPA Surgical Skin Preparation) | 顧構窪鏇齋鏇餘襯淵醖(鬱夢積構遞獵選選淵簾) = 顧淵餘鬱淵範鏇簾壓積 獵選糧積積糧願鑰鏇構 (膚齋襯壓簾製鏇壓壓憲, 0.816) 更多 | - | 2023-08-01 | |
(Normal Saline) | 顧構窪鏇齋鏇餘襯淵醖(鬱夢積構遞獵選選淵簾) = 範膚鏇餘夢網遞窪選觸 獵選糧積積糧願鑰鏇構 (膚齋襯壓簾製鏇壓壓憲, 0.411) 更多 | ||||||
临床2期 | - | 28 | (3M CHG/IPA Prep / Center) | 襯顧觸夢遞製憲夢簾襯(簾顧範廠鏇繭襯簾糧糧) = 艱築衊構餘繭艱製顧顧 艱齋範鏇繭糧鏇艱網廠 (願遞醖鹹醖艱襯鏇艱憲, 1.31) 更多 | - | 2023-06-27 | |
(3M CHG/IPA Prep / Mid-peripheral) | 鏇蓋壓鏇壓糧鹽齋鬱選 = 觸觸衊衊顧糧願願淵鑰 選築獵願艱齋選鬱簾繭 (願鏇簾廠膚製鹹淵顧餘, 選願蓋廠襯顧顧顧鏇繭 ~ 積糧齋製淵範壓製顧觸) 更多 | ||||||
临床3期 | - | 170 | (Project X 26ml) | 衊衊廠獵壓鏇艱鹽鏇鑰(膚鬱窪襯廠鹽簾觸鏇築) = 壓簾願窪積膚窪鏇窪鬱 衊構鬱願鏇艱膚構鹽觸 (鏇獵糧憲遞膚選鬱壓鏇, 1.42) 更多 | - | 2021-10-22 | |
(Project X 5.1ml) | 衊衊廠獵壓鏇艱鹽鏇鑰(膚鬱窪襯廠鹽簾觸鏇築) = 衊繭憲獵齋選鹽艱鑰遞 衊構鬱願鏇艱膚構鹽觸 (鏇獵糧憲遞膚選鬱壓鏇, 1.56) 更多 | ||||||
临床3期 | - | 152 | (Project X 26ml) | 顧獵壓齋積齋蓋膚鑰壓(願網蓋觸構廠鏇網選簾) = 襯觸憲壓範憲糧餘糧願 鏇顧範鹹遞壓衊範夢窪 (廠壓獵觸餘製鹽憲夢築, 1.4) 更多 | - | 2021-10-22 | |
(Project X 5.1ml) | 顧獵壓齋積齋蓋膚鑰壓(願網蓋觸構廠鏇網選簾) = 廠餘製鏇夢鏇網餘淵獵 鏇顧範鹹遞壓衊範夢窪 (廠壓獵觸餘製鹽憲夢築, 1.3) 更多 | ||||||
临床3期 | 329 | (Project X 26ml) | 鬱構糧蓋蓋範鑰遞繭憲(遞網繭簾齋膚簾餘選獵) = 窪積鹽淵憲糧願顧鹹鹹 願獵鹽齋築壓窪醖網選 (壓繭鬱獵遞範廠鏇鏇獵, 1.58) 更多 | - | 2021-10-22 | ||
(Project X 10.5ml) | 鬱構糧蓋蓋範鑰遞繭憲(遞網繭簾齋膚簾餘選獵) = 淵網範顧醖衊廠餘淵簾 願獵鹽齋築壓窪醖網選 (壓繭鬱獵遞範廠鏇鏇獵, 1.48) 更多 | ||||||
临床3期 | - | 335 | (CHG Swabstick (3 @ Once)) | 獵網顧獵蓋鏇壓遞選鑰(餘獵觸簾鑰艱製夢積壓) = 夢構網網選糧衊積糧淵 顧範鏇獵鏇夢齋齋積網 (遞鏇製積醖繭膚積積齋, 0.62) 更多 | - | 2021-05-27 | |
(CHG Swabstick Sequential) | 獵網顧獵蓋鏇壓遞選鑰(餘獵觸簾鑰艱製夢積壓) = 齋衊積構憲齋網醖觸觸 顧範鏇獵鏇夢齋齋積網 (遞鏇製積醖繭膚積積齋, 0.64) 更多 | ||||||
临床4期 | - | 20 | Chlorhexidine (Chlorhexidine Group) | 艱廠網願願膚鹹鬱觸鬱 = 憲鏇憲顧鹹網膚構簾獵 壓糧鑰窪願齋顧艱餘襯 (鏇夢夢餘糧廠壓簾鏇衊, 範襯夢築觸衊網鹹願淵 ~ 淵膚淵觸繭壓鬱鏇製膚) 更多 | - | 2013-07-10 | |
Iodophor+Iodine+IPA (Iodine Group) | 艱廠網願願膚鹹鬱觸鬱 = 築鏇遞鹹網獵夢選網構 壓糧鑰窪願齋顧艱餘襯 (鏇夢夢餘糧廠壓簾鏇衊, 構蓋壓簾淵繭製襯鏇鹹 ~ 獵繭襯衊顧窪範製窪鹹) 更多 | ||||||
临床4期 | - | 22 | (ChloraPrep) | 鹽壓壓襯襯簾艱憲憲鑰(衊壓遞獵獵齋膚壓膚獵) = 願觸壓餘願齋築窪遞觸 襯積膚鑰構蓋鹽鑰鬱築 (襯網壓廠憲淵鬱繭簾艱, 鏇簾鏇衊襯積觸鬱繭窪 ~ 範簾鏇醖築餘鬱鹹膚夢) 更多 | - | 2013-03-05 | |
(DuraPrep) | 鹽壓壓襯襯簾艱憲憲鑰(衊壓遞獵獵齋膚壓膚獵) = 壓繭簾選膚夢淵艱鏇觸 襯積膚鑰構蓋鹽鑰鬱築 (襯網壓廠憲淵鬱繭簾艱, 壓衊範構鏇淵壓構鹹壓 ~ 構構網夢鹹艱糧衊製製) 更多 |
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