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更新于：2025-03-21
Chlorhexidine Gluconate/Isopropyl Alcohol
葡萄糖氯己定/异丙醇
更新于：2025-03-21
概要
基本信息
非在研机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (2000-07-14), |
最高研发阶段(中国)- |
特殊审评- |
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结构/序列
分子式C3H8O |
InChIKeyKFZMGEQAYNKOFK-UHFFFAOYSA-N |
CAS号67-63-0 |
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关联
29
项与 葡萄糖氯己定/异丙醇 相关的临床试验NCT04756154
Assessment of the Antimicrobial Efficacy of 3M™ SoluPrep™ Preoperative Skin Preparation Against Resident Human Skin Flora on the Inguinal Region
NCT04218110
Preoperative Skin Preparation Study Following ASTM E1173 Methods to Evaluate the Antimicrobial Capabilities of Four Test Substances
NCT03861780
Pilot Evaluation of Two Test Materials With a Positive Control When Used as a Patient Preoperative Skin Preparation
100 项与 葡萄糖氯己定/异丙醇 相关的临床结果
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100 项与 葡萄糖氯己定/异丙醇 相关的转化医学
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100 项与 葡萄糖氯己定/异丙醇 相关的专利（医药）
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7
项与 葡萄糖氯己定/异丙醇 相关的文献（医药）2024-06-01Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
BD Chloraprep™ (“2 % chlorhexidine with 70 % isopropyl alcohol”) versus povidone iodine plus alcohol, for prevention of blood culture contamination at children: An investigator-initiated, open-label, single centre, randomized controlled trial
Article
作者: Şahinkaya, Şahika ; Devrim, İlker ; Sözen, Ceren ; Yaman, Yakup ; Kaçar, Pelin ; Ayhan, Fahri Yüce ; Yılmaz Çelebi, Miray ; Bayram, Süleyman Nuri ; Cem, Ela
INTRODUCTION:
One of the important problems that lower the diagnostic value of blood culture is contamination with skin organisms. The povidone-iodine, alcohol, and chlorhexidine gluconate alcohol are used for disinfection prior to blood sampling for culture.
METHODS:
The investigator-initiated, open label, single centre, randomised trial compared blood culture contamination rates between two groups of patients in which using a povidone iodine skin-preparation process with the contamination rate for using "2 % chlorhexidine with 70 % isopropyl alcohol" skin-disinfection. The patients who required sampling for blood cultures were included in the study and study period was from 15 March 2023 to 15 July 2023.
RESULTS:
A total of 400 blood cultures were obtained during the study, including 133 in the study group and 267 in the control group. In the total blood cultures, 11.75 % (n = 47) had microorganism isolation. Among them 39 (9.75 %) were contaminants and 8 (2 %) of them were true pathogens. The contaminant microorganisms were as following; 34 coagulase-negative Staphylococci, 3 Micrococcus spp, and 2 Streptococci viridans. The blood culture contamination rate in the study group was 5.3 % (n = 7) and 12.0 % (n = 32) in the control group, and significantly lower in the study group (p = 0.033). There is no significant difference regarding skin related side effects between two groups.
CONCLUSIONS:
This study, showed that 2 % chlorhexidine gluconate in 70 % isopropyl alcohol is more efficacious in children than 10 % povidone-iodine preparations for disinfecting the skin prior to blood specimen collection for prevention of blood culture contamination.
2022-10-01Orthopaedics & traumatology, surgery & research : OTSR
Surgical solutions for preoperative skin preparation in total hip arthroplasty: A cost-effectiveness analysis of Betadine® and Chloraprep™
Article
作者: Ollat, Didier ; Zadegan, Frédéric ; Terracher, Richard ; Chatelain, Léonard ; Rougereau, Grégoire
OBJECTIVE:
The purpose of our study was to compare the cost of surgical site skin preparation using ChloraPrep™ (2% chlorhexidine gluconate [CHG] and 70% isopropyl alcohol [IPA]) with skin cleansing using Betadine® Surgical Scrub and Betadine® 5% solution (povidone-iodine [PVI]) in total hip arthroplasty (THA).
HYPOTHESIS:
The hypothesis was that the ChloraPrep™ skin disinfection protocol reduces the cost of perioperative antisepsis.
METHODS:
A prospective database was created for all THAs performed at our university hospital between November 1st, 2020, and December 31st, 2020. Each surgeon was randomly assigned one type of antiseptic prior to the start of the study: one surgeon to the ChloraPrep™ group and one to the Betadine® group. In both groups, the enrollment stopped at the 15th patient. The costs related to consumables, waste disposal, and operating room occupancy time of each protocol were then assessed for each patient.
RESULTS:
The mean duration of the ChloraPrep™ protocol was 3.5±0.3minutes compared to 13.5±0.9minutes for the Betadine® protocol. The overall cost of a surgical site skin preparation involving all three steps was on average €46.8±4.2 for the ChloraPrep™ group compared to €155±10.9 for the Betadine® group (p<0.0001).
DISCUSSION:
Not only is the effectiveness of ChloraPrep™ already recognized but it also appears to have health economic benefits. However, further studies are needed to confirm this finding.
LEVEL OF EVIDENCE:
III, case control study.
2021-12-01JOURNAL OF HOSPITAL INFECTION3区 · 医学
Operative efficiency: comparison of methods to optimize the use of chlorhexidine gluconate applicators
3区 · 医学
Article
作者: Stelzer, J W ; Wellington, I J ; Solovyova, O ; Silver, J
BACKGROUND:
With the high costs of operating room time, minimizing potential causes of time waste is financially beneficial to surgeons and hospitals. The time needed to activate a chlorhexidine gluconate surgical solution applicator presents an opportunity for optimization. Many techniques are employed to expedite the process, but there have been no studies comparing these techniques.
AIM:
To determine the most efficient method for utilizing a chlorhexidine gluconate surgical prep applicator.
METHODS:
Six techniques were tested to determine which caused the sponge of a Chloraprep™ applicator to become saturated quickest. These were a single squeeze (control), up-and-down shaking, side-to-side shaking, pressing the sponge on a surface (dab), pressing with cotton swabs (poke), and continuously squeezing the lever of the applicator. The time between the internal glass breaking in the applicator to the time of sponge saturation with solution was measured for each technique. Times were then compared to determine which technique best expedited the process.
FINDINGS:
The side-to-side shake, up-and-down shake, and 'dab' techniques were each significantly faster than the control group. Side-to-side shaking had the fastest time to sponge saturation on average. The average difference in time to saturation between the side-to-side shake technique and the 'poke' technique may be as much as 27.5 s.
CONCLUSIONS:
Utilization of the side-to-side shake technique, as well as the up-and-down shake and 'dab' techniques, significantly expedite the time it takes to use a chlorhexidine gluconate applicator. The time savings from employing these techniques could result in significant financial benefits.
100 项与 葡萄糖氯己定/异丙醇 相关的药物交易
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外链
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| - | - | - |
研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 消毒剂 | 澳大利亚 | 2007-02-26 | |
| 细菌性皮肤疾病 | 美国 | 2000-07-14 |
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临床结果
临床结果
适应症
分期
评价
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临床3期 | - | 154 | (CHG/IPA Surgical Skin Preparation) | 製鹽鑰壓積鹹鏇遞獵遞(鹽廠齋廠糧襯鹹廠獵觸) = 膚窪鏇繭糧餘壓蓋鬱鬱 鹽獵夢糧壓艱繭鑰願製 (鏇範憲構鏇襯齋鹽餘積, 0.816) 更多 | - | 2023-08-01 | |
(Normal Saline) | 製鹽鑰壓積鹹鏇遞獵遞(鹽廠齋廠糧襯鹹廠獵觸) = 夢製選窪繭糧構糧膚廠 鹽獵夢糧壓艱繭鑰願製 (鏇範憲構鏇襯齋鹽餘積, 0.411) 更多 | ||||||
临床2期 | - | 28 | (3M CHG/IPA Prep / Center) | 構範鏇積鏇窪齋鑰願網(範範醖築餘鹽齋淵襯淵) = 築餘夢製廠製構選鏇鹹 選衊膚範餘積餘選壓築 (觸窪窪齋膚憲鹽簾淵鬱, 1.31) 更多 | - | 2023-06-27 | |
(3M CHG/IPA Prep / Mid-peripheral) | 網觸範鹽壓廠鹹醖艱鹽 = 襯構憲網憲簾簾醖繭襯 鏇網餘製壓壓鏇觸糧衊 (網鹹構選繭鹹獵鏇觸夢, 築簾醖餘範齋蓋獵糧窪 ~ 鑰積製顧鑰夢範鑰觸淵) 更多 | ||||||
临床3期 | 329 | (Project X 26ml) | 壓鑰網窪蓋衊築鬱艱構(鏇觸艱膚鬱膚範遞顧獵) = 築範壓壓鏇鹹願鹽選膚 糧製範窪鬱鏇醖壓範選 (憲鹽選鹹窪艱遞廠繭膚, 1.58) 更多 | - | 2021-10-22 | ||
(Project X 10.5ml) | 壓鑰網窪蓋衊築鬱艱構(鏇觸艱膚鬱膚範遞顧獵) = 鬱網夢築糧製膚糧製鹹 糧製範窪鬱鏇醖壓範選 (憲鹽選鹹窪艱遞廠繭膚, 1.48) 更多 | ||||||
临床3期 | - | 170 | (Project X 26ml) | 製蓋築構觸顧繭廠醖憲(夢廠衊獵蓋艱襯餘繭鏇) = 艱衊積遞餘糧範醖窪蓋 鬱廠構選鹽衊鏇築製餘 (製廠製願衊簾醖蓋齋繭, 1.42) 更多 | - | 2021-10-22 | |
(Project X 5.1ml) | 製蓋築構觸顧繭廠醖憲(夢廠衊獵蓋艱襯餘繭鏇) = 築廠簾衊簾膚襯鏇艱淵 鬱廠構選鹽衊鏇築製餘 (製廠製願衊簾醖蓋齋繭, 1.56) 更多 | ||||||
临床3期 | - | 152 | (Project X 26ml) | 淵糧網觸簾鏇齋憲蓋觸(鏇鏇製遞餘衊遞蓋築膚) = 選簾鹽積糧糧選廠繭範 齋艱淵積壓積壓築鹽遞 (醖膚齋齋觸窪範鏇艱糧, 1.4) 更多 | - | 2021-10-22 | |
(Project X 5.1ml) | 淵糧網觸簾鏇齋憲蓋觸(鏇鏇製遞餘衊遞蓋築膚) = 壓艱艱醖淵鬱糧顧夢積 齋艱淵積壓積壓築鹽遞 (醖膚齋齋觸窪範鏇艱糧, 1.3) 更多 | ||||||
临床4期 | - | 20 | Chlorhexidine (Chlorhexidine Group) | 築簾淵築鏇膚衊鑰鹹憲 = 鏇積醖鏇鏇壓糧製選齋 窪夢簾鏇積醖艱網壓觸 (範獵遞鑰鏇廠顧窪廠積, 糧餘繭範積鹽蓋積醖製 ~ 範艱蓋製構蓋鹽醖糧築) 更多 | - | 2013-07-10 | |
Iodophor+Iodine+IPA (Iodine Group) | 築簾淵築鏇膚衊鑰鹹憲 = 糧製願艱顧糧膚廠鹽淵 窪夢簾鏇積醖艱網壓觸 (範獵遞鑰鏇廠顧窪廠積, 範艱網觸顧觸夢選蓋齋 ~ 蓋製鹽衊衊窪鬱構觸衊) 更多 |
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