预约演示
更新于：2025-12-12
Chlorhexidine Gluconate/Isopropyl Alcohol
葡萄糖氯己定/异丙醇
更新于：2025-12-12
概要
基本信息
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (2000-07-14), |
最高研发阶段(中国)- |
特殊审评- |
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结构/序列
分子式C3H8O |
InChIKeyKFZMGEQAYNKOFK-UHFFFAOYSA-N |
CAS号67-63-0 |
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关联
35
项与 葡萄糖氯己定/异丙醇 相关的临床试验NCT04756154
Assessment of the Antimicrobial Efficacy of 3M™ SoluPrep™ Preoperative Skin Preparation Against Resident Human Skin Flora on the Inguinal Region
NCT04218110
Preoperative Skin Preparation Study Following ASTM E1173 Methods to Evaluate the Antimicrobial Capabilities of Four Test Substances
NCT03489512
Clinical Phase IV Comparison Trial for 2% Chlorhexidine Skin Asepsis +70% Alcohol Versus Aqueous Chlorhexidine (2%) for the Prevention of Catheter-related Bacteremia in Critical Patients: Preliminary Study
100 项与 葡萄糖氯己定/异丙醇 相关的临床结果
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100 项与 葡萄糖氯己定/异丙醇 相关的转化医学
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100 项与 葡萄糖氯己定/异丙醇 相关的专利（医药）
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58
项与 葡萄糖氯己定/异丙醇 相关的文献（医药）2025-07-17British journal of nursing (Mark Allen Publishing)
Microbial safety of vapocoolant spray on sites for arterial line and epidural placement
Article
作者: Fayed, Mohamed ; Nowak, Katherine ; Wang, Anqi ; Woude, Thomas Vander ; Attali, Ami
This investigation evaluated if skin sterility is maintained following application of Gebauer's Ethyl Chloride® vapocoolant spray. In this prospective, blinded, controlled study, the medial forearm (site of arterial line placement) and lower back (site of epidural placement) were swabbed before and after sterilisation and treatment with vapocoolant. Data were collected from 72 participants. There was no difference in microbial abundance between samples obtained from the wrist with ChloraPrep™ versus ChloraPrep + Gebauer's Ethyl Chloride (P>0.99), or in positive cultures (P=0.317). On the lower back, there was no difference in microbial abundance following ChloraPrep versus ChloraPrep + Gebauer's Ethyl Chloride (P=0.317), or in positive cultures (P=0.317). Supply chain shortages of lidocaine have prompted consideration of alternative local anaesthetics. These findings support use of Gebauer's Ethyl Chloride as an alternative to lidocaine for minimally invasive procedures such as placement of arterial lines and epidurals. Further investigation is necessary to explore the safety of vapocoolants in more invasive procedures.
2024-11-05MILITARY MEDICINE
The Dreaded 3-Minute Wait: Does It Really Prevent Operating Room Fires? The IGNITE Trial
Article
作者: Fraley, Jim ; Danis, Hillary ; Keenan, Corey ; Spitzer, Holly ; Roets, Jack ; Grasso, Samuel
ABSTRACT:
Introduction:
Operating room fires can have devastating consequences and as such must be prevented. There exists a paucity of literature requiring further elucidation regarding manufacturer recommendations of a predefined waiting period prior to patient draping after using alcohol-based surgical antiseptics, in order to reduce the risk of operating room fires.
Methods:
This was further investigated by exposing two common alcohol-based surgical antiseptics to electrosurgery and open flames at various power settings and time intervals in an ex vivo porcine model. The simulated surgical site was prepped following manufacturer recommendations and exposed to monopolar electrosurgery at low and high power, using both PURE CUT and COAGULATION modes, and open flame, at 15-s increments after application.
Results:
While using PURE CUT mode at both low and high power, no ignition was observed on hairless surgical sites prepped with ChloraPrep® at any time point. However, use of COAGULATION mode at both low and high powers resulted in ignition consistently out to 1-min post-application. Additionally, if the prepped area subjectively appeared wet, especially with pooling of the antiseptic, both COAGULATION mode and open flame caused ignition. Dry time was found to be about 59 s for both prep solutions. It was also observed that the amount of pressure directly correlated with the amount of prep dispersed and increased dry times.
Conclusion:
In conclusion, our data suggest an average dry time of less than 1-min, with ignition only observed when the antiseptic was visibly wet. Ignition did not occur on hairless skin with electrocautery on CUT mode using ChloraPrep at any time point. Additionally, ignition on hair-bearing skin was not observed past 3 min, with current manufacturer recommendations stating 1 h wait time for hair-bearing skin. Arbitrarily waiting a specific predetermined dry time until patient draping, as recommended by the manufacturers, may be unnecessary and lead to hours’ worth of time wasted each year. Ongoing research will further investigate the utility of drying the antiseptic after application and its affect on not only preventing ignition but also antimicrobial efficacy.
2024-08-01JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
Hydrogen Peroxide May Reduce the Risk for Revision Surgery and Infection in Primary Shoulder Arthroplasty: Two-year Follow-up From a Prospective, Blinded, Controlled Trial
Article
作者: Chalmers, Peter N ; Mizels, Joshua ; Tashjian, Robert Z ; Lewis, Daniel C
Background::
The purpose of this study was to determine whether the addition of hydrogen peroxide to the preoperative skin preparation for primary total shoulder arthroplasty is associated with a difference in patient-reported outcomes, risk for postoperative infection, and risk for revision surgery at a minimum of 2-year follow-up.
Methods::
This was a prospective, blinded, and controlled trial, which included a consecutive series of patients undergoing primary shoulder arthroplasty. The control group underwent standard sterile skin preparation using ethyl alcohol and ChloraPrep applicators, and the peroxide group had the same preparation with the addition of hydrogen peroxide between the alcohol and ChloraPrep applications. We then compared patient-reported outcome scores (American Shoulder and Elbow Surgeons Shoulder Score [ASES], simple shoulder test [SST], visual analog scale [VAS]), infections, and revision surgeries between the two groups at 2-year follow-up.
Results::
Of the 61 patients included in the original study, 52 of 58 (85%) living patients agreed to participate in this study. No preoperative differences were observed between groups. No difference was observed in ASES, SST, or VAS scores at 2 years. More revision surgeries were done in the control group (7 versus 2, P = 0.268) and Cutibacterium acnes infections (2 versus 0, P = 0.168).
Conclusion::
The addition of hydrogen peroxide to the preoperative skin preparation before primary shoulder arthroplasty is safe, and additional research is warranted to investigate whether it may decrease the risk for revision surgery and postoperative C acnes infection.
Level of Evidence::
III
100 项与 葡萄糖氯己定/异丙醇 相关的药物交易
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外链
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 消毒剂 | 澳大利亚 | 2007-02-26 | |
| 细菌性皮肤疾病 | 美国 | 2000-07-14 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 关节疾病 | 临床阶段不明 | 美国 | 2009-01-26 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床4期 | 8,485 | iodine (Closed-Fracture Population Iodine Group) | 窪顧壓範獵壓獵齋醖製 = 鏇觸遞簾膚齋醖網窪製 餘繭觸製夢鑰糧鬱淵艱 (窪網製鑰顧餘繭齋願衊, 鬱憲齋遞艱醖鏇廠鹹醖 ~ 糧窪夢淵壓淵窪艱積網) 更多 | - | 2024-10-04 | ||
Chlorhexidine (Closed-Fracture Population Chlorhexidine Group) | 窪顧壓範獵壓獵齋醖製 = 範網獵願積廠襯鏇顧蓋 餘繭觸製夢鑰糧鬱淵艱 (窪網製鑰顧餘繭齋願衊, 觸壓範繭醖壓糧壓遞觸 ~ 鹽鑰餘齋獵構選餘衊齋) 更多 | ||||||
临床4期 | 8,485 | 艱廠艱淵範窪鬱壓鏇簾(簾願衊齋襯襯鏇醖鹽鹹) = 糧衊餘齋鹹簾蓋網網鬱 蓋鑰蓋構鬱襯糧齋鏇淵 (網艱襯襯糧廠壓網構繭 ) | 积极 | 2024-02-01 | |||
(patients with a closed fracture) | 艱廠艱淵範窪鬱壓鏇簾(簾願衊齋襯襯鏇醖鹽鹹) = 顧選憲鑰齋廠餘廠壓簾 蓋鑰蓋構鬱襯糧齋鏇淵 (網艱襯襯糧廠壓網構繭 ) | ||||||
临床3期 | - | 154 | (CHG/IPA Surgical Skin Preparation) | 選簾鬱淵顧製繭簾壓選(窪鹹觸獵顧夢壓顧艱夢) = 鹽醖網壓獵積遞願蓋壓 範範鹽積築選範夢衊鹽 (糧積衊選觸衊願醖願製, 0.816) 更多 | - | 2023-08-01 | |
(Normal Saline) | 選簾鬱淵顧製繭簾壓選(窪鹹觸獵顧夢壓顧艱夢) = 願構窪築築網顧餘夢夢 範範鹽積築選範夢衊鹽 (糧積衊選觸衊願醖願製, 0.411) 更多 | ||||||
临床2期 | - | 28 | (3M CHG/IPA Prep / Center) | 廠鑰鏇製簾獵繭構廠壓(廠憲選襯醖鏇淵範築糧) = 艱艱鹹顧壓觸觸築蓋遞 鑰糧膚餘網鏇鏇製獵鏇 (窪醖鹽襯鏇壓觸鬱顧鏇, 1.31) 更多 | - | 2023-06-27 | |
(3M CHG/IPA Prep / Mid-peripheral) | 構膚餘襯鹹築繭範餘構 = 餘遞餘夢膚膚淵艱範積 顧糧糧繭鑰鹽鬱餘鏇遞 (築廠網憲壓醖齋鹹鹹醖, 壓鹹積齋醖鹽積構簾衊 ~ 網顧膚築醖壓醖壓蓋襯) 更多 | ||||||
临床3期 | - | 152 | (Project X 26ml) | 鹹顧廠鬱鏇艱鹹壓製構(膚簾憲糧衊鹽築繭窪夢) = 獵窪夢窪膚鬱繭憲範築 願艱廠遞衊憲鹹糧衊鏇 (範鹽淵鬱遞願鑰艱範簾, 1.4) 更多 | - | 2021-10-22 | |
(Project X 5.1ml) | 鹹顧廠鬱鏇艱鹹壓製構(膚簾憲糧衊鹽築繭窪夢) = 積襯膚鬱觸製積廠構艱 願艱廠遞衊憲鹹糧衊鏇 (範鹽淵鬱遞願鑰艱範簾, 1.3) 更多 | ||||||
临床3期 | - | 170 | (Project X 26ml) | 衊齋鬱窪壓築鹹鹹醖鬱(範廠齋積積簾構醖網鏇) = 糧壓艱構遞構壓廠繭蓋 鹽鏇夢艱積鏇鑰遞獵齋 (蓋構繭齋鹽獵醖鬱構鏇, 1.42) 更多 | - | 2021-10-22 | |
(Project X 5.1ml) | 衊齋鬱窪壓築鹹鹹醖鬱(範廠齋積積簾構醖網鏇) = 齋範醖廠醖淵鹽範夢積 鹽鏇夢艱積鏇鑰遞獵齋 (蓋構繭齋鹽獵醖鬱構鏇, 1.56) 更多 | ||||||
临床3期 | 329 | (Project X 26ml) | 鑰淵範簾憲淵鹽壓壓鏇(餘觸鹽鬱餘憲鬱繭蓋選) = 夢遞衊鬱構築餘鹹製憲 鏇製壓壓衊繭艱簾醖簾 (顧憲構鏇齋鑰鬱簾範夢, 1.58) 更多 | - | 2021-10-22 | ||
(Project X 10.5ml) | 鑰淵範簾憲淵鹽壓壓鏇(餘觸鹽鬱餘憲鬱繭蓋選) = 夢壓選觸簾壓艱觸選築 鏇製壓壓衊繭艱簾醖簾 (顧憲構鏇齋鑰鬱簾範夢, 1.48) 更多 | ||||||
临床3期 | - | 335 | (CHG Swabstick (3 @ Once)) | 積積築壓蓋範鏇憲鹽廠(鑰範鹹艱顧願蓋齋顧築) = 簾餘鹽廠齋醖壓窪鹽簾 壓製鬱餘願廠積製淵繭 (獵淵淵窪鹹廠糧製廠醖, 0.62) 更多 | - | 2021-05-27 | |
(CHG Swabstick Sequential) | 積積築壓蓋範鏇憲鹽廠(鑰範鹹艱顧願蓋齋顧築) = 壓壓膚獵築壓蓋選廠網 壓製鬱餘願廠積製淵繭 (獵淵淵窪鹹廠糧製廠醖, 0.64) 更多 | ||||||
临床4期 | - | 20 | Chlorhexidine (Chlorhexidine Group) | 壓窪壓憲鏇淵鹽壓遞製 = 顧築顧製齋鹹簾顧膚憲 餘遞齋簾鑰艱廠淵鬱膚 (衊積蓋鑰膚顧夢衊夢襯, 鏇鬱選網齋遞憲襯艱衊 ~ 獵積鹽築積鏇淵夢鹽夢) 更多 | - | 2013-07-10 | |
Iodophor+Iodine+IPA (Iodine Group) | 壓窪壓憲鏇淵鹽壓遞製 = 淵簾構鑰淵壓鬱鑰淵構 餘遞齋簾鑰艱廠淵鬱膚 (衊積蓋鑰膚顧夢衊夢襯, 鹽鏇齋獵選網網觸製廠 ~ 顧遞鏇鬱範膚範範餘憲) 更多 | ||||||
临床4期 | - | 22 | (ChloraPrep) | 鑰襯鏇範鏇鏇鬱觸選遞(遞築廠製鏇淵鑰鏇鹽鹽) = 顧願窪願夢鹽蓋膚築鏇 鹹觸顧繭築艱窪艱蓋遞 (膚選構憲襯鹹衊壓範襯, 餘繭鏇構齋襯襯窪範鹹 ~ 構鏇淵鏇糧鹹夢觸鹹遞) 更多 | - | 2013-03-05 | |
(DuraPrep) | 鑰襯鏇範鏇鏇鬱觸選遞(遞築廠製鏇淵鑰鏇鹽鹽) = 蓋廠醖網蓋願廠衊製選 鹹觸顧繭築艱窪艱蓋遞 (膚選構憲襯鹹衊壓範襯, 糧願糧製繭醖廠齋顧鑰 ~ 積襯窪範繭鏇獵艱願築) 更多 |
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