01 01April 四月2026 2026| |13:00 PM 下午1:00Europe/Amsterdam 欧洲/阿姆斯特丹Bayer’s strongest-ever pharma portfolio and promising pipeline drive future growth 拜耳有史以来最强大的医药产品组合和充满希望的管道推动未来增长Not intended for U.S. and UK Media 不适用于美国和英国媒体Summary 摘要Five growth catalysts fuel the pharma portfolio of Bayer / Record-breaking 2025 with five first-approvals (three new product approvals; two new indications) and six positive Phase III readouts / Multiple key pipeline milestones expected in 2026 in priority therapeutic areas / Bayer confirms dual ambition for Pharmaceuticals to return to mid-single-digit growth from 2027 onwards, and from 2028 to achieve an operating margin expansion towards 30 percent by 2030. 五大增长动力推动拜耳制药产品组合 / 2025年将创纪录迎来五个首次批准（三个新产品批准；两个新适应症）和六个积极的III期试验结果 / 预计2026年在重点领域将迎来多项关键管线里程碑 / 拜耳确认其制药业务的双重目标：从2027年起恢复中个位数增长，并从2028年起实现营业利润率逐步扩大，到2030年接近30%。Berlin, April 1, 2026 柏林，2026年4月1日– On the occasion of Bayer’s Pharma Media Day 2026, Stefan Oelrich, Member of the Board of Management of Bayer AG and President of the company’s Pharmaceuticals Division, revealed how a sustained focus on science- and business-prioritization is driving a projected growth trajectory towards 2030. – 在拜耳2026年医药媒体日之际，拜耳集团管理委员会成员、公司制药部门总裁斯特凡·奥尔里希透露，持续专注于科学和业务优先化如何推动公司预计到2030年的增长轨迹。“With our unwavering focus on our strategic priorities and scientific rigor, we are seeing the rewards of our transformative strategy to drive growth,” said “通过我们对战略重点和科学严谨性的坚定关注，我们正看到推动增长的转型战略带来的回报，”Stefan Oelrich, 斯特凡·奥尔里希，Member of the Board of Management of Bayer AG and President of the company’s Pharmaceuticals Division. “Thanks to our strongest ever Pharma portfolio, our multimodal pipeline, and an increasingly AI-enabled operating model, we are on track to return to mid-single-digit growth from 2027 onwards, and to expand our margin from 2028 towards 30 percent by 2030.”. 拜耳公司管理委员会成员兼公司制药部门总裁。“得益于我们有史以来最强大的制药产品组合、多模式的管道以及越来越以人工智能为驱动的运营模式，我们有望从2027年起恢复到中等个位数增长，并在2028年将利润率扩大至30%。”Five growth catalysts to drive Pharmaceuticals’ performance into the next decade 推动制药业未来十年发展的五大增长催化剂“Our intention is to be first- or best-in-class because patients deserve no less,” said “我们的目标是成为同类产品中的佼佼者，因为患者理应得到最好的，”Christine Roth 克里斯汀·罗斯, Executive Vice President, Global Head of Product Strategy and Commercialization and Member of the Pharmaceuticals Leadership Team at Bayer. “The bold choices we’ve made over the past few years, along with our empowered teams, are accelerating innovation and delivering real impact for patients and for Bayer.”. 拜耳制药执行副总裁、全球产品战略与商业化主管及制药领导团队成员。“我们在过去几年中做出的大胆选择，以及我们授权的团队，正在加速创新，并为患者和拜耳带来真正的影响力。”ASUNDEXIAN (Development Candidate) ASUNDEXIAN（开发候选人）Latest updates 最新更新Bayer has a factor XIa-inhibitor in clinical development. Asundexian has demonstrated superiority in reducing ischemic stroke, compared to placebo, when both were combined with antiplatelet therapy, in patients who experienced a non-cardioembolic ischemic stroke or high-risk transient ischemic attack (TIA).. 拜耳公司有一种因子XIa抑制剂正处于临床开发阶段。阿桑德昔在减少缺血性中风方面表现出优于安慰剂的效果，该效果是在与抗血小板疗法联合使用时观察到的，适用于经历过非心源性缺血性中风或高风险短暂性脑缺血发作（TIA）的患者。Asundexian has received Fast Track Designation from the U.S. Food and Drug Administration (FDA). 阿桑地昔获得了美国食品药品监督管理局（FDA）的快速通道资格。Factor XIa is a protein in the blood coagulation pathway. The goal of inhibiting Factor XIa is to uncouple hemostasis from thrombosis, thus preventing pathological clot formation while leaving hemostasis intact. 因子XIa是血液凝固途径中的一种蛋白质。抑制因子XIa的目标是将止血与血栓形成分离，从而防止病理性凝块形成，同时保持止血功能完好。 1,2,3 1,2,3To date, asundexian has not yet been approved by any health authority for use in any country, for any indication. 迄今为止，asundexian 尚未获得任何卫生当局的批准，也未在任何国家用于任何适应症。Why this matters 为什么这很重要Around 12 million people worldwide experience a stroke each year, 全世界每年大约有 1200 万人罹患中风，4 4of which 80 percent are ischemic strokes. 其中80％是缺血性中风。5 5Approximately one in five ischemic stroke survivors will have another stroke within five years, even with available secondary stroke prevention strategies. 大约五分之一的缺血性中风幸存者在五年内会再次中风，即使有可用的二级中风预防策略。6 6DAROLUTAMIDE / NUBEQA™ 达罗鲁胺 / NUBEQA™Latest updates 最新更新Darolutamide is the first androgen receptor inhibitor (ARi) for the treatment of patients with metastatic hormone-sensitive prostate cancer (mHSPC) in combination with androgen deprivation therapy (ADT), with or without chemotherapy. 达罗鲁胺是首个用于治疗转移性激素敏感性前列腺癌（mHSPC）的雄激素受体抑制剂（ARi），与雄激素剥夺疗法（ADT）联合使用，无论是否接受化疗。Bayer’s ambition is to globally lead this second generation class of ARis. 拜耳的雄心是在全球范围内引领第二代ARis类药物的发展。Looking ahead, a Phase III trial is evaluating darolutamide plus ADT vs ADT alone in HSPC, in patients with high-risk biochemical recurrence (BCR) with no evidence of metastatic disease by conventional imaging and a positive positron emission tomography / computer tomography (PSMA PET/CT) at baseline.. 展望未来，一项 III 期试验正在评估达洛鲁胺联合雄激素剥夺疗法 (ADT) 与单独使用 ADT 在高危生化复发 (BCR) 的激素敏感性前列腺癌 (HSPC) 患者中的效果，这些患者通过常规影像学检查未发现转移性疾病，但在基线时正电子发射断层扫描/计算机断层扫描 (PSMA PET/CT) 呈阳性。Darolutamide has a unique chemical structure. It inhibits the receptor function of androgens (male hormones) and through this inhibits the growth of prostate cancer cells. 达洛鲁胺具有独特的化学结构。它抑制雄激素（男性激素）的受体功能，从而抑制前列腺癌细胞的生长。Why this matters 这件事为什么重要Prostate cancer is the second most common cancer in men. 前列腺癌是男性中第二常见的癌症。7 7In 2022, almost 400,000 men died from the disease worldwide. 2022年，全球有近40万名男性死于该疾病。8 8FINERENONE / KERENDIA™ 非奈利酮 / 可申达™Latest updates 最新更新Finerenone is a selective, nonsteroidal mineralocorticoid receptor antagonist (nsMRA), and the first drug targeting the MR pathway that has demonstrated clinically proven heart and/or kidney benefits in five pivotal Phase III studies in patients with: Finerenone是一种选择性、非甾体类盐皮质激素受体拮抗剂（nsMRA），是首个在五项关键的III期研究中证明对心脏和/或肾脏有临床益处的针对MR通路的药物，适用于以下患者：o Heart failure with left ventricular ejection fraction (LVEF) ≥40% 左心室射血分数 (LVEF) ≥40% 的心力衰竭o Chronic kidney disease (CKD) associated with type 2 diabetes 与2型糖尿病相关的慢性肾病 (CKD)o CKD associated with type 1 diabetes 与1型糖尿病相关的慢性肾脏病o CKD of non-diabetic causes 非糖尿病原因引起的慢性肾脏病Based on its proven outcomes in heart and kidney disease, we expect finerenone to become an important pillar within comprehensive care. 基于其在心脏病和肾病方面已证明的疗效，我们预计finerenone将成为综合护理中的重要支柱。Finerenone is marketed as Kerendia™ or in selected countries as Firialta™, and is approved in more than 100 countries worldwide for the treatment of adult patients with CKD associated with type 2 diabetes. In the U.S., in the EU, in Japan and some other markets, finerenone is also approved for the treatment of heart failure (HF) with LVEF ≥40%. Finerenone 以 Kerendia™ 或在部分国家以 Firialta™ 的名称上市，已被全球 100 多个国家批准用于治疗与 2 型糖尿病相关的慢性肾病（CKD）成年患者。在美国、欧盟、日本及其他一些市场，finerenone 还被批准用于治疗左心室射血分数（LVEF）≥40% 的心力衰竭（HF）。Applications in HF in additional markets, including China, are under review.. 包括中国在内的其他市场的高频（HF）应用正在审查中。The clinical study program with finerenone currently comprises ten Phase III studies with dedicated programs in heart failure (HF) and CKD, respectively, five of which have been completed. 目前，非奈利酮的临床研究计划包括十个 III 期研究，其中分别针对心力衰竭（HF）和慢性肾脏病（CKD）的专项计划，其中五项已经完成。Finerenone is a selective nsMRA with a distinct mode of action addressing the inflammatory and fibrotic disease pathophysiology involved in both heart and kidney disease. Finerenone是一种选择性nsMRA，具有独特的作用机制，能够针对心脏和肾脏疾病中涉及的炎症和纤维化病理生理过程。Why this matters 为什么这很重要More than 875 million people globally are affected by CKD and/or HF, 全球有超过 8.75 亿人受到 CKD 和/或 HF 的影响，9,10 9,10with the likelihood of developing both conditions escalating due to global lifestyle trends, an aging population, and the rising incidence of diabetes. 由于全球生活方式趋势、人口老龄化以及糖尿病发病率的上升，这两种疾病同时发病的可能性也在增加。9,11,12,13,14 9，11，12，13，14Patients suffering from either CKD or HF face lower survival rates, and the risks of hospitalization, disease progression, and death increase when both conditions coexist. 慢性肾病或心衰患者生存率较低，当这两种疾病共存时，住院、疾病进展和死亡的风险都会增加。15 15ACORAMIDIS / BEYONTTRA™ ACORAMIDIS / BEYONTTRA™Latest updates 最新更新Beyonttra is designed to provide effective TTR tetramer stabilization by mimicking a naturally occurring 'protective mutation” of the TTR gene (T119M) that targets the root cause of transthyretin amyloidosis with cardiomyopathy (ATTR-CM). 贝昂特拉旨在通过模拟TTR基因（T119M）的自然“保护性突变”来提供有效的TTR四聚体稳定，该突变针对转甲状腺素蛋白淀粉样变心肌病（ATTR-CM）的根本原因。Bayer is striving for a rapid and sustained market-uptake of Beyonttra in ATTR-CM-treatment in Europe. 拜耳正在努力推动Beyonttra在欧洲ATTR-CM治疗中的快速且持续的市场应用。Beyonttra is approved in the EU for the treatment of wild-type or variant transthyretin amyloidosis in adult patients with cardiomyopathy (ATTR-CM). 贝恩特拉在欧盟被批准用于治疗患有心肌病的野生型或变异型转甲状腺素蛋白淀粉样变性成年患者（ATTR-CM）。16 16Why this matters 这件事为何重要ATTR-CM is an often underdiagnosed, progressive potentially fatal heart disease caused by the destabilization of transthyretin (TTR). This destabilization leads to the deposition of amyloid in the heart, which can result in significant impairments in heart function. ATTR-CM 是一种常被漏诊的、进行性的、可能致命的心脏病，由转甲状腺素蛋白 (TTR) 的不稳定引发。这种不稳定会导致淀粉样蛋白在心脏中沉积，从而可能显著损害心脏功能。17,18 17，18ATTR-CM is estimated to affect 400,000 people globally 据估计，ATTR-CM在全球影响40万人。19 19and approximately 190,000 people in Europe. 欧洲大约有190,000人。20 20ELINZANENTANT / LYNKUET™ ELINZANENTANT / LYNKUET™Latest updates 最新更新Elinzanetant is the first dual neurokinin (NK)-targeted therapy (NK‑1 and NK‑3 antagonist). Elinzanetant 是首个双重神经激肽（NK）靶向疗法（NK-1 和 NK-3 拮抗剂）。Elinzanetant is approved under the brand name Lynkuet™ in the U.S. and other markets for the treatment of vasomotor symptoms (VMS) associated with menopause, and in the EU for the treatment of moderate to severe VMS associated with menopause or caused by adjuvant endocrine therapy (AET) related to breast cancer, making it the only approved option in the EU in this indication.. Elinzanetant在美国和其他市场以品牌名Lynkuet™获批用于治疗与更年期相关的血管舒缩症状（VMS），并在欧盟获批用于治疗与更年期相关或由乳腺癌辅助内分泌治疗（AET）引起的中度至重度VMS，成为欧盟在该适应症中唯一获批的选项。Increasing evidence shows that declining estrogen activity leads to hyperactive kisspeptin, neurokinin B, and dynorphin (KNDy) - which express NK1 and NK3 receptors - leading to dysregulation of the centers that regulate temperature and sleep, resulting in VMS. 越来越多的证据表明，雌激素活性下降会导致吻肽、神经激肽B和强啡肽（KNDy）过度活跃——这些物质表达NK1和NK3受体——从而导致调节体温和睡眠的中枢功能失调，引发VMS。Elinzanetant works by antagonizing the NK1 and NK3 receptors, reducing frequency and severity of VMS, with additional benefits on improving sleep disturbance and quality of life. Elinzanetant通过拮抗NK1和NK3受体，减少VMS的频率和严重程度，并对改善睡眠障碍和生活质量有额外益处。Why this matters 为什么这很重要By 2030, the global population of women experiencing menopause is forecast to increase to 1.2 billion, with menopause affecting women at a time where they are very active socially and professionally. 到2030年，预计全球经历更年期的女性人口将增加到12亿，而更年期会在女性社交和职业活动都非常活跃的时期对她们产生影响。21 21In 2020, there were 2.3 million new cases of breast cancer globally, and nearly 70 percent of tumors being hormone-receptor positive, requiring anti-estrogen treatment which may trigger menopause symptoms. 2020 年，全球新增 230 万乳腺癌确诊病例，其中近 70% 的肿瘤为激素受体阳性，需要进行可能引发更年期症状的抗雌激素治疗。22,23,24,25 22,23,24,25Rejuvenated pipeline fuels future growth 焕然一新的产品线推动未来增长“Our rigorous strategy to rejuvenate our pipeline with innovative and differentiated assets is showing its potential, as seen in our record performance in 2025. Three new product approvals, two new indications for our growth drivers, as well as six positive Phase III readouts,” said “我们通过创新和差异化资产重振管道的严格战略展现了其潜力，正如我们在2025年创纪录的表现中所见。三项新产品获批，我们的增长驱动因素获得了两项新适应症，以及六项积极的三期试验结果。”Christian Rommel 克里斯蒂安·罗梅尔, Executive Vice President, Global Head of Research and Development and Member of the Pharmaceuticals Leadership Team. “In 2026, we anticipate several key milestones further validating our strategy of impact-by-innovation, such as precision medicine in our core therapeutic areas of cardiovascular and oncology, regenerative cell and gene therapies, as well as in molecular imaging.”. 执行副总裁，全球研发主管，制药领导团队成员。“到2026年，我们预计将迎来多个关键里程碑，进一步验证我们通过创新产生影响的战略，例如在心血管和肿瘤学等核心治疗领域的精准医疗、再生细胞和基因疗法，以及分子影像。”Advancements in precision drug development 精准药物开发的进展225Ac-PSMA-Trillium (BAY 3563254) 225Ac-PSMA-Trillium（BAY 3563254）Latest updates 最新更新225Ac-PSMA-Trillium (BAY 3563254) is an investigational targeted alpha therapy (TAT) for patients with advanced metastatic castration-resistant prostate cancer (mCRPC). 225Ac-PSMA-Trillium（BAY 3563254）是一种用于治疗晚期转移性去势抵抗性前列腺癌（mCRPC）患者的实验性靶向α疗法（TAT）。Encouraging results from the ongoing global Phase I first-in-human, dose-escalation PAnTHa study support advancing 225Ac-PSMA-Trillium to the next phase of clinical development. 正在进行的全球 I 期首次人体剂量递增 PAnTHa 研究的鼓舞人心的结果支持将 225Ac-PSMA-Trillium 推进到临床开发的下一阶段。TAT is a strategic pillar of precision oncology at Bayer, with the potential to accelerate novel treatment options for patients with mCRPC. TAT是拜耳精准肿瘤学的战略支柱，有可能加速为mCRPC患者提供新的治疗选择。Why this matters 为什么这很重要Prostate cancer is the second most common cancer in men worldwide 前列腺癌是全球男性中第二常见的癌症7 7with less than three years median overall survival among metastatic patients, who have developed castration-resistance. 在转移性去势抵抗患者中，中位总生存期不到三年。 26,27 26，27‘‘Small molecule medicines remain one of the most effective ways to deliver impactful therapies through their accessibility, predictability, and global scalability,” said “小分子药物仍然是通过其可及性、可预测性和全球可扩展性提供高效疗法的最佳方式之一，”Aleksandra Rizo 亚历山德拉·里佐, M.D, Ph.D, President and CEO, Vividion Therapeutics. “We are advancing oral therapies for cancer and immunologic diseases that target drivers previously considered undruggable, enabled by our chemoproteomics screening platform. With three internally developed molecules now in clinical development, we are focused on translating this work into potentially transforming new medicines for patients.”. 医学博士、哲学博士，Vividion Therapeutics公司总裁兼首席执行官。“我们正在推进针对以前被认为无法成药的癌症和免疫疾病驱动因子的口服疗法，这得益于我们的化学蛋白质组学筛选平台。随着三个内部研发的分子现已进入临床开发阶段，我们正专注于将这些研究成果转化为可能为患者带来变革的新药。”WRN inhibitor (VVD-214) WRN抑制剂（VVD-214）Latest updates 最新更新WRN inhibitor (VVD-214) is a novel covalent, irreversible inhibitor of the enzyme Werner helicase (WRN) designed to exploit the dependency of microsatellite instability (MSI)-high cancer cells on WRN-mediated DNA repair. This cancer-specific mechanism has the potential to impact disease progression and improve patient survival with limited toxicity and side effects. WRN抑制剂（VVD-214）是一种新型的共价、不可逆的沃纳解旋酶（WRN）抑制剂，旨在利用高微卫星不稳定性（MSI）癌细胞对WRN介导的DNA修复的依赖性。这种针对癌症的特定机制有可能影响疾病进展，并在毒性与副作用有限的情况下改善患者的生存率。It was the first covalent inhibitor of WRN to enter clinical trials worldwide.. 它是全球首个进入临床试验的WRN共价抑制剂。In a Phase I clinical trial VVD-214 was well tolerated and showed promising signs of activity in patients with MSI-high solid tumors. 在一期临床试验中，VVD-214 耐受性良好，并在高微卫星不稳定性实体瘤患者中显示出令人鼓舞的活性迹象。The company plans to continue the Phase Ib and initiate Phase II clinical trials evaluating VVD-214 in patients with advanced MSI-high or dMMR colorectal cancer. 公司计划继续进行Ib期临床试验，并启动II期临床试验，评估VVD-214在晚期MSI高或dMMR结直肠癌患者中的疗效。Why this matters 这件事为何重要Colorectal cancer (CRC) is the third most common cancer worldwide, with nearly two million new cases diagnosed each year. 结直肠癌（CRC）是全球第三大常见癌症，每年新诊断病例接近两百万。28 28Approximately 15 percent of CRC tumors are MSI-high, 大约15%的结直肠癌肿瘤为MSI高，29 29representing the largest MSI-high patient population and a significant opportunity for targeted therapies. VVD-214 also has potential for therapeutic benefit in other MSI-high cancers, including endometrial, ovarian, and gastric. 代表了最大的MSI高患者群体，并为靶向治疗提供了重要机会。VVD-214在其他MSI高的癌症中也具有潜在的治疗益处，包括子宫内膜癌、卵巢癌和胃癌。GIRK4 inhibitor (BAY 3670549) GIRK4抑制剂（BAY 3670549）Latest updates 最新更新GIRK4 inhibitor (BAY 3670549) is a highly selective G-protein-coupled inwardly rectifying potassium channel 4 (GIRK4) inhibitor, which has the potential to help control the electrical activity of heart cells in patients with atrial fibrillation (AFib). GIRK4抑制剂（BAY 3670549）是一种高选择性的G蛋白偶联内向整流钾通道4（GIRK4）抑制剂，具有帮助控制心房颤动（AFib）患者心肌细胞电活动的潜力。GIRK4 inhibitor derives from the strategic research alliance with the Broad Institute of MIT and Harvard. GIRK4抑制剂源自与麻省理工学院和哈佛大学Broad研究所的战略研究联盟。Phase I study initiated. 一期研究已启动。Why this matters 这件事为何重要AFib is the most common type of cardiac arrhythmia (irregular heart rhythm), affecting more than 60 million people worldwide, and a significant risk factor for stroke and heart failure. 心房颤动是最常见的心律失常（心跳不规律）类型，影响全球超过6000万人，并且是中风和心力衰竭的重要风险因素。30,31,32 30,31,32Sevabertinib 塞瓦贝替尼Latest updates 最新更新Sevabertinib is a new oral, reversible Tyrosine Kinase Inhibitor (TKI) which blocks certain enzymes called tyrosine kinases involved in the growth of cancer cells. 塞瓦伯替尼是一种新型的口服、可逆的酪氨酸激酶抑制剂（TKI），可阻断某些参与癌细胞生长的酪氨酸激酶酶。Sevabertinib has Breakthrough Therapy Designation in the U.S. and China as a first-line treatment for patients with HER2-mutant non-small cell lung cancer (NSCLC). Sevabertinib在美国和中国均获得了突破性疗法认定，作为HER2突变非小细胞肺癌（NSCLC）患者的一线治疗药物。HER2-mutant NSCLC is approved in the U.S. and Canada under the brand name Hyrnuo™ for adults with previously treated advanced HER2-mutant NSCLC. HER2突变型非小细胞肺癌在美国和加拿大以品牌名Hyrnuo™获批，用于治疗先前接受过治疗的晚期HER2突变型非小细胞肺癌成人患者。Why this matters 为什么这很重要NSCLC is the most common type of lung cancer, accounting for more than 85 percent of cases, 非小细胞肺癌是最常见的肺癌类型，占病例的85%以上，33 332-4 percent of which represent HER2-mutant NSCLC. 其中2-4％代表HER2突变的非小细胞肺癌。 34,35 34,35Gene therapy and cell therapy portfolios with potential to deliver transformative patient impact 具有交付变革性患者影响潜力的基因治疗和细胞治疗组合Gene Therapy 基因治疗“By combining AskBio’s integrated Adeno Associated Virus platform - from capsid innovation to manufacturing - with Bayer’s global development and operational capabilities, we are working to develop medicines with the potential to transform patient lives across both rare and more common diseases,” said . “通过将AskBio整合的腺相关病毒平台——从衣壳创新到制造——与拜耳的全球开发和运营能力相结合，我们正在努力开发有潜力改变罕见病和更常见疾病患者生活的药物，”该人士表示。Gustavo Pesquin 古斯塔沃·佩斯金, Chief Executive Officer, AskBio. ，首席执行官，AskBio。AB-1002 AB-1002Latest updates 最新更新AB-1002 is a single-dose investigational gene therapy being developed as a potential treatment for heart failure with reduced ejection fraction (HFrEF). AB-1002 是一种单剂量研究性基因疗法，正在开发作为治疗射血分数降低的心力衰竭 (HFrEF) 的潜在疗法。The final participant has been randomized in the Phase II study. II 期研究中的最后一名参与者已经随机化。Why this matters 为什么这很重要An estimated 64 million people worldwide are living with heart failure. Despite advances in treatment, mortality and morbidity remain very high. 据估计，全世界有6400万人患有心力衰竭。尽管治疗方面取得了进展，但死亡率和发病率仍然非常高。36,37 36，37Ametefgene parvec (AB-1005) 阿米特夫根副球菌 (AB-1005)Latest updates 最新更新Ametefgene parvec is an investigational one-time gene therapy designed to address the underlying biology of Parkinson’s Disease (PD), aiming to restore neuronal function and potentially slow disease progression. Ametefgene parvec 是一种研究性的一次性基因疗法，旨在解决帕金森病 (PD) 的潜在生物学机制，力求恢复神经元功能并可能减缓疾病进展。An ongoing Phase II trial enrolls participants across clinical centers in the U.S., Germany, Poland and the U.K. 一项正在进行的 II 期试验在美国、德国、波兰和英国的临床中心招募参与者。Why this matters 为什么这很重要The prevalence of PD has doubled over the past 25 years. Almost 12 million people live with PD globally. The effect of existing treatment options commonly fades after some years, and motor-fluctuations and treatment-dependent dyskinesia occur. 过去 25 年间，PD 的患病率翻了一番。全球约有 1200 万人患有 PD。现有治疗方案的效果通常在数年后减弱，并出现运动波动和治疗相关的运动障碍。38,39 38，39Cell Therapy 细胞治疗“For diseases characterized by irreversible cell loss, regenerative medicine offers a fundamentally new approach,” said “对于以不可逆的细胞损失为特征的疾病，再生医学提供了一种根本上的新方法，”Seth Ettenberg 塞思·埃滕贝格, President and CEO of BlueRock Therapeutics. “We are advancing novel cell therapies into clinical development along with scalable, reproducible manufacturing.” ，BlueRock Therapeutics 总裁兼首席执行官。“我们正在将新型细胞疗法推进到临床开发阶段，并实现可扩展且可重复的生产。”Bemdaneprocel 贝姆达内普罗塞尔Latest updates 最新更新Bemdaneprocel is a single-dose investigational cell therapy designed to replace the dopamine producing neurons that are lost in Parkinson’s Disease (PD). Bemdaneprocel 是一种单剂量研究性细胞疗法，旨在替代帕金森病 (PD) 中丧失的多巴胺生成神经元。Bemdaneprocel is currently under evaluation in a Phase III study across clinical centers in the U.S., Canada and Australia. 贝马丹普罗赛尔目前在美国、加拿大和澳大利亚的临床中心进行III期研究评估。Why this matters 为什么这很重要The prevalence of PD has doubled over the past 25 years. Almost 12 million people live with PD globally. The effect of existing treatment options commonly fades after some years, and motor-fluctuations and treatment-dependent dyskinesia occur. 过去 25 年间，帕金森病的患病率翻了一番。全球近 1200 万人患有帕金森病。现有治疗方案的效果通常在数年后减弱，并出现运动症状波动和治疗相关的运动障碍。38,39 38，39OpCT-001 OpCT-001Latest updates 最新更新OpCT-001 is an investigational induced pluripotent stem cell (iPSC) derived photoreceptor cell therapy for the treatment of primary photoreceptor diseases. OpCT-001 是一种研究性诱导多能干细胞 (iPSC) 衍生的光感受器细胞疗法，用于治疗原发性光感受器疾病。OpCT-001 has received U.S. FDA Fast Track designation and is progressing in its Phase I/IIa study. The U.S. FDA granted OpCT-001 Orphan Drug Designation for treating retinitis pigmentosa. OpCT-001 已获得美国 FDA 快速通道资格，并正在其 I/IIa 期研究中取得进展。美国 FDA 授予 OpCT-001 治疗视网膜色素变性的孤儿药资格。Why this matters 为什么这很重要Primary photoreceptor diseases are a subgroup of inherited retinal disorders, leading to irreversible vision loss in children and adults. Limited treatment options currently exist for treating primary photoreceptor diseases which affect an estimated 110,000 people in the U.S. alone. 原发性光感受器疾病是遗传性视网膜疾病的一个亚组，会导致儿童和成人不可逆的视力丧失。目前针对影响美国约11万人的原发性光感受器疾病的治疗选择非常有限。40,41,42 40，41，42Advancing innovation across Medical Imaging 推进医学影像领域的创新“Medical imaging is rapidly evolving to become more personalized and integrated into the patient’s journey,” said “医学影像技术正在迅速发展，变得更加个性化，并且融入患者的诊疗过程，”Konstanze Diefenbach 康斯坦策·迪芬巴赫, Head of Radiology R&D at Bayer. “At Bayer, we are pioneering the innovations that drive this evolution – from low-dose contrast agents and smarter, connected workflows to new molecular approaches. By enabling earlier, more accurate diagnosis, we empower clinicians to select precise treatment and improve care for their patients.”. 拜耳放射学研发部门负责人。“在拜耳，我们正在引领推动这一演变的创新——从低剂量对比剂、更智能互联的工作流程到新的分子方法。通过实现更早、更准确的诊断，我们助力临床医生选择精确的治疗方案，改善患者的护理。”Gadoquatrane 加多夸特ранLatest updates 最新更新Gadoquatrane is a next-generation high relaxivity low-dose macrocyclic gadolinium-based MRI contrast agent for detecting and visualizing pathologies in all body regions and the central nervous system in adults and pediatric patients including newborns. Gadoquatrane 是一种新一代高松弛度、低剂量的环状钆基MRI对比剂，用于检测和可视化成人及包括新生儿在内的儿科患者全身各区域及中枢神经系统的病变。Gadoquatrane delivers the lowest gadolinium dose of all macrocyclic MRI contrast agents, with an up to 60 percent gadolinium reduction per procedure compared to current options on the market while maintaining image quality. 加多曲酸提供了所有大环状MRI对比剂中最低的钆剂量，与市场上现有的选择相比，每次操作可减少高达60%的钆使用量，同时保持图像质量。Bayer announced in March 2026 the world’s first approval in Japan under the brand name Ambelvist™. Further submissions to health authorities worldwide are underway. 拜耳公司于2026年3月宣布，该药物已在全球首次获得日本的批准，品牌名为Ambelvist™。目前正向全球其他卫生当局提交申请。Why this matters 为什么这很重要MRI contrast agents support diagnosis, inform treatment, and enable monitoring of a vast variety of diseases. A low-dose MRI contrast agent matters because of reducing patients’ lifetime gadolinium exposure. Health authority guidance and medical societies consistently recommend the lowest gadolinium dose required to achieve diagnostic goals. 磁共振成像（MRI）造影剂辅助诊断、指导治疗并实现对多种疾病的监测。低剂量MRI造影剂之所以重要，是因为它能够减少患者一生中接触钆元素的总量。卫生主管部门和医学协会一致建议使用能达到诊断目的所需的最低钆剂量。This is relevant for all patients and particularly for those requiring multiple MRI examinations, for example with chronic conditions like cancer, as well as for those with renal impairment and for children. For 2024, it is estimated that over 60 million doses of gadolinium-based contrast agents were administered worldwide.. 这与所有患者都相关，尤其是那些需要多次进行核磁共振检查的患者，例如患有癌症等慢性疾病的患者，以及肾功能不全的患者和儿童。据估计，2024年全球使用了超过6000万剂含钆造影剂。43 43Molecular Tracers T-01 and AT-05 分子示踪剂 T-01 和 AT-05Latest updates 最新更新AT-01 and AT-05 are investigational non-invasive pan-amyloid molecular imaging agents specifically designed to detect amyloid deposits with high sensitivity and specificity, supporting accurate diagnosis of cardiac as well as other types of systemic amyloidosis. AT-01 和 AT-05 是研究性的非侵入性泛淀粉样蛋白分子成像剂，专门设计用于高灵敏度和高特异性地检测淀粉样蛋白沉积物，支持对心脏及其他类型的系统性淀粉样变病进行准确诊断。By entering into diagnostic tracers, Bayer reinforces its ambition to expand in molecular imaging, while bolstering its position in precision cardiology. 通过进入诊断示踪剂领域，拜耳加强了其在分子影像领域扩张的雄心，同时巩固了其在精准心脏病学领域的地位。AT-01 (124-Iodine evuzamitide) is a PET (Positron Emission Tomography) tracer and the first amyloid-deposit imaging agent to receive U.S. FDA Breakthrough Therapy Designation for cardiac amyloidosis and has Orphan Drug status in both the U.S. and EU, with its Phase III study having completed dosing.. AT-01（124-碘依夫肽）是一种PET（正电子发射断层扫描）示踪剂，也是首个获得美国FDA突破性疗法认定的心脏淀粉样变性淀粉样沉积成像剂，并在美国和欧盟拥有孤儿药资格，其III期研究已完成给药。AT-05 (99mTc-p5+14) is a SPECT (Single Photon Emission Computed Tomography) tracer currently in Phase I that has the potential to broaden diagnostic options. AT-05（99mTc-p5+14）是一种目前处于第一阶段的SPECT（单光子发射计算机断层扫描）示踪剂，有潜力拓宽诊断选择。Why this matters 为什么这很重要With new therapies emerging for often insufficiently treated conditions, it becomes increasingly relevant to precisely detect and monitor diseases on the molecular level. The development of AT-01 and AT-05 has the potential to address the urgent need for earlier and accurate diagnosis of systemic and specifically cardiac amyloidosis, a currently underdiagnosed and often fatal heart disease that affects more than 400,000 people globally.. 随着针对常被治疗不足的疾病的新疗法不断涌现，精确检测和监测分子水平上的疾病变得越来越重要。AT-01 和 AT-05 的开发有可能满足对系统性淀粉样变，特别是心脏淀粉样变早期且准确诊断的迫切需求。这是一种目前诊断不足且常常致命的心脏病，影响着全球超过 40 万人。44,45 44，45Boosting R&D productivity by synergizing in-house AI with strategic partnerships 通过将内部人工智能与战略合作伙伴关系协同作用，提升研发生产力“Our ambition is to leverage AI to increase R&D productivity by 40 percent by 2030,” said “我们的目标是利用人工智能，到2030年将研发生产力提高40%，”Sai Jasti 萨伊·贾斯蒂, Senior Vice President, Head of Data Science & Artificial Intelligence, Bayer Pharmaceuticals R&D. “By integrating AI platform architecture with anonymized patient-centric data, our data scientists are empowered to maximize our in-house biologics portfolio, validate AI models, and scale solutions, thereby ultimately speeding up drug discovery.”. 拜耳制药研发部高级副总裁，数据科学与人工智能主管表示：“通过将人工智能平台架构与匿名化的以患者为中心的数据相结合，我们的数据科学家能够最大化我们在生物制品领域的内部投资组合，验证人工智能模型并扩展解决方案，从而最终加速药物发现。”Bayer’s strategic partnerships with organizations Vanderbilt University Medical Center in the U.S., FinnGen in Finland, and PRECISE in Singapore, leverage a global ecosystem that combines anonymized data and AI-driven analytics, expediting drug discovery in critical areas like cardiovascular and renal diseases.. 拜耳与美国范德比尔特大学医学中心、芬兰 FinnGen 和新加坡 PRECISE 等机构的战略合作，利用了一个结合匿名数据和人工智能分析的全球生态系统，加速了在心血管和肾脏疾病等关键领域的药物研发进程。Bayer has also recently signed a partnership with Cradle, a company whose platform is designed to compress development timelines and advance higher-quality molecules into clinical development with greater speed and precision. 拜耳最近还与Cradle公司签署了一项合作协议，该公司的平台旨在压缩开发时间，并以更快的速度和更高的精度将更高质量的分子推进到临床开发阶段。Across the value chain, AI is increasingly becoming an integral part of Bayer’s operations. From end-to-end planning across products and worldwide markets to a next-generation suite of agentic tools, employees are empowered with AI-enabled ways of working. 在整个价值链中，人工智能正日益成为拜耳运营的组成部分。从跨产品和全球市场的端到端规划，到新一代的代理工具套件，员工都得到了人工智能赋能的工作方式的支持。About Bayer 关于拜耳Bayer is a global enterprise with core competencies in the life science fields of health care and nutrition. In line with its mission, “Health for all, Hunger for none,” the company’s products and services are designed to help people and the planet thrive by supporting efforts to master the major challenges presented by a growing and aging global population. 拜耳是一家在医疗保健和营养等生命科学领域具有核心竞争力的全球性企业。秉承“人人健康，无人饥饿”的使命，公司通过支持应对不断增长和老龄化全球人口所带来的重大挑战，设计其产品和服务以帮助人类和地球繁荣发展。Bayer is committed to driving sustainable development and generating a positive impact with its businesses. At the same time, the Group aims to increase its earning power and create value through innovation and growth. The Bayer brand stands for trust, reliability and quality throughout the world. In fiscal 2025, the Group employed around 88,000 people and had sales of 45.6 billion euros. 拜耳致力于推动可持续发展，并通过其业务产生积极影响。同时，集团旨在通过创新和增长提高盈利能力并创造价值。拜耳品牌在全球范围内代表信任、可靠性和质量。2025财年，集团拥有约88,000名员工，销售额达456亿欧元。R&D expenses amounted to 5.8 billion euros. For more information, go to . 研发费用总计达58亿欧元。欲了解更多信息，请访问 。www.bayer.com www.bayer.com. 。Find more information at 更多信息请访问https://pharma.bayer.com https://pharma.bayer.comFollow us on Facebook: 在Facebook上关注我们：http://www.facebook.com/bayer http://www.facebook.com/bayerForward-Looking Statements 前瞻性声明This release may contain forward-looking statements based on current assumptions and forecasts made by Bayer management. Various known and unknown risks, uncertainties and other factors could lead to material differences between the actual future results, financial situation, development or performance of the company and the estimates given here. 本发布可能包含基于拜耳管理层当前假设和预测的前瞻性声明。各种已知和未知的风险、不确定性和其他因素可能导致公司实际的未来结果、财务状况、发展或业绩与这里给出的估计存在重大差异。These factors include those discussed in Bayer’s public reports which are available on the Bayer website at . 这些因素包括拜耳公开报告中讨论的因素，该报告可在拜耳网站上查阅。www.bayer.com www.bayer.com. The company assumes no liability whatsoever to update these forward-looking statements or to conform them to future events or developments. 公司不承担任何更新这些前瞻性声明或使其符合未来事件或发展的责任。Bayer AG is a holding company with operating subsidiaries worldwide. References to “Bayer” or “the company” herein may refer to one or more subsidiaries as context requires. 拜耳集团是一家在全球拥有运营子公司的控股公司。文中提到的“拜耳”或“该公司”可能根据上下文需要指代一个或多个子公司。References 参考文献1 1Fredenburgh JC, Weitz JI. Factor XI as a target for new anticoagulants. 弗雷登伯格 JC，魏茨 JI。因子 XI 作为新型抗凝剂的靶点。Hamostaseologie 血液止血学. 2021;41(2):104–110. . 2021;41(2):104–110.2 2Fredenburgh JC, Gross PL, Weitz JI. Emerging anticoagulant strategies. 弗雷登伯格 JC，格罗斯 PL，魏茨 JI。新兴抗凝策略。Blood 血液. 2017;129(2):147–154. . 2017;129(2):147–154.3 3Weitz JI, Chan NC. Advances in antithrombotic therapy. Weitz JI，Chan NC。抗血栓治疗的进展。Arterioscler Thromb Vasc Biol 动脉硬化血栓血管生物. 2019;39(1):7–12. . 2019;39(1):7–12.4 4Feigin VL, et al. World Stroke Organization (WSO): global stroke fact sheet 2022. International Journal of Stroke. 2022 Jan;17(1):18-29. Feigin VL, 等。世界中风组织 (WSO)：2022年全球中风事实表。《国际中风杂志》。2022年1月；17(1): 18-29。5 5National Institute of Neurological Disorders and Stroke. Stroke Overview. 2025. Available at: 国家神经疾病和中风研究所。中风概述。2025年。可访问于： https://www.ninds.nih.gov/health-information/stroke/stroke-overview https://www.ninds.nih.gov/health-information/stroke/stroke-overview. Last accessed: March 2026. 最后访问时间：2026年3月。6 6Kolmos M, Christoffersen L, Kruuse C. Recurrent Ischemic Stroke – A Systematic Review and Meta-Analysis. Kolmos M，Christoffersen L，Kruuse C。复发性缺血性卒中——系统评价与荟萃分析。J Stroke Cerebrovasc Dis J Stroke Cerebrovasc Dis. 2021;30(8):105935. . 2021;30(8):105935.7 7National Cancer Institute. Cancer Stat Facts: Common Cancer Sites. Available at: 国家癌症研究所。癌症统计资料：常见癌症部位。可用地址：https://seer.cancer.gov/ https://seer.cancer.gov/statfacts/html/common.html. Last accessed: March 2026. statfacts/html/common.html。最后访问时间：2026年3月。8 8Bray F, 布拉伊 F，et al 等. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. 2022年全球癌症统计：GLOBOCAN对185个国家36种癌症的全球发病率和死亡率估计。CA Cancer J Clin CA 癌症临床期刊. 2024;74(3):229-63. . 2024；74（3）：229-63。9 9Francis A, et al. Chronic kidney disease and the global public health agenda: an international consensus. Francis A，等。慢性肾脏病与全球公共卫生议程：国际共识。Nat Rev Nephrol 自然综述：肾病学. 2024;20(7), 473-485. . 2024;20(7), 473-485.10 10Savarese G, et al. Global burden of heart failure: a comprehensive and updated review of epidemiology. 萨瓦雷塞 G 等。心力衰竭的全球负担：流行病学的全面和最新综述。Cardiovascular research. 心血管研究。2022;118(17):3272-87. 2022；118（17）：3272-87。11 11World Obesity Federation. World Obesity Atlas 2024. 2024. Available at: https:// data.worldobesity.org/publications/?cat=22. Last accessed: March 2026. 世界肥胖联合会。《世界肥胖地图集2024》。2024年。可访问网址：https://data.worldobesity.org/publications/?cat=22。最后访问时间：2026年3月。12 12Zhou B, et al. Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants. Lancet. 2021;398(10304): 957–80. 周 B 等。1990年至2019年全球高血压流行趋势及治疗与控制进展：对包含1.04亿参与者的1201项代表性人群研究的汇总分析。《柳叶刀》2021;398(10304): 957–80。13 13Ong KL, et al. Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021. Ong KL, 等。1990年至2021年全球、区域和国家糖尿病负担及2050年患病率预测：2021年全球疾病负担研究的系统分析。Lancet. 柳叶刀。2023; 402(10397): 203–34. 2023；402（10397）：203-34。14 14Brauer M, et al. Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet. 2024; 403(10440): 2162 - 2203. Brauer M, 等。1990-2021年全球204个国家和811个次国家级地区88个风险因素的全球负担及证据强度：《2021年全球疾病负担研究》的系统分析。《柳叶刀》。2024; 403(10440): 2162 - 2203。15 15Lam C, et al. Kidney Disease and Heart Failure: Recent Advances and Current Challenges: Conclusions From a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Lam C, 等。肾脏疾病与心力衰竭：近期进展与当前挑战——来自肾脏疾病：改善全球预后（KDIGO）争议会议的结论。J Am Coll Cardiol HF 美国心脏病学会杂志：心力衰竭. 2026:102943. doi: 2026:102943. doi:10.1016/j.jchf.2026.102943 10.1016/j.jchf.2026.102943. 。16 16Acoramidis SmPC. Available at: Acoramidis 药品特性摘要 (SmPC)。可于以下位置获取： https://www.ema.europa.eu/en/documents/product-information/beyonttra-epar-product-information_en.pdf https://www.ema.europa.eu/en/documents/product-information/beyonttra-epar-product-information_en.pdf. Last accessed: March 2026. 最后访问时间：2026年3月。17 17Lauppe RE, et al. Nationwide prevalence and characteristics of transthyretin amyloid cardiomyopathy in Sweden. Open Heart. 2021:8(2):e001755. doi: 10.1136/openhrt-2021-001755. Lauppe RE 等。瑞典全国转甲状腺素蛋白淀粉样变心肌病的患病率及特征。《开放心脏》。2021年；8(2):e001755。doi: 10.1136/openhrt-2021-001755。18 18Jain A, Zahra F. Transthyretin amyloid cardiomyopathy (ATTR-CM). Jain A，Zahra F. 转甲状腺素蛋白淀粉样变心肌病（ATTR-CM）。19 19ClinicalTrials.gov. Efficacy and Safety of AG10 in Subjects With Transthyretin Amyloid Cardiomyopathy (ATTRibute-CM). 2024. Available at: ClinicalTrials.gov。AG10在转甲状腺素蛋白淀粉样变心肌病（ATTRibute-CM）患者中的有效性和安全性。2024。可访问于：https://clinicaltrials.gov/study/NCT03860935 https://clinicaltrials.gov/study/NCT03860935. Last accessed: March 2026. 最后访问时间：2026年3月。20 20https://www.ema.europa.eu/en/documents/orphan-maintenance-report/beyonttra-orphan-designation-withdrawal-assessment-report-initial-authorisation_en.pdf https://www.ema.europa.eu/en/documents/orphan-maintenance-report/beyonttra-孤儿药资格撤销评估报告-初始授权_en.pdf21 21Hill K. The demography of menopause. 希尔 K. 更年期的人口统计学。Maturitas 成熟期. 1996;23(2):113-27. . 1996;23(2):113-27.22 22World Health Organization. Breast cancer. 2025. Available at: 世界卫生组织。乳腺癌。2025。可于以下网址获取：https://www.who.int/news-room/fact-sheets/detail/breast-cancer https://www.who.int/news-room/fact-sheets/detail/breast-cancer. 。Last accessed: March 2026. 最后访问时间：2026年3月。23 23Selli C, et al. Accurate prediction of response to endocrine therapy in breast cancer patients: current and future biomarkers. 塞利 C，等。准确预测乳腺癌患者内分泌治疗反应：当前和未来的生物标志物。Breast Cancer Research 乳腺癌研究 . 2016;18:118. doi: 10.1186/s13058-016-0779-0. . 2016;18:118. doi: 10.1186/s13058-016-0779-0.24 24Burstein HJ, et al. Adjuvant Endocrine Therapy for Women With Hormone Receptor-Positive Breast Cancer: ASCO Clinical Practice Guideline Focused Update. Burstein HJ, 等。激素受体阳性乳腺癌女性的辅助内分泌治疗：ASCO临床实践指南重点更新。Journal of Clinical Oncology 临床肿瘤学杂志. 2019;37(5):423-38. . 2019;37(5):423-38.25 25Cucciniello L, et al. Estrogen deprivation effects of endocrine therapy in breast cancer patients: Incidence, management and outcome. Cucciniello L，等。乳腺癌患者内分泌治疗的雌激素剥夺效应：发生率、管理及结果。Cancer Treatment Reviews 癌症治疗评论. 2023;120:102624. . 2023;120:102624.26 26Freedland SJ, et al. Real-world treatment patterns and overall survival among men with Metastatic Castration-Resistant Prostate Cancer (mCRPC) in the US Medicare population. Freedland SJ 等。美国医疗保险人群中转移性去势抵抗性前列腺癌（mCRPC）男性的实际治疗模式及总生存期。Prostate Cancer Prostatic Dis 前列腺癌前列腺疾病. 2024;27(2):327-33. . 2024;27(2):327-33.27 27Verry C, et al. Pattern of Clinical Progression Until Metastatic Castration-Resistant Prostate Cancer: An Epidemiological Study from the European Prostate Cancer Registry. Verry C, 等。直到转移性去势抵抗性前列腺癌的临床进展模式：来自欧洲前列腺癌登记处的一项流行病学研究。Target Oncol 靶向肿瘤学. 2022;17(4):441-51. . 2022;17(4):441-51.28 28Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. Sung H、Ferlay J、Siegel RL、Laversanne M、Soerjomataram I、Jemal A、Bray F。全球癌症统计2020：GLOBOCAN 对185个国家36种癌症的全球发病率和死亡率估计。CA Cancer J Clin CA 癌症临床期刊. 2021;71(3):209-249. doi: 10.3322/caac.21660. . 2021;71(3):209-249. doi: 10.3322/caac.21660.29 29Vilar E, Gruber SB. Microsatellite instability in colorectal cancer-the stable evidence. Vilar E，Gruber SB。结直肠癌中的微卫星不稳定性——稳定的证据。Nat Rev Clin Oncol 自然综述：临床肿瘤学 . 2010;7(3):153-62. . 2010;7(3):153-62.30 30Linz D, et al. Atrial fibrillation: epidemiology, screening and digital health 林茨D，等。心房颤动：流行病学、筛查与数字健康. 。The Lancet Regional Health – Europe 《柳叶刀区域健康——欧洲》. 2024;37(100786). Volume 37, 100786. . 2024;37(100786). 第37卷，100786页。31 31American Heart Association. Why Atrial Fibrillation Matters. 2025. Available at: 美国心脏协会。为什么心房颤动很重要。2025年。可用地址：https://www.heart.org/en/health-topics/atrial-fibrillation/why-atrial-fibrillation-af-or-afib-matters https://www.heart.org/en/health-topics/atrial-fibrillation/why-atrial-fibrillation-af-or-afib-matters. Last accessed: March 2026. 最后访问时间：2026年3月。32 32Kornej J, et al. Atrial fibrillation: global burdens and global opportunities. Kornej J, 等。心房颤动：全球负担与全球机遇。Heart. 心脏。2021;107:516-18. 2021；107：516-18。33 33Molina JR, et al. Non–Small Cell Lung Cancer: Epidemiology, Risk Factors, Treatment, and Survivorship. 莫利纳 JR，等。非小细胞肺癌：流行病学、风险因素、治疗和生存率。Mayo Clin Proc 梅奥诊所学报. 2008;83(5):584-94. . 2008;83(5):584-94.34 34Yu X, et al. HER2-Altered Non-Small Cell Lung Cancer: Biology, Clinicopathologic Features, and Emerging Therapies. 俞晓峰等。HER2改变的非小细胞肺癌：生物学、临床病理特征及新兴疗法。Front Oncol. 前沿肿瘤学。 2022;12-860313. doi: 10.3389/fonc.2022.860313. 2022;12-860313. doi: 10.3389/fonc.2022.860313.35 35Stephens P, et al. Lung cancer: intragenic ERBB2 kinase mutations in tumours. 斯蒂芬斯 P 等。肺癌：肿瘤内的 ERBB2 激酶基因突变。 Nature. 自然。2004;431(7008):525-26. 2004；431（7008）：525-26。36 36Savarese G, et al. Global burden of heart failure: a comprehensive and updated review of epidemiology. 萨瓦雷塞 G 等。心力衰竭的全球负担：流行病学的全面和最新综述。Cardiovasc Res 心血管研究. 2023;118(17):3272-87. . 2023;118(17):3272-87.37 37Myhre PL, et al. Digital tools in heart failure: addressing unmet needs. Myhre PL, 等。心力衰竭中的数字工具：解决未满足的需求。Lancet Digit Health 柳叶刀数字健康. 2024;6(10):e755-e766. . 2024；6(10):e755-e766。38 38Mayo Clinic. Parkinson’s disease. 2024. Available at: 梅奥诊所。帕金森病。2024。可访问于：https://www.mayoclinic.org/diseases-conditions/parkinsons-disease/diagnosis-treatment/drc-20376062 https://www.mayoclinic.org/diseases-conditions/parkinsons-disease/diagnosis-treatment/drc-20376062. Last accessed: March 2026. 最后访问时间：2026年3月。39 39Luo Y, et al. Global, regional, national epidemiology and trends of Parkinson's disease from 1990 to 2021: findings from the Global Burden of Disease Study 2021. 罗毅等。1990年至2021年全球、区域及国家帕金森病流行病学与趋势：2021年全球疾病负担研究结果。Front Aging Neurosci 衰老神经科学前沿. 2025;16:1498756. doi: 10.3389/fnagi.2024.1498756. . 2025;16:1498756. doi: 10.3389/fnagi/2024.1498756.40 40National Institute on Deafness and Other Communications Disorders. Usher Syndrome. 2017. Available at: 国家耳聋与其他沟通障碍研究所。 usher综合症。 2017。 可用地址：https://www.nidcd.nih.gov/health/usher-syndrome#b https://www.nidcd.nih.gov/health/usher-syndrome#b. Last accessed: March 2026. 最后访问时间：2026年3月。41 41Hamel CP. Cone rod dystrophies. Available at: Hamel CP。锥杆营养不良。可用资源：https://pmc.ncbi.nlm.nih.gov/articles/PMC1808442/ https://pmc.ncbi.nlm.nih.gov/articles/PMC1808442/. Last accessed: March 2026. 最后访问时间：2026年3月。42 42O’Neal TB, et al. Retinitis Pigmentosa. 奥尼尔 TB，等。视网膜色素变性。StatPearls StatPearls. 2024. Available at: . 2024. 可在以下地址获取：https://www.ncbi.nlm.nih.gov/books/NBK519518/ https://www.ncbi.nlm.nih.gov/books/NBK519518/. Last accessed: March 2026. 最后访问时间：2026年3月。43 43Endrikat, J et al. Rationales for Non-standard GBCA Dosing—Low?—High?—When? and Why?: A Literature-based Study. Endrikat, J 等。非标准GBCA剂量的理由——低？高？何时？为什么？：一项基于文献的研究。Investigative Radiology 放射学调查. 2025. doi: 10.1097/RLI.0000000000001259. . 2025. doi: 10.1097/RLI.0000000000001259.44 44Kim M, et al. Comparative Outcomes of a Transthyretin Amyloid Cardiomyopathy Cohort Versus Patients With Heart Failure With Preserved Ejection Fraction Enrolled in the TOPCAT Trial. J Am Heart Assoc. 2023;12(15):e029705. Kim M, 等。转甲状腺素蛋白淀粉样变心肌病队列与TOPCAT试验中射血分数保留的心力衰竭患者的比较结果。《美国心脏协会杂志》。2023；12（15）：e029705。https://doi.org/10.1161/JAHA.123.029705 https://doi.org/10.1161/JAHA.123.029705. 。45 45ClinicalTrials.gov. Efficacy and Safety of AG10 in Subjects With Transthyretin Amyloid Cardiomyopathy (ATTRibute-CM). Available at: ClinicalTrials.gov。AG10在转甲状腺素蛋白淀粉样变心肌病（ATTRibute-CM）患者中的有效性和安全性。可用地址：https://clinicaltrials.gov/study/NCT03860935 https://clinicaltrials.gov/study/NCT03860935. 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