作者: Kyle Potts ; Mathieu J.F. Crupi ; Julia Petryk ; Reza Rezaei ; Nikolas T. Martin ; Xiaohong He ; Stephen Boulton ; Réjean Lapointe ; D. William Cameron ; Douglas J. Mahoney ; Sarah Tucker ; Bradley Austin ; Jean-Francois Cailhier ; Taylor Jamieson ; Zaid Taha ; Emily E.F. Brown ; Sarwat T. Khan ; Ragunath Singaravelu ; Joanna Poutou ; Jack Whelan ; Christiano Tanese de Souza ; Taha Azad ; Abera Surendran ; Ricardo Marius ; Jonathan B. Angel ; Jean-Simon Diallo ; Rebecca Auer ; Jaahnavi Dave ; Carolina S. Ilkow ; Adrian Pelin ; John C. Bell

The coronavirus disease 2019 (COVID-19) pandemic requires the continued development of safe, long-lasting, and efficacious vaccines for preventive responses to major outbreaks around the world, and especially in isolated and developing countries. To combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), we characterize a temperature-stable vaccine candidate (TOH-Vac1) that uses a replication-competent, attenuated vaccinia virus as a vector to express a membrane-tethered spike receptor binding domain (RBD) antigen. We evaluate the effects of dose escalation and administration routes on vaccine safety, efficacy, and immunogenicity in animal models. Our vaccine induces high levels of SARS-CoV-2 neutralizing antibodies and favorable T cell responses, while maintaining an optimal safety profile in mice and cynomolgus macaques. We demonstrate robust immune responses and protective immunity against SARS-CoV-2 variants after only a single dose. Together, these findings support further development of our novel and versatile vaccine platform as an alternative or complementary approach to current vaccines.

1982-01-01·Australian Journal of Biological Sciences

Measurement of Organ Blood Flow using Tritiated Water. II. Uterine Blood Flow in Conscious Pregnant Ewes

Article

作者: Brown, BW ; H Oddy, V ; WJones, A

Total uterine blood flow was measured with a tritiated water (TOH) diffusion method and with radioactive microspheres in six, conscious, pregnant ewes.

1981-01-01·Australian Journal of Biological Sciences

Measurement of Organ Blood Flow Using Tritiated Water. I. Hind Limb Muscle Blood Flow in Conscious Ewes

Article

作者: Jones, AW ; Brown, BW ; Oddy, VH

Blood flow rates to a hind limb preparation, consisting predominantly of muscle, were obtained with tritiated water (TOR) diffusion and radioactive microsphere techniques in four conscious ewes (a total of seven comparisons).

100 项与 TOH-Vac1 相关的药物交易

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