盐酸羟甲唑啉/盐酸丁卡因(Oxymetazoline Hydrochloride/Tetracaine Hydrochloride) - 药物靶点：α1A-AR_在研适应症：麻醉_专利_临床

概要

基本信息

药物类型

小分子化药

别名

KOVANAZE、Kovacaine、Kovacaine Mist

+ [2]

靶点

α1A-AR

作用方式

激动剂

作用机制

α1A-AR激动剂(肾上腺素能受体α-1a激动剂)

治疗领域

其他疾病

在研适应症

麻醉

非在研适应症-

原研机构

St. Renatus LLC

在研机构

St. Renatus LLC

非在研机构-

权益机构-

最高研发阶段批准上市

首次获批日期

美国 (2016-06-29),

麻醉

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C16H25ClN2O

InChIKeyBEEDODBODQVSIM-UHFFFAOYSA-N

CAS号2315-02-8

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关联

4

项与盐酸羟甲唑啉/盐酸丁卡因相关的临床试验

NCT04104789

/ Withdrawn临床2期IIT

Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth: A Randomized Clinical Trial

The primary goal of the study is to compare the success rates of pulpal anesthesia (defined as ability to complete the intended dental procedure without the need for rescue anesthesia) between Kovanaze nasal mist and Articaine needle anesthesia.

开始日期2020-09-01

申办/合作机构

Virginia Commonwealth University

NCT04105985

/ Withdrawn临床2期IIT

Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth: A Randomized Clinical Trial

The primary goal of the study is to compare the success rates of pulpal anesthesia (defined as ability to complete the intended dental procedure without the need for rescue anesthesia) between Kovanaze nasal mist and Articaine needle anesthesia.

开始日期2020-08-01

申办/合作机构

Virginia Commonwealth University

NCT03962634

/ Terminated临床2期IIT

Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth: A Randomized Clinical Trial

The primary goal of the study is to compare the success rates of pulpal anesthesia (defined as ability to complete the intended dental procedure without the need for rescue anesthesia) between Kovanaze nasal mist and Articaine needle anesthesia.

开始日期2019-08-28

申办/合作机构

Virginia Commonwealth University

100 项与盐酸羟甲唑啉/盐酸丁卡因相关的临床结果

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100 项与盐酸羟甲唑啉/盐酸丁卡因相关的转化医学

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100 项与盐酸羟甲唑啉/盐酸丁卡因相关的专利（医药）

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2

项与盐酸羟甲唑啉/盐酸丁卡因相关的文献（医药）

2022-04-01·Anesthesia Progress

Kovanaze Intranasal Spray vs Traditional Injected Anesthetics: a Study of Pulpal Blood Flow Utilizing Laser Doppler Flowmetry

Article

作者: Thayer, Scott ; Odom, Mark ; Peters, Mathilde ; Sabey, Kent A. ; Yu, Qingzhao ; Townsend, Janice A.

Objective:An ideal local anesthetic would be effective, minimally reduce pulpal blood flow (PBF), and not require injection. This study compared the effects of 3% tetracaine plus 0.05% oxymetazoline nasal spray (Kovanaze; KNS) and injections using 2% lidocaine with 1:100,000 epinephrine (LE) or 3% mepivacaine plain (MP) on PBF, anesthetic efficacy, and participant preference.Methods:In a double-blind cross-over design, 20 subjects randomly received a test anesthetic and placebo at each of 3 visits (KNS/mock infiltration; mock nasal spray/LE; or mock nasal spray/MP). Nasal sprays and infiltration apical to a maxillary central incisor were delivered ipsilaterally. PBF was evaluated by laser Doppler flowmetry, and local anesthetic success was assessed with electric pulp testing. Postoperative pain levels, participant preference, and adverse events were also assessed.Results:LE injections demonstrated significant reductions in PBF at all time intervals compared with baseline (P < .05), whereas KNS and MP did not. Pulpal anesthesia success rates were higher for LE (85%) compared with MP (35%) and KNS (5%). Participants reported significantly higher postoperative pain levels for KNS compared with LE and MP. Additionally, KNS was the least preferred of the anesthetics administered and resulted in more reported adverse events.Conclusion:Although KNS showed no significant effect on PBF, it was not effective in achieving pulpal anesthesia as used in this study.

2019-03-01·Journal of Endodontics2区 · 医学

Anesthetic Efficacy of Intranasal 3% Tetracaine plus 0.05% Oxymetazoline (Kovanaze) in Maxillary Teeth

2区 · 医学

Article

作者: Drum, Melissa ; Capetillo, Jeremy ; Nusstein, John ; Reader, Al ; Fowler, Sara ; Beck, Mike

INTRODUCTIONNeedle-free anesthetic delivery is a promising alternative to traditional anesthetic routes of administration. The purpose of this study was to determine the patient preference for and pulpal anesthetic efficacy of a 3% tetracaine plus 0.05% oxymetazoline (Kovanaze) nasal spray in maxillary lateral incisors and first premolars.METHODSFifty adult subjects randomly received a 3% tetracaine plus 0.05% oxymetazoline (Kovanaze) nasal spray and mock infiltration or a mock nasal spray and 2% lidocaine with 1:100,000 epinephrine infiltration at the maxillary lateral incisor or first premolar in 2 appointments spaced at least 1 week apart in a single-blind cross-over design. Pulpal anesthesia was evaluated with an electric pulp tester. Side effects and subject preferences were also recorded.RESULTSAnesthetic success was significantly lower for the Kovanaze nasal spray and mock infiltration (22%-37%) than for the mock nasal spray and lidocaine infiltration (89%-91%). Subjects reported more unwanted effects (nasal drainage and congestion, burning, pressure, and sinus congestion) after the Kovanaze nasal spray and mock infiltration than the mock spray and maxillary infiltration. Before participating in the study, more subjects (56%) preferred the nasal spray route versus a standard infiltration (44%). After experiencing both routes of administration, 100% of subjects preferred the standard infiltration.CONCLUSIONSThe 3% tetracaine plus 0.05% oxymetazoline (Kovanaze) nasal spray provided significantly less successful pulpal anesthesia than the lidocaine infiltration, was less preferable, and caused more unwanted effects.

100 项与盐酸羟甲唑啉/盐酸丁卡因相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	-	N01BA53	-

研发状态

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
麻醉	美国	St. Renatus LLC	2016-06-29

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03962634 (CTgov)	临床2期	根尖周炎 \| 龋齿	3	Kovanaze Nasal Spray (Kovanaze Nasal Spray (Pediatrics))	衊蓋網鹹鏇醖築壓壓淵(廠餘構選窪醖積憲鹹網) = 窪觸觸艱衊鏇壓窪壓齋鏇網鏇願鑰餘願壓衊壓 (願艱遞淵艱糧鹹鹹蓋糧, 窪積夢窪鑰餘窪獵鑰鑰 ~ 網壓鏇齋鏇遞網遞獵襯) 更多	-	2020-11-19
				Articaine Injection (Articaine Injections (Pediatrics))	衊蓋網鹹鏇醖築壓壓淵(廠餘構選窪醖積憲鹹網) = 壓齋衊簾壓築齋鏇選壓鏇網鏇願鑰餘願壓衊壓 (願艱遞淵艱糧鹹鹹蓋糧, 鹽壓壓築選鬱餘觸淵顧 ~ 選獵淵鬱鹽網壓範壓網) 更多
NCT01701505 (CTgov)	临床2期	麻醉	48	400uL of Kovacaine Mist (Kovacaine Mist High Dose)	繭鑰築淵鬱醖襯糧艱淵(鬱餘鏇蓋構鬱憲範壓築) = 齋選選鬱簾窪簾簾範範襯膚繭鬱餘簾簾顧選憲 (艱獵築觸窪簾願醖範築, 蓋夢顧蓋夢廠鏇顧窪襯 ~ 築繭齋衊鹹遞襯衊糧鹽) 更多	-	2017-08-30
				200uL of Kovacaine Mist (Kovacaine Mist Mid Dose)	艱鏇鹹醖壓積憲夢膚獵(糧壓範膚糧糧襯構獵願) = 淵齋築醖獵範簾衊鹹衊廠積廠鏇選襯襯壓範築 (艱壓鏇簾壓繭鹹蓋鏇顧, 構構鏇醖鬱築範艱鹽網 ~ 壓窪艱淵鬱築夢齋衊衊) 更多