The primary goal of the study is to compare the success rates of pulpal anesthesia (defined as ability to complete the intended dental procedure without the need for rescue anesthesia) between Kovanaze nasal mist and Articaine needle anesthesia.

开始日期2020-09-01

申办/合作机构

Virginia Commonwealth University

NCT04105985 / Withdrawn临床2期IIT

Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth: A Randomized Clinical Trial

开始日期2020-08-01

申办/合作机构

Virginia Commonwealth University

NCT03962634 / Terminated临床2期IIT

Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth: A Randomized Clinical Trial

开始日期2019-08-28

申办/合作机构

Virginia Commonwealth University

100 项与盐酸羟甲唑啉/盐酸丁卡因相关的临床结果

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100 项与盐酸羟甲唑啉/盐酸丁卡因相关的转化医学

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100 项与盐酸羟甲唑啉/盐酸丁卡因相关的专利（医药）

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项与盐酸羟甲唑啉/盐酸丁卡因相关的文献（医药）

2022-04-01·Anesthesia Progress

Kovanaze Intranasal Spray vs Traditional Injected Anesthetics: a Study of Pulpal Blood Flow Utilizing Laser Doppler Flowmetry

Article

作者: Odom, Mark ; Thayer, Scott ; Peters, Mathilde ; Sabey, Kent A. ; Yu, Qingzhao ; Townsend, Janice A.

Objective:An ideal local anesthetic would be effective, minimally reduce pulpal blood flow (PBF), and not require injection. This study compared the effects of 3% tetracaine plus 0.05% oxymetazoline nasal spray (Kovanaze; KNS) and injections using 2% lidocaine with 1:100,000 epinephrine (LE) or 3% mepivacaine plain (MP) on PBF, anesthetic efficacy, and participant preference.Methods:In a double-blind cross-over design, 20 subjects randomly received a test anesthetic and placebo at each of 3 visits (KNS/mock infiltration; mock nasal spray/LE; or mock nasal spray/MP). Nasal sprays and infiltration apical to a maxillary central incisor were delivered ipsilaterally. PBF was evaluated by laser Doppler flowmetry, and local anesthetic success was assessed with electric pulp testing. Postoperative pain levels, participant preference, and adverse events were also assessed.Results:LE injections demonstrated significant reductions in PBF at all time intervals compared with baseline (P < .05), whereas KNS and MP did not. Pulpal anesthesia success rates were higher for LE (85%) compared with MP (35%) and KNS (5%). Participants reported significantly higher postoperative pain levels for KNS compared with LE and MP. Additionally, KNS was the least preferred of the anesthetics administered and resulted in more reported adverse events.Conclusion:Although KNS showed no significant effect on PBF, it was not effective in achieving pulpal anesthesia as used in this study.

2019-03-01·Journal of Endodontics2区 · 医学

Anesthetic Efficacy of Intranasal 3% Tetracaine plus 0.05% Oxymetazoline (Kovanaze) in Maxillary Teeth

2区 · 医学

Article

作者: Drum, Melissa ; Capetillo, Jeremy ; Nusstein, John ; Reader, Al ; Fowler, Sara ; Beck, Mike

INTRODUCTIONNeedle-free anesthetic delivery is a promising alternative to traditional anesthetic routes of administration. The purpose of this study was to determine the patient preference for and pulpal anesthetic efficacy of a 3% tetracaine plus 0.05% oxymetazoline (Kovanaze) nasal spray in maxillary lateral incisors and first premolars.METHODSFifty adult subjects randomly received a 3% tetracaine plus 0.05% oxymetazoline (Kovanaze) nasal spray and mock infiltration or a mock nasal spray and 2% lidocaine with 1:100,000 epinephrine infiltration at the maxillary lateral incisor or first premolar in 2 appointments spaced at least 1 week apart in a single-blind cross-over design. Pulpal anesthesia was evaluated with an electric pulp tester. Side effects and subject preferences were also recorded.RESULTSAnesthetic success was significantly lower for the Kovanaze nasal spray and mock infiltration (22%-37%) than for the mock nasal spray and lidocaine infiltration (89%-91%). Subjects reported more unwanted effects (nasal drainage and congestion, burning, pressure, and sinus congestion) after the Kovanaze nasal spray and mock infiltration than the mock spray and maxillary infiltration. Before participating in the study, more subjects (56%) preferred the nasal spray route versus a standard infiltration (44%). After experiencing both routes of administration, 100% of subjects preferred the standard infiltration.CONCLUSIONSThe 3% tetracaine plus 0.05% oxymetazoline (Kovanaze) nasal spray provided significantly less successful pulpal anesthesia than the lidocaine infiltration, was less preferable, and caused more unwanted effects.

100 项与盐酸羟甲唑啉/盐酸丁卡因相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	-	N01BA53	-

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适应症	国家/地区	公司	日期
麻醉	美国	St. Renatus LLC	2016-06-29

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03962634 (CTgov)	临床2期	根尖周炎 \| 龋齿	3	Kovanaze Nasal Spray (Kovanaze Nasal Spray (Pediatrics))	廠構艱壓鏇選簾築願鹽(築遞壓構構艱醖窪顧襯) = 艱鹹鹹鏇淵獵壓廠積窪鹹製鬱衊鹽蓋鑰膚蓋製 (淵膚觸餘襯餘積觸艱衊, 鬱蓋遞憲鹹築鹽製簾艱 ~ 鬱構繭鬱壓壓觸窪鹽蓋) 更多	-	2020-11-19
				Articaine Injection (Articaine Injections (Pediatrics))	廠構艱壓鏇選簾築願鹽(築遞壓構構艱醖窪顧襯) = 構鏇夢蓋範鏇糧構繭壓鹹製鬱衊鹽蓋鑰膚蓋製 (淵膚觸餘襯餘積觸艱衊, 鹹醖製窪蓋觸廠糧繭簾 ~ 鏇鹹蓋艱獵獵鹽廠網憲) 更多
NCT01701505 (CTgov)	临床2期	麻醉	48	400uL of Kovacaine Mist (Kovacaine Mist High Dose)	製蓋夢窪糧糧艱襯網糧(築膚願繭簾遞觸顧選壓) = 鏇壓選繭艱簾簾齋窪築願簾繭蓋網鹹齋衊積選 (鏇範壓繭餘壓鏇網膚艱, 壓鏇夢夢鑰觸鏇憲齋鏇 ~ 網鏇簾夢鏇艱獵夢窪構) 更多	-	2017-08-30
				200uL of Kovacaine Mist (Kovacaine Mist Mid Dose)	襯鹹願淵觸選膚觸夢淵(製壓繭壓襯願壓網簾壓) = 淵襯構鬱廠襯衊積網艱醖窪願積築鏇醖壓鏇製 (構範積廠構範鏇壓顧積, 積蓋蓋醖壓簾築艱獵觸 ~ 觸簾艱膚範構選積夢夢) 更多
NCT01479517 (CTgov)	临床2期	麻醉	30	Kovacaine Mist 0.1 mL x 4 sprays (Kovacaine Mist 0.1 mL x 4 Sprays)	鏇憲夢膚築淵構網選鹹(遞鹹廠願鏇製顧艱膚選) = 齋蓋糧淵獵鑰願廠夢築鏇膚壓壓壓鏇顧積壓構 (獵選獵夢壓憲選衊鹽壓, 衊願繭構積構膚網憲鑰 ~ 鹹夢襯糧製壓壓簾繭選) 更多	-	2016-12-29
				Kovacaine Mist 0.2 mL x 2 sprays (Kovacaine Mist 0.2 mL x 2 Sprays)	鏇憲夢膚築淵構網選鹹(遞鹹廠願鏇製顧艱膚選) = 餘顧衊餘憲淵夢艱繭構鏇膚壓壓壓鏇顧積壓構 (獵選獵夢壓憲選衊鹽壓, 鏇窪構範膚壓遞遞膚遞 ~ 醖夢糧鹽蓋糧築獵築窪) 更多